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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | Petroleum Geology in Deepwater Settings in a Passive Continental Margin of a Marginal Sea:A Case Study from the South China Sea显示文摘Deepwater oil and gas exploration has become a global hotspot in recent years and the study of the deep waters of marginal seas is an important frontier research area.The South China Sea(SCS)is a typical marginal sea that includes Paleo SCS and New SCS tectonic cycles.The latter includes continental marginal rifting,intercontinental oceanic expansion and oceanic shrinking,which controlled the evolution of basins,and the generation,migration and accumulation of hydrocarbons in the deepwater basins on the continental margin of the northern SCS.In the Paleogene,the basins rifted along the margin of the continent and were filled mainly with sediments in marine-continental transitional environments.In the Neogene–Quaternary,due to thermal subsidence,neritic-abyssal facies sediments from the passive continental margin of the SCS mainly filled the basins.The source rocks include mainly Oligocene coal-bearing deltaic and marine mudstones,which were heated by multiple events with high geothermal temperature and terrestrial heat flow,resulting in the generation of gas and oil.The faults,diapirs and sandstones controlled the migration of hydrocarbons that accumulated principally in a large canyon channel,a continental deepwater fan,and a shelf-margin delta. | ZHANG Gongcheng FENG Congjun YAO Xingzong JI Mo YANG Haizhang QU Hongjun ZENG Qingbo ZHAO Zhao SUN Rui | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 6 |
| 3 | Source-sink System and Sedimentary Model of Progradational Fan Delta Controlled by Restricted Ancient Gully:An Example in the Enping Formation in the Southern Baiyun Sag,Pearl River Mouth Basin,Northern South China Sea显示文摘Tectonic activity occurred during the depositional period of the Enping Formation in the southern Baiyun Sag in the Pearl River Mouth Basin,with a series of synsedimentary faults and a set of large fan delta reservoir bodies developing.There is no data from drilling,cores,etc.for this area,so this paper applies three-dimensional seismic data to study the structural style of the steep slope zone,the seismic facies characteristics of fan deltas,and the source-sink system and sedimentary model of the Enping Formation.The control action of tectonic activity on fan deltaic sedimentary systems is studied by combining interpretation of fault systems,dissection of structural styles,seismic reflection structure,seismic facies geometry,and seismic attribute analysis,together with theoretical analysis of the source-sink deposition process.The Baiyun Sag has experienced tectonic activity since the Eocene,and a series of synsedimentary faults are developed in the southern steep slope zone.Under the common control of multiple large synsedimentary faults,a large ancient gully formed in the steep slope zone in the south,which gradually widened from south to north.The uplift area in the southern part of the sag was exposed for a long time during the deposition of the Enping Formation and consequently suffered weathering and erosion.The resulting sediments were transported through a system of provenance channels composed of slopes and an ancient gully to the depression area,where they were deposited and eventually converged to form a large fan delta.The fan delta presents the overall characteristics of NS strong wedge reflection and EW strong domal reflection—thick in the middle part and thin in the wings.It displays a lobe-shaped distribution on the plane,with the fan root pointing to the south slope.According to differences in reflection intensity from bottom to top,it can be subdivided into three stages of progradational sedimentary bodies—the southern uplift and denudation zone,the large ancient gully,and the fan delta—which together constitute a complete source-sink system.This represents a sedimentary model of progradational fan delta under the overall joint control of the re stricted ancient gully and syndepositional faults. | FENG Congjun YAO Xingzong YANG Haizhang LI Daming SUN Mengsi | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 4 |
| 4 | On factorization of entire func- tions satisfying differential equations 显示文摘 | Urabe H Yang Congjun | 1991 | Kodai Math J1991，14，1： | 1 |
| 5 | Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling显示文摘Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity inhibitors.Here,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus sp.C1.HN-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte death.This protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional regulation.Knockdown of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown hepatocytes.Notably,the ER stress and lipotoxicity amelioration was associated with PLA2.Both HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated lipotoxicity.In contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of HN-001.Additionally,HN-001 treatment suppressed the downstream pro-apoptotic JNK pathway.In vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and fibrogenesis.These effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling suppression.These data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates. | Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
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