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| 1 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 2 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 3 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 4 | Spatiotemporal changes in water,land use,and ecosystem services in Central Asia considering climate changes and human activities显示文摘Central Asia is located in the hinterland of Eurasia,comprising Kazakhstan,Uzbekistan,Kyrgyzstan,Turkmenistan,and Tajikistan;over 93.00%of the total area is dryland.Temperature rise and human activities have severe impacts on the fragile ecosystems.Since the 1970s,nearly half the great lakes in Central Asia have shrunk and rivers are drying rapidly owing to climate changes and human activities.Water shortage and ecological crisis have attracted extensive international attention.In general,ecosystem services in Central Asia are declining,particularly with respect to biodiversity,water,and soil conservation.Furthermore,the annual average temperature and annual precipitation in Central Asia increased by 0.30℃/decade and 6.9 mm/decade in recent decades,respectively.Temperature rise significantly affected glacier retreat in the Tianshan Mountains and Pamir Mountains,which may intensify water shortage in the 21st century.The increase in precipitation cannot counterbalance the aggravation of water shortage caused by the temperature rise and human activities in Central Asia.The population of Central Asia is growing gradually,and its economy is increasing steadily.Moreover,the agricultural land has not been expended in the last two decades.Thus,water and ecological crises,such as the Aral Sea shrinkage in the 21st century,cannot be attributed to agriculture extension any longer.Unbalanced regional development and water interception/transfer have led to the irrational exploitation of water resources in some watersheds,inducing downstream water shortage and ecological degradation.In addition,accelerated industrialization and urbanization have intensified this process.Therefore,all Central Asian countries must urgently reach a consensus and adopt common measures for water and ecological protection. | YU Yang CHEN Xi Ireneusz MALIK Malgorzata WISTUBA CAO Yiguo HOU Dongde TA Zhijie HE Jing ZHANG Lingyun YU Ruide ZHANG Haiyan SUN Lingxiao | 2021 | Journal of Arid Land2021，13，9： | 2 |
| 5 | Trace elements in tree rings and their environmental effects: A case study in Xi’an City显示文摘Using wet digested method and ICP mass spectrometer, we analyzed the concentration of five trace elements (Cd, Mn, P, Zn and Pb) for the tree rings from both urban and suburbs of Xi'an. At the urban sampling site, one Chinese mahogany (Toona sinensis) disc and one phoenix tree (Firmiana simplex) disc were sampled from a steelworks in Xi'an City. At the suburb site, a Chinese mahogany disc was collected from a village in the south of the City. In addition, some soils near the roots of the sampled trees were collected. The analysis results indicate that the concentration of each of the five elements in annual rings has a positive correlation with the production of the steelworks. Statistical calculations show that Pb and Mn elements were stable without lag effects. That means these two elements do not move between rings. Cd displayed one year moving, P two years and Zn three years. These results are quite similar to those found by other methods. | LIU Yu TA WeiYuan BAO TingYi YANG ZengYue SONG HuiMing LIU Na WANG WeiPing ZHANG HongYi ZHANG Wei AN ZhiSheng | 2009 | Science China Earth Sciences2009，52，4： | 2 |
| 6 | Generation of transgenic oriental melon resistant to zucchini yellow mosaic virus by an improved cotyledon-cutting method 显示文摘 | Wu HW Yu TA Raja JA | 2009 | Plant Cell Rep2009，28，7： | 1 |
| 7 | Comparison of phannacokinetics and safety of voriconazole intravenous-to-oral switch in immunocompromised children and healthy adults显示文摘 | DRISCOLL TA YU L C FRANGOUL H | 2011 | Antimicrob Agents Chemother2011，55，12： | 1 |
| 8 | Enhancement of in vitro growth of papaya multishoots by aeration显示文摘 | Lai CC Yu TA Yeh SD | 1998 | Plant Cell Tissue and Organ Culture1998，53，： | 1 |
| 9 | Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells显示文摘 | Yu JJ Robb VA Morrison TA | 2009 | Proc Natl Acad Sci USA2009，106，8： | 1 |
| 10 | Involvement of Bcl-2 family genes and Fas signaling system in primary and secondary male germ cell apoptosis induced by 2-brom oprapane in rat显示文摘 | YU X KUBO ta WANG R | | 0，，01： | 1 |
| 11 | New diagnosis approach to epoxy resin transformer partial discharge using acoustic technology显示文摘 | Li Jung Chen Ta Peng Tsao Yu Hsun Lin | 2005 | IEEE Transa- ctions on Power Delivery2005，20，4： | 1 |
| 12 | Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines显示文摘 | Chung TD Yu JJ Kong TA | 2000 | Prostate2000，42，1： | 1 |
| 13 | Fh3 ligand promotes the generation of a distinct CD34( + )human natural killer cell progenitor that responds to interleukin - 15 显示文摘 | Yu H Fehniger TA Fuchshuber P | 1998 | Blood1998，，92： | 1 |
| 14 | Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells显示文摘 | Yu JJ Robb VA Morrison TA | 2009 | Proc Natl Acad Sci USA2009，106，8： | 1 |
| 15 | chemopreventive and adjuvant therapeutic potential of pomegranate for human breast cancer 显示文摘 | K im ND Meh ta R Yu W | 2002 | Breast Cancer Research and Treatment2002，71，3： | 1 |
| 16 | Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells显示文摘 | Yu JJ Robb VA Morrison TA | 2009 | Proc Natl Acad Sci U S A2009，106，： | 1 |
| 17 | Comparison of culture methods for monitoring legionella species in hospital potable water systems and recommendations for standardization of such method显示文摘 | Ta AC Stout JE Yu VL | 1995 | J Clin Microbiol1995，33，8： | 1 |
| 18 | Interleukin-6 activates phosphatidylinositol-3 kinase,which inhibits apoptosis in human prostate cancer cell lines显示文摘 | Chung TD Yu JJ Kong TA | 2000 | Prostate2000，42，： | 1 |
| 19 | Selected antimicrobial resistance during composting of manure from cattle administered sub-therapeutic antimicrobials 显示文摘 | Sharma R Larney FJ Chen J Yanke LJ Morrison M Topp E McAllister TA Yu Z | 2009 | J Environ Qual2009，38，2： | 1 |
| 20 | Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers 显示文摘 | Yeager MP Colacchio TA Yu CT | 1995 | Anesthesiology1995，83，3： | 1 |
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