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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | Cropland cover change in Northeast China during the past 300 years显示文摘Land use/cover change induced by human activities has emerged as a 'global' phenomenon with Earth system consequences. Northeast China is an area where the largest land cultivation activities by migrants have happened in China during the past 300 years. In this paper, methods including documentary data calibration and multi-sourced data conversion model are used to reconstruct historical cropland cover change in Northeast China during the past 300 years. It is concluded that human beings have remarkably changed the natural landscape of the region by land cultivation in the past 300 years. Cropland area has increased almost exponentially during the past 300 years, especially during the past 100 years when the ratio of cropland cover changed from 10% to 20%. Until the middle of the 19th century, the agricultural area was still mainly restricted in Liaoning Province. From the late 19th century to the early 20th century, dramatic changes took place when the northern boundary of cultivation had extended to the middle of Heilongjiang Province. During the 20th century, three agricultural regions with high ratio of cropland cover were formed after the two phases of spatial expansion of cropland area in 1900s—1930s and 1950s—1980s. Since 1930s—1940s, the expansion of new cultivated area have invaded the forest lands especially in Jilin and Heilongjiang Provinces. | YE Yu FANG XiuQi REN YuYu ZHANG XueZhen CHEN Li | 2009 | Science China Earth Sciences2009，52，8： | 21 |
| 3 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 4 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 5 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 6 | A review on photoelectrochemical cathodic protection semiconductor thin films for metals显示文摘Photoelectrochemical(PEC) cathodic protection is considered as an environment friendly method for metals anticorrosion. In this technology, a n-type semiconductor photoanode provides the photogenerated electrons for metal to achieve cathodic protection. Comparing with traditional PEC photoanode for water splitting, it requires the photoanode providing a suitable cathodic potential for the metal, instead of pursuit ultimate photon to electric conversion efficiency, thus it is a more possible PEC technology for engineering application. To date, great efforts have been devoted to developing novel n-type semiconductors and advanced modification method to improve the performance on PEC cathodic protection metals. Herein, recent progresses in this field are summarized. We highlight the fabrication process of PEC cathodic protection thin film, various nanostructure controlling, doping, compositing methods and their operation mechanism. Finally, the current challenges and future potential works on improving the PEC cathodic protection performance are discussed. | Yuyu Bu Jin-Ping Ao | 2017 | Green Energy & Environment2017，2，4： | 12 |
| 7 | Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury显示文摘 | Fang, Fei Yang, Yuyu Yuan, Zhibin Gao, Yuqi Zhou, Jiliang Chen, Qi Xu, Yong | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 12 |
| 8 | MTBAC: A Mutual Trust Based Access Control Model in Cloud Computing显示文摘As a new computing mode,cloud computing can provide users with virtualized and scalable web services,which faced with serious security challenges,however.Access control is one of the most important measures to ensure the security of cloud computing.But applying traditional access control model into the Cloud directly could not solve the uncertainty and vulnerability caused by the open conditions of cloud computing.In cloud computing environment,only when the security and reliability of both interaction parties are ensured,data security can be effectively guaranteed during interactions between users and the Cloud.Therefore,building a mutual trust relationship between users and cloud platform is the key to implement new kinds of access control method in cloud computing environment.Combining with Trust Management(TM),a mutual trust based access control(MTBAC) model is proposed in this paper.MTBAC model take both user's behavior trust and cloud services node's credibility into consideration.Trust relationships between users and cloud service nodes are established by mutual trust mechanism.Security problems of access control are solved by implementing MTBAC model into cloud computing environment.Simulation experiments show that MTBAC model can guarantee the interaction between users and cloud service nodes. | LIN Guoyuan WANG Danru BIE Yuyu LEI Min | 2014 | China Communications2014，11，4： | 12 |
| 9 | Potential influence of water level changes on energy flows in a lake food web显示文摘Large seasonal water-level fluctuations may influence isotopic signatures of primary producers and the types and amounts of these potential food sources accessible to aquatic fauna of Poyang Lake,the largest freshwater lake in China.In this study,the isotopic signatures of primary producers and consumers were determined,stable carbon and nitrogen isotope analysis and mixing models were combined to investigate the influence of water levels on the diet and isotopic composition of Poyang Lake fish and invertebrates.Five potential food sources (seston,benthic organic matter,aquatic macrophytes,attached algae,and terrestrial plants),4 species of invertebrates,and 10 species of fish were collected from the lake area during dry and wet seasons between January 2009 and April 2010.The δ 13C values of invertebrates and most fish were within the range of δ 13C values of the potential food sources for both seasons.The δ 13C values of invertebrates and most fish were lower in the dry season than in the wet season,whereas the δ 15N values exhibited different patterns for different species.Mixing models indicated that the most important food sources for common lake fauna were seston in the dry season and aquatic macrophytes and terrestrial plants in the wet season.The fauna were more omnivorous in the wet season than in the dry season.The food web dynamics of Poyang Lake are strongly influenced by changes in the abundance and accessibility of different basal food sources that occur because of seasonal flood pulses.The trophic links within the aquatic communities of Poyang Lake are modified by water-level fluctuations. | WANG YuYu YU XiuBo LI WenHua XU Jun CHEN YuWei FAN Na | 2011 | Chinese Science Bulletin2011，56，26： | 11 |
| 10 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 11 | Global land-surface air temperature change based on the new CMA GLSAT data set显示文摘The China Meteorological Administration(CMA)has recently developed a new global monthly homogenized land-surface air temperature data set.Based on this data set,we reanalyzed the change in global annual mean land-surface air temperature(LSAT)during three time periods(1901–2014,1979–2014 and 1998–2014).The results show that the linear trends of global annual mean LSAT were 0.104°C/decade,0.247°C/decade and 0.098°C/decade for the three periods,respectively.The trends were statistically significant except for the period 1998–2014,the period that | Xiubao Sun Guoyu Ren Wenhui Xu Qingxiang Li Yuyu Ren | 2017 | Science Bulletin2017，62，4： | 10 |
| 12 | In vivo evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2 diabetics with normoalbuminuria versus microalbuminuria显示文摘这个工作试图估计散开的价值加权的成像(DWI ) 和在有希望地与 normoalbuminuria (NAU ) 对 microalbuminuria (MAU ) 在类型 2 糖尿病的病人检测早阶段的肾损害的散开张肌成像(DTI ) 。有正常的肾功能的 30 个 T2DM 病人的一个总数被招募并且分到 NAU 组(n = 14 ) 或 MAU 组(n = 16 ) 根据 8 h,一夜间尿的蛋白尿排泄率(AER ) 结果。健康检查接受者的一个当代的队作为控制被包括(n = 12 ) 。DWI 和 DTI 扫描用 SE 单个射击的 EPI,和明显的散开系数(模数转换器) 在双边的肾上被执行,肾的实质的部分 anisotropy (FA ) 从模数转换器和三个组的 FA 地图是坚定的。模数转换器和 FA 价值在三个组之中被比较。根据有 400 s/mm 的 b 价值的 DWI <啜class=“ a-plus-plus ”> MAU 和 NAU 组显著地显示出的 2 ,与健康控制相比降低了吝啬的模数转换器价值( P 3 公里<啜class=“ a-plus-plus ”> 2 /s]比的稍微低 NAU 组[( 2.31 b >水平枌?枌?? | Xiaoyan Chen Wenxia Xiao Xinchun Li Jianxun He Xiaochun Huang Yuyu Tan | 2014 | Frontiers of Medicine2014，8，4： | 10 |
| 13 | Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice显示文摘Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism.Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation.Here,we report celastrol,a traditional Chinese medicine,can improve high fat diet-induced metabolic syndrome through suppressing resistin-induced inflammation.Mechanistically,celastrol binds to adenylyl cyclase associated protein 1(CAP1)and inhibits the interaction between CAP1 and resistin,which restrains the cyclic adenylate monophosphate(cAMP)-protein kinase A(PKA)-nuclear factor kappa-B(NF-kB)signaling pathway and ameliorates high fat diet-induced murine metabolic syndrome.Knockdown of CAP1 in macrophages abrogated the resistin-mediated inflammatory activity.In contrast,overexpression of CAP1 in macrophages aggravated inflammation.Taken together,our study identifies celastrol,which directly targets CAP1 in macrophages,might be a promising drug candidate for the treatment of inflammatory metabolic diseases,such as metabolic syndrome. | Yuyu Zhu Ning Wan Xinni Shan Guoliang Deng Qiang Xu Hui Ye Yang Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 9 |
| 14 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 15 | Regulating Zn Deposition via an Artificial Solid–Electrolyte Interface with Aligned Dipoles for Long Life Zn Anode显示文摘Aqueous zinc ion batteries show prospects for next-generation renewable energy storage devices.However,the practical applications have been limited by the issues derived from Zn anode.As one of serious problems,Zn dendrite growth caused from the uncontrollable Zn deposition is unfavorable.Herein,with the aim to regulate Zn deposition,an artificial solid–electrolyte interface is subtly engineered with a perovskite type material,BaTiO3,which can be polarized,and its polarization could be switched under the external electric field.Resulting from the aligned dipole in BaTiO3 layer,zinc ions could move in order during cycling process.Regulated Zn migration at the anode/electrolyte interface contributes to the even Zn stripping/plating and confined Zn dendrite growth.As a result,the reversible Zn plating/stripping processes for over 2000 h have been achieved at 1 mA cm^(−2) with capacity of 1 mAh cm−2.Furthermore,this anode endowing the electric dipoles shows enhanced cycling stability for aqueous Zn-MnO2 batteries.The battery can deliver nearly 100%Coulombic efficiency at 2 Ag^(−1) after 300 cycles. | Kai Wu Jin Yi Xiaoyu Liu Yang Sun Jin Cui Yihua Xie Yuyu Liu Yongyao Xia Jiujun Zhang | 2021 | Nano-Micro Letters2021，13，5： | 8 |
| 16 | On the Design and Temporal Petri Net Verification of Grid Commerce Architecture显示文摘 | DU Yuyue JIANG Changjun | 2008 | Chinese Journal of Electronics2008，17，2： | 6 |
| 17 | Property analysis of logic Petri nets by marking reachability graphs显示文摘 | Yuyue DU Yuhui NING | 2014 | Frontiers of Computer Science2014，8，4： | 6 |
| 18 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 19 | Butterfly distribution of Earth's radiation belt relativistic electrons induced by dayside chorus显示文摘Previous theoretical studies have shown that dayside chorus can produce butterfly distribution of energetic electrons in the Earth's radiation belts by preferentially accelerating medium pitch angle electrons, but this requires the further confirmation from highresolution satellite observation. Here, we report correlated Van Allen Probes data on wave and particle during the 11-13 April,2014 geomagnetic storm. We find that a butterfly pitch angle distribution of relativistic electrons is formed around the location L = 4.52, corresponding to the presence of enhanced dayside chorus. Using a Gaussian distribution fit to the observed chorus spectra, we calculate the bounce-averaged diffusion rates and solve two-dimensional Fokker-Planck equation. Numerical results demonstrate that acceleration by dayside chorus can yield the electron flux evolution both in the energy and butterfly pitch angle distribution comparable to the observation, providing a further evidence for the formation of butterfly distribution of relativistic electrons driven by very low frequency(VLF) plasma waves. | jin yuyue yang chang he yihua liu si zhou qinghua xiao fuliang | 2018 | Science China(Technological Sciences)2018，61，2： | 5 |
| 20 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
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