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| 1 | Panax notoginseng saponins ameliorates experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/Stat3 pathways显示文摘OBJECTIVE: To investigate the inhibitory effect of Panax notoginseng saponins(PNS) on liver fibrosis and explore the underlying mechanisms.METHODS: Carbon tetrachloride(CCl4)-treated rats and hepatic stellate cells(HSCs) were used. The effect of PNS on CCl4-induced liver fibrosis was studied with histochemical and biochemical analysis.Transforming growth factor(TGF)-β1, α-smooth muscle actin(α-SMA), and collagen Ι m RNA expression were determined by reverse transcriptase-polymerase chain reaction(RT-PCR). Meanwhile, the protein expression levels of α-SMA, collagen Ι, phosphorylation-Janus activated kinase signal transducer(p-Jak2) / Jak2, and phosphorylation-activator of transcription(p-Stat)3 / Stat3 were determined by immunohistochemistry and / or immunoblotting.RESULTS: PNS treatment significantly improved the liver function of rats as indicated by decreased serum enzymatic activities of alanine aminotransferase and aspartate aminotransferase. Histopathological results indicated that PNS alleviated liver damage and reduced the formation of fibrous septa. Moreover, PNS significantly decreased liver hydroxyproline and significantly attenuated expressions of collagen Ⅰ, α-SMA, TGF-β1, p-Jak2 / Jak2,and p-Stat3 / Stat3 in the rat liver fibrosis model and HSCs.CONCLUSION: PNS can relieve liver fibrosis by modulating Jak2/Stat3 signaling transduction pathway, which may be one of its mechanisms to suppress hepatic fibrosis. | Jiang Hui Gao Jiarong Wang Yongzhong Zhang Jiafu Han Yanquan Wei Liangbing Liu Xiaochuang Wu Jian | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 28 |
| 2 | THE NORMALITY OF CAYLEY GRAPHS OF FINITE ABELIAN GROUPS WITH VALENCY 5显示文摘We call a Cayley digraph X = Cay(G, S) normal for G if the right regular representation of G is normal in the full automorphism group Ant(X) of X. In this paper, we give a classification of all nonnormal Cayley graphs of finite abelian groups with valency 5. | Young-Gheel Baik (Department of Applied Mathematics Pukyong National University Pusan 608-737, Korea) FENG Yanquan (Department of Mathematics, Northern Jiaotong University, Beijing 100044, China) Hyo-Seob Sim (Department of Applied Mathematics, Pukyong National University, Pusan 608-737, Korea) | 2000 | Systems Science and Mathematical Sciences2000，13，4： | 17 |
| 3 | Super-resolution fluorescence-assisted diffraction computational tomography reveals the threedimensional landscape of the cellular organelle interactome显示文摘The emergence of super-resolution(SR)fluorescence microscopy has rejuvenated the search for new cellular substructures.However,SR fluorescence microscopy achieves high contrast at the expense of a holistic view of the interacting partners and surrounding environment.Thus,we developed SR fluorescence-assisted diffraction computational tomography(SR-FACT),which combines label-free three-dimensional optical diffraction tomography(ODT)with two-dimensional fluorescence Hessian structured illumination microscopy.The ODT module is capable of resolving the mitochondria,lipid droplets,the nuclear membrane,chromosomes,the tubular endoplasmic reticulum,and lysosomes.Using dual-mode correlated live-cell imaging for a prolonged period of time,we observed novel subcellular structures named dark-vacuole bodies,the majority of which originate from densely populated perinuclear regions,and intensively interact with organelles such as the mitochondria and the nuclear membrane before ultimately collapsing into the plasma membrane.This work demonstrates the unique capabilities of SR-FACT,which suggests its wide applicability in cell biology in general. | Dashan Dong Xiaoshuai Huang Liuju Li Heng Mao Yanquan Mo Guangyi Zhang Zhe Zhang Jiayu Shen Wei Liu Zeming Wu Guanghui Liu Yanmei Liu Hong Yang Qihuang Gong Kebin Shi Liangyi Chen | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 4 | Analysis of the Microstructure and Mechanical Properties during Inertia Friction Welding of the Near-α TA19 Titanium Alloy显示文摘The current research of titanium alloy on friction welding process in the field of aero-engines mainly focuses on the linear friction welding.Compared to the linear friction welding,inertial friction welding of titanium alloy still has important application position in the welding of aero-engine rotating assembly.However,up to now,few reports on inertial friction welding of titanium alloy are found.In this paper,the near-alpha TA19 titanium alloy welded joint was successfully obtained by inertial friction welding(IFW)process.The microstructures and mechanical properties were investigated systematically.Results showed that the refined grains within 15‒20μm and weak texture were found in the weld zone due to dynamic recrystallization caused by high temperature and plastic deformation.The weld zone consisted of acicularα′martensite phase,αp phase and metastableβphase.Most lath-shapedαs andβphase in base metal were transformed into acicular martensiteα′phase and metastableβphase in thermo-mechanically affected zone and heat affected zone.As a result,the microhardness of welded joint gradually decreased from the weld zone to the base metal.Tensile specimens in room temperature and high temperature of 480℃ were all fractured in base metal illustrating that the inertia friction welded TA19 titanium alloy joint owned higher tensile strength compared to the base metal. | Yanquan Wu Chunbo Zhang Jun Zhou Wu Liang Yunlei Li | 2020 | Chinese Journal of Mechanical Engineering2020，33，6： | 3 |
| 5 | Fabrication of Periodic Nanostructures Using AFM Tip-Based Nanomachining:Combining Groove and Material Pile-Up Topographies显示文摘This paper presents an atomic force microscopy(AFM)tip-based nanomachining method to fabricate periodic nanostructures.This method relies on combining the topography generated by machined grooves with the topography resulting from accumulated pile-up material on the side of these grooves.It is shown that controlling the distance between adjacent and parallel grooves is the key factor in ensuring the quality of the resulting nanostructures.The presented experimental data show that periodic patterns with good quality can be achieved when the feed value between adjacent scratching paths is equal to the width between the two peaks of material pile-up on the sides of a single groove.The quality of the periodicity of the obtained nanostructures is evaluated by applying one-and two-dimensional fast Fourier transform(FFT)algorithms.The ratio of the area of the peak part to the total area in the normalized amplitude–frequency characteristic diagram of the cross-section of the measured AFM image is employed to quantitatively analyze the periodic nanostructures.Finally,the optical effect induced by the use of machined periodic nanostructures for surface colorization is investigated for potential applications in the fields of anti-counterfeiting and metal sensing. | Yanquan Geng Yongda Yan Jiqiang Wang Emmanuel Brousseau Yanwen Sun Yazhou Sun | 2018 | Engineering2018，4，6： | 3 |
| 6 | A Simulated Investigation of Ductile Response of GaAs in Single-Point Diamond Turning and Experimental Validation显示文摘In this paper,molecular dynamic(MD)simulation was adopted to study the ductile response of single-crystal GaAs during single-point diamond turning(SPDT).The variations of cutting temperature,coordination number,and cutting forces were revealed through MD simulations.SPDT experiment was also carried out to qualitatively validate MD simulation model from the aspects of normal cutting force.The simulation results show that the fundamental reason for ductile response of GaAs during SPDT is phase transition from a perfect zinc blende structure(GaAs-I)to a rock-salt structure(GaAs-II)under high pressure.Finally,a strong anisotropic machinability of GaAs was also found through MD simulations. | Pengfei Fan Fei Ding Xichun Luo Yongda Yan Yanquan Geng Yuzhang Wang | 2020 | Nanomanufacturing and Metrology2020，3，4： | 2 |
| 7 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 8 | CD8 + T cell response in HLA-A*0201 transgenic mice is elicited by epitopes from SARS-CoV S protein显示文摘 | Kai Zhao Binyan Yang Yanquan Xu Changyou Wu | 2010 | Vaccine2010，，41： | 2 |
| 9 | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway显示文摘Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits.However,the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated.We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis.In the current study,we show that Rheb has distinct effects on thermogenic gene expression in brown and beige fat.Fat-specific knockout of Rheb decreased protein kinase A(PKA)activity and thermogenic gene expression in brown adipose tissue of high-fat diet-fed mice.On the other hand,overexpression of Rheb activated PKA and increased uncoupling protein 1 expression in brown adipocytes.Mechanistically,Rheb overexpression in brown adipocytes increased Notch expression,leading to disassociation of the regulatory subunit from the catalytic subunit of PKA and subsequent PKA activation.Our study demonstrates that Rheb,by selectively modulating thermogenic gene expression in brown and beige adipose tissues,plays an important role in regulating energy homeostasis. | Wen Meng Xiuci Liang Ting Xiao Jing Wang Jie Wen Hairong Luo Jianhui Teng Yanquan Fei Qinghai Zhang Bilian Liu Fang Hu juli Bai Meilian Liu Zhiguang Zhou Feng Liu | 2019 | Journal of Molecular Cell Biology2019，11，9： | 2 |
| 10 | Thermal Error Modeling by Integrating GA and BP Algorithms for the Highspeed Spindle 显示文摘 | Huang Yanquan Zhang Jie Li Xu | 2014 | The International Journal of Advanced Manufacturing Technology2014，71，912： | 1 |
| 11 | In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica显示文摘 | HAN Yanquan HUANG Zhengming YANG Xinbo | 2008 | J Ethnopharmacol2008，118，1： | 1 |
| 12 | Trace metal elements: a bridge between host and intestinal microorganisms显示文摘Trace metal elements, such as iron, copper, manganese, and zinc, are essential nutrients for biological processes. Although their intake demand is low, they play a crucial role in cell homeostasis as the cofactors of various enzymes. Symbiotic intestinal microorganisms compete with their host for the use of trace metal elements. Moreover, the metabolic processes of trace metal elements in the host and microorganisms affect the organism's health. Supplementation or the lack of trace metal elements in the host can change the intestinal microbial community structure and function. Functional changes in symbiotic microorganisms can affect the host's metabolism of trace metal elements. In this review, we discuss the absorption and transport processes of trace metal elements in the host and symbiotic microorganisms and the effects of dynamic changes in the levels of trace metal elements on the intestinal microbial community structure. We also highlight the participation of trace metal elements as enzyme cofactors in the host immune process. Our findings indicate that the host uses metal nutrition immunity or metal poisoning to resist pathogens and improve immunity. | Yong Ma Yanquan Fei Sujuan Ding Hongmei Jiang Jun Fang Gang Liu | 2023 | Science China(Life Sciences)2023，66，9： | 1 |
| 13 | Retention mechanism of ampheteric starch/polyaluminum silicate sulfate on wheat straw pulps显示文摘 | Liu Wenxia Long Yanquan Wang Qichang | 2000 | 4th INWPPC2000，2，： | 1 |
| 14 | Semi-supervised locality discriminant projection显示文摘 | MAO Yu ZHOU Yanquan U Hao | 2012 | Procedia Engineering2012，29，3： | 1 |
| 15 | Pentavalent symmetric graphs of order 2p^3显示文摘A graph is symmetric or 1-regular if its automorphism group is transitive or regular on the arc set of the graph, respectively. We classify the connected pentavalent symmetric graphs of order 2p^3 for each prime p. All those symmetric graphs appear as normal Cayley graphs on some groups of order 2p^3 and their automorphism groups are determined. For p = 3, no connected pentavalent symmetric graphs of order 2p^3 exist. However, for p = 2 or 5, such symmetric graph exists uniquely in each case. For p 7, the connected pentavalent symmetric graphs of order 2p^3 are all regular covers of the dipole Dip5 with covering transposition groups of order p^3, and they consist of seven infinite families; six of them are 1-regular and exist if and only if 5 |(p- 1), while the other one is 1-transitive but not 1-regular and exists if and only if 5 |(p ± 1). In the seven infinite families, each graph is unique for a given order. | YANG DaWei Feng YanQuan | 2016 | Science China Mathematics2016，59，9： | 1 |
| 16 | An Enhanced Half Circle Family Window显示文摘AnEnhancedHalfCircleFamilyWindowHuangYanquan(SchoolofElectricalEngineering,SouthwestJiaotongUniversity,Chengdu610031,China)An... | Huang Yanquan(School of Electrical Engineering,Southwest Jiaotong University,Chengdu 610031,China) | 1995 | Journal of Modern Transportation1995，12，1： | 1 |
| 17 | On the normality of Cayley graph of abelian groups显示文摘 | Baik Young-Gheel Feng Yanquan Hyo-Seob Sim | 1998 | A slgebra Colloq1998，5，： | 1 |
| 18 | Molecular spectrum of thalassemia in tropical Hainan Island of southern China:high allele frequency with low health burden显示文摘Thalassemia is the most common monogenetic disorder prevalent in tropical and subtropical regions.It is mainly classified into aandβ-thalassemia according to which globin chain is affected(Taher et al.,2018).Thalassemia mutations present significant genetic diversity,which causing absent(a~0 andβ~0)or reduced(a+andβ+)synthesis of globin chains.Consequently,homozygotes or compound heterozygotes of different thalassemia alleles can lead to various clinical phenotypes. | Yanquan Lai Fangchao Tao Yu Zou Min Huang Kaiting Lin Yang Li Weilun Huang Wanjun Zhou | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 19 | Com-putational study and optimization of laminar heat transferand pressure lossof double - layer microchannelsfor chipliquid cooling 显示文摘 | Xie Gongnan Liu Yanquan Bengt Sunden | 2013 | Journal of Thermal Science and Engi-neering Applications2013，5，： | 1 |
| 20 | On the normality of Cayley graph of abelian groups显示文摘 | BAIK Young-Gheel FENG Yanquan SIM Hyo-Seob XU Mingyao | 1998 | Slgebra Colloq1998，5，： | 1 |
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