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| 1 | The IAP family: endogenous caspase inhibitors with multiple biological activities显示文摘IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain.We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byIAPs on signal transduction, cell cycle, and apoptosis. | YANG YI LI, XIAO MING LI(Laboratory of Immune Cell Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) | 2000 | Cell Research2000，10，3： | 19 |
| 2 | Physicochemical and Sensory Properties of japonica Rice Varied with Production Areas in China显示文摘Northeast of China and Jiangsu Province are major production areas of japonica rice in China.Rice from northeast of China is well-known for its good-eating and appearance quality,and that from Jiangsu Province is viewed as inferior.However,little is known concerning the difference in physicochemical and sensory properties of rice between the major two production areas.Analysis of 16 commercial rice samples showed marked differences in physicochemical properties,including chalky grain rate,contents of amylose and protein and pasting properties between the two main areas.Northeastern rice contained more shortchain amylopectin as compared with Jiangsu rice.However,Jiangsu rice is comparable to northeastern rice in terms of sensory quality including overall acceptability and textural properties of springiness,stickiness and hardness as evaluated by trained panel.Our results indicated the limitation of conventional index of physicochemical properties,and suggested the necessity of identification of new factors controlling rice sensory property.In addition,the taste analyzer from Japan demonstrates limitation in distinguishing the differences between northeastern and Jiangsu rice,and therefore needs localization to fit China. | YANG Xiao-yu LIN Zhao-miao LIU Zheng-hui Md A Alim BI Jun-guo LI Gang-hua WANG Qiang-sheng WANG Shao-hua DING Yan-feng | 2013 | Journal of Integrative Agriculture2013，12，10： | 8 |
| 3 | Comparison of microstructure and mechanical properties of titanium/ steel composite plates by two manufacturing processes显示文摘 | Xuan Yang Chang-gen Shi Yu-heng Ge Md Nahid Hasan Sabuj | 2018 | Journal of Iron and Steel Research(International)2018，25，3： | 7 |
| 4 | Sedimentary and geochemical evidence of Eocene climate change in the Xining Basin, northeastern Tibetan Plateau显示文摘The northeastern Tibetan Plateau began to grow during the Eocene and it is important to understand the climatic history of Asia during this period of so-called ‘doubthouse' conditions. However, despite major advances in the last few decades,the evolutionary history and possible mechanisms of Eocene climate change in the northeastern Tibetan Plateau remain unclear.The Xining Basin in the northeastern Tibetan Plateau contains a continuous sequence of Early to Late Eocene non-marine sediments which provides the opportunity to resolve long-term climate changes during this period. In this study, we report the results of analyses of lithofacies, sediment color and geochemistry of bulk samples collected from the Xijigou section of the Xining Basin. An abrupt lithofacies change between the Early(~52–40 Ma) and Late Eocene(~40–34 Ma) indicates a change in the depositional environment from a shallow lake to a playa lake in response to a significant climatic shift. During ~52–40 Ma,higher values of sediment redness(a*), redness/lightness(a*/L*) and higher modified Chemical Index of Weathering(CIW′)indicate a relatively warm and humid climate, while from ~40–34 Ma the lower values of a*, a*/L*and lower CIW′ imply subhumid to semi-arid climatic conditions. The paleoclimatic records indicate a long-term(~52–34 Ma) trend of decreasing chemical weathering, consistent with global climate change. An abrupt sharp excursion of the proxy records during ~42–40 Ma suggests a relatively brief warm interval, corresponding to the Middle Eocene Climatic Optimum(MECO). We suggest that global cooling substantially reduced humidity in inner Asia, resulting in sub-humid to semi-arid climatic conditions after 40 Ma in the Xining Basin, which may have been responsible for the long-term trend of decreasing chemical weathering during the Eocene. | Abu Sadat Md SAYEM Zhengtang GUO Haibin WU Chunxia ZHANG Fan YANG Guoqiao XIAO Zhilin HE | 2018 | Science China Earth Sciences2018，61，9： | 6 |
| 5 | Putrescine, spermidine, and spermine play distinct roles in rice salt tolerance显示文摘Polyamines(PAs) play diverse roles in plant growth and development,as well as responses to environmental stimuli.In this study,the effects of PAs on rice salt tolerance were investigated.Salt stress resulted in the alteration of endogenous PAs levels in rice roots and leaves,where spermidine(Spd) and spermine(Spm) contents were increased,and putrescine(Put) content was decreased.RT-qPCR analysis revealed that PAs biosynthesis-related genes ADC1,ODC,and Arginase were significantly downregulated by salt treatment;however,SAMDC transcription was significantly upregulated.Exogenous Spm enhanced rice salt tolerance remarkably;however,exogenous Put and Spd undermined rice salt tolerance.Transgenic rice plants overexpressing SAMDC display a higher ratio of Spm/(Put+Spd) and enhanced salt tolerance.Salt stress also increased polyamine oxidase activities in rice,resulting in elevated reactive oxygen species(ROS) production.Our findings revealed that accumulation of Put and Spd substantially reduced salt tolerance in rice,likely by facilitating ROS production;whereas,conversion of Put and Spd to Spm contributes to rice salt tolerance. | Md Azizul ISlam PANG Jin-huan MENG Fan-wei LI Ya-wen XU Ning YANG Chao LIU Jun | 2020 | Journal of Integrative Agriculture2020，19，3： | 5 |
| 6 | Prevalence of fatty liver in Japanese children and relationship to obesity显示文摘 | Kunihiko Tominaga MD Dr Ph John H. Kurata PhD Dr. Yang K. Chen MD Edward Fujimoto DHSc MPH Shouhei Miyagawa Ichiro Abe MSA Yoshimasa Kusano BS | | Digestive Diseases and Sciences0，，： | 5 |
| 7 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 8 | Tailored PEDOT:PSS hole transport layer for higher performance in perovskite solar cells: Enhancement of electrical and optical properties with improved morphology显示文摘Precise control over the charge carrier dynamics throughout the device can result in outstanding performance of perovskite solar cells(PSCs).Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)is the most actively studied hole transport material in p-i-n structured PSCs.However,charge transport in the PEDOT:PSS is limited and inefficient because of its low conductivity with the presence of the weak ionic conductor PSS.In addition,morphology of the underlying PEDOT:PSS layer in PSCs plays a crucial role in determining the optoelectronic quality of the active perovskite absorber layer.This work is focused on realization of a non-wetting conductive surface of hole transport layer suitable for the growth of larger perovskite crystalline domains.This is accomplished by employing a facile solventengineered(ethylene glycol and methanol)approach resulting in removal of the predominant PSS in PEDOT:PSS.The consequence of acquiring larger perovskite crystalline domains was observed in the charge carrier dynamics studies,with the achievement of higher charge carrier lifetime,lower charge transport time and lower transfer impedance in the solvent-engineered PEDOT:PSS-based PSCs.Use of this solventengineered treatment for the fabrication of MAPbI3 PSCs greatly increased the device stability witnessing a power conversion efficiency of 18.18%,which corresponds to^37%improvement compared to the untreated PEDOT:PSS based devices. | Khan Mamun Reza Ashim Gurung Behzad Bahrami Sally Mabrouk Hytham Elbohy Rajesh Pathak Ke Chen Ashraful Haider Chowdhury Md Tawabur Rahman Steven Letourneau Hao-Cheng Yang Gopalan Saianand Jeffrey WElam Seth BDarling Qiquan Qiao | 2020 | Journal of Energy Chemistry2020，29，5： | 4 |
| 9 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 10 | Effect of dopamine on electrical activity of isolated stomach muscle in cats显示文摘 | Yang Hyeok Jo MD Sang Soo Sim PhD Hyun Choi MD Dr. Myung Suk Kim MD | 1989 | Digestive Diseases and Sciences1989，，4： | 3 |
| 11 | Flexibility Prediction of Aggregated Electric Vehicles and Domestic Hot Water Systems in Smart Grids显示文摘With the growth of intermittent renewable energy generation in power grids,there is an increasing demand for controllable resources to be deployed to guarantee power quality and frequency stability.The flexibility of demand response(DR)resources has become a valuable solution to this problem.However,existing research indicates that problems on flexibility prediction of DR resources have not been investigated.This study applied the temporal convolution network(TCN)-combined transformer,a deep learning technique to predict the aggregated flexibility of two types of DR resources,that is,electric vehicles(EVs)and domestic hot water system(DHWS).The prediction uses historical power consumption data of these DR resources and DR signals(DSs)to facilitate prediction.The prediction can generate the size and maintenance time of the aggregated flexibility.The accuracy of the flexibility prediction results was verified through simulations of case studies.The simulation results show that under different maintenance times,the size of the flexibility changed.The proposed DR resource flexibility prediction method demonstrates its application in unlocking the demand-side flexibility to provide a reserve to grids. | Junjie Hu Huayanran Zhou Yihong Zhou Haijing Zhang Lars Nordströmd Guangya Yang | 2021 | Engineering2021，7，8： | 3 |
| 12 | Selenocysteine tRNAs as Central Components of Selenoprotein Biosynthesis in Eukaryotes显示文摘Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we exarnine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); (iii) the effect of selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis of the modified bases on Sec tRNA in Xenopus | SANG ICK PARK JIN Mo PARK HAROLD S. CHITTUM EUN SUNG YANG BRADLEY A. CARLSON BYEONG JAE LEE AND DOLPH L. HATFIELD(Laboratory of Experimental Chrcinogenesis, National Cancer Insti tute, National Institutes of Health, Bethesda, MD 20892USA Laboratory o | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 13 | Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning’s success显示文摘 | Michael V. Cohen MD Xi-Ming Yang James M. Downey | 2008 | Basic Research in Cardiology2008，，5： | 2 |
| 14 | A Gene Expression Profile for Vascular Invasion can Predict the Recurrence After Resection of Hepatocellular Carcinoma: a Microarray Approach显示文摘 | Ming-Chih Ho MD Jen-Jen Lin PhD Chiung-Nien Chen MD PhD Chaur-Chin Chen PhD Hsinyu Lee PhD Ching-Yao Yang MD Yen-Hsuan Ni MD PhD King-Jen Chang MD PhD Hey-Chi Hsu DDS Fon-Jou Hsieh MD Po-Huang Lee MD PhD | 2006 | Annals of Surgical Oncology2006，，11： | 1 |
| 15 | Focal cooling for epilepsy:an alternative therapy that might actually work显示文摘 | Rothman SM Smyth MD Yang XF | 2005 | Epilepsy Behav2005，7，： | 1 |
| 16 | Effects of Berberine on LipidMetabolism in Hats 显示文摘 | Yin J Chen MD Yang Y | 2003 | Journal of Shan^iai Jiaotong University(Medical Science)2003，，： | 1 |
| 17 | The effects of tibial rotati on on the patellofemoral joint:assessment of the changes in situ strain in the peripatellav retina culum and the patellofemoral contalt pressunes and areas显示文摘 | Lee TQ Yang BY Sandusky MD | 2001 | J Rehabil Res Dev2001，38，5： | 1 |
| 18 | Needle localization for excision- al biopsy of breast lesions : comparison of effect of use of full-field digital versus screen-film mammographic guidance on proocedure time显示文摘 | Wei Tse Yang MD Gary J | 2004 | Radiology2004，231，1： | 1 |
| 19 | Characterization of the 3a protein of SARS-assoeiated coronavirus in infected vero E6 cells and SARS patients显示文摘 | Zeng R Yang RF Shi MD | 2004 | J Mol Biol2004，341，1： | 1 |
| 20 | Companison of Pre-and Postcontrast 3D Time-of-fight MR Angiography for the Evaluation of Distal Intracranial Branch Occlusion sinacuteischemicstroke显示文摘 | Yang JJ Hill MD Mornsh WF | 2002 | AJNR2002，23，4： | 1 |
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