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| 1 | Identification of an HLA-A~* 0201-restricted CD8^+ T-cell epitope SSp-1 of SARS-CoV spike protein显示文摘A novel coronavirus, severe acute respiratory syndrome (SA RS)-associated coronavirus (SARS-CoV), has been identified as the causal agent of SARS. Spike (S) protein is a major structural glycoprotein of the SARS virus and a potential target for SARS-specific cell-mediated immune responses. A pa nel of S protein-derived peptides was tested for their binding affinity to HLA -A *0201 molecules. Peptides with high affinity for HLA-A *0201 were then as se ssed for their capacity to elicit specific immune responses mediated by cytotoxi c T lymphocytes (CTLs) both in vivo, in HLA-A2.1/K b transgenic mice, a nd in vitro, from peripheral blood lymphocytes (PBLs) harvested from healthy HLA-A 2.1 + donors. SARS-CoV protein-derived peptide-1 (SSp-1 RLNEVAKNL), induced pepti de-specific CTLs both in vivo (transgenic mice) and in vitro (human PBL s), which specifically released interferon-gamma (IFN-gamma) upon stimulation with SSp-1-pulsed autologous dendritic cells (DCs) or T2 cells. SSp-1-specif ic CTLs also lysed major histocompatibility complex (MHC)-matched tumor cell lines engineered to express S proteins. HLA-A *0201-SSp-1 tetramer staining re vealed the presence of significant populations of SSp-1-specific CTLs in SSp- 1-induced CD8 + T cells. We propose that the newly identified epitope SSp-1 w ill help in the characterization of virus control mechanisms and immunopathology in SARS-CoV infection, and may be relevant to the development of immunotherape utic approaches for SARS. | WangB ChenH JiangX ZhangM WanT LiN ZhouX WuY YangF YuY WangX YangR CaoX | 2004 | 第二军医大学学报2004，25，9： | 21 |
| 2 | Reconfiguring the Logical Topology With Performance Guarantees in WDM Networks显示文摘To improve the network performance after traffic demand changes, reconfiguring the logical topology is necessary. We present an ILP algorithm to find out the least lightpath changes needed with guaranteed network performance. | Fengqing Liu, Qingji Zeng, Xu Zhu, Xudong YangR&D Center for Broadband Optical Networking Techonology.Shanghai Jiaotong University Shanghai 200030, P.R. China, Tel: +86-21-62932166, Fax: +86-21-62932166, E-mail:liufengqing_1975@sjtu.edu.cn | 2003 | 光学学报2003，23，S1： | 2 |
| 3 | Effects of nitrogen fertilizer and irrigation rate on nitrate present in the profile of a sandy farmland in Northwest China 显示文摘 | YangR Wang X F | 2011 | Proeedia Environmental Sciences2011，11，： | 1 |
| 4 | Fuzzy Numbers and Fuzzification of the Choquet Integral 显示文摘 | YANGR WANG Z Y HENG P A | 2005 | Fuzzy Sets and Systems2005，151，1： | 1 |
| 5 | Collagenintendon,ligment,and bone healing显示文摘 | Yangrs shaikhra et al | 1995 | Cline Orthop1995，316，： | 1 |
| 6 | Reactivities of in situ and ex situ coal chars during gasification in steam at 1000~1400 ℃显示文摘 | PENG F F LEE I C YANGR Y K | 1995 | Fuel Process Technol1995，41，3： | 1 |
| 7 | Galectins:structure,functionandtherapeuticpotential显示文摘 | YangR Y RabinovichG A LiuFT | 2008 | ExpertRevMolMed2008，10，6： | 1 |
| 8 | Effects of food processing on the nutrient composition of Pyropia yezoensis products revealed by NMR-based metabolomic analysis 显示文摘 | YeYF YangR LouYJ ChenJJ YanXJ TangHR | 2014 | Journal of Food and Nutrition Research2014，2，10： | 1 |
| 9 | Effect ofantioxidant caDacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet显示文摘 | YangR LeG LiA etal | 2006 | Nutriton2006，22，： | 1 |
| 10 | A numericalmodelingofanabsorptionprocessonaliquidfallingfilm 显示文摘 | YangR WoodB D | 1992 | SolarEnergy1992，48，3： | 1 |
| 11 | Positivefeedbackbetweenmycorrhizalfungiandplantsinfluencesplantinvasionsuccessandresistancetoinvasion显示文摘 | ZhangQ YangR TangJ etal | 2010 | PLoSOne2010，5，12： | 1 |
| 12 | First detection of a novel HIV type 1 CRF01_ AE/07_BC recombinant among an epidemiologically linked cohort of IDUs in Jiangsu, China 显示文摘 | Guo H Guo D Wei JF Yang H Huan X Tsui SK YangR Zhang C | 2009 | AIDS Res Hum Ret- roviruses2009，25，4： | 1 |
| 13 | Globalphos- phoproteomic effects of natural tyrosine kinase inhibi- tor, genistein, on signaling pathways 显示文摘 | YANGR XIAOCL HEGW etal | 2010 | Pro- teomics2010，10，： | 1 |
| 14 | Selective catalytic reduction of ni- trogen oxides by ammonia over Fe3~ exchanged TiO2-pil- lared clay catalysts 显示文摘 | Long R Q YangR T | 1999 | J Catal1999，186，2： | 1 |
| 15 | Protective effectsof andrographolide analogue AL-1 on ROS-induced RIN-mbeta cell death by inducing ROS generation显示文摘 | YanGR Zhou HH Wang Y | 2013 | PLoS 0ne2013，8，63： | 1 |
| 16 | Deactivation of the vanadia catalyst in the selective catalytic reduction process显示文摘 | ChenJ P BuzanowskiM A YangR T | | 0，，10： | 1 |
| 17 | Amulticenterrandomizedcontrolledtrialofrecombinanthumanthrombopoietintreatmentinpatientswithprimaryimmunethrombocytopenia显示文摘 | WangS YangR ZouP etal | 2012 | IntJHematol2012，96，2： | 1 |
| 18 | 显示文摘 | Takahashi A YangFH YangR T | 2002 | Ind Eng Chem Res2002，41，： | 1 |
| 19 | Dual Catalysis Mechanism of Alcohnol Sol- vent and Cu Catalyst for a New Methanol Synthesis Method 显示文摘 | YangR ZhangY Tsubaki N | 2005 | Catal Commun2005，6，4： | 1 |
| 20 | 显示文摘 | Huang H Y YangR T Chinn D | 2003 | Ind Eng Chem Res2003，42，12： | 1 |
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