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| 1 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 2 | Movement and strain conditions of active blocks in the Chinese mainland显示文摘The definition of active block is given from the angles of crustal deformation and strain. The movement and strain parameters of active blocks are estimated according to the unified velocity field composed of the velocities at 1598 GPS stations obtained from GPS measurements carried out in the past years in the Chinese mainland and the surrounding areas. The movement and strain conditions of the blocks are analyzed. The active blocks in the Chinese mainland have a consistent E-trending movement component, but its N and S components are not consistent. The blocks in the western part have a consistent N-trending movement and the blocks in the eastern part have a consistent S-trending movement. In the area to the east of 90°E, that is the area from Himalayas block towards NE, the movement direction of the blocks rotates clockwisely and the movement rates of the blocks are different. Generally, the movement rate is large in the west and south and small in the east and north with a difference of 3 to 4 times between the rates in the west and east. The distributions of principal compressive strain directions of the blocks are also different. The principal strain of the blocks located to the west of 90oE is basically in the SN direction, the principal compressive strain of the blocks in the northeastern part of Qingzang plateau is roughly in the NE direction and the direction of principal compressive strain of the blocks in the southeastern part of Qingzang plateau rounds clockwisely the east end of Himalayas structure. In addition, the principal strain and shear strain rates of the blocks are also different. The Himalayas and Tianshan blocks have the largest principal compressive strain and the maximum shear strain rate. Then, Lhasa, Qiangtang, Southwest Yunnan (SW Yunnan), Qilian and Sichuan-Yunan (Chuan-Dian) blocks followed. The strain rate of the blocks in the eastern part is smaller. The estimation based on the stain condition indicates that Himalayas block is still the area with the most intensive tectonic activity and it shortens in the NS direction at the rate of 15.2±1.5 mm/a. Tianshan block ranks the second and it shortens in the NS direction at the rate of 10.1±0.9 mm/a. At present, the two blocks are still uprising. It can be seen from superficial strain that the Chinese mainland is predominated by superficial expansion. Almost the total area in the eastern part of the Chinese mainland is expanded, while in the western part, the superficial compression and expansion are alternatively distributed from the south to the north. In the Chinese mainland, most EW-trending or proximate EW-trending faults have the left-lateral or left-lateral strike-slip relative movements along both sides, and most NS-trending faults have the right-lateral or right-lateral strike-slip relative movements along both sides. According to the data from GPS measurements the left-lateral strike-slip rate is 4.8±1.3 mm/a in the central part of Altun fault and 9.8±2.2 mm/a on Xianshuihe fault. The movement of the fault along the block boundary has provided the condition for block movement, so the movements of the block and its boundary are consistent, but the movement levels of the blocks are different. The statistic results indicate that the relative movement between most blocks is quite significant, which proves that active blocks exist. Himalayas, Tianshan, Qiangtang and SW Yunnan blocks have the most intensive movement; China-Mongolia, China-Korea (China-Korea), Alxa and South China blocks are rather stable. The mutual action of India, Pacific and Philippine Sea plates versus Eurasia plate is the principal driving force to the block movement in the Chinese mainland. Under the NNE-trending intensive press from India plate, the crustal matter of Qingzang plateau moves to the NNE and NE directions, then is hindered by the blocks located in the northern, northeastern and eastern parts. The crustal matter moves towards the Indian Ocean by the southeastern part of the plateau. | LI Yanxing (李延兴) YANG Guohua (杨国华) LI Zhi (李 智) GUO Liangqian (郭良迁) HUANG Cheng (黄珹) ZHU Wenyao (朱文耀) FU Yang (符 养) WANG Qi (王 琪) JIANG Zaisen (江在森) WANG Min (王 敏) | 2003 | Science China Earth Sciences2003，46，z2： | 17 |
| 3 | Coherent beam combining of high powerfiber lasers: Progress and prospect显示文摘The recent research progress of coherent beam combining of high power fiber lasers is reviewed. Key technologies like coherently combinable fiber laser, phase control of multiple beams and beam tilling are specially analyzed. Prospects for single coherently combinable high power fiber amplifier, beam tilling and target-in-the-loop control for propagation in real atmosphere are presented. | LIU ZeJin ZHOU Pu XU XiaoJun WANG XiaoLin MA YanXing | 2013 | Science China(Technological Sciences)2013，56，7： | 16 |
| 4 | Deregulation of brain insulin signaling in Alzheimer's disease显示文摘Contrary to the previous belief that insulin does not act in the brain, studies in the last three decades have demonstrated important roles of insulin and insulin signal transduction in various functions of the central nervous system. Deregulated brain insulin signaling and its role in molecular pathogenesis have recently been reported in Alzheimer's disease(AD). In this article, we review the roles of brain insulin signaling in memory and cognition, the metabolism of amyloid β precursor protein, and tau phosphorylation. We further discuss defi ciencies of brain insulin signaling and glucose metabolism, their roles in the development of AD, and recent studies that target the brain insulin signaling pathway for the treatment of AD. It is clear now that deregulation of brain insulin signaling plays an important role in the development of sporadic AD. The brain insulin signaling pathway also offers a promising therapeutic target for treating AD and probably other neurodegenerative disorders. | Yanxing Chen Yanqiu Deng Baorong Zhang Cheng-Xin Gong | 2014 | Neuroscience Bulletin2014，30，2： | 15 |
| 5 | Deep-learning-based phase control method for tiled aperture coherent beam combining systems显示文摘We incorporate deep learning(DL)into tiled aperture coherent beam combining(CBC)systems for the first time,to the best of our knowledge.By using a well-trained convolutional neural network DL model,which has been constructed at a non-focal-plane to avoid the data collision problem,the relative phase of each beamlet could be accurately estimated,and then the phase error in the CBC system could be compensated directly by a servo phase control system.The feasibility and extensibility of the phase control method have been demonstrated by simulating the coherent combining of different hexagonal arrays.This DL-based phase control method offers a new way of eliminating dynamic phase noise in tiled aperture CBC systems,and it could provide a valuable reference on alleviating the long-standing problem that the phase control bandwidth decreases as the number of array elements increases. | Tianyue Hou Yi An Qi Chang Pengfei Ma Jun Li Dong Zhi Liangjin Huang Rongtao Su Jian Wu Yanxing Ma Pu Zhou | 2019 | High Power Laser Science and Engineering2019，7，4： | 10 |
| 6 | High power all-fiberized and narrow-bandwidth MOPA system by tandem pumping strategy for thermally induced mode instability suppression显示文摘An all-fiberized and narrow-bandwidth master oscillator power amplification(MOPA) system with record output power of 4 kW level and slope efficiency of 78% is demonstrated. Tandem pumping strategy is tentatively introduced into the narrow-bandwidth MOPA system for thermally induced mode instability(TMI) suppression. The stimulated Brillouin scattering(SBS) effect is balanced by simply using one-stage phase modulation technique. With different phase modulation signals, SBS limited output powers of 336 W, 1.2 kW and 3.94 kW are respectively achieved with spectral bandwidths accounting for 90% power of ~0.025, 0.17 and ~0.89 nm. Compared with our previous 976 nm pumping system, TMI threshold is overall boosted to be >5 times in which tandem pumping increases the TMI threshold of >3times. The beam quality(M~2 factor) of the output laser is well within 1.5 below the TMI threshold while it is ultimately saturated to be 1.86 with the influence of TMI at maximal output power. Except for SBS and TMI, stimulated Raman scattering(SRS) effect will be another challenge for further power scaling. In such a high power MOPA system, multidetrimental effects(SBS, SRS and TMI) will coexist and may be mutual-coupled, which could provide a well platform for further comprehensively investigating and optimizing the high power, narrow-bandwidth fiber amplifiers. | Pengfei Ma Hu Xiao Daren Meng Wei Liu Rumao Tao Jinyong Leng Yanxing Ma Rongtao Su Pu Zhou Zejin Liu | 2018 | High Power Laser Science and Engineering2018，6，4： | 9 |
| 7 | Deep-learning-assisted, two-stage phase control method for high-power mode-programmable orbital angular momentum beam generation显示文摘High-power mode-programmable orbital angular momentum(OAM)beams have received substantial attention in recent years.They are widely used in optical communication,nonlinear frequency conversion,and laser processing.To overcome the power limitation of a single beam,coherent beam combining(CBC)of laser arrays is used.However,in specific CBC systems used to generate structured light with a complex wavefront,eliminating phase noise and realizing flexible phase modulation proved to be difficult challenges.In this paper,we propose and demonstrate a two-stage phase control method that can generate OAM beams with different topological charges from a CBC system.During the phase control process,the phase errors are preliminarily compensated by a deep-learning(DL)network,and further eliminated by an optimization algorithm.Moreover,by modulating the expected relative phase vector and cost function,all-electronic flexible programmable switching of the OAM mode is realized.Results indicate that the proposed method combines the characteristics of DL for undesired convergent phase avoidance and the advantages of the optimization algorithm for accuracy improvement,thereby ensuring the high mode purity of the generated OAM beams.This work could provide a valuable reference for future implementation of high-power,fast switchable structured light generation and manipulation. | TIANYUE HOU YI AN QI CHANG PENGFEI MA JUN LI LIANGJIN HUANG DONG ZHI JIAN WU RONGTAO SU YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，5： | 8 |
| 8 | A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases显示文摘The development of broad-spectrum antivirals against human coronaviruses(HCoVs)is critical to combat the current coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,as well as future outbreaks of emerging CoVs.We have previously identified a polyethylene glycol-conjugated(PEGylated)lipopeptide,EK1C4,with potent pan-CoV fusion inhibitory activity.However,PEG linkers in peptide or protein drugs may reduce stability or induce anti-PEG antibodies in vivo.Therefore,we herein report the design and synthesis of a series of dePEGylated lipopeptide-based pan-CoV fusion inhibitors featuring the replacement of the PEG linker with amino acids in the heptad repeat 2 C-terminal fragment(HR2-CF)of HCoV-OC43.Among these lipopeptides,EKL1C showed the most potent inhibitory activity against infection by SARS-CoV-2 and its spike(S)mutants,as well as other HCoVs and some bat SARS-related coronaviruses(SARSr-CoVs)tested.The dePEGylated lipopeptide EKL1C exhibited significantly stronger resistance to proteolytic enzymes,better metabolic stability in mouse serum,higher thermostability than the PEGylated lipopeptide EK1C4,suggesting that EKL1C could be further developed as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Jie Zhou Wei Xu Zezhong Liu Chao Wang Shuai Xia Qiaoshuai Lan Yanxing Cai Shan Su Jing Pu Lixiao Xing Youhua Xie Lu Lu Shibo Jiang Qian Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 9 | Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by SARS-Co V-2 has posed a significant threat to global public health and economy,thus calling for the rapid development of effective therapeutics and prophylactics.Repurposing existing medicines with clinical safety profiles offers a more rapid hope of combating COVID-19pandemic than developing a new therapeutic. | Yanxing Cai Wei Xu Chenjian Gu Xia Cai Di Qu Lu Lu Youhua Xie Shibo Jiang | 2020 | Virologica Sinica2020，35，6： | 4 |
| 10 | High-peak-power temporally shaped nanosecond fiber laser immune to SPM-induced spectral broadening显示文摘High-peak-power transform-limited narrow-linewidth nanosecond all-fiber lasers are desired in a range of applications.However,their linewidths will be broadened by self-phase modulation(SPM).We propose a novel concept that generates transform-limited laser pulses by temporally shaping the pulse seed.The impact of the pulse shape on SPM-induced spectral broadening was studied numerically and experimentally.It was found theoretically that the square-shape pulsed laser is immune to SPM-induced spectral broadening.Based on this principle,we built a high-peak-power,linearly polarized,square-shape nanosecond all-fiber laser in a master oscillator power amplifier(MOPA)configuration.Stimulated Brillouin scattering(SBS)limited peak powers of 4.02 kW,5.06 kW,6.52 kW and 9.30 kW were obtained at pulse widths of 8 ns,7 ns,6 ns and 5 ns.Thanks to the square-shape pulsed seed,the linewidths at maximum peak power remained at 129.5 MHz,137.6 MHz,156.2 MHz and 200.1 MHz,respectively,close to the transform-limited values of110.8 MHz,126.6 MHz,147.7 MHz and 177.3 MHz. | Rongtao Su Pengfei Ma Pu Zhou Zilun Chen Xiaolin Wang Yanxing Ma Jian Wu Xiaojun Xu | 2019 | High Power Laser Science and Engineering2019，7，2： | 4 |
| 11 | Selective adsorption of silver ions from aqueous solution using polystyrene-supported trimercaptotriazine resin显示文摘Trimercaptotriazine-functionalized polystyrene chelating resin was prepared and employed for the adsorption of Ag(I)from aqueous solution.The adsorbent was characterized according to the following techniques:Fourier transform infrared spectroscopy,elemental analysis,scanning electron microscopy and the Brunauer-Emmet-Teller method.The effects of initial Ag(I)concentration,contact time,solution pH and coexisting ions on the adsorption capacity of Ag(I)were systematically investigated.The maximum adsorption capacity of Ag(I)was up to 187.1 mg/g resin at pH 0.0 and room temperature.The kinetic experiments indicated that the adsorption rate of Ag(I)onto the chelating resin was quite fast in the first 60 min and reached adsorption equilibrium after 360min.The adsorption process can be well described by the pseudo second-order kinetic model and the equilibrium adsorption isotherm was closely fitted by the Langmuir model.Moreover,the chelating resin could selectively adsorb more Ag(I)ions than other heavy metal ions including:Cu(II),Zn(II),Ni(II),Pb(II)and Cr(III)during competitive adsorption in the binary metal species systems,which indicated that it was a highly selective adsorbent of Ag(I)from aqueous solution. | Shiming Wang Hongling Li Xiaoya Chen Min Yang Yanxing Qi | 2012 | Journal of Environmental Sciences2012，24，12： | 4 |
| 12 | Impacts of river impoundment on the riverine water chemistry composition and their response to chemical weathering rate显示文摘当前,世界范围的大多数河强烈地被扣押了。河建水坝成为一个大问题,不是仅仅在导致物理阻塞在之间在上游并且下游地,而且在里面破坏河的自然连续性。但是水质量的断绝是经常忽视了研究,它介绍挑战给传统的河地球化学。在水坝在上游、下游的水的基本化学理解变化,我们在 Wujiang 河盆,和 Hongjiadu 在系列调查了 Miaotiao 河水库, Wujiang 河的上面的活动范围上的 Dongfeng 水库。化学捱过率分别地用水坝的水库表面并且下游地的水化学数据是计算的,在每座水库。结果证明捱过率的化学药品之间的差别从水库表面水计算了,水坝下游的水在有一更长的水保留时间的水库是更大的。在有在学习水库之中的最长的水保留时间的 Hongjiadu 水库,这差别到达 9% 。作为结果,河建水坝的影响,特别在系列的水库的影响,当计算河盆的化学捱过率时,应该被考虑[出版摘要] | Yang GAO Baoli WANG Xiaolong LIU Yuchun WANG Jing ZHANG Yanxing JIANG | 2013 | Frontiers of Earth Science2013，7，3： | 3 |
| 13 | Comprehensive investigation on producing high-power orbital angular momentum beams by coherent combining technology显示文摘High-power orbital angular momentum(OAM)beams have distinct advantages in improving capacity and data receiving for free-space optical communication systems at long distances.Utilizing the coherent combination of a beam array technique and helical phase approximation by a piston phase array,we have proposed a generating system for a novel high-power beam carrying OAM,which could overcome the power limitations of a common vortex phase modulator and a single beam.The characteristics of this generating method and the orthogonality of the generated OAM beams with different eigenstates have been theoretically analyzed and verified.Also a high-power OAM beam produced by coherent beam combination(CBC)of a six-element hexagonal fiber amplifier array has been experimentally implemented.Results show that the CBC technique utilized to control the piston phase differences among the array beams has a high efficiency of 96.3%.On the premise of CBC,we have obtained novel vortex beams carrying OAM of±1 by applying an additional piston phase array modulation on the corresponding beam array.The experimental results agree approximately with the theoretical analysis.This work could be beneficial to areas that need high-power OAM beams,such as ultra-long distance free-space optical communications,biomedical treatments,and powerful trapping and manipulation under deep potential wells. | Dong Zhi Tianyue Hou Pengfei Ma Yanxing Ma Pu Zhou Rumao Tao Xiaolin Wang Lei Si | 2019 | High Power Laser Science and Engineering2019，7，2： | 3 |
| 14 | Nonlinear photoresponse of metallic graphene-like VSe2 ultrathin nanosheets for pulse laser generation显示文摘Vanadium diselenide(VSe2), a typical metallic behaviour material among transition metal dichalcogenides(TMDCs) family, exhibits excellent photoelectric characteristics with a zero band gap, missing applicaiotn in pulse generation. In this work, a high-quality VSe2 saturable absorber(SA) was synthesized through a liquid-phase exfoliation method. The saturable absorption of obtained VSe2-SA was characterized systematically. The measured modulation depth was 9.9%, and the saturated intensity was 533.8 μJ/cm2. By incorporating this optical modulator into a ytterbium-doped fiber laser cavity, a stable passively Q-switched laser could be achieved. The pulse had the central wavelength of 1064.03 nm. As the pump power was increased, the repetition rate increased from 24.3 k Hz to 35.6 k Hz, and the pulse duration decreased from7.21 μs to 5.27 μs. The output power had the maximum value of 28.55 m W. These results indicated that VSe2 is an effective candidate to generate pulse laser due to its excellent nonlinear optical properties and universal photoelectric response, which may advance the applications of VSe2-based nonlinear optics and photoelectric devices. | Tao WANG Xinyao SHI Jin WANG Yijun XU Jie CHEN Zhuo DONG Man JIANG Pengfei MA Rongtao SU Yanxing MA Jian WU Kai ZHANG Pu ZHOU | 2019 | Science China(Information Sciences)2019，62，12： | 3 |
| 15 | Review on key technologies and typical applications of multi-station integrated energy systems显示文摘To realize the low-carbon development of power systems,digital transformation,and power marketization reform,the substation,data center,energy storage,photovoltaic,and charging stations are important components for the construction of new infrastructure.The integration infrastructure represented by multi-station integrated energy systems(MSIESs)represents the development trend,and its connotation and denotation are not immutable.This study firstly analyzed the components of MSIESs and their sub-stations and overall characteristics,and proposed an overall architecture for MSIESs.Thereafter,this system was characterized in detail from three aspects:planning and design,operation control,and market operation.The planning and construction of MSIESs was analyzed from the aspects of planning and design process,typical fusion subsystems,supply and demand prediction,and capacity determination;the operational control of MSIESs was analyzed from the aspects of model construction,coordination control,and safety assessment.Moreover,the market operation of MSIESs was examined from the aspects of the business model and spot market.Furthermore,the technical development trend of MSIESs has been explored in this study. | Zhenlan Dou Chunyan Zhang Wei Wang Dan Wang Qiqi Zhang Yanxing Cai Ruitian Fan | 2022 | Global Energy Interconnection2022，5，3： | 2 |
| 16 | Neural network approach to the reconstruction of free form surfaces for reverse engineering 显示文摘 | Gup YanX | 1995 | Computer Aided Design1995，27，1： | 2 |
| 17 | Monolithic high-average-power linearly polarized nanosecond pulsed fiber laser with near-diffraction-limited beam quality显示文摘An all-fiberized high-average-power narrow linewidth ns pulsed laser with linear polarization is demonstrated. The laser system utilizes a typical master oscillator power amplifier(MOPA) configuration. The stimulated Brillouin scattering(SBS) is effectively suppressed due to the short fiber length and large mode area in the main amplifier, combined with the narrow pulse duration smaller than the phonon lifetime of SBS effect. A maximal output power of 466 W is obtained with a narrow linewidth of ~203.6 MHz, and the corresponding slope efficiency is ~80.3%. The pulse duration is condensed to be ~4 ns after the amplification, corresponding to the peak power of 8.8 kW and the pulse energy of 46.6 μJ. Neardiffraction-limited beam quality with an M2 factor of 1.32 is obtained at the output power of 442 W and the mode instability(MI) is observed at the maximal output power. To the best of our knowledge, this is the highest average output power of the all-fiberized narrow linewidth ns pulsed fiber laser with linear polarization and high beam quality, which is a promising source for the nonlinear frequency conversion, laser lidar, and so on. | Long Huang Pengfei Ma Daren Meng Lei Li Rumao Tao Rongtao Su Yanxing Ma Pu Zhou | 2018 | High Power Laser Science and Engineering2018，6，3： | 2 |
| 18 | Measurement for coordinated development of"four modernizations" and its efficiency ofprefecture level cities or above in China显示文摘The efficient and coordinated development of industrialization, urbanization, informatization and agricultural modernization(so called 'Sihua Tongbu' in China, and hereinafter referred to as 'four modernizations') is not only a practical need but also an important strategic direction of integrating urban-rural development and regional development in recent China. This paper evaluated the comprehensive, coupling and coordinated developmental indices of 'four modernizations' of China's 343 prefecture-level administrative units, and calculated their efficiency of 'four modernizations' in 2001 and 2011. The efficiency evaluation index system was established. The efficiencies and their changing trend during the period 2001–2011 were investigated using the data envelopment analysis(DEA) model. Spatial-temporal pattern of the efficiency of China's prefecture-level units was explored by using exploratory spatial data analysis(ESDA). Finally, the main influencing factors were revealed with the aid of geographically weighted regression(GWR) model. Results indicate that the comprehensive, coupling and coordinated developmental indices and efficiency of 'four modernizations' of China's prefecture-level administrative units have obvious spatial differences and show diverse regional patterns. Overall, the efficiency is relatively low, and only few units with small urban populations and economic scale are in DEA efficiencies. The efficiency changing trends were decreasing during 2001–2011, with a transfer of high efficiency areas from inland to eastern coastal areas. The difference between urban and rural per capita investment in fixed assets boasts the greatest influence on the efficiency. | jinghu pan yanxing hu | 2016 | Research in Cold and Arid Regions2016，8，2： | 2 |
| 19 | Early changes to the extracellular space in the hippocampus under simulated microgravity conditions显示文摘The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains unclear.In this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 group.The tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both groups.The diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 group.The alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 group.Our findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS. | Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu | 2022 | Science China(Life Sciences)2022，65，3： | 2 |
| 20 | Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex显示文摘The development and plasticity of central auditory system can be influenced by the change of peripheral neuronal activity. However, the molecular mechanism participating in the process remains elusive. Brain-derived neurotrophic factor(BDNF) binding with its functional receptor tropomyosin receptor kinase B(TrkB) has multiple effects on neurons. Here we used a rat model of auditory deprivation by bilateral cochlear ablation, to investigate the changes in expression of BDNF and Trk B in the auditory cortex after auditory deprivation that occurred during the critical period for the development of central auditory system. Reverse transcription-quantitative polymerase chain reaction(RTqPCR) and immunohistochemistry methods were adopted to detect the m RNA and protein expression levels of BDNF and TrkB in the auditory cortex at 2, 4, 6 and 8 weeks after surgery, respectively. The change in the expression of BDNF and TrkB mRNAs and proteins followed similar trend. In the bilateral cochlear ablation groups, the BDNF-TrkB expression level initially decreased at 2 weeks but increased at 4 weeks followed by the reduction at 6 and 8 weeks after cochlear removal, as compared to the age-matched sham control groups. In conclusion, the BDNF-TrkB signaling is involved in the plasticity of auditory cortex in an activity-dependent manner. | Yuxing Wang Ou Xu Yanxing Liu Hong Lu | 2017 | Journal of Otology2017，12，1： | 2 |
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