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| 1 | Back propagation artificial neural network for community Alzheimer's disease screening in China显示文摘Alzheimer's disease patients diagnosed with the Chinese Classification of Mental Disorders diagnostic criteria were selected from the community through on-site sampling. Levels of macro and trace elements were measured in blood samples using an atomic absorption method, and neurotransmitters were measured using a radioimmunoassay method. SPSS 13.0 was used to establish a database, and a back propagation artificial neural network for Alzheimer's disease prediction was simulated using Clementine 12.0 software. With scores of activities of daily living, creatinine, 5-hydroxytryptamine, age, dopamine and aluminum as input variables, the results revealed that the area under the curve in our back propagation artificial neural network was 0.929 (95% confidence interval: 0.868-0.968), sensitivity was 90.00%, specificity was 95.00%, and accuracy was 92.50%. The findings indicated that the results of back propagation artificial neural network established based on the above six variables were satisfactory for screening and diagnosis of Alzheimer's disease in patients selected from the community. | Jun Tang Lei Wu Helang Huang Jiang Feng Yefeng Yuan Yueping Zhou Peng Huang Yan Xu Chao Yu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 2 | Comparison study on strategies to prepare nanocrystalline Li2ZrO3-based absorbents for CO2 capture at high temperatures显示文摘比较研究在策略上被进行了因为为 CO2 的综合 nanocrystalline Li2ZrO3 和 Kdoped Li2ZrO3 吸收剂在高温度捕获,包括固态并且液体阶段方法,柠檬酸盐线路,和帮助淀粉的大音阶的第五音胶化方法与 freeze-drying 结合了技术。包括举起率和吸收能力,吸收性质被 thermogravimetric 分析(TGA ) 在不同 CO2 部分压力综合吸收剂调查。nanosized Li2ZrO3 晶体由柠檬酸盐线路展览综合了更快的举起并且一更高,将近, stoichiometric 吸收能力比那些综合了由固态并且液体阶段方法。做 K 进 Li2ZrO3 能显著地改进 CO2 的举起率,特别在低 CO2 部分压力。为做 K 的 Li2ZrO3 的合成,而帮助淀粉的大音阶的第五音胶化方法与 freeze-drying 结合了,柠檬酸盐线路有差的重制度和可伸缩性技术在上面可再现、容易可伸缩,并且因此综合的吸收剂拥有优秀 CO2 俘获性质。 | Qiang XIAO Xiaodan TANG Yefeng LIU Yijun ZHONG Weidong ZHU | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 5 |
| 3 | Citrate route t o prepare K-doped LizZrO sorbents with excellent CO2 capture p roperties显示文摘 | Qiang Xiao Xiaodan Tang Yefeng Liu | 2011 | Chemical Engineering Journal2011，174，： | 1 |
| 4 | Elucidating the selectivity of dyotropic rearrangements of β-lactones:a computational survey显示文摘The dyotropic rearrangement of β-lactones is a neglected treasure in the family of multi-bond reactions and pericyclic reactions.Despite its appealing synthetic potential,the complicated migration selectivity greatly limits its widespread application.In this work,we report the first systematic and comprehensive computational study on the dyotropic rearrangements of β-lactones.The use of the double-hybrid functional ensures the accuracy of results.On the basis of the present study and our previous work,five methods to control the reaction selectivity of dyotropic rearrangements of β-lactones have been summarized,providing valuable references for synthetic chemists to design and develop brand-new type dyotropic reactions. | Jingyang Zhang Yumiao Ma Ke Qiu Bo Li Zhengwen Xue Boxue Tian Yefeng Tang | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 5 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity显示文摘The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including neurodegeneration.NAD-boosting agents can provide neuroprotective benefits.Here,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage pathway.We obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active site.The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming.Importantly,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt toxicity.These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline. | Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang | 2022 | Cell Research2022，32，6： | 0 |
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