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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma. | Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS | 2003 | 癌症2003，22，7： | 8 |
| 3 | Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice显示文摘 | Yu S Khor TO Cheung KL | | 0，，： | 1 |
| 4 | Resurfacing tophaceous gout in the foot with anterolateral thigh flap 显示文摘 | Ou KL Tzeng YS Yu CC | 2010 | Microsurgery2010，30，1： | 1 |
| 5 | Venous thromboembolism in southern Chinese patients with systemic lupus erythematosus显示文摘 | Mok CC Ho LY Yu KL | 2010 | Clin Rheumatol2010，29，6： | 1 |
| 6 | Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes显示文摘 | Yu HS Chang KL Yu CL | 1996 | J Invest Dermatol1996，107，4： | 1 |
| 7 | Neuroprotective and anti-in- flammatory activities of atorvastatin in a rat ehronic constriction injury model显示文摘 | Chu LW Chen JY Yu KL | 2012 | Int J Immunopathol Pharmacol2012，25，1： | 1 |
| 8 | CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis显示文摘 | Chen H Fok KL Yu S et a/ | 2011 | Mol Hum Reprod2011，17，7： | 1 |
| 9 | Age-related changes in oxytocin-, arginine vasopressin-and nitric oxide synthase-expressing neurons in the supraoptic nucleus of the rat 显示文摘 | Yu KL Tamada Y Suwa F | 2006 | Life Sei2006，78，10： | 1 |
| 10 | The Hippo pathway: regulators and reg- ulations显示文摘 | Yu FX Guan KL | 2013 | Genes Dev2013，27，4： | 1 |
| 11 | Proto-oncogenes and P53 protein expression in normal cervical stratified squamous epithelium and cervical intra-epithelial neoplasia显示文摘 | Ngan HY LiuSS Yu H Liu KL Cheung AN | 1999 | Eur J Cancer1999，35，10： | 1 |
| 12 | Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy显示文摘 | Yu Jia-shing Christman KL Chin E | 2009 | J Thorac Cardiovasc Surg2009，137，1： | 1 |
| 13 | Calcium influx through hyperpo-larization-activated cation channels ( I (h) channels) contributes to activity-evoked neuronal secretion 显示文摘 | Yu X Duan KL Shang CF | 2004 | Proc Natl Acad Sci USA2004，101，4： | 1 |
| 14 | Glioma stem cell research for the development of immunotherapy显示文摘 | Ji J Black KL Yu JS | | 0，，01： | 1 |
| 15 | HIF-2alpha regulates Oct-4: effects of hypoxia on stern cell function, embryonic development, and tumor growth显示文摘 | Covello KL Kehler J Yu H | 2006 | Genes Dev2006，20，5： | 1 |
| 16 | pH-dependent changes inphotoaffinity labeling patterns of the HI influenza virushemagglutinin by using an inhibitor of viral fusion 显示文摘 | Cianci C Yu KL Dischino DD | 1999 | J Virol1999，73，3： | 1 |
| 17 | HIF-2alpha regulates Oct-4:effects of hypoxia on stem cell function,embryonic development, and tumor growth显示文摘 | Covello KL Kehler J Yu H | 2006 | Genes Dev2006，20，5： | 1 |
| 18 | HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth 显示文摘 | Covello KL Kehler J Yu H | 2006 | Genes Dev2006，20，5： | 1 |
| 19 | Glioma stem cell research for the development of immunotherapy显示文摘 | Ji J Black KL Yu JS | | 0，，01： | 1 |
| 20 | Enhanced iNOS expression inleukocytes and circulating endothelial cells is associated withthe progression of coronary artery lesions in acute Kawasakidisease显示文摘 | Yu X Hirono Kl’Ichida F | 2004 | Pediatr Res2004，55，4： | 1 |
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