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| 1 | Relationship between petroleum hydrocarbon and plankton in a mesocosm experiment显示文摘A mesocosm experiment was carried out from May 26 to June 1, 1998 at the location of 30’52’N, 122’36’E, the Changjiang Estuary, in order to measure the influence of petroleum hydrocar- bon to the ecosystem, furthermore, to estimate the environmental capacity. In the experiment, it is found that the petroleum hydrocarbon can, in some degree, enhance the growth of diatom, but inhibit the growth of dinoflagellate. In general, the petroleum hydrocarbon can inhibit the growth of both Phytoplankton and zooplankton, and can the inhibit the growth of total plankton (including phytoplankton and zooplankton) as well. A kinetic model was presented to estimate the uptake/release rate constants of petroleum hydrocarbon by plankton, and thereafter, the uptake and release rate constants (k1, k2), bioconcentration factor (BCF) as well as the petroleum bydrocarbon influenced influenced uptake and release rate constants of nutrients by phytoplankton (kup, krel) were obtained. The results imply that the bioconcentration of petroleum hydrocarbon by plankton is fairly large and petroleum hydrocarbon caused no significant influence on the uptake of N- NO3, but significant influence on that of P -PO4. In addition, the application of kinetic model for the bioconcentration of volatile organic toxic compound by organism suggests that the uptake of petroleum hydrocarbon by plankton was an important process for the environmental capacity of petroleum hydrocarbon. | Shi Xiaoyong, Wang Xiulin, Han Xiurong, Jiang Yu Zhu Mingyuan, Chen Shang, Koshikawa Hiroshi (1. Ocean University of Qingdao, Qingdao 266003, China 2. First Institute of Oceanology, Qingdao 266061, China 3. National Institute for Environmental Studies, Ja | 2001 | Acta Oceanologica Sinica2001，20，2： | 12 |
| 2 | Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy显示文摘AIM:To evaluate the predictive value of the lymph node(LN) ratio(LNR,number of metastatic LNs/ examined LNs) for recurrence in patients with rectal cancer and to compare its applicability according to preoperative chemoradiotherapy(PCRT).METHODS:From 2000 to 2009,967 patients with metastatic LNs after curative resection for locally advanced rectal cancer were identified.Patients were categorized according to PCRT(PCRT vs No PCRT).The cut-off LNR was determined based on the p N1 vs p N2 when the recommended number of LNs was harvested.The 5-year recurrence-free survival(RFS) rates using the Kaplan-Meier method were compared according to p/yp N stage and the LNR in each group.RESULTS:Among patients with the same p/yp N stage,the 5-year RFS rate differed according to the LNR.In addition,the 5-year RFS rate was significantly different between p N and LNR groups in patients with No PCRT.In PCRT group,however,only LNR was associated with prognosis.On multivariate analysis,both p N and LNR were significant independent prognostic factors for 5-year RFS in the No PCRT group.In the PCRT group,only LNR category was found to be associated with RFS(HR = 2.36,95%CI:1.31-3.84,and P = 0.001).CONCLUSION:The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with PCRT.Current p N categories could not discriminate between prognostic groups of RFS after PCRT. | In Ja Park Chang Sik Yu Seok-Byung Lim Yong Sik Yoon Chan Wook Kim Tae Won Kim Jong Hoon Kim Jin Cheon Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 8 |
| 3 | Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease显示文摘AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) patients.METHODS This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 mo.RESULTS During the follow-up period, 66 patients(25.4%) underwent a second operation for disease recurrence.At 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence. | Kwan Mo Yang Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Sang Hyoung Park Byong Duk Ye Suk-Kyun Yang Jin Cheon Kim | 2017 | World Journal of Gastroenterology2017，23，38： | 3 |
| 4 | Intestinal endometriosis:Diagnostic ambiguities and surgical outcomes显示文摘BACKGROUND Endometriosis is a common disease for women of reproductive age. However,when it involves intestines, it is difficult to diagnose preoperatively because its symptoms overlap with other diseases and the results of evaluations can be unspecific. Thus it is important to know the clinical characteristics of intestinal endometriosis and how to exactly diagnose.AIM To analyze patients in whom intestinal endometriosis was diagnosed after surgical treatments, and to evaluate the clinical characteristics of preoperatively misdiagnosed cases.METHODS We retrospectively reviewed the pathologic reports of 30 patients diagnosed as having intestinal endometriosis based on surgical specimens between January2000 and December 2017. We reviewed their clinical characteristics and surgical outcomes.RESULTS Twenty-three(76.6%) patients showed symptoms associated with endometriosis,with dysmenorrhea being the most common(n = 9, 30.0%). Thirteen patients(43.3%) had a history of pelvic surgeries. Ten patients(33.3%) had a history of treatment for endometriosis. Only 4 patients(13.3%) had a diagnosis of endometriosis based on endoscopic biopsy findings. According to preoperative evaluations, 13 patients(43.3%) had an initial diagnosis of pelvic endometriosis and 17 patients(56.6%) were misdiagnosed as having other diseases. The most common misdiagnosis was submucosal tumor in the large intestine(n = 8, 26.7%),followed by malignancies of the colon/rectum(n = 3, 10.0%) and ovary(n = 3,10.0%). According to the Clavien-Dindo classification, 5 complications were grade I or II and 2 complications were grade IIIa. The median follow-up period was 26.9(0.6-132.1) mo, and only 1 patient had a recurrence of endometriosis.CONCLUSION Intestinal endometriosis is difficult to diagnose preoperatively because it mimics various intestinal diseases. Thus, if women of reproductive age have ambiguous symptoms and signs with nonspecific radiologic and/or endoscopic findings,intestinal endometriosis should be included in the differential diagnosis. | Jun Woo Bong Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim | 2019 | World Journal of Clinical Cases2019，7，4： | 3 |
| 5 | Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer显示文摘AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant treatment.RESULTS: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT. | Kyungyeon Hwang In Ja Park Chang Sik Yu Seok-Byung Lim Jong Lyul Lee Yong Sik Yoon Chan Wook Kim Jin Cheon Kim | 2015 | World Journal of Gastroenterology2015，21，2： | 3 |
| 6 | Identification of the polymorphycally expressed CYP2C19 and the wild - type CYP2C19 - ILE359 allele as low- Km catalysts of cyclophosphamide and ifosfamide actication 显示文摘 | Chang TK Yu L Goldstein JA | 1997 | Pharmacogenetics1997，7，： | 1 |
| 7 | Relationship between os?teocalcin and glucose metabolism in postmenopausal women显示文摘 | Im JA Yu BP Jeon JY | 2008 | Clin Chim Acta2008，396，12： | 1 |
| 8 | Effects of interleukin-10(IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat显示文摘 | Plunkett JA Yu CG Easton JM | 2001 | Exp Neurol2001，168，1： | 1 |
| 9 | Serum and urine markers of bone metabolism during the year after hip fracture 显示文摘 | Yu -Yahiro JA Michael RH Dubin NH | 2001 | J Am Geriatr Soc2001，49，： | 1 |
| 10 | Fatal Epstein - Barr Virus Myocarditis in a Child with Repetitive Myocarditis 显示文摘 | Hebert MM Yu C Towbin JA | 1995 | Pediatr Lab Med1995，15，： | 1 |
| 11 | Edge-Preserving Tomographic Reconstruction with Nonlocal Regularization 显示文摘 | Yu DF Fessler JA | 2002 | IEEE Trans Med Imag2002，21，3： | 1 |
| 12 | Caveolin-1 and lipid mi- crodomains regulate Gs trafficking and attenuate Gs/adenylyl cycla- se sigualing显示文摘 | Alien JA Yu JZ Dave RH | 2009 | Mol Pharmacol2009，76，5： | 1 |
| 13 | Fatal Epstein-Barr Vi rus myocarditis in a child with repetitive myocarditis 显示文摘 | Hebert MM Yu C Towbin JA | 1995 | Pediatr Lab Med1995，15，5： | 1 |
| 14 | Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration显示文摘 | Yu JA Deakin NO Turner CE | 2009 | Mol Biol Cell2009，20，： | 1 |
| 15 | Induced pluripo- tent stem cell lines derived from human somatic cells 显示文摘 | Yu J Vodyanik MA Thomson JA | 2007 | Science2007，318，5858： | 1 |
| 16 | Generation of transgenic oriental melon resistant to zucchini yellow mosaic virus by an improved cotyledon-cutting method 显示文摘 | Wu HW Yu TA Raja JA | 2009 | Plant Cell Rep2009，28，7： | 1 |
| 17 | Cll-acetate and F-18FDG PET for men ith prostate cancer bone metastases: relative find- ings and response to therapy显示文摘 | Yu EY Muzi M Hackenbracht JA | 2011 | Clin Nucl Med2011，36，3： | 1 |
| 18 | Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol显示文摘 | Rosato RR Almenara JA Yu C | 2004 | Mol Pharmacol2004，65，3： | 1 |
| 19 | Formation of the structure of chars during devolatilization of pulverized coal and its thermoproperties: A review 显示文摘 | Yu J Lucas JA Wall T F | 2007 | Progress in Energy and Combustion Science2007，，33： | 1 |
| 20 | Group IIa sPLA2inhibition attenuates NF-κB activity and promotes apoptosis oflung cancer cells显示文摘 | Yu JA Kalatardi S Dohse J | 2012 | Anticancer Res2012，32，9： | 1 |
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