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| 1 | Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma显示文摘Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was discussed.Methods: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by WB.Results: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated markers.Conclusions: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and invasion.Our study also suggests that POSTN may serve as a therapeutic biomarker in HB patients. | Lu Chen Xiangdong Tian Wenchen Gong Bo Sun Guangtao Li Dongming Liu Piao Guo Yuchao He Ziye Chen Yuren Xia Tianqiang Song Hua Guo | 2019 | Cancer Biology & Medicine2019，16，1： | 3 |
| 2 | Electrospinning direct preparation of SnO2/Fe2O3 heterojunction nanotubes as an efficient visible-light photocatalyst显示文摘 | Zhu Chengquan Li Yuren Su Qing | 2013 | Journal of Alloys and Compounds2013，575，6： | 1 |
| 3 | Numerical and Analytical Modeling ofSwitched Reluctance Machines 显示文摘 | Zhang Zhihui Li Yuren | 2012 | Journal of Computers2012，7，12： | 1 |
| 4 | Preparation and properties of magnetic Fe3O4-chitosan nanoparticles 显示文摘 | Li Guiyin Jiang Yuren Huang Kelong | 2008 | Journal of Alloys and Compounds2008，466，12： | 1 |
| 5 | Numerical and analytical mod-eling of switched reluctance machines显示文摘 | ZHANG Zhihui LI Yuren | 2012 | Journal of Com-puters2012，7，12： | 1 |
| 6 | Molecular Mechanisms of Traditional Chinese Medicine Resculpture Effect on the Process of Tumor Immunoedit ing显示文摘 | Li Jie Lin Hongsheng Wang Xiaotong Zhang Yuren | 2014 | World Science and Technology2014，9，20： | 1 |
| 7 | Research on Voltage Regulator System of Aircraft Power Generation System 显示文摘 | Liang Bo Li Yuren Xu Lei and Lu Jiuli | 2012 | Ad- vances in Mechanics Engineering ( ICMEE2012 )2012，，： | 1 |
| 8 | Electrospinning direct preparation of SnO 2 /Fe 2 O 3 heterojunction nanotubes as an efficient visible-light photocatalyst显示文摘 | Chengquan Zhu Yuren Li Qing Su Bingan Lu Jiaqi Pan Jiawang Zhang Erqing Xie Wei Lan | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 9 | Novel alkyl bis (hydroxycarbamoyl) propionic acids for flotation separation of diaspore against aluminosilicate显示文摘 | Jiang Yuren Li Xinxin Feng Rui | 2012 | Minerals Separation and Purification Technology2012，，5： | 1 |
| 10 | Microrheological Insights into the Dynamics of Amyloplasts in Root Gravity-Sensing Cells显示文摘在察觉到严肃的房间的 Amyloplast 沉积的 Biomechanical 分析。 | Zhongyu Zheng Junjie Zou Hanhai Li Shan Xue Yuren Wang Jie Le | 2015 | Molecular Plant2015，8，4： | 1 |
| 11 | Microstructure and mechanical properties of a novel Zr-based bulk metallic glass composite显示文摘Zr48.5Cu46.5Al5 bulk metallic glass (BMG) com- posites with diameters of 3 and 4 mm were prepared through suction casting in an arc melting furnace by modulating the alloy composition around the monothetic BMG composition of the high glass forming ability. Microstructural charac- terization reveals that the composites contain micron-sized CuZr phase with martensite structure, as well as nano-sized Zr2Cu crystalline particles and Cu10Zr7 plate-like phase em- bedded in an amorphous matrix. Room temperature com- pression tests showed that the composites exhibited signifi- cant strain hardening and obvious plastic strain of 7.7% for 3 mm and 6.4% for 4 mm diameter samples, respectively. | SUN Yufeng WANG Yuren GUO Jian WEI Bingchen LI Weihuo | 2005 | Chinese Science Bulletin2005，50，24： | 1 |
| 12 | Research on Simulation of Aircraft Electro-Hydrostatic Actuator Anti-Skid Braking System显示文摘 | Liang Bo Li Yuren Zhang Zhihui | 2011 | Third International Conference on Measuring Technology and Mechatronics Automation2011，，： | 1 |
| 13 | Preparation of Cu-based Bulk Metallic Glass Matrix Composites显示文摘在 situ 包含的金属性的玻璃(BMG ) 矩阵 composites 形成了的 Cu_(47 )Ti_(34 )Zr_(11 ) Ni_8 体积 TiC 粒子和 delta-TiCu 树突阶段被铜开发模子演员组。composites 的热稳定性和微观结构被调查。房间温度耐压试验表明合成样品展出更高的破裂力量和 0.2 percent-0.5 百分比的不同塑料紧张,把 Ti_(34 ) 与 correspondingCu_(47 ) 的作比较 Zr_(11 ) Ni_8 整体的 BMG。 | Yufeng SUN Yuren WANG Bingchen WEI Weihuo LI | 2006 | Journal of Materials Science & Technology2006，22，1： | 1 |
| 14 | Laser-Induced Recoverable Fluorescence Quenching of Perovskite Films at a Microscopic Grain Scale显示文摘Understanding the fundamental properties of metal-halide perovskite materials is driving the development of novel optoelectronic applications.Here,we report the observation of a recoverable laser-induced fluorescence quenching phenomenon in perovskite films with a microscopic grain-scale restriction,accompanied by spectral variations.This fluorescence quenching depends on the laser intensity and the dwell time under Auger recombination dominated conditions.These features indicate that the perovskite lattice deformation may take the main responsibility for the transient and show a new aspect to understand halide perovskite photostability.We further modulate this phenomenon by adjusting the charge carrier recombination and extraction,revealing that efficient carrier transfer can improve the bleaching resistance of perovskite grains.Our results provide future opportunities to attain high-performance devices by tuning the perovskite lattice disorder and harvesting the energetic carriers. | Yuren Xiang Yameng Cao Wenqiang Yang Rui Hu Sebastian Wood Bowei Li Qin Hu Fan Zhang Jujie He Mozhgan Yavari Jinlai Zhao Yunlong Zhao Jun Song Junle Qu Rui Zhu Thomas P.Russell S.Ravi P.Silva Wei Zhang | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 15 | Mutations in Exons of the CYP17-Ⅱ Gene Affect Sex Steroid Concentration in Male Japanese Flounder(Paralichthys olivaceus)显示文摘As a specific gene of fish,cytochrome P450c17-Ⅱ(CYP17-Ⅱ) gene plays a key role in the growth,development and reproduction level of fish.In this study,the single-stranded conformational polymorphism(SSCP) technique was used to characterize polymorphisms within the coding region of CYP17-Ⅱ gene in a population of 75 male Japanese flounder(Paralichthys olivaceus).Three single nucleotide polymorphisms(SNPs) were identified in CYP17-Ⅱ gene of Japanese flounder.They were c.G594A(p.G188R),c.G939A and c.G1502A(p.G490D).SNP1(c.G594A),located in exon 4 of CYP17-Ⅱ gene,was significantly associated with gonadosomatic index(GSI).Individuals with genotype GG of SNP1 had significantly lower GSI(P < 0.05) than those with geno-type AA or AG.SNP2(c.G939A) located at the CpG island of CYP17-Ⅱ gene.The mutation changed the methylation of exon 6.Indi-viduals with genotype AA of SNP2 had significantly lower serum testosterone(T) level and hepatosomatic index(HSI) compared to those with genotype GG.The results suggested that SNP2 could influence the reproductive endocrine of male Japanese flounder.How-ever,the SNP3(c.G1502A) located in exon 9 did not affect the four measured reproductive traits.This study showed that CYP17-Ⅱ gene could be a potentially useful candidate gene for the research of genetic breeding and physiological aspects of Japanese flounder. | MA Ruiqin HE Feng WEN Haishen LI Jifang SHI Bao SHI Dan LIU Miao MU Weijie ZHANG Yuanqing HU Jian HAN Weiguo ZHANG Jianan WANG Qingqing YUAN Yuren LIU Qun | 2012 | Journal of Ocean University of China2012，11，1： | 0 |
| 16 | Manipulation of Colloidal Droplets in Space and the Instability of Thermocapillary Convection in Large Prandtl Number Liquid Bridge in Microgravity显示文摘In 2016 and 2017, SJ-10 and TG-2 satellites were launched. In this short paper, we report recent progress on the studies of manipulation of colloidal droplets and instability of thermocapillary convection in large Prandtl number liquid bridge that based on the space experiments boarding SJ-10 and TG-2 satellites,separately. It was shown that the colloidal droplets can be successfully formed and manipulated in microgravity through the patterned substrates. In another aspect, the coffee-ring effect was observed at the first time in space. For the studies of the instability of thermocapillary convection in large Prandtl number liquid bridge in microgravity, our experiments in TG-2 broadened the way of such kind of study and abundant experimental results are emerging. | WANG Yuren DUAN Li KANG Qi LAN Ding LI Weibing | 2018 | 空间科学学报2018，38，5： | 0 |
| 17 | Deformation behavior during nanoindentation in Ce-based bulk metallic glasses显示文摘The deformation behavior and the ef- fect of the loading rate on the plastic deformation in Ce-based bulk metallic glasses (BMGs) were inves- tigated through nanoindentation tests. The results showed that the loading rate dependence of plastic deformation during nanoindentation measurements in the Ce-based BMGs is quite unique in contrast to that of other BMG alloys. The load-displacement (P-h) curves of Ce60Al15Cu10Ni15 BMG exhibit a homoge- neous plastic deformation at low loading rates, and a prominent serrated flow at high strain rates, whereas, the P-h curves of Ce65Al10Cu10Ni10Nb5 exhibit ho- mogenous plastic deformation at all studied loading rates. The room temperature creep behavior could clearly be observed in these two alloys. The mecha- nism of the unique plastic deformation feature in the Ce-based BMGs was studied. | ZHANG Lingchen XING Dongmei ZHANG Taihua WEI Bingchen LI Weihuo WANG Yuren | 2006 | Chinese Science Bulletin2006，51，13： | 0 |
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