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| 1 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 2 | Genetic variation in growth traits and stem–branch characteristics and their relationships to Eucalyptus clones显示文摘Eucalyptus has become an important genus in China because it displays adaptability to a wide range of site conditions and produces pulp wood and veneer on short rotations. The aim of this study was to estimate genetic parameters and relationships and consider implications for development of clonal forestry. We assessed growth traits, stem–branch characteristics, crown diameter and height of fresh branch for 20 Eucalyptus hybrid clones in China measured at the age of 44 months. Analysis of variance showed that there were significant differences in growth traits, height of fresh branch and stem straightness among clones. Significant differences in height, volume,crown diameter, height of fresh branch and branch size among replicates were also recorded. Coefficients of variation ranged from 9.84 to 28.54 % for growth traits, 12.03 to 17.25 % for stem–branch characteristics, 18.26 % for crown diameter and 11.73 % for height of fresh branch.Estimates of repeatabilities for height, diameter at breast height over bark, volume, crown diameter, height of fresh branch, stem straightness and branch size at clone mean level were 0.86, 0.80, 0.80, 0.54, 0.85, 0.77 and 0.44 respectively. Diameter at breast height over bark and height had strongly positive phenotypic and genotypic correlations with volume, ranging from 0.96 to 1.00. The positive genotypic and phenotypic correlations between growth traits and other studied traits suggested that fast growing clones always had bigger crown diameter, higher height of fresh branch, straighter stems and relatively smaller branches. | Shijun Wu Zhaohua Lu Jianmin Xu Guangchao Chen Yingan Zhu Guangyou Li | 2015 | Journal of Forestry Research2015，26，4： | 2 |
| 3 | Classification of lactic acid bacteria isolated from chigee and mare milk collected in Inner Mongolia显示文摘 | YingAn Yoshikazu Adachi Yasuki Ogawa | 2004 | Animal science journal2004，75，3： | 1 |
| 4 | A novel ant colony system based on traditional Chinese medicine theory显示文摘 | Wang Chaoxue Cui Yingan Li Xue etal | 2006 | Inter- national Journal of Computer Science and Network Security2006，6，5： | 1 |
| 5 | Self-assembled 3-D Flower-shaped SnO2 Nanostructures with Improved Electrochemical Performance for Lithium Storage显示文摘 | YANG Rong GUA Yingan LI Yaoqi | 2010 | Acta Mater2010，58，： | 1 |
| 6 | Overexpression of FADD enhances 5-fluorouracil-induced apoptosis in colorectal adenocarcinoma cells显示文摘 | Anning Yin Yingan Jiang Xianfeng Zhang Hesheng Luo | 2010 | Medical Oncology2010，，2： | 1 |
| 7 | Numerical Investi- gation of the Effect of Rotors? Geometric Structure on Mixing Properties of Continuous Mixer显示文摘 | YingAn Weimin Yang Yumei Ding | 2012 | Engineering Materials2012，501，： | 1 |
| 8 | Surface modelling of human population distribution in China显示文摘 | Yue Tianxiang Wang Yingan Liu Jiyuan | 2005 | Ecological Modelling2005，181，4： | 1 |
| 9 | MSPD scenarios of spatial distribution of human population in China 显示文摘 | Yue Tianxiang Wang Yingan Liu Jiyuan | 2005 | Population and Environment2005，26，3： | 1 |
| 10 | Numerical simulation of population distribution in China显示文摘 | YUE Tianxiang WANG Yingan CHEN Shupeng | 2003 | Population andEnvironment2003，25，2： | 1 |
| 11 | Growth Differentiation Factor-5 Stimulates the Growth and Anabolic Metabolism of Articular Chondrocytes显示文摘 | Xu Peng Yao Jianfeng Guo Xiong Zhang Yingan Klaus yon der Mark | 2009 | 美中国际创伤杂志2009，8，1： | 1 |
| 12 | Surface modeling of human population distribution in China 显示文摘 | Yue Tianxiang Wang Yingan Liu jiyuan | 2005 | Ecological Modelling2005，181，4： | 1 |
| 13 | Effects of the phytoplanktivorous silver carp ( Hypophthalmichthys molitrixon ) on plankton and the hepatotoxic microcystins in an enclosure experiment in a eutrophic lake, Lake Shichahai in Beijing显示文摘 | Xia Zhang Ping Xie Le Hao Nichun Guo Yingan Gong Xiulin Hu Jun Chen Gaodao Liang | 2006 | Aquaculture2006，，1： | 1 |
| 14 | Present Situation of Eucalypts Breeding and Future Prospect in China显示文摘Breeding is the major procedure in forest research.The basic goal in all of breeding program is to expand the frequency of favorable alleles or the frequency of specific combinations of favorable alleles in the breeding populations through recurrent selection in order to improve the performance of individual plants.During the past three decades,an increase in research on breeding has improved Eucalyptus productivity,and to some extent our standing of their effects on tree growth and on wood properties.Unfortunately,very little information about breeding on the review of Eucalyptus grown in China has been published even though this species was introduced some 120 years ago.This paper reviews the available information regarding research status and prospect of breeding under Chinese ecological conditions and to outline some suggestions to them.According to the present research situation of breeding,we would recommend that:generalizing empirical and useful practices;developing highvalue products;creating more clones for demand;carrying out intensively research over different species and clones for different cultivation goals at different sites over time;above all,applying breeding strategy,especially for multiple generations and interspecific hybrid breeding. | Shijun Wu Jianmin Xu Zhaohua Lu Guangchao Chen Yingan Zhu Wenzhong Guo Peining Song | 2015 | 林学研究进展(中英文版)2015，3，2： | 0 |
| 15 | Growth Traits of Toona Ciliata under Different Fertilization Levels in Guangdong Province显示文摘Toona ciliate,which belongs to Toona of Meliaceae,is a rare and native timber species in China.However,little progress has been made in the cultivation of Toona ciliate.The height and diameter at breast height of Toona ciliata were assessed for fertilization cultivation techniques aged 1 year.Analysis of variance showed that there were significant differences on height among different treatments and replicates and the difference on diameter at breast height among different replicate was also significantly.Treatment with 200 g urea(N>46.5%)+60 g superphosphate(P2O5>12.0%)+100 g potassium chloride(K2O>60.0%)could improve the height and diameter at breast height of Toona ciliate.In summary,more fertilizer could not always improve the growth traits and the site location could affect the growth significantly,therefore more test trials should be carried out before diffusion. | Shijun Wu Jianmin Xu Guangchao Chen Yang Hu Guangyou Li Yingan Zhu Xiaoling Chen | 2016 | 林学研究进展(中英文版)2016，4，1： | 0 |
| 16 | Dirichlet process and its developments: a survey显示文摘The core of the nonparametric/semiparametric Bayesian analysis is to relax the particular parametric assumptions on the distributions of interest to be unknown and random,and assign them a prior.Selecting a suitable prior therefore is especially critical in the nonparametric Bayesian fitting.As the distribution of distribution,Dirichlet process(DP)is the most appreciated nonparametric prior due to its nice theoretical proprieties,modeling flexibility and computational feasibility.In this paper,we review and summarize some developments of DP during the past decades.Our focus is mainly concentrated upon its theoretical properties,various extensions,statistical modeling and applications to the latent variable models. | Yemao XIA Yingan LIU Jianwei GOU | 2022 | Frontiers of Mathematics in China2022，17，1： | 0 |
| 17 | IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis显示文摘Background and Aims:Liver cirrhosis can lead to liver failure and eventually death.Macrophages are the main contributors to cirrhosis and have a bidirectional role in regulating matrix deposition and degradation.Macrophage-based cell therapy has been developed as an alternative to liver transplantation.However,there is insufficient evidence regarding its safety and efficacy.In this study,we aimed to explore the effect of combining insulin-like growth factor 2(IGF2)with bone marrow-derived macrophages(BMDMs)to treat mice with liver cirrhosis.Methods:We assessed liver inflammation,fibrosis regression,liver function,and liver regeneration in mice with CCl4-induced cirrhosis and treated with BMDM only or IGF2+BMDM.We performed in vitro experiments in which activated hepatic stellate cells(HSCs)were co-cultured with macrophages in the presence or absence of IGF2.The polarity of macrophages and the degree of inhibition of HSCs were examined.The effect of IGF2 on macrophages was also verified by the overexpression of IGF2.Results:Combining IGF2 with BMDM reduced liver inflammation and fibrosis and increased hepatocyte proliferation.Combining IGF2 with BMDM was more effective than using BMDM alone.In vitro experiments demonstrated that IGF2 inhibited HSCs activation by upregulating NR4A2 to promote the anti-inflammatory macrophages phenotype.IGF2 also increased the synthesis of matrix metalloproteinases(MMPs)by macrophages,which may explain why administering IGF2 combined with BMDM was more effective than administering BMDM only.Conclusions:Our study provides a theoretical basis for the future use of BMDM-based cell therapy to treat liver cirrhosis. | Lichao Yao Xue Hu Mengqin Yuan Qiuling Zhang Pingji Liu Lian Yang Kai Dai Yingan Jiang | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
| 18 | Developing, testing and application of rodent population dynamics and capture models based on an adjusted Leslie matrix-based population approach显示文摘 | Liyong Fu Shouzheng Tang Yingan Liu Ram P. Sharma Huiru Zhang Yuancai Lei Hong Wang Xinyu Song | 2014 | International Journal of Biomathematics2014，7，3： | 0 |
| 19 | Mitochondrial dysfunction: A promising therapeutic target for liver diseases显示文摘The liver is an important metabolic and detoxification organ and hence demands a large amount of energy,which is mainly produced by the mitochondria.Liver tissues of pa-tients with alcohol-related or non-alcohol-related liver diseases contain ultrastructural mito-chondrial lesions,mitochondrial DNA damage,disturbed mitochondrial dynamics,and compromised ATP production.Overproduction of mitochondrial reactive oxygen species in-duces oxidative damage to mitochondrial proteins and mitochondrial DNA,decreases mito-chondrial membrane potential,triggers hepatocyte inflammation,and promotes programmed cell death,all of which impair liver function.Mitochondrial DNA may be a poten-tial novel non-invasive biomarker of the risk of progression to liver cirrhosis and hepatocellular carcinoma in patients infected with the hepatitis B virus.We herein present a review of the mechanisms of mitochondrial dysfunction in the development of acute liver injury and chronic liver diseases,such as hepatocellular carcinoma,viral hepatitis,drug-induced liver injury,alcoholic liver disease,and non-alcoholic fatty liver disease.This review also discusses mito-chondrion-centric therapies for treating liver diseases. | Ping Chen Lichao Yao Mengqin Yuan Zheng Wang Qiuling Zhang Yingan Jiang Lanjuan Li | 2024 | Genes & Diseases2024，11，3： | 0 |
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