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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Maize ZmFDR3 localized in chloroplasts is involved in iron transport显示文摘Iron is an essential nutrient for plant metabolism such that Fe-limited plants display chlorosis and suffer from reduced photosynthetic efficiency. Differential display previously identified genes whose expression was elevated in Fe-deficient maize roots. Here,we describe the functional characterization of one of the genes identified in the screen,ZmFDR3 (Zea maize Fe-deficiency-related). Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport. ZmFDR3 contains a domain found in FliN-proteins of the type III secretion system and is predicted to localize to the thylakoid of plastids. Fluorescence immunocytochemistry showed that ZmFDR3 is localized in the plastids of roots,stems and leaves,with high expression found in guard cell chloroplasts. Transgenic tobacco expressing a 35S-ZmFDR3 construct contains elevated iron content,displays well arranged thylakoid membranes and has photosynthetic indices that are higher than those of the wild type. Together,these results suggest that ZmFDR3 functions in chloroplast iron transport. | HAN JianHui1,SONG XiuFang1,LI Peng1,YANG HuiJun2 & YIN LiPing1 1 College of Life Science,Capital Normal University,Beijing 100048,China 2 Department of Biological Sciences,University of South Carolina,Columbia,SC 29208,USA | 2009 | Science China(Life Sciences)2009，52，9： | 7 |
| 3 | Xenobiotics and loss of tolerance in primary biliary cholangitis显示文摘Data from genome wide association studies and geoepidemiological studies established that a com-bination of genetic predisposition and environmental stimulation is required for the loss of tolerance in primary biliary cholangitis(PBC).The serologic hallmark of PBC are the presence of high titer anti-mitochondrial autoantibodies(AMA)that recognize the lipoyl domain of the mitochondrial pyruvate dehydrogenase E2(PDC--E2)subunit.Extensive efforts have been directed to investigate the molecular basis of AMA.Recently,experimental data has pointed to the thesis that the breaking of tolerance to PDC--E2 is a pivotal event in the initial etiology of PBC,including environmental xenobiotics including those commonly found in cos-metics and food additives,suggesting that chemical modification of the PDC--E2 epitope may render its vulnerable to become a neo-antigen and trigger an immune response in genetically susceptible hosts.Here,we will discuss the natural history,genetics and immunobiology of PBC and structural constraints of PDC--E2 in AMA recognition which makes it vulnerable to chemical modification. | Jinjun Wang Guoxiang Yang Alana Mari Dubrovsky Jinjung Choi Patrick SC Leung | 2016 | World Journal of Gastroenterology2016，22，1： | 4 |
| 4 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 5 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 6 | Dietary melatonin selectively reverses age-related changes in cortical cytokine mRNA levels,and their responses to an inflammatory stimulus显示文摘 | Sharman KG Sharman EH Yang E Bondy SC | 2002 | Neurobiol Aging2002，23，4： | 2 |
| 7 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 8 | The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer显示文摘 | Chiang WL Chu SC Yang SS | 2002 | Cancer Lett2002，188，： | 1 |
| 9 | Tumor cyclooxygenase 2/ prostaglandin E2 dependent promotion of Foxp3 expression and CD4 ^+ CD25 ^+ T regulatory cell activities in lung cancer显示文摘 | Sharma S Yang SC Zhu L | 2005 | Cancer Res2005，65，52： | 1 |
| 10 | Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Cancer Research2000，60，12： | 1 |
| 11 | Tumor cyclooxygenase-2 dependent suppression of dendritic cell function显示文摘 | Sharma S Stolina M Yang SC | 2003 | Clin Cancer Res2003，9，： | 1 |
| 12 | Body distribution of camptothecin solid lipid nanoparticles after oral administration 显示文摘 | Yang SC Zhu JB Lu Y | 1999 | Pharm Res1999，16，5： | 1 |
| 13 | Excessive matrix metallo- proteinase -9 in the plasma of community - acquired pneumonia显示文摘 | Yang SF Chu SC Chiang IC | 2005 | Clin Chim Acta2005，352，： | 1 |
| 14 | Impact of cement leakage into disks on the development of adjacent vertebral compression fractures显示文摘 | Chen WJ Kao YH Yang SC | 2010 | J Spinal Disord Tech2010，1，： | 1 |
| 15 | Polyketal copolymers:A new acid-sensitive delivery vehicle for treating acute inflamma-tory diseases显示文摘 | YANG SC BHIDE M CRISP IN | 2008 | Bioconjug Chem2008，19，6： | 1 |
| 16 | Cyclin DI overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer显示文摘 | Keum JS Kong G Yang SC | 1999 | B r J Cancer1999，81，1： | 1 |
| 17 | Cutaneous manifestations of human immunodeficiency virus infection in Taiwan显示文摘 | Tzung TY Yang CY Chao SC el al | 2004 | Kaohsi-ung J Med Sci2004，20，5： | 1 |
| 18 | Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain 显示文摘 | Yang SC Lu LF Cai Y | 1999 | J Controlled Release1999，59，3： | 1 |
| 19 | Intraoperative ultrasono-graphically guided exrisional hiopsy or vacuum-assisteHcore ne-edle biopsy for iionpalpable breast lesions 显示文摘 | Chen SC Yang HR Hwang TL | 2003 | Ann Surg2003，238，5： | 1 |
| 20 | Tumor cyclooxygenase-2/prostaglan-din E2-dependent promotion of FOXP3 expression and CD4+ CD T reg- ulatory cell aetivities in lung eaneer 显示文摘 | Sharma S Yang SC Zhu L | 2005 | Cancer Res2005，65，12： | 1 |
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