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| 1 | Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy显示文摘在这研究,我们在场有 NH 4+2 ultrathin nanosheets 的准备 > 用一个自底向上的热水的方法和在导致光的 photothermal 癌症的这材料的潜在的申请的置闰治疗。我们的结果表明有 150 nm 的一种尺寸的 nanosheets 在宽广在红外线附近的波长区域是高度吸水、展出的强壮的轻吸收和优秀 photostability。在里面 vitro 试验性的结果显示了 nanosheets 的好 biocompatibility。更尤其是,我们的在里面 vivo antitumor 实验说明了从有 808 nm 激光的 2 nanosheets 能高效地杀死的 1T-WS 的照耀发源的那导致光的 photothermal 脱离肿瘤房间;这些效果不仅在细胞的水平而且在老鼠的生活机关被获得。这结果可以在新奇 photothermal 治疗导致二维的分层的材料的新应用,另外的 photothermal 联系领域。 | Qin Liu Chunyang Sun Qun He Adnan Khalil Ting xiang Daobin Liu Yu Zhou Jun Wang Li Song | 2015 | Nano Research2015，8，12： | 6 |
| 2 | Preparation, characterization and electrochemical properties of mesoporous LiFe_(0.99)Mo_(0.01)PO_4/C显示文摘A mesoporous LiFe0.99Mo0.01PO4/C composite was synthesized by the sol-gel method using (NH4)2MoO4 as a doping starting material. The formation of conductive carbon, metal doping and mesopores was achieved simultaneously in the prepared material. The characterizations of crystal structures and microstructures were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), extended X-ray-absorption fine-structure (EXAFS) and X-ray-absorption near-structure spectroscopy (XANES), while the surface area was determined using N2 adsorption techniques. Cyclic voltammetry (CV) and charge-discharge cycling performance were used to characterize its electrochemical properties. The sample possessed uniformly distributed mesopores with an average pore size of 4 nm, and the specific surface area was about 69.368 m2/g. The results show that the reversible capacity of mesoporous LiFe0.99Mo0.01PO4/C is about 160 mAh/g at 0.1C, 135 mAh/g at 1C and 90 mAh/g at 5C, respectively. The capacity fading is neglectable. | YU Chunyang WANG Zhongli CHEN Yu XIA Dingguo CHU Wangsheng WU Ziyuc | 2009 | Rare Metals2009，28，4： | 4 |
| 3 | Expressed sequence tags analysis revealing the taxonomic position and fatty acid biosynthesis in an oleaginous green microalga,Myrmecia incisa Reisigl(Trebouxiophyceae,Chlorophyta)显示文摘cDNA library of Myrmecia incisa H4301 was constructed using λ phage vectors.The library consisted of 1.5×10 6 clones with a recombination rate of 90%,and 1942 clones were randomly sequenced.All 1854 readable expressed sequence tags(ESTs) were clustered into 596 non-redundant sequences(NRSs),among which 126 NRSs were from 1384 ESTs,showing a high redundancy.Among the 596 NRSs,30 were ribosomal RNA,and 152 significantly matched with those available in NCBI database and JGI Genome Portal,the latter were divided into nine subcategories.Overall,59 NRSs were involved in photosynthesis,the respiratory electron transport chain,ATP synthesis,oxidation reduction,fatty acid biosynthesis,glucose metabolism,protein metabolism,and small molecular metabolism,suggesting that these genes were abundantly transcribed during energy and substance metabolism.Acyl-carrier protein,ferrodoxin and fatty acid elongase genes obtained from this cDNA library enabled presumption of a possible biosynthesis pathway of ArA in M.incisa.Codon usage analysis of 142 NRSs with 17798 codons in the predicted coding regions showed that the average G+C content level of the total codons was 55.39%,and that of the third position in base trimers was 66.42%,indicating a strong bias toward cytosine and/or guanosine in this algal genome.Among all synonymous codons,NAG was most favored,while NUA was most avoided.Phylogenic trees inferred from ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit genes and the extra partial sequences of 18S rRNA obtained from this library demonstrated that M.incisa belonged to Trebouxiophyceae and was significantly clustered with M.incisa SAG 2007,Lobosphaera tirolensis,M.bisecta,and Parietochloris incisa,but was clearly distant from P.pseudoalveolaris and P.alveolar.Transmission electron microscopy revealed pyrenoids traversed by many parallel thylakoids membranes,while starch grains were only clearly observed when cells were grown under nitrogen stress.Based on combined investigation of the phylogeny and morphological characteristics,it is proposed that M.incisa be kept in the genus Myrmecia in which there might be two parallel groups,one living freely and another symbiotic species. | OUYANG LongLing DU DaoHai YU ShuiYan LI ChunYang ZHANG ChengWu GAO HongJian ZHOU ZhiGang | 2012 | Chinese Science Bulletin2012，57，25： | 4 |
| 4 | Short-pulsed Raman fiber laser and its dynamics显示文摘We provide a perspective review over the recent development of short-pulsed Raman fiber lasers(RFLs),which can provide laser emissions with flexible wavelengths for a variety of applications as well as an excellent platform to investigate various nonlinear pulse dynamics behaviors that cannot be captured in conventional rare-earth(RE)doped counterparts.Various pulse generation techniques have been explored in RFLs.However,the output pulse performance in terms of the pulse energy,duration and stability from short-pulsed RFLs is still inferior to their RE-doped counterparts despite significant advances made over the past few decades.Therefore,more efforts are required to improve these targets.In this review,we present a detailed overview of the short-pulsed RFLs based on different mechanisms from the principle to the experiment,including the Q-switching,gainswitching,mode-locking,synchronous pumping and other innovative techniques.In addition,Raman-induced pulse dynamics in ultrafast RFLs and RE-doped mode-locked fiber lasers(MLFLs)are briefly reviewed.Finally,a perspective outlook for the future ultrafast RFLs is provided based on their potential applications in industrial and scientific research areas. | Jun Liu Jiadong Wu Hualong Chen Yu Chen Zhenhong Wang Chunyang Ma Han Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，1： | 4 |
| 5 | Testing three pipelines for 18S rDNA-based metabarcoding of soil faunal diversity显示文摘A number of basic and applied questions in ecology and environmental management require the characterization of soil and leaf litter faunal diversity. Recent advances in high-throughput sequencing of barcode-gene amplicons ('metabarcoding') have made it possible to survey biodiversity in a robust and efficient way. However, one obstacle to the widespread adoption of this technique is the need to choose amongst many candidates for bioinformatic processing of the raw sequencing data. We compare three candidate pipelines for the processing of 18S small subunit rDNA metabarcode data from solid substrates: (i) USEARCH/CROP, (ii) Denoiser/UCLUST, and (iii) OCTUPUS. The three pipelines produced reassuringly similar and highly correlated assessments of community composition that are dominated by taxa known to characterize the sampled environments. However, OCTUPUS appears to inflate phylogenetic diversity, because of higher sequence noise. We therefore recommend either the USEARCH/CROP or Denoiser/UCLUST pipelines, both of which can be run within the QIIME (Quantitative Insights Into Microbial Ecology) environment. | YANG ChenXue JI YingQiu WANG XiaoYang YANG ChunYang YU Douglas W. | 2013 | Science China(Life Sciences)2013，56，1： | 2 |
| 6 | Hybrid coordinated strategy of downlink coordinated multi-point transmission显示文摘Coordinated multi-point(CoMP) transmission is put forward in the long term evolution-advanced(LTE-A) system to improve both average and cell-edge throughput. CoMP-joint processing(JP) scheme can get a larger cell-edge throughput and a lower bit error rate(BER) than the CoMP-coordinated beamforming(CB) scheme, but it also has higher complexity due to data sharing. A hybrid coordinated strategy with parameter α, which indicates the proportion of users employing the CoMP-JP scheme,is proposed to apply the CoMP-JP scheme to improve the poorer communication quality of cell edge and employ the CoMP-CB scheme for other users to enhance average throughput and spectral efficiency. This paradigm selects users defined by the certain threshold of signal to interference plus noise power ratio(SINR)corresponding to the parameter α to the CoMP-JP scheme. This paper compares the BER performance between the block diagonalization(BD) based precoding and the linear precoders by maximizing signal to leakage and noise ratio(SLNR), and also indicates that the SLNR based precoding algorithm gets lower BER than the BD based precoding algorithm with certain signal-to-noise ratios(SNRs). Finally, this paper discusses that the system performance is partially affected by the percentage of CoMP-JP users and concludes that 50% of users sorted to communicate under the CoMP-JP scheme will reach the best system performance. | Zhuoming Li Yuqi Liu Yu Zhang Peng Wang Chunyang Tian Xuejun Sha | 2015 | Journal of Systems Science & Complexity2015，28，5： | 2 |
| 7 | A functional hyperbranched binder enabling ultra-stable sulfur cathode for high-performance lithium-sulfur battery显示文摘Binders are of vital importance in stabilizing the cathodes to enhance the cycling stability of lithiumsulfur(Li-S) batteries. However, conventional binders are typically confronted with the drawback of inability for adsorbing lithium polysulfide(Li PS), thus resulting in severe active material losing and rapid capacity fading. Herein, a novel water-soluble hyperbranched poly(amidoamine)(HPAA) binder with controllable hyperbranched molecular structure and abundant amino end groups for Li-S battery is designed and fabricated, which can improve efficient adsorption for Li PS and stability of the sulfur cathodes. Besides, the strong intermolecular hydrogen bonds in HPAA binder can contribute to the structural stability of S cathode and integration of the conductive paths. Therefore, the Li-S battery with this functional binder exhibits excellent cycle performance with a capacity retention of 91% after 200 cycles at 0.1 C.Even at a high sulfur loading of 5.3 mg cm-2, a specific capacity of 601 mA h g-1 can also be achieved.Density functional theory(DFT) calculation further demonstrates that the enhanced electrochemical stability derives from the high binding energy between amino groups and LiP S and the wide electrochemical window(6.87 e V) of HPAA molecule. Based on the above all, this functional polymer will lighten a new species of binders for eco-friendly sulfur cathodes and significantly promote the practical applications of high-performance Li-S batteries. | Xiang Luo Xianbo Lu Xiaodong Chen Ya Chen Chunyang Yu Dawei Su Guoxiu Wang Lifeng Cui | 2020 | Journal of Energy Chemistry2020，29，11： | 2 |
| 8 | Highly conductive polymer nanocomposites for emerging high voltage power cable shields:experiment,simulation and applications显示文摘High voltage power cables play a critical role in global electricity transmission and distribution.The currently used power cables cannot fulfil the green and sustainable requirement of modern society because of the thermoset nature of cable insulation and shields.This study is aimed at developing thermoplastic shields for high voltage power cable,which is one bottleneck restricting the development of environmental-friendly cables.Using carbon black(CB)as the main conductive component and a small amount of carbon nanotubes(CNTs)or graphene as the second filler,highly conductive polypropylene based composite materials were prepared for potential shield applications.It was found that,at a fixed conductive filler loading,the replacement of a small amount CB by CNTs can significantly enhance the electrical conductivity and suppress its temperature dependence.However,when CB was replaced by graphene,only limited enhancement of electrical conductivity could be achieved and the electrical conductivity is still highly dependent on temperature.Dissipative particle dynamics simulations demonstrated that the enhanced conduction property in the CNTs-containing composites could be understood by the shorter average distance between CB and CNTs.Finally,the coordination between the newly developed conductive composites and the environmental-friendly thermoplastic polypropylene insulation was evaluated via high voltage direct current measurements,and the results revealed that the CNTs-containing composites showed excellent suppression effect on the space charge injection and accumulation in the insulation.This research paved a new way for developing environmental-friendly high voltage power cable shields. | Xingyi Huang Boyang Sun Chunyang Yu Jiandong Wu Jun Zhang Pingkai Jiang | 2020 | High Voltage2020，5，4： | 2 |
| 9 | Effects of surface roughness on interfacial dynamic recrystallization and mechanical properties of Ti-6Al-3Nb-2Zr-1Mo alloy joints produced by hot-compression bonding显示文摘The influence of surface roughness on the interfacial dynamic recrystallization kinetics and mechanical properties of Ti-6 Al-3 Nb-2 Zr-1 Mo hot-compression bonding joints was systematically investigated.It is found that for the bonding interface of rough surfaces,elongated fine grains are formed at the bonding interface due to shear deformation of the interfacial area.As the surface roughness increases,the proportion of elongated grains drastically decreases as they further reorient to form equiaxed grains along the bonding interface of rougher surfaces resulting from severe incompatible deformation of the interface area.Meanwhile,high-density geometrically necessary dislocations accumulate around the interfacial recrystallization area to accommodate the incompatible strain and lattice rotation.A rotational dynamic recrystallization mechanism is thereby proposed to rationalize the formation of fine interfacial recrystallization grains during bonding of rough surfaces.In contrast to that of rough surfaces,bonding interface of polished surfaces exists in the form of straight interface grain boundaries without fine grains under the same deformation conditions.While with the increase of deformation strain,small grain nuclei form along the bonding interface,which is associated with discontinuous dynamic recrystallization assisted by strain-induced boundary migration of interface grain boundaries.Moreover,the bonding joints of rough surfaces show lower elongation compared with that of polished surfaces.This is because the formation of heterogeneous fine grains with low Schmid factor along the bonding interface of rough surfaces,leading to worse compatible deformation capability and thereby poor ductility of bonding joints. | Bijun Xie Zhenxiang Yu Haiyang Jiang Bin Xu Chunyang Wang Jianyang Zhang Mingyue Sun Dianzhong Li Yiyi Li | 2022 | Journal of Materials Science & Technology2022，，1： | 2 |
| 10 | A Novel Time-aware Frame Adjustment Strategy for RFID Anti-collision显示文摘Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyzes the deficiencies of the state-of-the-arts algorithms and proposes a novel sub-frame-based algorithm with adaptive frame breaking policy to lower the tag identification time for EPC global C1 Gen2 UHF RFID standard.Through the observation of slot statistics in a sub-frame,the reader estimates the tag quantity and efficiently calculates an optimal frame size to fit the unread tags.Only when the expected average identification time in the calculated frame size is less than that in the previous frame size,the reader starts the new frame.Moreover,the estimation of the proposed algorithm is implemented by the look-up tables,which allows dramatically reduction in the computational complexity.Simulation results show noticeable throughput and time efficiency improvements of the proposed solution over the existing approaches. | Haipeng Chen Kexiong Liu Chunyang Ma Yu Han Jian Su | 2018 | Computers, Materials & Continua2018，，11： | 2 |
| 11 | High-loading single cobalt atoms on ultrathin MOF nanosheets for efficient photocatalytic CO_(2) reduction显示文摘Based on suitable scaffolds,constructing high-loading single-atom catalysts is a promising strategy to achieve highly efficient catalysis.Herein,using ultrathin metal-organic framework(MOF)nanosheets(2.4±0.5 nm)as the support,single-atom catalysts with high cobalt loading(6.0 wt%)were constructed(denoted as Co-MNSs)by a simple bottom-up synthetic strategy.The catalytic system of Co-MNSs exhibited an outstanding photocatalytic CO_(2)-to-CO evolution rate of 7,041μmol g^(-1)h^(-1)and a selectivity of 86%in aqueous media under visible-light irradiation,which has reached the top level of the reported MOF-based photocatalysts.The control experiments and theoretical calculation revealed that the Co-N_(4)moiety in the MOF nanosheets acted as the active site for the photocatalytic CO_(2)-to-CO conversion.The boosted photocatalytic performance could be ascribed to the high aspect-ratio of layered Co-MNSs providing abundant accessible active sites on their surfaces,which reduced the energy barrier,improved the charge separation efficiency,and also facilitated the adsorption of CO_(2)to form the reactive radicals of*COOH.Our study provides an appealing strategy for constructing high-loading single-atom catalysts and demonstrates the significance of 2D ultrathin MOF nanosheets as the support in boosting CO_(2)photoreduction efficiency. | Quan Zuo Rui Cui Lei Wang Yuling Wang Chunyang Yu Liang Wu Yiyong Mai Yongfeng Zhou | 2023 | Science China Chemistry2023，66，2： | 2 |
| 12 | Sex-specific association between coffee consumption and incident chronic kidney disease: a population-based analysis of 359,906 participants from the UK Biobank显示文摘Background:The risk for chronic kidney disease(CKD)is influenced by genetic predisposition,sex,and lifestyle.Previous research indicates that coffee is a potentially protective factor in CKD.The current study aims to investigate whether sex disparity exists in the coffee–CKD association,and whether genetic risk of CKD or genetic polymorphisms of caffeine metabolism affect this association.Methods:A total of 359,906 participants from the UK Biobank who were enrolled between 2006 and 2010 were included in this prospective cohort study,which aimed to estimate the hazard ratios for coffee intake and incident CKD using a Cox proportional hazard model.Allele scores of CKD and caffeine metabolism were additionally adjusted for in a subsample with qualified genetic data(n=255,343).Analyses stratified by genetic predisposition,comorbidities,and sex hormones were performed.Tests based on Bayesian model averaging were conducted to ascertain the robustness of the results.Results:Coffee was inversely associated with CKD in a dose-dependent manner.The effects of coffee did not differ across different strata of genetic risk for CKD,but were more evident among slower genetically predicted caffeine metabolizers.Significant sex disparity was observed(P value for interaction=0.013),in that coffee drinking was only associated with the risk reduction of CKD in females.Subgroup analysis revealed that testosterone and sex hormone-binding globulin(SHBG),but not estradiol,modified the coffee–CKD association.Conclusions:In addition to the overall inverse coffee–CKD association that was observed in the general population,we could also establish that a sex disparity existed,in that females were more likely to experience the benefit of the association.Testosterone and SHBG may partly account for the sex disparity. | Lei Tang Lina Yang Wenwen Chen Chunyang Li Yu Zeng Huazhen Yang Yao Hu Yuanyuan Qu Huan Song Xiaoxi Zeng Ping Fu | 2022 | Chinese Medical Journal2022，，12： | 2 |
| 13 | Preparation of Nano-structured LiFe_xMn_(1-x)PO_4(x=0,0.2,0.4) by Reflux Method and Research on the Influences of Fe(Ⅱ) Substitution显示文摘Nano structured LiFexMn1-xPO4(x=0,0.2,0.4) materials were successfully prepared by one-step reflux method in a water/PEG400 mixed solvent, and were coated by carbon using glucose as the precursor. The materials were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The electrochemical properties of the materials were investigated by galvanostatic cycling, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). It was found that the materials consisted of nanorods with a diameter of 50 nm and a length of 500 nm. Galvanostatic cycling showed that the capacity of LiMnPO 4 could be largely increased by Fe2+ substitution. At a current rate of C/20, the capacity of the three samples (x=0,0.2,0.4) were 47, 107 and 150 mA·h·g-1 , respectively. CV result showed that the Fe2+ substitution could decrease the polarization during charging/discharging, accelerating the electrochemical process. EIS result showed that the Fe2+ substitution could decrease the charge transfer resistance between the electrode and electrolyte, | Zhao Yang Hongming Yu Chunyang Wu Gaoshao Cao Jian Xie Xinbing Zhao | 2012 | Journal of Materials Science & Technology2012，28，9： | 2 |
| 14 | Generalized Twin-Shear Stress Yield Criterion and Its Generalization 显示文摘 | Yu Maohong He Linan Liu Chunyang | 1992 | Chinese Science Bulletin1992，37，64： | 1 |
| 15 | Synthesises, characterizations and electrochemical properties of spherical-like LiFePO4 by hydrothermal method 显示文摘 | Wang Zhongli Su Shaoui Yu Chunyang | 2008 | Journal of Power Sources2008，184，2： | 1 |
| 16 | Fenton Pre-Oxidation Followed by Microbial Degradation for Removing Crude Oil from Contaminated Soil显示文摘Through the Fenton pre-oxidation followed by microbial degradation,this study gave full play to its advantages while avoiding its shortcomings for the remediation of crude oil contaminated soil.The Fenton reagent coupled with different volumes of H2O2 was applied to the oil contaminated soil and then the microbial agents were introduced to biodegrade the residual oil for 15 days.The correlation between the characteristics of residual oil in soil,the changes in soil physical-chemical property after the Fenton pre-oxidation,and the biodegradation were analyzed in this paper.The results show that the above factors are strongly correlated with the subsequent biodegradation rate,and the order of correlation is as follows:the ratio of TOC to NH4+-N(R^2=0.9513)>the ratio of light oil components to the heavy oil components(R^2=0.9095)>the proportion of hydrocarbons with carbon chain number of less than C23(R^2=0.8259)>the crude oil content(R^2=0.7603)>the soil pH(R^2=0.7492)>the number of microorganisms(R^2=0.6506).During the biodegradation and pre-oxidation reactions of heavy oil components,an appropriate C:N ratio turns out to be the most critical factor in this study. | Gao Chunyang Zhang Yu Han Zhantao Song Quanwei Chen Changzhao Chen Hongkun Zheng Jin | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，3： | 1 |
| 17 | Species-specific responses to drought,salinity and their interactions in Populus euphratica and P.pruinosa seedlings显示文摘干旱和盐胁迫是严重的非生物胁迫因子,限制植物的生长和生产力,特别是在沙漠地区。本研究采用两种沙漠杨树—胡杨(Populus euphratica)和灰杨(P.pruinosa)幼苗,比较它们对干旱、盐胁迫和两者交互胁迫的耐受性。研究了在干旱、盐胁迫和交互胁迫下,胡杨和灰杨在生长、光合能力和色素含量、非结构性碳水化合物浓度、Cl−分配、渗透调节和活性氧积累等方面的物种特异性响应。研究结果表明,与胡杨相比,灰杨在干旱、盐胁迫,特别是交互胁迫下表现出更高的生长抑制作用,光合作用下降,气孔关闭和活性氧积累,抗氧化酶活性和渗透调节能力下降。此外,在盐胁迫下,胡杨限制了盐从根部向叶片的转运,并且向粗根分配的Cl−较多,向叶片分配的Cl−较少,而灰杨向叶片分配较多的Cl−。表明这两种杨树存在着物种特异性变化,在干旱、盐胁迫,特别是交互胁迫下,灰杨受到更大的负面作用。因此,在未来干旱和盐胁迫加重的气候环境下,在生态恢复和植树造林时,应考虑这两种杨树对干旱和盐胁迫的物种特异性响应和耐受性。 | Lei Yu Haojie Dong Zhijun Li Zhanjiang Han Helena Korpelainen Chunyang Li | 2020 | Journal of Plant Ecology2020，13，5： | 1 |
| 18 | Evolutionary artificial neural networks: a review显示文摘 | Shifei Ding Hui Li Chunyang Su Junzhao Yu Fengxiang Jin | 2013 | Artificial Intelligence Review2013，，： | 1 |
| 19 | Facile Preparation of Water-Soluble and Cytocompatible Small-Sized Chitosan-Polydopamine Nanoparticles显示文摘 | Yunzhou Ni Feng Chen Leilei Shi Gangsheng Tong Jie Wang Huimei Li Chunyang Yu Yongfeng Zhou | 2017 | Chinese Journal of Chemistry2017，35，6： | 1 |
| 20 | Safety and immunogenicity of a modified COVID-19 mRNA vaccine,SYS6006,as a fourth-dose booster following three doses of inactivated vaccines in healthy adults:an open-labeled Phase 1 trial显示文摘The continuous emergence of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants led to a rapid decline in protection efficacy and neutralizing titers even after three doses of COVID-19 vaccines.Here,we report an open-labeled Phase I clinical trial of a modified mRNA vaccine(SYS6006)as a fourth-dose booster in healthy adults.Eighteen eligible participants,who had completed three doses of inactivated COVID-19 vaccines,received a fourth boosting dose of SYS6006-20μg.Eighteen convalescent COVID-19 patients were enrolled for the collection of serum samples as a comparator of immunogenicity.The primary endpoint of this trial was titers of anti-receptor binding domain of spike glycoprotein(RBD)antibodies of the Omicron strain(BA.2 and BA.4/5)in serum;titers of neutralizing antibodies against pseudovirus of the Omicron strain(BA.2 and BA.4/5).The secondary endpoint was the incidence of adverse events within 30 days after the boosting.The exploratory endpoint was the cellular immune responses(interferon gamma,IFN-γ).This trial was registered with the Chinese Clinical Trial Registry website.No serious adverse events were reported within 30 days after vaccination.No Grade 3 fever or serious adverse event was reported in the SYS6006 group.Notably,SYS6006 elicited higher titers and longer increases in anti-RBD antibodies and neutralizing antibodies(>90 days)compared with the convalescent group(P<0.0001)against Omicron strain(BA.2 and BA.4/5).Besides,higher positive spots of T-cell-secreting IFN-γwere observed in the SYS6006 group than those in the convalescent group(P<0.05).These data demonstrated that SYS6006 was well tolerated and highly immunogenic,generating a stronger and more durable immune response against different variants of SARS-CoV-2. | Yuzhou Gui Ye Cao Jiajin He Chunyang Zhao Wei Zheng Ling Qian Jie Cheng Chengyin Yu Chen Yu Kun Lou Gangyi Liu Jingying Jia | 2023 | Life Metabolism2023，2，3： | 1 |
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