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3篇 您的检索式：作者名="Yosuke Ohtake"

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		题名	作者	年代	出处	被引量
	1	PTEN inhibition and axon regeneration and neural repair显示文摘The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog(PTEN) appears critical to control the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in conditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Importantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury.	Yosuke Ohtake Umar Hayat Shuxin Li	2015	Neural Regeneration Research2015，10，9：	14
	2	Reactive astrocyte scar and axon regeneration:suppressor or facilitator?显示文摘Several major factors are known to contribute to CNS axon regenerative failure after injury,including reduced intrinsic growth capacity of developed neurons and extrinsic factors mediating axon outgrowth.For the latter,a non-permissive environment around the lesion and the lack of sufficient neurotrophic support within the adult CNS play important roles(Sil-	Yosuke Ohtake George M.Smith Shuxin Li	2016	Neural Regeneration Research2016，11，7：	2
	3	The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury显示文摘	Yosuke Ohtake Dongsun Park P.M. Abdul-Muneer Hui Li Bin Xu Kartavya Sharma George M. Smith Michael E. Selzer Shuxin Li	2014	Biomaterials2014，，：	1

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