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| 1 | Entecavir vs lamivudine therapy for na?ve patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure显示文摘AIM:To investigate the short-term and long-term efficacy of entecavir versus lamivudine in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure(ACLF).METHODS:This was a single center,prospective cohort study.Eligible,consecutive hospitalized patients received either entecavir 0.5 mg/d or lamivudine 100mg/d.All patients were given standard comprehensive internal medicine.The primary endpoint was survival rate at day 60,and secondary endpoints were reduction in hepatitis B virus(HBV)DNA and alanine aminotransferase(ALT)levels,and improvement in Child-Turcotte-Pugh(CTP)and model for end-stage liver disease(MELD)scores at day 60 and survival rate at week 52.RESULTS:One hundred and nineteen eligible subjects were recruited from 176 patients with severe acute exacerbation of chronic hepatitis B:65 were included in the entecavir group and 54 in the lamivudine group(full analysis set).No significant differences were found in patient baseline clinical parameters.At day 60,entecavir did not improve the probability of survival(P=0.066),despite resulting in faster virological suppression(P<0.001),higher rates of virological response(P<0.05)and greater reductions in the CTP and MELD scores(all P<0.05)than lamivudine.Intriguingly,at week 52,the probability of survival was higher in the entecavir group than in the lamivudine group[42/65(64.6%)vs 26/54(48.1%),respectively;P=0.038].The pretreatment MELD score(B,1.357;95%Cl:2.138-7.062;P=0.000)and virological response at day30(B,1.556;95%Cl:1.811-12.411;P=0.002),were found to be good predictors for 52-wk survival.CONCLUSION:Entecavir significantly reduced HBV DNA levels,decreased the CTP and MELD scores,and thereby improved the long-term survival rate in patients with spontaneous reactivation of hepatitis B presenting as ACLF. | Yang Zhang Xiao-Yu Hu Sen Zhong Fang Yang Tao-You Zhou Guo Chen Yan-Yan Wang Jian-Xing Luo | 2014 | World Journal of Gastroenterology2014，20，16： | 42 |
| 2 | The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells显示文摘AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP on the proliferation of NIH 3T3 cells was measured by incorporation of 3H-TdR. Receptor-binding assay of 125I-AFP was performed to detect the properties of AFP receptor in NIH 3T3 cells. The influences of AFP on the [cAMP]i and the activities of protein kinase A (PKA) were determined. Western blot was used to detect the change of K-ras P21 protein expression. RESULTS The proliferation of NIH 3T3 cells treated with 0-80 mg/L of AFP was significantly enhanced. The Scatchard analysis indicated that there were two classes of binding sites with KD of 2.722×10-9M (Bmax=12810 sites per cell) and 8.931× 10-SM (Bmax=l19700 sites per cell) respectively. In the presence of AFP (20 mg/L), the content of cAMP and activities of PKA were significantly elevated . The level of K-ras P21 protein was upregulated by AFP at the concentration of 20 mg/L. The monoclonal antibody against AFP could reverse the effects of AFP on the cAMP content, PKA activity and the expression of K-ras p21 gene. CONCLUSION The effect of AFP on the cell proliferation was achieved by binding its receptor to trigger the signal transduction pathway of cAMP-PKA and alter the expression of K- ras p21 gene. | MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG HE, Guo GUANG DU, GANG LI1 Department of Biochemistry and Molecular Biology, 2 Department of Biophysics, Health Science Center, Peking University, Beijing 100083, China | 2002 | Cell Research2002，12，2： | 27 |
| 3 | Glycerol-3-Phosphate Acyltransferase 6 (GPAT6) Is Important for Tapetum Development in Arabidopsis and Plays Multiple Roles in Plant Fertility显示文摘Glycerol-3-phosphate acyltransferase (GPAT ) 调停为 glycerolipids 的形成的起始的合成的步,哪个生物的膜的主要部件和主管存储了精力的形式的行为。GPAT6 是 Arabidopsis GPAT 家庭的一个成员,它为在萼片和花瓣的角质生合成是关键的。在这个工作,在花药开发和工厂富饶的 GPAT6 的功能的分析被执行。GPAT6 高度在花药开发期间在 tapetum 和小孢子被表示。猛烈异种, gpat6,在种子生产引起了巨大的减小。GPAT6 的脱离引起了有缺点的 tapetum 开发与的表演减少了 endoplasmic 蜂窝胃的这份报告(嗯) 在 tapetum 的侧面,它大部分导致了花粉谷物和有缺点的花粉的流产围形成。另外,花粉萌芽和花粉试管延伸在变异的工厂被影响。而且,双变异的分析证明 GPAT6 和 GPAT1 用四个和雄蕊细丝延伸在小孢子的版本上做联合效果。这个工作证明 GPAT6 在 Arabidopsis 在雄蕊开发和富饶起多重作用。 | Xiao-Chuan Li Jun Zhu Jun Yang Guo-Rui Zhang Wei-Feng Xing Sen Zhang Zhong-Nan Yang | 2012 | Molecular Plant2012，5，1： | 25 |
| 4 | Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia:a single-blind randomized controlled trial显示文摘OBJECTIVE: To observe the effect of Sancaijiangtang powders on plasma nitric oxide and endothelin-1 levels. We sought to identify the common pathological link and mechanism of action for Traditional Chinese medicine in type 2 diabetes mellitus and vascular dementia,and to explicate the material basis for treating the different diseases with the same method in Traditional Chinese Medicine.METHODS: In total,168 patients with type 2 diabetes mellitus and vascular dementia were enrolled in the study,and randomly divided into two groups by simple randomization. Patients in the treatment group received oral Sancaijiangtang powders with pioglitazone hydrochloride three times daily,while patients in the control group received pioglitazone hydrochloride alone. The treatment course was for12 weeks. Mini-mental state examinations(Chinese version) and Montreal Cognitive Assessments(Beijing version) were performed,and fasting plasma glucose,fasting insulin,hemoglobin A1 c,homeostasis model assessment of insulin resistance,plasma nitric oxide and endothelin-1 levels were measured before and after the treatment.RESULTS: The post-treatment levels for all measurements in both groups were better than pre-treatment levels(P < 0.05). The post-treatment levels for all measurements in the treatment group were better than the levels measured in the control group(P < 0.05).CONCLUSION: Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. Sancaijiangtang powders could improve the release of nitric oxide and inhibit the secretion of endothelin-1. Therefore,the material basis exists for treating the different diseases with the same method in Traditional Chinese Medicine. | Guo Qiang Cao Wenzhai Zhao Huan Zhu Yuxia Yang Dongdong Zhong Sen Chen Qiu | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 24 |
| 5 | Soil Erosion and Vegetation Succession in Alpine Kobresia Steppe Meadow Caused by Plateau Pika——A Case Study of Nagqu County, Tibet显示文摘This paper evaluated the impacts of mounds created by the plateau pika (Ochotona curzoniae) on the vege- tation composition, structure, and species diversity of an alpine Kobresia steppe meadow in Nagqu County, Tibet Autonomous Region, China. Based on mound height or the depth of erosion pit, we defined five stages of erosion and compared the floristic features of communities at these stages with those in undisturbed sites. In the study area, the mounds and pits covered up to 7% of the total area. Lancea tibetica, Lamiophlomis rotata, and Potentilla bifurca were the dominant species in erosion pits, and Kobresia pygmaea, the dominant species in undisturbed sites, became a com- panion species in eroded areas. In the process of erosion, the original vegetation was covered by soil ejected by the pika, then the mounds were gradually eroded by wind and rain, and finally erosion pits formed. The vegetation coverage in- creased with increasing erosion stages but remained significantly lower than that in undisturbed sites. Improved coverage eventually reduced soil erosion, and pit depth eventually stabilized at around 20cm. Aboveground biomass increased with increasing erosion stage, but the proportion of low-quality forage reached more than 94%. The richness index and Shannon-Wiener index increased significantly with increasing erosion stage, but the richness index in mound and pit areas was significantly lower than that in undisturbed sites. | WEI Xinghu LI Sen Yang Ping Cheng Huaishun | 2007 | Chinese Geographical Science2007，17，1： | 22 |
| 6 | Hybrid QoS-aware semantic web service composition strategies显示文摘Hybrid QoS model which consists of certain and uncertain expressions has strong power of semantic QoS description. For solving the hybrid QoS-aware semantic web service composition problem,this paper presents an Uncertain Multi-attribute decision making based Composition algorithm(UMC) . The UMC includes two parts. First,UMC-Core can be used to synthetically evaluate the hybrid service quality information. Second,UMC-DH(Distributed and Heuristic framework for UMC) aims at enhancing the run-time performance of UMC when the problem space increases. The simulation results show that the UMC has lower execution cost,higher approximation ratio and success ratio than other similar approaches. | YANG FangChun SU Sen LI Zhen | 2008 | Science in China(Series F)2008，51，11： | 19 |
| 7 | Gastrodin prevents steroid-induced osteonecrosis of the femoral head in rats by anti-apoptosis显示文摘 | Zheng Huifeng Yang Erping Peng Hao Li Jianping Chen Sen Zhou Jianlin Fang Hongsong Qiu Bo Wang Zhe | 2014 | Chinese Medical Journal2014，，22： | 17 |
| 8 | Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway显示文摘Stroke is an acute cerebrovascular disease caused by ruptured or blocked blood vessels.For the prevention of ischemic stroke,the coagulation state of blood and cerebrovascular protection should be considered.Our previous study has shown that salvianolic acid A(SAA),which is a water-soluble component from the root of Salvia Miltiorrhiza Bge,prevents thrombosis with a mild inhibitory effect on platelet aggregation.In this study we investigated the preventive effects of SAA on cerebrovascular endothelial injury caused by ischemia in vivo and oxygen-glucose deprivation(OGD)in vitro,and explored the underlying mechanisms.An autologous thrombus stroke model was established in SD rats by electrocoagulation.SAA(10 mg/kg)was orally administered twice a day for 5 days before the operation.The rats were sacrificed at 24 h after the operation.We showed that pretreatment with SAA significantly improved the neurological deficits,intracerebral hemorrhage,BBB disruption,and vascular endothelial dysfunction as compared with model group.In human brain microvascular endothelial cells(HBMECs),pretreatment with SAA(10μM)significantly inhibited OGD-induced cell viability reduction and degradation of tight junction proteins(ZO-1,occludin,claudin-5).Furthermore,we found that SAA inhibited the upregulation of Src signaling pathway in vivo and vitro and reversed the increased expression of matrix metalloproteinases(MMPs)after ischemic stroke.In conclusion,our results suggest that SAA protects cerebrovascular endothelial cells against ischemia and OGD injury via suppressing Src signaling pathway.These findings show that pretreatment with SAA is a potential therapeutic strategy for the prevention of ischemic stroke. | Cheng-di Liu Nan-nan Liu Sen Zhang Guo-dong Ma Hai-guang Yang Ling-lei Kong Guan-hua Du | 2021 | Acta Pharmacologica Sinica2021，42，3： | 15 |
| 9 | OsMYB103 is required for rice anther development by regulating tapetum development and exine formation显示文摘The Arabidopsis AtMYB103 gene is required for anther development,but whether the homologous gene in rice has the same role is unclear.Sequence analysis indicated that the rice OsMYB103 gene shares a high sequence similarity with AtMYB103.Therefore,we investigated the functional role of OsMYB103 in anther development using an RNAi approach.The OsMYB103 RNA transcript was expressed most abundantly in flowers,specifically in the tapetum,premeiotic pollen mother cells,and meiotic PMCs.OsMYB103-RNAi transgenic lines grew normally during their vegetative phase but displayed reduced male fertility,a phenotype that was associated with downregulated OsMYB103 transcript levels.Expression of OsMS2,an ortholog of the Arabidopsis AtMS2 gene,was also dramatically reduced in the transgenic plants.Knockdown of OsMYB103 led to defects in tapetum development,and most of the microspores in mature anthers lacked exines.Moreover,OsMYB103 could partially rescue the male sterility phenotype of an AtMYB103 knockout mutant ms188.Taken together,these results indicate that OsMYB103 does have an important role in rice tapetum and microspore development. | ZHANG Sen FANG ZiJun ZHU Jun GAO JuFang YANG ZhongNan | 2010 | Chinese Science Bulletin2010，55，29： | 12 |
| 10 | CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys显示文摘Dear Editor,PINK1 mutations cause autosomal recessive and early-onset Parkinson’s disease(PD)with selective neurodegeneration.Unfortunately,current PINK1 knockout(KO)mouse1,2 and pig models3,4 are unable to recapitulate the selective and overt neurodegeneration seen in PD patients.Furthermore,endogenous Pink1 in the mouse brain is expressed at very low levels and can only be detected via immunoprecipitation,5 meaning that PINK1’s function in the mammalian brain needs to be assessed using larger animals that are closer to humans.We previously used CRISPR/Cas9 to target the monkey gene in one-cell stage embryos.6 Using the same approach,we designed two gRNAs to target exon 2(T1)and exon 4(T2),which encode a kinase domain in the PINK1 gene of rhesus monkeys(Fig.1a).CRISPR/Cas9 and PINK1 gRNAs were injected into one-cell stage rhesus monkey embryos.A T7E1 assay and sequencing of PCR products from the injected embryos showed high efficiency(61.5%)in targeting PINK1(Fig.1b and Supplementary information,Fig.S1).Transfer of 87 embryos to 28 surrogate rhesus monkeys resulted in 11 pregnancies(39.2%)(Fig.1b).Eleven fetuses developed to term and were born naturally.Of these live monkeys,eight carried PINK1 mutations(M),and three were wild type(WT).However,three mutant monkeys(M1,M3 and M4)were newborn triplets that struggled to survive and died 3-4 days after birth.One WT newborn monkey also died after a difficult labor.Another mutant monkey(M2)died 7 days after birth without noticeable warning signs or symptoms.The other three mutant monkeys(M6,M7 and M8)have lived for three years;M5,however,reduced its food intake and showed weakness at the age of 1.5 years,and died 30 days after anesthesia for MRI examination. | Weili Yang Yunbo Liu Zhuchi Tu Chong Xiao Sen Yan Xishan Ma Xiangyu Guo Xiusheng Chen Peng Yin Zhengyi Yang Su Yang Tianzi Jiang Shihua Li Chuan Qin Xiao-Jiang Li | 2019 | Cell Research2019，29，4： | 12 |
| 11 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 12 | COVERAGE PERFORMANCES ANALYSIS ON COMBINED-GEO-IGSO SATELLITE CONSTELLATION显示文摘The Combined-GEO-IGSO constellation is the combination of Geostationary Earth Orbit(GEO) satellite and Inclining GeoSynchronous Orbit(IGSO) satellite.The Combined-GEO-IGSO constellation can integrate the advantages of GEO and IGSO to achieve regional coverage.In order to discuss the performances of the Combined-GEO-IGSO constellation,the performances of coverage,elevation,diversity,and transmission are simulated in China and surrounding regions by Satellite Tool Kit(STK).The simulation results show that:the combined constellation can reach higher multi-satellite coverage and higher communication elevation in China and surrounding areas;the Doppler shift,delay,and propagation loss of this constellation have little impact on the system.As regional coverage constellation,the Combined-GEO-IGSO is feasible. | Jiang Yong Yang Sen Zhang Gengxin Li Guangxia | 2011 | Journal of Electronics(China)2011，28，2： | 12 |
| 13 | A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis显示文摘Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque psoriasis.We conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque psoriasis.Methods:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 weeks.The primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week 12.Results:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,P<0.05)and placebo(13.9%,P<0.05)groups.The proportion of patients achieving an sPGA score 0 or 1 was 66.3%in the benvitimod group and 63.9%in the calcipotriol group,which were both significantly higher than that in the placebo group(34%,P<0.05).In the long-term follow-up study,50.8%of patients experienced recurrence.After retreatment with 1%benvitimod,73.3%of patients achieved an sPGA score of 0 or 1 again at week 52.Adverse events included application site irritation,follicular papules,and contact dermatitis.No systemic adverse reactions were reported.Conclusion:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis. | Lin Cai Gen-Hui Chen Qian-Jin Lu Min Zheng Yu-Zhen Li Jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun Jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，24： | 11 |
| 14 | Comprehensive analysis of NAC transcription factors and their expression during fruit spine development in cucumber (Cucumis sativus L.)显示文摘The cucumber(Cucumis sativus L.)is an important vegetable crop worldwide,and fruit trichomes or spines are an important trait for external fruit quality.The mechanisms underlying spine formation are not well understood,but the plant-specific NAC family of transcription factors may play important roles in fruit spine initiation and development.In this study,we conducted a genome-wide survey and identified 91 NAC gene homologs in the cucumber genome.Clustering analysis classified these genes into six subfamilies;each contained a varying number of NAC family members with a similar intron–exon structure and conserved motifs.Quantitative real-time PCR analysis revealed tissue-specific expression patterns of these genes,including 10 and 12 that exhibited preferential expression in the stem and fruit,respectively.Thirteen of the 91 NAC genes showed higher expression in the wild-type plant than in its near-isogenic trichome mutant,suggesting their important roles in fruit spine development.Exogenous application of four plant hormones promoted spine formation and increased spine density on the cucumber fruits;several NAC genes showed differential expression over time in response to phytohormone treatments on cucumber fruit,implying their essential roles in fruit-trichome development.Among the NAC genes identified,12 were found to be targets of 13 known cucumber micro-RNAs.Collectively,these findings provide a useful resource for further analysis of the interactions between NAC genes and genes underlying trichome organogenesis and development during fruit spine development in cucumber. | Xingwang Liu Ting wang Ezra Bartholomew Kezia Black Mingming Dong Yaqi Zhang Sen Yang Yanling Cai Shudan Xue Yiqun Weng Huazhong Ren | 2018 | Horticulture Research2018，5，1： | 10 |
| 15 | In-situ TiC Reinforced Composite Coating Produced by Powder Feeding Laser Cladding显示文摘合成涂层在中等碳钢底层上与各种各样的形状和尺寸的 TiC 粒子增强了的 Ni 底合金被多层的激光 cladding 生产。Thechemical 作文,微观结构和 cladded 层的表面形态学用精力被分析散 X 光检查光谱学(EDX ) ,扫描电子显微镜(SEM ) ,和 X-raydiffractometry (XRD ) 。试验性的结果显示出那一在涂层和底层之间的优秀冶金的结合被获得。涂层的微观结构主要由 7-Ni 树突, CrB 的小数量, Ni_3B, M_(23 ) C_6 和驱散的 TiC 粒子组成。更多并且更大的 TiC 粒子在重叠地区形成了,它导致了一稍微这个地区的 highermicrohardness。涂层的最大的微坚硬关于 HV_(0.2 ) 是在微观结构上处理参数的激光的 1200 Theeffects,涂层的性质也被调查。 | Sen YANG Wenjin LIU Minlin ZHONG | 2006 | Journal of Materials Science & Technology2006，22，4： | 9 |
| 16 | The apricot(Prunus armeniaca L.)genome elucidates Rosaceae evolution and beta-carotenoid synthesis显示文摘Apricots,scientifically known as Prunus armeniaca L,are drupes that resemble and are closely related to peaches or plums.As one of the top consumed fruits,apricots are widely grown worldwide except in Antarctica.A high-quality reference genome for apricot is still unavailable,which has become a handicap that has dramatically limited the elucidation of the associations of phenotypes with the genetic background,evolutionary diversity,and population diversity in apricot.DNA from P.armeniaca was used to generate a standard,size-selected library with an average DNA fragment size of~20 kb.The library was run on Sequel SMRT Cells,generating a total of 16.54 Gb of PacBio subreads(N50=13.55 kb).The high-quality P.armeniaca reference genome presented here was assembled using long-read single-molecule sequencing at approximately 70×coverage and 171×Illumina reads(40.46 Gb),combined with a genetic map for chromosome scaffolding.The assembled genome size was 221.9 Mb,with a contig NG50 size of 1.02 Mb.Scaffolds covering 92.88%of the assembled genome were anchored on eight chromosomes.Benchmarking Universal Single-Copy Orthologs analysis showed 98.0%complete genes.We predicted 30,436 protein-coding genes,and 38.28%of the genome was predicted to be repetitive.We found 981 contracted gene families,1324 expanded gene families and 2300 apricot-specific genes.The differentially expressed gene(DEG)analysis indicated that a change in the expression of the 9-cis-epoxycarotenoid dioxygenase(NCED)gene but not lycopene beta-cyclase(LcyB)gene results in a lowβ-carotenoid content in the white cultivar“Dabaixing”.This complete and highly contiguous P.armeniaca reference genome will be of help for future studies of resistance to plum pox virus(PPV)and the identification and characterization of important agronomic genes and breeding strategies in apricot. | Fengchao Jiang Junhuan Zhang Sen Wang Li Yang Yingfeng Luo Shenghan Gao Meiling Zhang Shuangyang Wu Songnian Hu Haoyuan Sun Yuzhu Wang | 2019 | Horticulture Research2019，6，1： | 9 |
| 17 | NanoSIMS analytical technique and its applications in earth sciences显示文摘Despite the significant improvement on spatial resolution,Nano SIMS still preserves relatively high mass resolution,sensitivity,and analytical precision.It has become an important analytical platform to determine chemical compositions of solid materials,and has been widely used in space,earth,life,and materials sciences,etc.By using a Cs+ion beam with a size as small as 50nm scanning over sample surfaces,we are able to obtain high spatial resolution images of up to 7 species simultaneously.When utilizing Faraday cup,high analytical precision of 0.3‰–0.5‰(1SD)for C,O and S isotopic analysis can be achieved.Although this precision level is still lower than that of conventional SIMS,it already meets the major requirements of Earth Sciences.In 2011,the first Nano SIMS of China(Cameca Nano SIMS 50L)was installed at Institute of Geology and Geophysics,Chinese Academy of Sciences.Based on the working mechanism and analytical modes of the instrument,this paper will systematically introduce the analytical methods established with the Nano SIMS and their potential applications in earth sciences.These methods include trace element distribution images in mineral zoning,high spatial resolution(2–5?m)Pb-Pb and U-Pb dating,water content and H isotopic analysis for silicate glass and apatite,C isotopic analysis for diamond and graphite,O isotopic analysis for carbonate,S isotopic analysis for sulfides.In addition,the specific requirements for sample preparation will also be introduced in order to facilitate domestic earth scientists’use. | YANG Wei HU Sen ZHANG JianChao HAO JiaLong LIN YangTing | 2015 | Science China Earth Sciences2015，58，10： | 9 |
| 18 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 19 | Iterative selection algorithm for service composition in distributed environments显示文摘In service oriented architecture(SOA) ,service composition is a promising way to create new services. However,some technical challenges are hindering the application of service composition. One of the greatest challenges for composite service provider is to select a set of services to instantiate composite service with endto-end quality of service(QoS) assurance across different autonomous networks and business regions. This paper presents an iterative service selection algorithm for quality driven service composition. The algorithm runs on a peer-to-peer(P2P) service execution environment―distributed intelligent service execution(DISE) ,which provides scalable QoS registry,dynamic service selection and service execution services. The most significant feature of our iterative service selection algorithm is that it can work on a centralized QoS registry as well as cross decentralized ones. Network status is an optional factor in our QoS model and selection algorithm. The algorithm iteratively selects services following service execution order,so it can be applied either before service execution or at service run-time without any modification. We test our algorithm with a series of experiments on DISE. Experimental results illustrated its excellent selection and outstanding performance. | SU Sen LI Fei YANG FangChun | 2008 | Science in China(Series F)2008，51，11： | 8 |
| 20 | Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019:protocol of a randomized controlled trial显示文摘Background:At the end of 2019,a novel coronavirus outbreak causative organism has been subsequently designated the 2019 novel coronavirus(2019-nCoV).The effectiveness of adjunctive glucocorticoid therapy in the management of 2019-nCoV-infected patients with severe lower respiratory tract infections is not clear,and warrants further investigation.Methods:The present study will be conducted as an open-labeled,randomized,controlled trial.We will enrol 48 subjects from Chongqing Public Health Medical Center.Each eligible subject will be assigned to an intervention group(methylprednisolone via intravenous injection at a dose of 1-2 mg/kg/day for 3 days)or a control group(no glucocorticoid use)randomly,at a 1:1 ratio.Subjects in both groups will be invited for 28 days of follow-up which will be scheduled at four consecutive visit points.We will use the clinical improvement rate as our primary endpoint.Secondary endpoints include the timing of clinical improvement after intervention,duration of mechanical ventilation,duration of hospitalization,overall incidence of adverse events,as well as rate of adverse events at each visit,and mortality at 2 and 4 weeks.Discussion:The present coronavirus outbreak is the third serious global coronavirus outbreak in the past two decades.Oral and parenteral glucocorticoids have been used in the management of severe respiratory symptoms in coronavirus-infected patients in the past.However,there remains no definitive evidence in the literature for or against the utilization of systemic glucocorticoids in seriously ill patients with coronavirus-related severe respiratory disease,or indeed in other types of severe respiratory disease.In this study,we hope to discover evidence either supporting or opposing the systemic therapeutic administration of glucocorticoids in patients with severe coronavirus disease 2019. | Yuan-Yuan Qin Yi-Hong Zhou Yan-Qiu Lu Feng Sun Sen Yang Vijay Harypursat Yao-Kai Chen | 2020 | Chinese Medical Journal2020，，9： | 8 |
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