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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Bat origin of a new human coronavirus:there and back again显示文摘A novel coronavirus reported to cause pneumonia in 41 people during December 2019 in Wuhan,the capital of Hubei province,China,was identified and designated as the 2019 novel coronavirus(2019-nCoV)(Zhu et al.,2020;Li et al.,2020).Infection with 2019-nCoV results in clusters of severe respiratory illness similar to that caused by severe acute respiratory syndrome coronavirus(SARS-CoV)and is associated with high mortality(Chen et al.,2020;Huang et al.,2020).This new coronavirus belongs to genus Betacoronavirus,family Coronaviridae,with a single-stranded,positive-sense RNA genome,but genetically distinct from SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV). | Xiang Li Yuhe Song Gary Wong Jie Cui | 2020 | Science China(Life Sciences)2020，63，3： | 3 |
| 3 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 4 | Human Endogenous Retroviruses as Biomedicine Markers显示文摘Human endogenous retroviruses(HERVs)were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral“fossils”.The human genome is embedded with a considerable amount of HERVs,witnessing the long-term evolutionary history of the viruses and the host.Most HERVs have lost coding capability during selection but still function in terms of HERV-mediated regulation of host gene expression.In this review,we summarize the roles of HERV activation in response to viral infections and diseases,and emphasize the potential use of HERVs as biomedicine markers in the early diagnosis of diseases such as cancer,which provides a new perspective for the clinical application of HERVs. | Yuhe Song Xiang Li Xiaoman Wei Jie Cui | 2021 | Virologica Sinica2021，36，5： | 1 |
| 5 | Changes in Several Physiological and Biochemical Indices of Maize Seedling Roots Caused by Drought Stress显示文摘The changes in several physiological and biochemical indices of seedling roots of new maize variety Qingnong 8 were studied under the simulated drought condition with 18% PEG-6000 and water shortage. The results showed that under drought conditions,the contents of soluble protein and malonialdehy( MDA) and the activities of superoxide dismutase( SOD) and peroxidase( POD) in roots of maize seedlings significantly increased,and the increasing amplitude reduced after water shortage for 96 h. The re-watering treatment results after 48 h water shortage showed that the SOD and POD activities and the MDA content could recover to normal level,and the soluble protein content was lower than normal content. This study showed that the maize seedlings of Qingnong 8 suffered drought injury could grow normally after re-watering treatment. | Cui Limei Wang Xinxin Xuan Huidong Song Xiyun Pei Yuhe | 2015 | Plant Diseases and Pests2015，6，4： | 1 |
| 6 | Anticancer,Anti-inflammatory and Antibacterial Effects of Aloin and Its Molecular Mechanism显示文摘Aloin is the main medicinal component extracted from Aloe vera.It is a natural anthraquinone compound,with anticancer,anti-inflammatory and antibacterial and other biological functions.This paper reviews the pharmacological action and related mechanisms of aloin,in order to provide a theoretical basis for the development and utilization of aloin. | Ting XU Wenshuang HOU Yuhe CUI Anqi WANG Jiazhu LI Chenghao JIN | 2023 | Medicinal Plant2023，14，6： | 0 |
| 7 | Review on marine collagen peptides induce cancer cell apoptosis,necrosis,and autophagy by reducing oxidized free radicals显示文摘Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or enzymes.MCPs have a range of structures and biological activities and are widely present in marine species.MCPs also have a small molecular weight,are easily modified,and absorbed by the body.These properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging activities.MCPs of specific molecular weights have significant anti-tumor activity and no toxic side effects.Thus,MCPs have the potential use as anti-cancer adjuvant drugs.Free radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well known.In this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice. | YINGHUA LUO YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO WENSHUANG HOU JIAN LIU YUHE CUI TING XU CHENGHAO JIN | 2023 | BIOCELL2023，47，5： | 0 |
| 8 | Erratum to: Bat origin of a new human coronavirus: there and back again显示文摘We miscalculated identities of several genes, and the corrected Table 1 should be as follows:a、 This table demonstrates identities of 2019-nCoV WIV04 (GenBank Accession No. MN996528.1) compared with bat SARSr-CoV RaTG13 (GenBank Accession No. MN996532.1) and SARS-CoV BJ01 (GenBank Accession No. AY278488.2). | Xiang Li Yuhe Song Gary Wong Jie Cui | 2020 | Science China(Life Sciences)2020，63，7： | 0 |
| 9 | Preparation Process,Pharmacological Activity and Molecular Mechanism of Valepotriate显示文摘In recent years,with the continuous development of the medicinal value of valepotriate and the great attention of scholars.The traditional extraction and purification process can no longer meet the current market standards and needs.The modern technology of valepotriate is of great significance to its application and development.This paper reviews the extraction and purification process,molding process and pharmacological activity of valepotriate,providing a theoretical basis for the research and application of valepotriate. | Jinglong CAO Jian LIU Yannan LI Hui XUE Wenshuang HOU Ting XU Yuhe CUI Chenghao JIN | 2023 | Medicinal Plant2023，14，1： | 0 |
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