|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bench-to-bedside strategies for osteoporotic fracture: from osteoimmunology to mechanosensation显示文摘Osteoporosis is characterized by a decrease in bone mass and strength, rendering people prone to osteoporotic fractures caused by low-energy forces. The primary treatment strategy for osteoporotic fractures is surgery;however, the compromised and comminuted bones in osteoporotic fracture sites are not conducive to optimum reduction and rigid fixation. In addition, these patients always exhibit accompanying aging-related disorders, including high inflammatory status, decreased mechanical loading and abnormal skeletal metabolism, which are disadvantages for fracture healing around sites that have undergone orthopedic procedures. Since the incidence of osteoporosis is expected to increase worldwide, orthopedic surgeons should pay more attention to comprehensive strategies for improving the poor prognosis of osteoporotic fractures. Herein, we highlight the molecular basis of osteoimmunology and bone mechanosensation in different healing phases of elderly osteoporotic fractures, guiding perioperative management to alleviate the unfavorable effects of insufficient mechanical loading, high inflammatory levels and pathogen infection. The well-informed pharmacologic and surgical intervention, including treatment with anti-inflammatory drugs and sufficient application of antibiotics, as well as bench-to-bedside strategies for bone augmentation and hardware selection, should be made according to a comprehensive understanding of bone biomechanical properties in addition to the remodeling status of osteoporotic bones, which is necessary for creating proper biological and mechanical environments for bone union and remodeling. Multidisciplinary collaboration will facilitate the improvement of overall osteoporotic care and reduction of secondary fracture incidence. | Yong Xie Licheng Zhang Qi Xiong Yanpan Gao Wei Ge Peifu Tang | 2019 | Bone Research2019，7，3： | 10 |
| 2 | GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions显示文摘Aim: To investigate the inhibitory effect of a new compound of GLB on tumor metastasis in vivo and analyze its actions on tumor cell adhesion to clarify its mechanism. Methods: The effect of GLB on tumor metastasis was analyzed by Lewis lung carcinoma model. The pathological morphology of lung alveolar was evaluated by hematoxylin-eosin staining. The effect of GLB on the proliferation of human prostate cancer cell (PC-3M, with a high metastatic characteristic) was studied using the Mq-T method, and its actions on PC-3M cell adhesion to human umbilical vein endothelial cells (HUVEC) and laminin were analyzed in vitro. Results: GLB (100 mg·kg^-1·d^-1 for 28 d, ig) reduced the number of lung colonies of Lewis lung carcinoma metastasis significantly (P<0.05). Simultaneously, GLB could mitigate the damage of lung alveolar caused by metastasic tumor deposits. In vitro, GLB inhibited dramatically the adhesion of PC-3M cells to HUVEC (P<0.01) and laminin (P<0.05), without cytotoxic or anti-proliferative action on PC-3M cells. Conclusion: GLB has anti-tumor metastatic activity, which partly depends on its inhibition of tumor adhesion. | YanPAN Qian-liuSONG Yan-huaLIN NingLU He-ruingYU XueojunLI | 2005 | Acta Pharmacologica Sinica2005，26，7： | 4 |
| 3 | Preparation of PVA/H_3PW_(12)O_(40) Fiber Mats显示文摘Poly(vinyl alcohol) (PVA) fiber mats containing 20 and 80 wt% H3PW12O40 were prepared by using electrospinning technique. The fiber mats were characterized by IR, XRD spectra and scanning electron microscope (SEM). The diameter of the fiber mats is ca. 400 nm. | JianGONG ChangLuSHAO GuoChengYANG YanPAN LunYuQU | 2004 | Chinese Chemical Letters2004，15，3： | 1 |
| 4 | Proteomic A nalysis of Estrogen- Mediated Signal Transduction in Osteoclasts Formation显示文摘 | Qi Xiong Peifu Tang Yanpan Gao | 2015 | Biomed Res Int2015，，59： | 1 |
| 5 | Synthesis and Characterization of Aminated Poly (2,6-dimethyl-1,4-phenylene oxide)显示文摘 | YanPan YuHuiHuang BingLiao | 1996 | Joural of Applied Polymer Science1996，，61： | 1 |
| 6 | Proteomics analysis of human umbilical vein endothelial cells (HUVEC) after treatment with low molecular weight heparin显示文摘AIM: The endothelium is involved in the generation and the regulation of multiple physiological and pathological processes of blood vessels. Previously we confirmed low molecular weight heparin (LMWH) could inhibit tumor metastasis by protecting human umbilical vein endothelial cells (HUVEC). To understand the effects of LMWH on the protein expression of HUVEC, we performed a comprehensive proteomics to survey global changes in proteins after LMWH treatment in HUVEC cells. METHODS: | YanPAN Jun-huaWANG He-mingYU Xue-junLI | 2004 | Acta Pharmacologica Sinica2004，25，11： | 0 |
| 7 | Cell density mediated pericellular hypoxia and COCl2 induced hypoxia leads to AQPI induction under isotonic conditions in vitro显示文摘Recently, many reports have linked aquaporin 1 (AQPI)protein overexpression with tumorigenesis, tumor growth and progression, but the underlying mechanisms on regulating of AQP1 protein expression are still not clear. We hypothesized that hypoxia might play an important role in AQP1 induction during tumorigenesis as well as at the late stages of tumor development. To prove this hypothesis, we studied the | NingLU YanPAN Yan-huaLIN Jun-weiGAO Tian-luoLEI He-mingYU Xue-junLI | 2004 | Acta Pharmacologica Sinica2004，25，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员