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| 1 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 2 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 3 | Effect of emodin and sandostatin on metabolism of eicosanoids in acute necrotizing pancreatitis显示文摘INTRODUCTIONIn order to study the therapeutic mechanisms ofemodin,an extract of Rhubarb (Rhizoma et RadixRhei,a traditional Chinese herbal medicine),andsandostatin in the treatment of acute necrotizingpancreatitis (ANP),we used the two drugs in ratmodels of the disease and observed the changes ofplasma thromboxane-2(TXB2),6-keto-prostaglandin F1α(6-keto-PGF1α)and prostaglandinE2(PEG2). | Jian Xin Wu Jia Yu Xu Yao Zong Yuan | 2000 | World Journal of Gastroenterology2000，6，2： | 19 |
| 4 | Geometric Approach for Kinematic Analysis of a Class of 2-DOF Rotational Parallel Manipulators显示文摘Euler angles are commonly used as the orientation representation of most two degrees of freedom(2-DOF) rotational parallel mechanisms(RPMs),as a result,the coupling of two angle parameters leads to complexity of kinematic model of this family of mechanisms.While a simple analytical kinematic model with respect to those parameters representing the geometrical characteristics of the mechanism,is very helpful to improve the performance of RPMs.In this paper,a new geometric kinematic modeling approach based on the concept of instantaneous single-rotation-angle is proposed and used for the 2-DOF RPMs with symmetry in a homo-kinetic plane.To authors' knowledge,this is a new contribution to parallel mechanisms.By means of this method,the forwards kinematics of 2-DOF RPMs is derived in a simple way,and three cases i.e.4-4R mechanism(Omni-wrist III),spherical five-bar one,and 3-RSR&1-SS one demonstrate the validity of the proposed geometric method.In addition,a novel 2-DOF RPM architecture with virtual center-of-motion is presented by aid of the same method.The result provides a useful tool for simplifying the model and extending the application of the RPMs. | DONG Xin YU Jingjun CHEN Bin ZONG Guanghua | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 11 |
| 5 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 6 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 7 | Numeration and type synthesis of 3-DOF orthogonal translational parallel manipulators显示文摘Low-degree-of-freedom (Low-DOF) parallel manipulators (PMs) have drawn extensive interests, particularly in type synthesis in which two main formal approaches were established by using the reciprocal screw system theory and Lie group theory. This paper aims at numeration and type synthesis of orthogonal translational parallel manipulators (OTPMs) by resorting to an integration of the group- based method and graphical representation of the topology. For this purpose, the concept of Cartesian DOF-characteristic matrix, orig- inated from displacement subgroup and displacement submanifold, is proposed. A new approach based on the combination of the atlas of Cartesian DOF-characteristic matrix and the displacement group-theoretic method is addressed for both exhaustive classi cation and type synthesis of OTPMs. The proposed approach is prone to construct an orthogonal structure and is easy to realize the complete clas- si cation and exhaustive enumeration of this class of low-DOF PMs. | Jingjun Yu Jian S. Dai Shusheng Bi Guanghua Zong | 2008 | Progress in Natural Science:Materials International2008，18，5： | 10 |
| 8 | 基于“酥梨”芽转录组的简单序列重复(SSR)标记开发(英文)显示文摘研究目的:基于转录组数据开发具有扩增率高和跨物种转移性的基因组编码区内的SSR(genic-SSR)标记,为梨属植物的分子系统发育关系和遗传多样性相关研究提供新的方法。创新要点:首次利用梨属植物的转录组测序(RNA-seq)数据结合M-13荧光尾巴高效率地开发了104个genic-SSR标记,并成功将其应用于梨属植物的系统发育关系研究中。研究方法:应用生物信息学软件从转录组测序数据中搜索SSR位点和设计相应引物,结合高效的M-13荧光尾巴的方法筛选多态性高的SSR标记。重要结论:转录组数据能够为梨属植物分子系统发育关系和遗传多样性研究提供新的SSR标记来源。 | Xiao-yan YUE Guo-qin LIU Yu ZONG Yuan-wen TENG Dan-ying CAI | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，4： | 9 |
| 9 | A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics显示文摘作为一个新家庭二维(2D ) nanomaterials,因为高效, MXenes 最近包括精力在万用的应用吸引了许多注意存储和电气化学,而是他们到 biomedicine 的特定的申请很少被报导了特别为 theranostic nanomedicine,即,并发的诊断成像和治疗。这研究第一次显示出表面设计和 2D Ti 3 由 GdW 10-based polyoxometalates (POM ) 的集成的 C 2 MXene nanosheets。这些多功能的 GdW 10@Ti3 C 2 合成 nanosheets 向过高热的治疗提供磁性的回声(先生) 或计算断层摄影术(CT ) 向肿瘤房间或异种皮移植的成像指导。没有进一步的出现,一个肿瘤有效地在观察时期期间被根除。是综合的到 Ti 310 nanoclusters > C 2 nanosheets 被表明基于他们的唯一的作文为提高对比的 CT 和先生成像用作一个对比代理人,因此为诊断成像的指导显示出潜力并且为肿瘤过高热 nanotherapy 监视。在 GdW 10@Ti3 C 2 合成 nanosheets 被表明保证他们的随后的翻译进医疗。这研究为由表面工程和 multifunctionalization 拓宽 MXenes 的生物医学的应用提供新奇策略,它被期望在 nanotheranostics 支持 MXenes 的生物医学的应用的进一步的探索。 | Luyan Zong Huixia Wu Han Lin Yu Chen | 2018 | Nano Research2018，11，8： | 9 |
| 10 | Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice显示文摘Hyperglycemia-caused podocyte injury plays a crucial role in the progress of diabetic kidney disease.Podoplanin,one of the podocyte-associated molecules,is closely related to the integrity of the glomerular filtration barrier.A number of studies demonstrate that berberine could ameliorate renal dysfunction in diabetic mice with nephropathy,but the molecular mechanisms have not been fully elucidated.In this study,we explored the relationship between the renoprotective effect of berberine and podoplanin expression in streptozotocin(STZ)-induced diabetic mice as well as mouse podocytes(MPC5 cells)cultured in high glucose(HG,30 mM)medium.We found that the expression levels of podoplanin were significantly decreased both in the renal glomerulus of STZ-induced diabetic mice and HG-cultured MPC5 cells.We also demonstrated that NF-κB signaling pathway was activated in MPC5 cells under HG condition,which downregulated the expression level of podoplanin,thus leading to increased podocyte apoptosis.Administration of berberine(100,200 mg/kg every day,ig;for 8 weeks)significantly improved hyperglycemia and the renal function of STZ-induced diabetic mice and restored the expression level of podoplanin in renal glomerulus.In high glucose-cultured MPC5 cells,treatment with berberine(30-120μM)dose-dependently decreased the apoptosis rate,increased the expression of podoplanin,and inhibited the activation of NF-κB signaling pathway.When podoplanin expression was silenced with shRNA,berberine treatment still inhibited the NF-κB signaling pathway,but its antiapoptotic effect on podocytes almost disappeared.Our results suggest that berberine inhibits the activation of NF-κB signaling pathway,thus increasing the podoplanin expression to exert renoprotective effects. | Jing Yu Guan-nan Zong Hao Wu Ke-qin Zhang | 2019 | Acta Pharmacologica Sinica2019，40，12： | 8 |
| 11 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of intracerebral haemorrhage显示文摘Aim This evidence-based guideline aims to present current and comprehensive recommendations for the diagnosis and management of spontaneous intracerebral haemorrhage(ICH).Methods A formal literature search was conducted on MEDLINE(1 January 1990 to 30 June 2019).Data were synthesised using evidence tables.The members of the working group met by teleconference to update and formulate data-based recommendations.The recommendations are graded according to levels of evidence grading algorithm of the Chinese Stroke Association.The guideline draft has been reviewed by Chinese Stroke Association Stroke Council Guideline Writing Committee.Results Evidence-based guideline is proposed for the management of patients with ICH.The focus of the guideline is divided into the diagnosis and aetiology of ICH,management of ICH in emergency department,surgical treatment for removal of hematoma,management of complications and prevention of secondary ICH.Conclusions This guideline provides a framework for ICH management.Early active and reasonable treatment may improve the clinical outcome of patients. | Yong Cao Songlin Yu Qian Zhang Tao Yu Yanfang Liu Zhenghui Sun Meng Zhao Wen Wang Ji Zong Zhao | 2020 | Stroke & Vascular Neurology2020，5，4： | 8 |
| 12 | A unified approach to type synthesis of both rigid and flexure parallel mechanisms显示文摘Type synthesis of both rigid and compliant parallel mechanisms has become a hot issue in the field of mechanisms and robotics research in recent years. A unified approach to type synthesis of the two classes of mechanisms, however, has not been referred and investigated up to date. Based on the state-of-art analysis for several major type synthesis approaches related to rigid and compliant mechanisms, respectively, it proves feasible to establish a unified methodology for type synthesis of these two classes of mechanisms. That is a synthesis philosophy in terms of the hierarchy mapping between mathematic, physical, and mechanical building blocks in the framework of screw theory, as addressed in this paper. The key point of the proposed method lies in establishing the mapping among three different building blocks (i.e. geometric building block, kinematic or constraint building block, and mechanical building block). As a result, it makes the whole type synthesis process simple and visible. By using the proposed method, two examples are taken to verify the effectiveness for the type synthesis of both rigid and flexure mechanisms. The content of this paper may provide a theoretical frame for constructing a visualized algorithm or software about the unified type synthesis (or conceptual design) of both rigid and flexure parallel mechanisms. | YU JingJun LI ShouZhong PEI Xu BI ShuSheng ZONG GuangHua | 2011 | Science China(Technological Sciences)2011，54，5： | 8 |
| 13 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 14 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 15 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 16 | Novel Annulus-shaped Flexure Pivot in Rotation Application and Dimensionless Design显示文摘Large-deflection flexure pivot is widely used in high precision rotation application, but there are less flexure configurations and simple and convenient design methods. This paper presents a novel large-deflection curved-compliant annulus-shaped flexure pivot composed of six curved beam flexure elements. It can offer more than 10°angular stroke theoretically. Firstly, main-motion pseudo-rigid-body method is introduced to establish the flexure pivot model. Although pseudo-rigid-body method can be used to analyze the large-deformation flexure pivot performance, the method is definitely a laborious and difficult task for designing this novel flexure pivot. In order to simply the designing process, dimension-design graphs based on the parametric models and finite element analysis is presented. Using the dimension-design method as a tool, the designers can determine the optimal geometry rapidly, based on the stiffness and rotation demands of an annulus-shaped flexure pivot. Finally, dimension-design graph examples are given whose primary design aims to achieve a rotation stroke of annulus-shaped flexure pivot. The finite element analysis results show that the relative designing error between anticipative rotation stroke and graph design result is less than 4%. The dimensionless method used in designing annulus-shaped flexure pivot can reduce design process in both time and complexity. The novel annulus-shaped flexure pivot and dimension-design method are helpful supplement to configuration and design method of large-deflection flexure pivot. | BI Shusheng ZHAO Shanshan SUN Minglei YU Jingjun ZONG Guanghua | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 7 |
| 17 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 18 | Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives显示文摘A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized.Their structures were confrmed by melting points,IR,1H NMR,and elemental analysis and ESI-MS or HRMS.Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 mg/mL,with mortality no less than 95%.Compounds 6a,6c,6f,6l showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 mg/mL.Collectively,our data demonstrate a new strategy for control of insects and viruses. | Yue-Dong Li Wu-Tao Mao Zhi-Jin Fan Juan-Juan Li Zhen Fang Xiao-Tian Ji Xue-Wen Hua Guang-Ning Zong Feng-Yun Li Chao-Lun Liu Jian-Hua Yu | 2013 | Chinese Chemical Letters2013，24，12： | 7 |
| 19 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 20 | Anti-proton contamination design of the imaging energetic electron spectrometer based on Geant4 simulation显示文摘The measurement of energetic particles plays an important role in the space environment monitoring and space weather forecasting.The accuracy of the energetic electron measurement is seriously influenced by the proton contamination.An anti-proton contamination design for the sensor of imaging energetic electron spectrometer is introduced in this paper.According to the electron and proton spectrum on the typical satellite orbits calculated by the radiation belt models,the efficiency of the anti-proton contamination design is estimated by the Geant4 simulation and the design is optimized based on the simulation results. | LUO Lin ZOU Hong ZONG QiuGang WANG LingHua CHEN HongFei SHI WeiHong YU XiangQian | 2015 | Science China(Technological Sciences)2015，58，8： | 7 |
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