|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimization of H_2O_2 dosage in microwave-H_2O_2 process for sludge pretreatment with uniform design method显示文摘A microwave-H2O2 process for sludge pretreatment exhibited high efficiencies of releasing organics,nitrogen,and phosphorus,but large quantities of H2O2 residues were detected.A uniform design method was thus employed in this study to further optimize H2O2 dosage by investigating effects of pH and H2O2 dosage on the amount of H2O2 residue and releases of organics,nitrogen,and phosphorus.A regression model was established with pH and H2O2 dosage as the independent variables,and H2O2 residue and releases of organics,nitrogen,and phosphorus as the dependent variables.In the optimized microwave-H2O2 process,the pH value of the sludge was firstly adjusted to 11.0,then the sludge was heated to 80°C and H2O2 was dosed at a H2O2:mixed liquor suspended solids(MLSS)ratio of 0.2,and the sludge was finally heated to 100°C by microwave irradiation.Compared to the microwave-H2O2 process without optimization,the H2O2 dosage and the utilization rate of H2O2 in the optimized microwave-H2O2 process were reduced by 80% and greatly improved by 3.87 times,respectively,when the H2O2:MLSS dosage ratio was decreased from 1.0 to 0.2,resulting in nearly the same release rate of soluble chemical oxygen demand in the microwave-H2O2 process without optimization at H2O2:MLSS ratio of 0.5. | Qingcong Xiao Hong Yan Yuansong Wei Yawei Wang Fangang Zeng Xiang Zheng | 2012 | Journal of Environmental Sciences2012，24，12： | 12 |
| 2 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 3 | Applications of Metal–Organic Frameworks and Their Derivatives in Electrochemical CO_(2)Reduction显示文摘Electrochemically reducing CO_(2)to more reduced chemical species is a promising way that not only enables the conversion of intermittent energy resources to stable fuels,but also helps to build a closed-loop anthropogenic carbon cycle.Among various electrocatalysts for electrochemical CO_(2)reduction,multifunctional metal–organic frameworks(MOFs)have been employed as highly efficient and selective heterogeneous electrocatalysts due to their ultrahigh porosity and topologically diverse structures.Up to now,great progress has been achieved in the design and synthesis of highly active and selective MOF-related catalysts for electrochemical CO_(2)reduction reaction(CO_(2)RR),and their corresponding reaction mechanisms have been thoroughly studied.In this review,we summarize the recent progress of applying MOFs and their derivatives in CO_(2)RR,with a focus on the design strategies for electrocatalysts and electrolyzers.We first discussed the reaction mechanisms for different CO_(2)RR products and introduced the commonly applied electrolyzer configurations in the current CO_(2)RR system.Then,an overview of several categories of products(CO,HCOOH,CH_(4),CH_(3)OH,and multi-carbon chemicals)generated from MOFs or their derivatives via CO_(2)RR was discussed.Finally,we offer some insights and perspectives for the future development of MOFs and their derivatives in electrochemical CO_(2)reduction.We aim to provide new insights into this field and further guide future research for large-scale applications. | Chengbo Li Yuan Ji Youpeng Wang Chunxiao Liu Zhaoyang Chen Jialin Tang Yawei Hong Xu Li Tingting Zheng Qiu Jiang Chuan Xia | 2023 | Nano-Micro Letters2023，15，8： | 2 |
| 4 | Modifications in retrostemal reconstruction after oesophago-gastrectomy may reduce the incidence of anastomotic leakage显示文摘 | Hong Hu Ting Ye Yawei Zhang | 2012 | Euro- pean Journal of Cardio-Thoracic Surgery2012，，42： | 1 |
| 5 | Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs显示文摘Trophoblast stem cells (TSCs), which can be derived from the trophoectoderm of a blastocyst, have the ability to sustain self-renewal and differentiate into various placental trophoblast cell types. Meanwhile, essential insights into the molecular mechanisms controlling the placental development can be gained by using TSCs as the cell model. Esrrb is a transcription factor that has been shown to play pivotal roles in both embryonic stem cell (ESC) and TSC, but the precise mechanism whereby Esrrb regulates TSC-specific transcriptome during differentiation and reprogramming is still largely unknown. In the present study, we elucidate the function of Esrrb in self-renewal and differentiation of TSCs, as well as during the induced TSC (iTSC) reprogramming. We demonstrate that the precise level of Esrrb is critical for stem state maintenance and further trophoblast differentiation of TSCs, as ectopically expressed Esrrb can partially block the rapid differentiation of TSCs in the absence of fibroblast growth factor 4. However, Esrrb depletion results in downregulation of certain key TSC-specific transcription factors, consequently causing a rapid differentiation of TSCs and these Esrrb-deficient TSCs lose the ability of hemorrhagic lesion formation in vivo. This function of Esrrb is exerted by directly binding and activating a core set of TSC-specific target genes including Cdx2, Eomes, Sox2, Fgfr4, and Bmp4. Furthermore, we show that Esrrb overexpression can facilitate the MEF-to-iTSC conversion. Moreover, Esrrb can substitute for Eomes to generate GEsTM-iTSCs. Thus, our findings provide a better understanding of the molecular mechanism of Esrrb in maintaining TSC self-renewal and during iTSC reprogramming. | Haibo Gao Rui Gao Linfeng Zhang Wenchao Xiu Ruge Zang Hong Wang Yong Zhang Jiayu Chen Yawei Gao Shaorong Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 1 |
| 6 | Dislocation evolution in 316L stainless steel subjected to uniaxial ratchetting deformation显示文摘 | Guozheng Kang Yawei Dong Hong Wang Yujie Liu Xiaojuan Cheng | 2010 | Materials Science & Engineering A2010，，21： | 1 |
| 7 | Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation显示文摘Chromatin remodeling is essential for epigenome reprogramming after frilization.However,the underlying mechanisms of chromatin remodeling remain to be explored.Here,we investigated the dynamic changes in nucleosome occupancy and positioning in pronucleus-stage zygotes using ultra low-input MNase seq.We observed distinct features of inheritance and reconstruction of nucleosome positioning in both paternal and maternal genomes.Genome wide de novo nucleosome occupancy in the paternal genome was observed as early as 1 h after the injection of sperm into ooplasm.The nucleosome positioning pattern was continually rebuilt to form nucleosome-depleted regions(NDRs)at promoters and transcription factor(TF)binding sites with differential dynamics in paternal and maternal genomes.NDRs formed more quickly on the promoters of genes involved in zygotic genome activation(ZGA),and this formation is closely linked to histone acetylation,but not transcription elongation or DNA replication.Importantly,we found that NDR establishment on the binding motifs of specific TFs might be associated with their potential pioneer functions in ZGA.Further investigations suggested that the predicted factors MLX and RFX1 played important roles in regulating minor and major ZGA,respectively.Our data not only elucidate the nucleosome positioning dynamics in both male and female pronuclei fllowing frtiliatin,but also provide an eficient method for identifying key transcription regulators during development. | Chenfei Wang Chuan Chen Xiaoyu Liu Chong Li Qiu Wu Xiaolan Chen Lingyue Yang Xiaochen Kou Yanhong Zhao Hong Wang Yawei Gao Yong Zhang Shaorong Gao | 2022 | Cell Research2022，32，9： | 1 |
| 8 | Modifications in retrostemal reconstruction after oesophagogastrectomy may reduce the incidence of anastomotic leakage显示文摘 | Hong Hu Ting Ye Yawei Zhang | 2012 | European Journal of Cardio - Thoracic Surgery2012，，42： | 1 |
| 9 | Family history of malignancies and risk of breast cancer: prospective data from the Shanghai women’s health study显示文摘 | Briseis A. Kilfoy Yawei Zhang Xiao-Ou Shu Yu-Tang Gao Bu-Tian Ji Gong Yang Hong Lan Li Nathaniel Rothman Wong-Ho Chow Wei Zheng | 2008 | Cancer Causes & Control2008，，10： | 1 |
| 10 | High efficiency D-A structured luminogen with aggregation-induced emission and mechanochromic characteristics显示文摘A novel luminogen, CZ2TPAN, with typical D-A architecture was obtained. It shows intramolecular charge transfer and aggregation-induced emission characteristics with high solid-state efficiency of 65.3%. Moreover, it exhibits reversible mechanochromic behavior between crystalline and amorphous states with remarkable emission color change from green (504 nm) to yellow (545nm). | LU YaWei TAN YeQiang GONG YongYang LI Hong YUAN WangZhang ZHANG YongMing TANG Ben Zhong | 2013 | Chinese Science Bulletin2013，58，22： | 1 |
| 11 | Audio-visual keyword transformer for unconstrained sentence-level keyword spotting显示文摘As one of the most effective methods to improve the accuracy and robustness of speech tasks,the audio-visual fusion approach has recently been introduced into the field of Keyword Spotting(KWS).However,existing audio-visual keyword spotting models are limited to detecting isolated words,while keyword spotting for unconstrained speech is still a challenging problem.To this end,an Audio-Visual Keyword Transformer(AVKT)network is proposed to spot keywords in unconstrained video clips.The authors present a transformer classifier with learnable CLS tokens to extract distinctive keyword features from the variable-length audio and visual inputs.The outputs of audio and visual branches are combined in a decision fusion module.As humans can easily notice whether a keyword appears in a sentence or not,our AVKT network can detect whether a video clip with a spoken sentence contains a pre-specified keyword.Moreover,the position of the keyword is localised in the attention map without additional position labels.Exper-imental results on the LRS2-KWS dataset and our newly collected PKU-KWS dataset show that the accuracy of AVKT exceeded 99%in clean scenes and 85%in extremely noisy conditions.The code is available at http://gffzz188fe103f8f1460aspuo5upppffqq6f09.ffgz.tsg.suse.edu.cn/jialeren/AVKT. | Yidi Li Jiale Ren Yawei Wang Guoquan Wang Xia Li Hong Liu | 2024 | CAAI Transactions on Intelligence Technology2024，9，1： | 0 |
| 12 | Comparison of mini-probe endoscopic ultrasonography with computed tomography scan in preoperative staging of esophageal cancer显示文摘Objective:To compare mini-probe endoscopic ultrasonography(MCUS)with computed tomography(CT)in pre-operative T and N staging of esophageal cancer,and to find out the MCUS parameters to judge lymph nodes metastasis for esophageal cancer.Methods:Thirty-five patients received both MCUS and CT preoperatively,on both of which the T and N stages were determined.The accuracy,sensitivity,specificity,positive predicting value and negative predicting value were compared with the postoperative pathological results.Results:The accuracy of MCUS was 85.7% in T staging and 85.7% and 80.0% in N staging by two different methods,which were 45.7% and 74.3%,respectively,by CT.Conclusion:MCUS is better than CT in preoperative staging for esophageal cancer.The ratio of short to long axis(S/L)combined with short axis is a useful way to determine lymph nodes metastasis. | Hong Hu Jiaqing Xiang Yawei Zhang Jie Chen Yajia Gu Longsheng Miao Longfei Ma | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，6： | 0 |
| 13 | 体细胞重编程中Oct4协同预置的表观遗传重排进行层级式DNA结合显示文摘核心全能转录因子Oct4在小鼠体细胞重编程中起重要作用。 | Jun Chen Xiaolong Chen Min Li Xiaoyu Liu Yawei Gao Xiaochen Kou Yanhong Zhao Weisheng Zheng Xiaobai Zhang Yi Huo Chuan Chen You Wu Hong Wang 江赐忠 高绍荣 | 2017 | 科学新闻2017，0，4： | 0 |
| 14 | Management of esophageal mucosa with high-grade dysplasia显示文摘Objective:Early detection and treatment in patients with esophageal cancer is the most effective way to improve the prognosis. Patients with high-grade dysplasia(HGD) in esophageal mucosa might be involved with early esophageal cancer,but the management of the disease is controversial. The purpose of our study was to explore the management of esophageal mucosa with HGD. Methods:We retrospectively analyzed 10 patients with HGD in esophageal mucosa,who underwent esophagectomy in Cancer Hospital of Fudan University from 1999 to 2006. The surgical approach,postoperative morbidity,in-hospital complications and pathological results of the patients were analyzed. Basing on our data together with other studies,we aimed at looking for an appropriate management for patients with HGD. Results:Of the 10 patients who received esophagectomy,the pathological results showed that 2(20%) cases were in situ carcinoma and 8(80%) cases were invasive cancer with no regional lymph nodes involved. 30-day mortality was 0. One patient experienced cervical anastomotic leakage,but healed in 2 weeks. There was no pulmonary complication. Conclusion:Most patients with HGD actually have occult carcinoma. High percentage of patients with HGD would develop into cancer during their lifetime. Esophagectomy is now a selective approach for the treatment of the patients with HGD. | Jiaqing Xiang,Hecheng Li,Shilei Liu,Yawei Zhang,Hong Hu,Longfei Ma,Longsheng Miao Department of Thoracic Surgery,Cancer Hospital of Fudan University Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，3： | 0 |
| 15 | Correction to:Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘CORRECTION TO:PROTEIN CELL(2021)http://gffzzd3cc09b8251d45dfopuo5upppffqq6f09.ffgz.tsg.suse.edu.cn/10.1007/S13238-021-00837-8 In the original publication of the article figure 1 is incorrectly published.The correct Figure 1 is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit http://gffzzeb6f7f563f66445dspuo5upppffqq6f09.ffgz.tsg.suse.edu.cn/licenses/by/4.0/. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2022 | Protein & Cell2022，13，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员