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您的检索式：作者名="Ya Chee Lim"
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| 1 | Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression显示文摘Src 家庭酷氨酸 kinases (SFK ) 的异常激活在多重稳固的肿瘤和 hematological 癌症指导转移的开始和药抵抗的开发。因为 SFK 的 oncogenic 变化是稀罕事件,在癌症的 SFK 的异常激活由于二个主要在上游的禁止者的 dysregulation 是可能的:C 终端 Src kinase (Csk ) 和它的相当或相同的事物 Csk 相应的 kinase (Chk/Matk ) 。Csk 和 Chk/Matk 禁止 SFK 由有选择地 phosphorylating 在他们的 C 终端尾巴的禁止的酷氨酸残余。另外, Chk/Matk 能也采用 noncatalytic 禁止 SFK 的多重活跃形式的禁止的机制,建议那 Chk/Matk 是能够抑制 SFK 的多重活跃形式的活动的一个万用的禁止者。增长证据建议 Chk/Matk 在象 colorectal 和肺癌那样的几癌症是由 epigenetic silencing 或错误感觉变化的潜在的肿瘤 suppressor downregulated。尽管有在癌症的 Chk/Matk 的潜在的意义,很少对它的结构和规定被知道。这评论集中于 Chk/Matk 表示和活动是在癌症的 downregulated 的由机制。明确地,我们估计了在癌症由 epigenetic silencing 和错误感觉变化表明 Chk/Matk 的 downregulation 的证据。另外的焦点是肿瘤 Chk/Matk 的镇压机制。评论的最后的焦点在进 Chk/Matk 表示和肿瘤的 epigenetic silencing 的机制的调查的临床的应用上 Chk/Matk 的镇压机制;明确地,我们讨论了他们怎么能用作癌症治疗学为癌症和特定的 SFK 禁止者的早诊断有益于 biomarkers 的发展。 | Gahana Advani Anderly C. Chueh Ya Chee Lim Amardeep Dhillon Heung-Chin Cheng | 2015 | Frontiers in Biology2015，10，3： | 1 |
| 2 | Stretchable magnesium-air battery based on dual ions conducting hydrogel for intelligent biomedical applications显示文摘Flexible and bio-integrated electronics have attracted great attention due to their enormous contributions to personalized medical devices.Power sources,serving as one of the most important components,have been suffering from many problems,including deficient biocompatibility,poor stretchability,and unstable electrical outputs under deformed conditions,which limits the practical applications in flexible and bio-integrated electronics.Here,we reported a fully stretchable magnesium(Mg)–air battery based on dual-ions-conducting hydrogels(SDICH).The high-performance battery enables long-term operation with lighting 120 lighting emitting diodes(LEDs)for over 5 h.Benefiting from the advanced materials and mechanical designs,the battery exhibits stability electrical outputs under stretching,which allows to operate ordinarily under various mechanical deformations without performance decay.Furthermore,the great biocompatibility of the battery offers great opportunity for biomedical applications,which is demonstrated by a self-adaption wound dressing system.The in vitro and in vivo results prove that the self-adaption wound dressing can effectively prevent wound inflammation and promote wound healing.By exploiting thermal feedback mechanics,the system can adjust antibiotic release rate and dosage spontaneously according to the real-time wound conditions.The proposed fully stretchable Mg-air battery and self-adaption wound dressing display great potential in skin-integrated electronics and personalized medicine. | Xingcan Huang Yiming Liu Wooyoung Park Zhao Zhao Jiyu Li Chee Kent Lim Tsz Hung Wong Chun Ki Yiu Yuyu Gao Jingkun Zhou HuLi Ling Zhao Jian Li Binbin Zhang Ya Huang Rui Shi Dengfeng Li Jiaying Mo Jinpei Wang Chao Zhang Yuhang Li Zuankai Wang Xinge Yu | 2023 | InfoMat2023，5，3： | 0 |
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