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| 1 | Preparation, characterization, release kinetics, and in vitro cytotoxicity of calcium silicate cement as a risedronate delivery system显示文摘 | Tianxing Gong Zhiqin Wang Yubiao Zhang Changshan Sun Quanzu Yang Tom Troczynski Urs O. H?feli | 2014 | J Biomed Mater Res2014，，7： | 1 |
| 2 | A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer显示文摘Objective:DNA methylation alterations are early events in carcinogenesis and immune signalling in lung cancer.This study aimed to develop a model based on short stature homeobox 2 gene (SHOX2)/prostaglandin E receptor 4gene (PTGER4) DNA methylation in plasma,appearance subtype of pulmonary nodules (PNs) and low-dose computed tomography (LDCT) images to distinguish early-stage lung cancers.Methods:We developed a multimodal prediction model with a training set of 257 individuals.The performance of the multimodal prediction model was further validated in an independent validation set of 42 subjects.In addition,we explored the association between SHOX2/PTGER4 DNA methylation and driver gene mutations in lung cancer based on data from The Cancer Genome Atlas (TCGA) portal.Results:There were significant differences between the early-stage lung cancers and benign groups in the methylation levels.The area under a receiver operator characteristic curve (AUC) of SHOX2 in patients with solid nodules,mixed ground-glass opacity nodules and pure ground-glass opacity nodules were 0.693,0.497 and 0.864,respectively,while the AUCs of PTGER4 were 0.559,0.739 and 0.619,respectively.With the highest AUC of0.894,the novel multimodal prediction model outperformed the Mayo Clinic model (0.519) and LDCT-based deep learning model (0.842) in the independent validation set.Database analysis demonstrated that patients with SHOX2/PTGER4 DNA hypermethylation were enriched in TP53 mutations.Conclusions:The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs.A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis. | Jing Zhang Haohua Yao Chunliu Lai Xue Sun Xiujuan Yang Shurong Li Yubiao Guo Junhang Luo Zhihua Wen Kejing Tang | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 3 | Selective flotation of chalcopyrite from pyrite via seawater oxidation pretreatment显示文摘The flotation separation of chalcopyrite from pyrite has attracted increasing attention due to the consumption of vast water resources and depressants.This study proposed the seawater oxidation pretreatment for non-depressant flotation separation of chalcopyrite from pyrite,as an effective and environmentally friendly strategy.Without the addition of depressants,seawater oxidation for 3 d effectively depressed pyrite flotation,with the highest recovery difference greater than 70%and a selectivity index greater than 6 between chalcopyrite and pyrite.The surface investigation showed that pyrite surface was more readily oxidized to form hydrophilic Fe oxidants/oxyhydroxides,as compared to that of chalcopyrite.Further UV-visible spectrophotometer and Fourier transform infrared spectrum(FTIR)results indicated that xanthate was less adsorbed onto the treated pyrite surface,resulting in un-floatable particles.Chalcopyrite surface was changed slightly due to seawater oxidation,thereby insignificantly affecting its flotation.The coordination theory was further used to reveal the combination mechanisms between xanthate and pyrite or chalcopyrite.This study therefore provides a promising strategy to effectively separate chalcopyrite from pyrite,especially in the freshwater-deficient area. | Wanqing Li Yubiao Li Zhonghong Wang Xu Yang Wen Chen | 2023 | International Journal of Mining Science and Technology2023，33，10： | 0 |
| 4 | Effect of Metformin on Lactate Metabolism in Normal Hepatocytes under High Glucose Stress in Vitro显示文摘To study the effect of metformin on lactate metabolism in hepatocytes in vitro under high glucose stress.Method:LO2 hepatocytes was cultured in vitro,hepatocytes were randomly divided into blank control group,25 mmol/L glucose solution,27 mmol/L glucose solution,29 mmol/L glucose solution,31 mmol/L glucose solution,33 mmol/L glucose solution,35 mmol/L glucose solution treatment group,after determining the optimal concentration as 31 mmol/L,use 30 mmol/L metformin solution,and then divided into blank control group,normal hepatocytes+the optimal concentration of glucose solution,normal hepatocytes+metformin solution,normal hepatocytes+.The optimal concentration of glucose solution normal hepatocytes+metformin solution,calculate the number of hepatocytes on cell count plate respectively in the 12 h,24 h,48 h,and use the lactic acid kit to determine the lactic acid value of the cell culture medium of normal liver cells+optimal concentration glucose solution and normal liver cells+optimal concentration glucose solution+metformin solution at 12 h,24 h,and 48 h,respectively.Results:There was no significant change in the lactic acid concentration but significant increase in the number of surviving hepatocytes in the high-glycemic control group compared with that in the high-glycemic control group without metformin.Conclusions:Metformin has no significant effect on lactic acid metabolism of hepatocytes under high glucose stress in vitro,and has a protective effect on hepatocytes under high glucose stress.Based on this,it is preliminarily believed that metformin is not the direct factor leading to diabetic lactic acidosis. | Jianhao Wu Qinnan Zhang Yubiao Yang Chunyue Wang Xindi Yue Zhilu Li Pingping Yan | 2021 | Journal of Advances in Medicine Science2021，4，2： | 0 |
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