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| 1 | Satellite lithium-ion battery remaining useful life estimation with an iterative updated RVM fused with the KF algorithm显示文摘Lithium-ion batteries have become the third-generation space batteries and are widely utilized in a series of spacecraft.Remaining Useful Life(RUL) estimation is essential to a spacecraft as the battery is a critical part and determines the lifetime and reliability.The Relevance Vector Machine(RVM) is a data-driven algorithm used to estimate a battery's RUL due to its sparse feature and uncertainty management capability.Especially, some of the regressive cases indicate that the RVM can obtain a better short-term prediction performance rather than long-term prediction.As a nonlinear kernel learning algorithm, the coefficient matrix and relevance vectors are fixed once the RVM training is conducted.Moreover, the RVM can be simply influenced by the noise with the training data.Thus, this work proposes an iterative updated approach to improve the long-term prediction performance for a battery's RUL prediction.Firstly, when a new estimator is output by the RVM, the Kalman filter is applied to optimize this estimator with a physical degradation model.Then, this optimized estimator is added into the training set as an on-line sample, the RVM model is re-trained, and the coefficient matrix and relevance vectors can be dynamically adjusted to make next iterative prediction.Experimental results with a commercial battery test data set and a satellite battery data set both indicate that the proposed method can achieve a better performance for RUL estimation. | Yuchen SONG Datong LIU Yandong HOU Jinxiang YU Yu PENG | 2018 | Chinese Journal of Aeronautics2018，31，1： | 29 |
| 2 | Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo显示文摘The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes.In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant.The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes.The cell growth in three scaffolds was not affected by the macro-pore sizes.The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone.The scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore sizes.This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis. | Jinyu Li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng | 2016 | Regenerative Biomaterials2016，3，5： | 16 |
| 3 | Theoretical study on Manson-Coffin equation for physically short cracks and lifetime prediction显示文摘The Manson-Coffin equation has been widely applied to the prediction of fatigue lifetime.But this equation does not explicitly express the relation between the fatigue lifetime and the crack length.The present paper proposes that the grain size can be re-placed by the maximum non-damaging crack length.Thus,the growth rate will decrease to zero when the crack reaches this size.Combining with the theory of the fatigue short crack propagation,we derived the relations between physically short crack's initiation-propagation rates and material's mechanical properties,as well as crack length,stress and strain.With the derived relations,fatigue lifetime of short cracks can be successfully predicted by basic mechanical properties.Similar to the format of Manson-Coffin equation,our relations uncover the essence of Manson-Coffin equation which may reveal the short crack's initiation-propagation mechanism.Predictions of fatigue lifetime using our relations were compared with the results of well-known experiments.Good agreement is found in many aspects,such as coefficients,exponents,as well as fatigue life-times,especially for short cracks around 10 micrometers.Predictions on the short crack propagation rates are also compared for 16 types of carbon steels.Satisfactory consistency shows that our relations have wide applicability. | HU YanDong HU ZhiZhong CAO ShuZhen | 2012 | Science China(Technological Sciences)2012，55，1： | 14 |
| 4 | Novel Mobility Formula for Parallel Mechanisms Expressed with Mobility of General Link Group显示文摘The determination of virtual constraints is always one of the key and difficult problems in traditional mobility calculation.To make mobility calculation simple,considering avoiding virtual constraints,some new formulae have been presented,however these formulae can hardly intuitively reflect general link group’s restrictions on output member and its influences on independence of output parameters,which is premise to the judgment of the properties of mobility.Towards the problem to reveal the intrinsic relationship between the degree of freedom(DOF)of a mechanism,the link group,and the dimension of output parameters,also to avoid determination of virtual constraint,based on the new concepts of the'DOF of general link group'and'node parameters',a new formula in the calculation of the mobility of mechanisms is presented that is expressed with DOFs of the general link groups and rank of motion parameters of base point of the output link.It is named GOM(mobility of groups and output parameter)formula.On the basis of new concepts of'effective parameters'and'invalid parameters',a rule is put forward for solving the DOF of mechanisms with invalid parameters by GOM formula,that is,the base point parameters are the subset of effective parameters of link group.Thereafter,several examples are enumerated and the results coincide with the prototype data,which proves the validity of the proposed formula.Meanwhile,it is obtained that the necessary and sufficient condition for the judgment of output parameters independence is that each of the DOF of the link group is not less than zero.The proposed formula which is simple in calculation provides theoretical basis for the judgment of independence of output parameters and provides references for type synthesis of novel parallel mechanisms with independence requirements of their output parameters. | ZHANG Yitong LU Wenjuan MU Dejun YANG Yandong ZHANG Lijie ZENG Daxing | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 14 |
| 5 | Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing显示文摘Tracing the emergence of the first hematopoietic stem cells(HSCs)in human embryos,particularly the scarce and transient precursors thereof,is so far challenging,largely due to the technical limitations and the material rarity.Here,using single-cell RNA sequencing,we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis.The transcriptomically defined HSC-primed hemogenic endothelial cells(HECs)were captured at Carnegie stage(CS)12-14 in an unbiased way,showing an unambiguous feature of arterial endothelial cells(ECs)with the up-regulation of RUNX1,MYB and ANGPTL Importantly,subcategorizing CD34+CD45-ECs into a CD44+population strikingly enriched HECs by over 10-fold.We further mapped the developmental path from arterial ECs via HSC-primed HECs to hematopoietic stem progenitor cells,and revealed a distinct expression pattern of genes that were transiently over-represented upon the hemogenic fate choice of arterial ECs#including EMCN,PROCR and RUNX1T1.We also uncovered another temporally and molecularly distinct intra-embryonic HEC population,which was detected mainly at earlier CS 10 and lacked the arterial feature.Finally,we revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSCprimed HECs.The cellular and molecular programs that underlie the generation of the first HSCs from HECs in human embryos,together with the ability to distinguish the HSC-primed HECs from others,will shed light on the strategies for the production of clinically useful HSCs from pluripotent stem cells. | Yang Zeng Jian He Zhijie Bai Zongcheng Li Yandong Gong Chen Liu Yanli Ni Junjie Du Chunyu Ma Lihong Bian Yu Lan Bing Liu | 2019 | Cell Research2019，29，11： | 14 |
| 6 | Enhanced nutrients removal from municipal wastewater through biological phosphorus removal followed by partial nitritation/anammox显示文摘 | Yandong Yang Liang Zhang Hedong Shao Shujun Zhang PengchaoGu Yongzhen Peng | 2017 | Frontiers of Environmental Science & Engineering2017，11，2： | 10 |
| 7 | Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings显示文摘Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°. | Yandong Wang Nan Lu Hongbo Xu Gang Shi Miaojun Xu Xiaowen Lin Haibo Li Wentao Wang Dianpeng Qi Yanqing Lu Lifeng Chi | 2010 | Nano Research2010，3，7： | 8 |
| 8 | Comparison of Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy for Iris Parameter Measurements in Patients with Primary Angle Closure Glaucoma显示文摘Purpose: To compare the repeatability and consistency of anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in measuring iris parameters in patients with primary angle closure glaucoma. Methods: Twenty-two patients (38 eyes) with primary angle closure glaucoma,including 5 eyes with acute angle closure glaucoma,10 fellow eyes of acute angle closure glaucoma, and 23 eyes with chronic angle closure glaucoma, were recruited consecutively in our hospital. All subjects underwent anterior scanning by AS-OCT and UBM. Peripheral iris thickness (PIT) and iris curvature (IC) in the anterior segment image obtained by AS-OCT and UBM were measured twice. The reproducibility of these two scans was evaluated by the intraclass correlation coefficient (ICC). A paired t-test was used to compare the difference between the two scans and the 95% limits of agreement (LoA) were calculated. Results:The ICCs of PIT and IC measured by UBM were 0.892 and 0.936 respectively, while for AS-OCT these values were 0.629 and 0.859, respectively. UBM had a higher reproducibility in both PIT and IC measurements as compared with AS-OCT.Differences in PIT measurement between AS-OCT and UBM(P=0.331).were not statistically significant, the 95% LoA (-0.178~0.156) mm was 36.1~41.2% of the mean. The IC was 0.053 mm smaller when measured by UBM than by AS-OCT (P=0.017), with the 95% LoA (-0.100~0.206) mm, or 36.2~74.6% of the mean.Conclusion:UBM had a higher reproducibility in measuring iris parameters than AS-OCT. The consistency between AS- OCT and UBM in measuring iris parameters was low in primary angle closure glaucoma patients. (Eye Science 2013; 28:1-6) | Zhonghao Wang Di Chen Yangfa Zeng Yandong Wang Xuanwei Liang Xing Liu | 2013 | Eye Science2013，28，1： | 8 |
| 9 | Recharge sources and chemical composition types of groundwater and lake in the Badain Jaran Desert, northwestern China显示文摘在 Badain Jaran 沙漠基于湖水和浅地下水的离子化学药品作文的分析,这份报纸在荒芜的区域讨论了离子化学药品作文,湖水的空间变化,和湖水和地下水的可能的供应来源的特征。结果证明 pH,咸度, TDS 和湖水的电的电导率比地下水的那些大。水样品的离子内容被 Na+ 和 Cl 统治。大多数更高的咸度湖是 Na (K)-Cl-(SO4) 类型,并且低咸度湖的一些属于 Na-(Mg )-(Ca)-Cl-(SO4)-(HCO3) 类型。大多数地下水是 Na-(Ca )-(Mg)-Cl-(SO4)-(HCO3) 类型,把湖,和仅仅在场的一些归因于 subsaline Na-Cl-SO4 类型,流动在盐的湖下面。在东南的湖的 pH,咸度, TDS 和电的电导率是相对低的,并且有稍微碱的湖。在北湖的 pH,咸度, TDS 和电的电导率比东南的湖的那些大得多,并且北湖是中等碱、盐的。在 Badain Jaran 沙漠的东南的部分,到北方表演的来自南方的湖水的离子化学药品特征 subsaline salinehypersaline 的一个变化趋势。离子在的化学作文的变化趋势最近 9 年显示大多数离子内容在 Boritaolegai, Badain, Nuoertu 和 Huhejilin 湖有一点儿减小,它清楚地声明新鲜的水供应的数量在 9 年的时期正在增加。湖水的离子化学药品作文表明湖水的流动方向从东南到在 Badain Jaran 沙漠的西北。离子化学药品作文,沙层水水平高度的潮湿内容和湖水和地下水的层次簇分析证明湖水被降水的本地降雨和渗入主要在 Yabulai 山和 Heishantou 山供应,并且从 Qilian 山的供应是几乎不可能的。 | SHAO Tianje ZHAO Jingbo ZHOU Qi DONG Zhibao MA Yandong | 2012 | Journal of Geographical Sciences2012，22，3： | 7 |
| 10 | Parallel Manufacturing for Industrial Metaverses:A New Paradigm in Smart Manufacturing显示文摘To tackle the complexity of human and social factors in manufacturing systems, parallel manufacturing for industrial metaverses is proposed as a new paradigm in smart manufacturing for effective and efficient operations of those systems, where Cyber-Physical-Social Systems(CPSSs) and the Internet of Minds(Io M) are regarded as its infrastructures and the 'Artificial systems', 'Computational experiments'and 'Parallel execution'(ACP) method is its methodological foundation for parallel evolution, closed-loop feedback, and collaborative optimization. In parallel manufacturing, social demands are analyzed and extracted from social intelligence for product R&D and production planning, and digital workers and robotic workers perform the majority of the physical and mental work instead of human workers, contributing to the realization of low-cost, high-efficiency and zero-inventory manufacturing. A variety of advanced technologies such as Knowledge Automation(KA), blockchain, crowdsourcing and Decentralized Autonomous Organizations(DAOs) provide powerful support for the construction of parallel manufacturing, which holds the promise of breaking the constraints of resource and capacity, and the limitations of time and space. Finally, the effectiveness of parallel manufacturing is verified by taking the workflow of customized shoes as a case,especially the unmanned production line named Flex Vega. | Jing Yang Xiaoxing Wang Yandong Zhao | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 6 |
| 11 | On fractional control method for four-wheel-steering vehicle显示文摘Four-wheel-steering (4WS) system can enhance vehicle cornering ability by steering the rear wheels in accordance with the front wheels steering and vehicle status. With such steering control system, it becomes possible to improve the lateral stability and handling performance. In this paper, a new control method for 4WS vehicle is proposed, its rear wheels steering angle is in accordance with the angle of front wheels steering and vehicle yaw rate, and the effects of front wheels steering angle velocity are considered by adopting the fractional derivative theory. Some design specifications for control law are also given. The effects of the control method are verified by a kind of numerical scheme presented in this paper. The dynamic characteristics such as the side-slip angle and the yaw angle velocity of the vehicle gravity center are compared among three kinds of vehicles with different control methods. And the kinematics characteristics such as turning radius between 4WS and 2WS are also discussed. Nu- merical simulation shows that the control method presented can improve the transient response and reduce the turning radius of 4WS vehicle. | CHEN Ning CHEN Nan CHEN YanDong | 2009 | Science China(Technological Sciences)2009，52，3： | 6 |
| 12 | Approximate design of optimal tracking controller for time-delay systems显示文摘Successive approximate design of the optimal tracking controller for linear systems with time-delay is developed. By applying the successive approximation theory of differential equations, the two-point boundary value (TPBV) problem with both time-delay and time-advance terms derived from the original optimal tracking control (OTC) problem is transformed into a sequence of linear TPBV prob- lems without delay and advance terms. The solution sequence of the linear TPBV problems uniformly converges to the solution of the original OTC problem The obtained OTC law consists of analytic state feedback terms and a compensation term which is the limit of the adjoint vector sequence. The com- pensation term can be obtained from an iteration formula of adjoint vectors. By using a finite term of the adjoint vector sequence, a suboptimal tracking control law is revealed. Numerical examples show the effectiveness of the algorithm. | TANG Gongyou LI Chao ZHAO Yandong | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 13 | Morphologic characteristics and growth interface stability of nano-micron FeS_2 whiskers显示文摘Micromorphology is further studied on the basis of our previous researches concerned with the nano-micron FeS2 whisker. There are obvious differences in the intensive degree, diameter and micromorphology among the FeS2 whiskers growing in different stages. From the early to late stage, the intensive degree increases, the diameter decreases, and the surface micro-morphology changes following the regularity: protrusive nodulation → coarse → smooth → flat. According to the theory of crystal growth, the geological setting and processes of whisker formation, we discuss the stability and evolution of crystal growth interface of FeS2 whisker occurring in Gengzhuang gold deposit (Shanxi Province, China). The results suggest that the negative temperature gradient and the supercooling appear in the early stage of the whisker growth, whereas the positive temperature gradient of reposeful state appears in the late stage. In the whisker growth stage, the component concentration changes through the three stages: severely nonhomogeneous in the early stage, relatively homogeneous in the middle stage, more homogeneous in the late stage. The general changing process of the interfacial state is from unstable to stable. Micromorphology of FeS2 whisker in Gengzhuang is the result of synergism of temperature, component concentration and stability of crystal interface phase in hydrothermal system. The micromorphology not only reflects the physical and chemical characteristics of the hydrothermal system during the whisker growth, but also indicates the stability characteristics of the interface phase and records the changing process of the whisker growth. | HUANG Fei WANG RuCheng ZHANG WenLan YAO YuZeng PENG YanDong KOU DaMing | 2009 | Chinese Science Bulletin2009，54，23： | 6 |
| 14 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 15 | COMPARISONS AMONG THE SOLUTIONS OF FIBER TEXTURE VECTOR显示文摘COMPARISONSAMONGTHESOLUTIONSOFFIBERTEXTUREVECTORWANGYandong,A.VadonandJ.J.Heizmann(LMPC/ISGMP,UniversitedeMetz,F-57045MetzCED... | WANG Yandong, A. Vadon and J.J. Heizmann(LMPC/ISGMP, Universite de Metz, F-57045 Metz CEDEX 01, France)ZUO Liang(Department of Materials Science and Engineering, Northeastern University, Shenyang 110006, China) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，3： | 5 |
| 16 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 17 | DATA MODEL AND VISUALIZATION OF 3D CITY LANDSCAPE BASED ON INTEGRATED DATABASES显示文摘Data acquisition and modeling are the two important, difficult and costful aspects in a Cybercity project. 2D-GIS is mature and can manage a lot of spatial data. Thus 3D-GIS should make the best of data and technology of 2D-GIS. Construction of a useful synthetic environment requires integration of multiple types of information like DEM, texture images and 3D representation of objects such as buildings. In this paper, the method for 3D city landscape data model and visualization based on integrated databases is presented. Since the data volume of raster are very huge, special strategies(for example, pyramid gridded method) must be adopted in order to manage raster data efficiently. Three different methods of data acquisition, the proper data structure and a simple modeling method are presented as well. At last, a pilot project of Shanghai Cybercity is illustrated. | Li Deren Wang Yandong Zhu Qing Gong Jianya | 1999 | Geo-Spatial Information Science1999，2，1： | 5 |
| 18 | Degradation of phenol in industrial wastewater over the F–Fe/TiO_2 photocatalysts under visible light illumination显示文摘F–Fe/TiO_2 composite photocatalyst was synthesized by a facile one-step hydrothermal method and then characterized by XRD, XPS and UV–Vis DRS. The catalyst of F–Fe/TiO_2 exhibited the highest photodegradation rate for phenol as compared with pure TiO_2, F/TiO_2, Fe/TiO_2, F0.38–Fe0.13–TiO_2 and Fe(III)/F-TiO_2 under visible light irradiation. The simulated conditions of industrial phenolic wastewater including initial phenol concentration,visible light intensity, p H and different anions were investigated in the presence of F–Fe/TiO_2 photocatalyst. In addition, as expected, the F–Fe/TiO_2 photocatalyst displayed excellent stability, showing a potential industrial application for the treatment of phenolic wastewater. | Yandong Liu Shijian Zhou Fu Yang Hua Qin Yan Kong | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 4 |
| 19 | Study on the Water Quality and Protection Measures of Dongting Lake显示文摘From nitrogen and phosphorus,chemical oxygen demand,phytoplankton,and eutrophication,this article analyzes the current situation of water quality in the Dongting Lake area,and discusses the factors influencing the water quality of Dongting Lake. Based on the actual production,geographic characteristics and outstanding problem of grim water pollution situation in the Dongting Lake area,some specific proposed measures are put forward in order to provide the basis and reference for the future pollution control in the Dongting Lake area,such as strengthening the industrial pollution control,developing ecological agriculture,and enhancing ecological restoration and water quality early warning. | Zhangquan ZENG Canming ZHANG Xiquan LI Nan Yang Yandong NIU Zijian WU | 2015 | Asian Agricultural Research2015，7，1： | 4 |
| 20 | Protective effect of Chushizi(Fructus Broussonetiae)on acetaminophen-induced rat hepatitis by inhibiting the Toll-like receptor 3/c-Jun N-terminal kinase/c-jun/c-fos/janus protein tyrosine kinase/activators of transcription 3 pathway显示文摘OBJECTIVE:To observe the intervention of Chushizi(Fructus Broussonetiae)(CSZ)on drug-induced liver injury(DILI)in rats,as well as indicators of liver function,serum levels of inflammatory cytokines,and expression of proteins and m RNA associated with toll-like receptor 3(TLR3)and the signal transducer and activator of transcription 3(STAT3)pathway in the liver[TLR3,janus protein tyrosine kinase 2(JAK2),c-jun,c-fos,c-Jun N-terminal kinase 2(JNK2),and STAT3].METHODS:Forty specified pathogen free grade Sprague-Dawley rats were randomly divided into the control group,the model group,the silybin group and the CSZ group.Rats were given acetaminophen(APAP)to trigger DILI.Histopathology of the liver was observed by hematoxylin-eosin staining.The levels of alanine aminotransferase(ALT),aspartate transaminase(AST),direct bilirubin(DBIL),and total bilirubin(TBIL)in serum were detected by a semi-automatic biochemical instrument.Content of tumor necrosis factor alpha(TNF-α),interleukin(IL)-6,IL-13,and IL-22 in serum were detected by the enzyme-linked immunosorbent assay,the expression of TLR3,phosphorylation of JAK2(p-JAK2),while c-jun and c-fos proteins in the liver were determined by immunohistochemistry;expression of JNK2,and STAT3 in the liver were assayed by Western blot and real-time quantitative polymerase chain reaction.P-JNK2 and p-STAT3 in the liver were assayed by Western blot.RESULTS:After treatment,the activity of ALT,AST,and concentrations of TBIL,DBIL,TNF-α,IL-6,as well as IL-13 in serum,were lower than those in the model group,and expression of p-JAK2,TLR3,c-jun,c-fos,p-STAT3,and p-JNK2 could be downregulated.CONCLUSION:Our findings suggest that CSZ is a valid medicine to alleviate APAP-induced DILI,while its partial mechanism may regulate the TLR3/JNK/c-jun/c-fos/JAK/STAT3 pathway. | Zhang Yandong Biao Yaning Chu Xinqiao Hao Lei Shi Cheng Liu Yu Zhang Yixin Wang Xi | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
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