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| 1 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 2 | 卵巢黏液性肿瘤中的间变性癌显示文摘 | Provenza C Young R H Prat J. 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 5 |
| 3 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 4 | Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis显示文摘Importin 蛋白质原来通过原子毛孔在蛋白质运输为他们的中央角色被描绘,唯一的细胞内部的入口到原子核。这个重要函数必须紧被调整由抄写因素和另外的原子蛋白质控制存取到 genomic DNA,到完成细胞的行为影响的适当调整房间命运。调停 Importin 的 nucleocytoplasmic 运输依靠他们货物的特定的识别,与到不同、重叠的蛋白质子集的每 importin 绑定。importin 功能的知识关于三个关键发展系统实质地膨胀了:胚胎的干细胞,肌肉房间和细菌排队。自从为调整 nucleocytoplasmic 运输的潜力被建议贡献精子发生,在十年,我们和其它证明了进原子核的渡船抄写因素执行的 importins 另外的角色,它控制房间命运。这评论从哺乳动物的精子发生的研究介绍关键调查结果揭示男富饶和不孕由产生的潜在的新小径。germline 开始的这些研究照亮 importin 蛋白质在管理细胞的区别的新方法,经由指导到不同细胞内部的分隔空间并且由决定细胞的压力回答的蛋白质包括。 | Kate L Loveland Andrew T Major Romaly Butler Julia C Young David A Jan Yoichi Miyamoto | 2015 | Asian Journal of Andrology2015，17，4： | 3 |
| 5 | 韩国社会工作教育中的文化能力问题显示文摘近年来,在多元文化主义背景的影响下,社会工作的文化能力培养已成为韩国社会工作发展的当务之急。检视了韩国不同文化族群的分布,提出培养文化共融能力的理论框架,并讨论了文化能力培养在韩国社会工作发展中的有效性,以及如何在韩国社会工作教育中真正落实文化能力培养,并对社会工作的文化能力教育中潜在的影响和要点进行了讨论。 | Jun Sung Hong Charu Stokes Soo-Jung Byoun Sharlene B C L Furuto Young Sook Kim 张宇 宋洁 | 2014 | 社会工作与管理2014，14，A04： | 3 |
| 6 | 伴有浆细胞分化的套细胞淋巴瘤显示文摘 | Young K H Chan W C Fu K 黄文斌(摘译) | 2006 | 临床与实验病理学杂志2006，22，5： | 2 |
| 7 | What is the most cost-effective strategy to screen for second primary colorectal cancers in male cancer survivors in Korea?显示文摘AIM:To identify a cost-effective strategy of second primary colorectal cancer (CRC) screening for cancer survivors in Korea using a decision-analytic model.METHODS: A Markov model estimated the clinical and economic consequences of a simulated 50-year-old male cancer survivors' cohort, and we compared the results of eight screening strategies: no screening, fecal occult blood test (FOBT) annually, FOBT every 2 years, sigmoidoscopy every 5 years, double contrast barium enema every 5 years, and colonoscopy every 10 years (COL10), every 5 years (COL5), and every 3 years (COL3). We included only direct medical costs, and our main outcome measures were discounted lifetime costs, life expectancy, and incremental cost-effectiveness ratio (ICER).RESULTS: In the base-case analysis, the non-dominated strategies in cancer survivors were COL5, and COL3. The ICER for COL3 in cancer survivors was $5593/life-year saved (LYS), and did not exceed $10000/LYS in one-way sensitivity analyses. If the risk of CRC in can- cer survivors is at least two times higher than that in the general population, COL5 had an ICER of less than $10500/LYS among both good and poor prognosis of index cancer. If the age of cancer survivors starting CRC screening was decreased to 40 years, the ICER of COL5 was less than $7400/LYS regardless of screening compliance.CONCLUSION: Our study suggests that more strict and frequent recommendations for colonoscopy such as COL5 and COL3 could be considered as economically reasonable second primary CRC screening strategies for Korean male cancer survivors. | Sang Min Park Sun-Young Kim Craig C Earle Seung-Yong Jeong Young Ho Yun | 2009 | World Journal of Gastroenterology2009，15，25： | 2 |
| 8 | LOV to BLUF: Flavoprotein Contributions to the Optogenetic Toolkit显示文摘Optogenetics 是联合光、基因的途径 non-invasively 与优美空间与时间的控制防碍细胞的事件的一块新兴的地。尽管它从神经科学原来产生了, optogenetics 对许多不同生物系统的学习广泛地适用,从这种技术产生的应用程序的范围继续增加。而且,使用设计新 optogenetic 工具的光敏感的蛋白质的全部剧目很快正在膨胀。察觉到的光,氧,或电压和 Blue-Light-Utilizing 黄素腺嘌 dinucleotide (一度时髦的风尚)(BLUF )(LOV ) 领域代表新贡献者到 optogenetic 工具箱。这些小(100140-amino 酸) 黄素蛋白模块从对 UV-A/blue 光作出回应的植物和细菌的光敏电阻器被导出。在最近的年里,可观的进步在揭开被成为了 LOV 和 BLUF 领域的 photoactivation 机制。这知识在合成 photoswitches 的设计被使用了并且荧光灯有在房间生物学和生物工学的应用的记者。在这评论,我们总结 LOV 和 BLUF photosensors 的光化学的性质并且加亮一些这些黄素蛋白怎么正在被采用人工地调整并且想象的最近的进展许多生物过程。 | John M. Christie Jayde Gawthorne Gillian Young Niall J. Fraser^c and Andrew J. Roe | 2012 | Molecular Plant2012，5，3： | 2 |
| 9 | A method for rapid determination of lactose显示文摘 | Teles F F Young C K Stull J W | 1978 | J Dairy Sci1978，61，： | 2 |
| 10 | Polyp detection rates using magnification with narrow band imaging and white light显示文摘AIM: To compare the yield of adenomas between narrow band imaging and white light when using high definition/magnification. METHODS: This prospective, non-randomized comparative study was performed at the endoscopy unit of veteran affairs medical center in Phoenix, Arizona. Consecutive patients undergoing first average risk colorectal cancer screening colonoscopy were selected. Two experienced gastroenterologists performed all the procedures that were blinded to each other's findings. Demographic details were recorded. Data are presented as mean ± SEM. Proportional data were compared using the χ2 test and means were compared using the Student's t test. Tandem colonoscopy was performed in a sequential and segmental fashion using one of 3 strategies: white light followed by narrow band imaging [Group A: white light(WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by white light(Group C: WL → WL). Detection rate of missed polyps and adenomas were evaluated in all three groups. RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for the colonoscopy was similar in the 3 groups(23.8 ± 0.7, 22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C, respectively), it reached statistical significance between Groups B and C(P < 0.05). The cecal intubation time in Groups B and C was longer than for Group A(6.5 ± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P < 0.05). The withdrawal time for Groups A and C was longer than Group B(18.9 ± 0.7 min and 17.6 ± 0.6min vs 15.7 ± 0.4 min; P < 0.05). Overall miss rate for polyps and adenomas detected in three groups during the second look was 18% and 17%, respectively(P = NS). Detection rate for polyps and adenomas after first look with white light was similar irrespective of the light used during the second look(WL → WL: 13.7% for polyps, 12.6% for adenomas; WL → NBI: 14.2% for polyps, 11.3% for adenomas). Miss rate of polyps and adenomas however was significantly higher when NBI was used first(29.3% and 30.3%, respectively; P < 0.05). Most missed adenomas were ≤ 5 mm in size. There was only one advanced neoplasia(defined by size only) missed during the first look. CONCLUSION: Our data suggest that the tandem nature of the procedure rather than the optical techniques was associated with the detection of additional polyps' and adenomas. | Nooman Gilani Sally Stipho James D Panetta Sorin Petre Michele A Young Francisco C Ramirez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 2 |
| 11 | BaTiO3 particles prepared by microwave-assisted hydrothermal reaction using titanium acylate precursors 显示文摘 | GUANG J C HYUN S K YOUNG S C | 1999 | Material Letters1999，41，： | 2 |
| 12 | Fas antigen expression on CD 34+human marrow cells is induced by interferon-gammasu-pression in vitro 显示文摘 | Maciejewski JP Selleri C young NS | 1995 | Blood1995，85，11： | 1 |
| 13 | Micro--injection Molding with the Infrared Assisted Mold Heating System显示文摘 | Yu M C Young W B Hsu P M | 2007 | Material Science and Engineering A2007，，： | 1 |
| 14 | More than folding:localized functions of cytosolic chapemmes显示文摘 | YOUNG J C BARRAL J M HARD U F | 2003 | Trends Biochem Sci2003，28，： | 1 |
| 15 | Spectrum of electrophysiologic and electropharmacologic characteristics of verapamil-sensitive ventricular tachycardia in patients without strucral heart disease显示文摘 | Lauer MR Young C | 1996 | Am J Cardiol1996，77，8： | 1 |
| 16 | Reconstruction for renal artery aneurysm: Operative techniques and long-term results显示文摘 | Jong A H Young K W | 2003 | J Vas Surg2003，37，2： | 1 |
| 17 | Time-dependent fundamental solutions for homogeneous diffusion problems显示文摘 | Young D L Tsai C C Murugesan K Fan C M Chen C W | 2004 | Engineering Analysis with Boundary Elements2004，28，： | 1 |
| 18 | A rapid,sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry显示文摘 | YOUNG C L ASH D DRISKELL W J BOYER A E MARTINEZ R A SILKS L A BARR J R | 2004 | Anal Toxicol2004，28，5： | 1 |
| 19 | Immunolocalization of type III collagen in human articular cartilage prepared by high- pressure eryofixation, freeze-substitution, and low-temperature embedding显示文摘 | Young R D Lawrence P A Duanee V C | 1995 | J Histochem Cytochem1995，43，4： | 1 |
| 20 | Fatty acid genotypes of Virginia-type peanut cultivars显示文摘 | Isleib T G Young C T Knauft D A | 1996 | Crop Sci1996，36，3： | 1 |
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