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| 1 | Tumor-responsive copper-activated disulfiram for synergetic nanocatalytic tumor therapy显示文摘Exploring alternative biomedical use of traditional drugs in different disease models is highly important as it can reduce the cost of drug development and overcome several critical issues of traditional chemodrugs such as low chemotherapeutic efficiency,severe side effect,and drug resistance.Disulfiram(DSF),a clinically approved alcohol-aversion drug,was recently demonstrated tofeature tumor-growth suppression effect along with the co-administration of Cu^(2+)species,but direct Cu^(2+)administration mode might cause severe toxicity originating from low Cu^(2+)accumulation into the tumor and nonspecific Cu^(2+)distribution-induced cytotoxicity.Based on the intriguing drug-delivery performance of nanoscale metal-organic frameworks(MOFs),we herein construct HKUST nMOFs as the Cu^(2+)self-supplying nanocarriers for efficient delivery of the D SF drug.The mildly acidic condition of tumor microenvironment initially triggered the release of Cu ions from HKUST nMOFs,which further reacted with the encapsulated DSF toform toxic Cu(DDTC)2(activation)for tumor chemotherapy.Especially,during the Cu(DDTC)2 complexation,Cu^(+)species were formed concomitantly,triggering the intratumoral nanocatalytic therapy for the generation of reactive oxygen species to synergistically destroying the tumor cells/tissue.As a result,synergetic tumor-responsive chemotherapy and nanocatalytic therapy are enabled by DSF@HKU ST nanodrugs,as demonstrated by the dominant anticancer efficacy with satisfied biocompatibility both in vitro and in vivo.The present work offers a sophisticated strategy for tumor-responsive nontoxic-to-toxic therapeutic with high biocompatibility. | Hao Chen Xi Li Minfeng Huo Liying Wang Yu Chen Wei Chen Bailiang Wang | 2021 | Nano Research2021，14，1： | 1 |
| 2 | Structural analysis of collapsed, and twisted and collapsed, multiwalled carbon nanotubes by atomic force microscopy 显示文摘 | Kowalewski T Ruoff R | 2001 | Physical Review Letters2001，86，： | 1 |
| 3 | Tensile loading of ropes of single wan carbon rlanotubes and their mechanical properties显示文摘 | Yu Minfeng Files B S Arepalli S | 2000 | Physics Review Letters2000，84，24： | 1 |
| 4 | Tensile loading of ropes of single wall carbon nanotubes and their mechanical properties显示文摘 | Yu Minfeng Files B S Arepalli S | 2000 | Physics Review Letters2000，84，24： | 1 |
| 5 | Strength and breaking mechanism of multi-walled carbon Nanotubes under tensile load 显示文摘 | Oleg Loure Mark J | 2000 | Science2000，287，： | 1 |
| 6 | Nanoscale characterization of isolated individual type I collagen fibrils: polarization and piezoelectricity 显示文摘 | Majid Minary-Jolandan Yu Minfeng | 2009 | Nanotechnology2009，20，8： | 1 |
| 7 | Strength and breaking mechanism of multiwalled carbon nanotubes under tensile load显示文摘 | Yu Minfeng Lourie Oleg Mark J Dyer | 2000 | Science2000，287，： | 1 |
| 8 | One dimensional BaTiO3 nanowire显示文摘 | Wang Zhaoyu Hu Jie Yu Minfeng | 2006 | ADD1 Phvs lett2006，，： | 1 |
| 9 | Vertical,capacitive microelectromechanical switches produced via direct writing of copper wires显示文摘Three-dimensional(3D)direct writing based on the meniscus-confined electrodeposition of copper metal wires was used in this study to develop vertical capacitive microelectromechanical switches.Vertical microelectromechanical switches reduce the form factor and increase the area density of such devices in integrated circuits.We studied the electromechanical characteristics of such vertical switches by exploring the dependence of switching voltage on various device structures,particularly with regard to the length,wire diameter,and the distance between the two wires.A simple model was found to match the experimental measurements made in this study.We found that the electrodeposited copper microwires exhibit a good elastic modulus close to that of bulk copper.By optimizing the 3D structure of the electrodes,a volatile electromechanical switch with a sub-5 V switching voltage was demonstrated in a vertical microscale switch with a gap distance as small as 100 nm created with a pair of copper wires with diameters of~1μm and heights of 25μm.This study establishes an innovative approach to construct microelectromechanical systems with arbitrary 3D microwire structures for various applications,including the demonstrated volatile and nonvolatile microswitches. | Zhiran Yi Jianjun Guo Yining Chen Haiqing Zhang Shuai Zhang Gaojie Xu Minfeng Yu Ping Cui | 2016 | Microsystems & Nanoengineering2016，2，1： | 0 |
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