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| 1 | Effect of dietary soy oil, glucose, and glutamine on growth performance, amino acid profile, blood profile, immunity, and antioxidant capacity in weaned piglets显示文摘Weaning stress results in gastrointestinal dysfunction and depressed performance in pigs. This study aimed to investigate the effect of soy oil, glucose, and glutamine on the growth and health of weaned piglets. Compared with those in the glutamine group, piglets in the glucose and soy oil groups had greater average daily gain, average daily feed intake, and gain: feed ratio from day 0 to 14, and gain: feed ratio for the overall period. There were no differences with regard to serum amino acids among the three groups on day 14, except glycine and threonine. The serum concentration of histidine, serine, threonine, proline, and cysteine was the highest in the glutamine group, while the content of glycine and lysine in the soy oil group on day 28 was the highest among all groups. Piglets fed with glutamine had greater serum glucose and creatinine on day 14, high-density lipoprotein on day 28, and serum IgG and IgM on day 28. Piglets in the glutamine group demonstrated lower serum total superoxide dismutase on day 14 and 28; however, they demonstrated higher total superoxide dismutase and total antioxidant capacity in the duodenum and ileum on day 14. Weaned pigs supplemented with glucose or soy oil demonstrate better growth performance possibly due to their enhanced feed intake, whereas those supplemented with glutamine may have improved immunity and intestinal oxidative capacity. | Dinghong Lv Xia Xiong Huansheng Yang Meiwei Wang Yijie He Yanhong Liu Yulong Yin | 2018 | Science China(Life Sciences)2018，61，10： | 20 |
| 2 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 3 | Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice显示文摘African swine fever(ASF) is a lethal hemorrhagic disease that affects wild and domestic swine. The etiological agent of ASF is African swine fever virus(ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries. No commercial vaccines are available to prevent ASF. In this study, we generated a recombinant Newcastle disease virus(r NDV) expressing ASFV protein 72(p72) by reverse genetics and evaluated its humoral and cellular immunogenicity in a mouse model. The recombinant virus, r NDV/p72, replicated well in embryonated chicken eggs and was safe to use in chicks and mice. The p72 gene in r NDV/p72 was stably maintained through ten passages. Mice immunized with r NDV/p72 developed high titers of ASFV p72 specific Ig G antibody, and had higher levels of Ig G1 than IgG2 a. Immunization also elicited T-cell proliferation and secretion of IFN-γ and IL-4. Taken together, these results indicate that r NDV expressing ASFV p72 might be a potential vaccine candidate for preventing ASF. | Xinxin Chen Jifei Yang Yanhong Ji Edward Okoth Bin Liu Xiaoyang Li Hong Yin Qiyun Zhu | 2016 | Virologica Sinica2016，31，2： | 18 |
| 4 | Metamorphism of the northern Liaoning Complex:Implications for the tectonic evolution of Neoarchean basement of the Eastern Block,North China Craton显示文摘As one of the areas where typical late Archean crust is exposed in the Eastern Block of the North China Craton,the northern Laioning Complex consists principally of tonalitic-trondhjemitic-granodioritic(TTG) gneisses,massive granitoids and supracrustal rocks.The supracrustal rocks,named the Qingyuan Group, consist of interbedded amphibolite,hornblende granulite,biotite granulite and B1F.Petrological evidence indicates that the amphibolites experienced the early prograde(M1),peak(M2) and post-peak(M3) metamorphism.The early prograde assemblage(M1) is preserved as mineral inclusions,represented by actinotite + hornblende + plagioclase + epidote + quartz + sphene,within garnet porphyroblasts.The peak assemblage(M2) is indicated by garnet + clinopyroxene + hornblende + plagioclase + quartz + ilmenite, which occur as major mineral phases in the rock.The post-peak assemblage(M3) is characterized by the garnet + quartz symplectite.The P—T pseudosections in the NCFMASHTO system constructed by using THERMOCALC define the P-T conditions of Ml,M2 and M3 at 490-550℃/<4.5 kbar,780-810℃/7.65- 8.40 kbar and 630-670℃/8.15-9.40 kbar,respectively.As a result,an anticlockwise P-T path involving isobaric cooling is inferred for the metamorphic evolution of the amphibolites.Such a P-T path suggests that the late Archean metamorphism of the northern Liaoning Complex was related to the intrusion and underplating of mantle-derived magmas.The underplating of voluminous mantle-derived magmas leading to metamorphism with an anticlockwise P-T path involving isobaric cooling may have occurred in continental magmatic arc regions,above hot spots driven by mantle plumes,or in continental rift environments. A mantle plume model is favored because this model can reasonably interpret many other geological features of late Archean basement rocks from the northern Liaoning Complex in the Eastern Block of the North China Craton as well as their anticlockwise P—T paths involving isobaric cooling. | Kam Kuen Wu Guochun Zhao Min Sun Changqing Yin Yanhong He Pui Yuk Tam | 2013 | Geoscience Frontiers2013，4，3： | 14 |
| 5 | Surplus dietary isoleucine intake enhanced monounsaturated fatty acid synthesis and fat accumulation in skeletal muscle of finishing pigs显示文摘Background: Isoleucine(Ile) has been implicated in the regulation of energy homeostasis and adipogenesis.However,the impact of surplus dietary Ile intake on muscle lipogenesis remains unknown.The present study aimed to investigate the impact of dietary supplementation of extra-Ile on lipogenesis,fatty acid profile and lipid accumulation in skeletal muscle in finishing pigs.Methods: Forty-eight barrows with initial body weight of 77.0 ± 0.1 kg were allotted to one of two groups and fed diets containing 0.39%,0.53% standardized ileal digestible(SID) Ile with six replicates per treatment and four pigs per replicate for 30 d.Results: Dietary Ile intake significantly improved the intramuscular fat(IMF) content and monounsaturated fatty acid(MUFA) concentration in the skeletal muscle(P < 0.05),and decreased the drip loss and shear force(P < 0.05) without influencing the growth performance of pigs(P > 0.05).Moreover,the phosphorylation of adenosine monophosphate activated protein kinase α(AMPKα) and acetyl coenzyme A carboxylase(ACC) proteins that monitor lipid metabolism were decreased in skeletal muscle of pigs offered extra-Ile diet(P < 0.05).The mRNA expression of adipose-specific genes adipocyte determination and differentiation factor 1(ADD1),fatty acid synthase(FAS),and stearoyl-CoA desaturase(SCD) were upregulated and the activity of SCD was increased as well(P < 0.05).Conclusions: Surplus dietary Ile intake could increase IMF accumulation and MUFA synthesis in skeletal muscle through depressing the phosphorylation of AMPKα-ACC and stimulating the expression and activity of SCD,and increasing the capability of lipogenesis in skeletal muscle. | Yanhong Luo Xin Zhang Zhengpeng Zhu Ning Jiao Kai Qiu Jingdong Yin | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 9 |
| 6 | Anti-β2 glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two receptors: apolipoprotein E receptor 2' and glycoprotein I ba显示文摘 | Wenjing Zhang Fei Gao Donghe Lu Na Sun Xiaoxue Yin Meili Jin Yanhong Liu | 2016 | Frontiers of Medicine2016，10，1： | 8 |
| 7 | Impact of insect-resistant GM rice on pesticide use and farmers' health in China显示文摘The economic benefits of insect-resistant genetically modified(GM) crops have been well documented, but the impact of such crops and the consequent reduction in pesticide use on farmers' health remains largely unknown. Through the analysis of the data collected from the physical examination from farmers in China, we show that GM rice significantly reduces pesticide use and the resultant not only visible but also invisible adverse effects on farmers' neurological, hematological, and electrolyte system. Hence, the commercialization of GM rice is expected to improve the health of farmers in developing countries, where pesticide application is necessary to mitigate crop loss. | HUANG JiKun HU RuiFa QIAO FangBin YIN YanHong LIU HuaiJu HUANG ZhuRong | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 8 | Development of a disease-specific health-related quality of life questionnaire for patients with post-stroke spasticity显示文摘OBJECTIVE:This study was designed to develop a disease-specific health-related quality of life(HR-QOL) measure for patients with post-stroke spasticity.METHODS:Based on responses from 20 patients with post-stroke spasticity and an extensive literature search,items potentially used to measure these patients' recovery status were identified and the Apoplexy Spastic-Paralysis Questionnaire(ASPQ) was formed.A sample of 106 patients was then tested twice using the ASPQ,the Self-rating Depression Scale(SDS) and the Stroke-specific Quality of Life(SS-QOL).Clinicians also examined all the patients using the Ashworth Scale(AS).Internal reliability was assessed using Cronbach's coefficient α,while construct validity was determined using principal component analysis(PCA).Empirical validity was evaluated between patients with depression and those without depression by single factor analysis.Sensitivity was examined by calculating the Spearman correlation coefficient between the changes in scores of the ASPQ,the AS and the SS-QOL.RESULTS:The ASPQ had adequate internal consistency reliability(α=0.874) and sensitivity,with significant correlations between the changes in scores of the AS,the SS-QOL and the ASPQ,with three domains.In a construct validity test,six factors were extracted;the overall variance explained by all factors was 72.6%.For empirical validity,mean values of 19 items and 3 domains were all higher in the depressive patients than in the non-depressive patients.CONCLUSION:The ASPQ is a reliable and valid self-rating scale for measuring the HR-QOL in patients with post-stroke spasticity. | Yanhong Zhang Baoyan Liu Zhishun Liu Yin Wang Hong Zhao Mingjie Zi Liping Wang Hong Liu Zhen Chen Ying Xie | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 5 |
| 9 | Synthesis and Characterization of Sphere-like Pt Nanoparticles Supported on DWCNT/WO_3 Nanorods with Electrocatalytic Activity显示文摘Tungsten oxide(WO3) nanorods, which were used to load platinum(Pt) nanoparticles, were investigated. H2WO4 nanorods with diameters from 10 to 50 nm were obtained when tungsten precursor was added into homogenous double-walled carbon nanotubes(DWCNT) and ethylene glycol(EG) solution.Nanosized rod-like WO3 were achieved after calcination of the DWCNT/H2WO4 composite. Sphere-like Pt nanoparticles were loaded on the surface of the nanorods by EG in-situ reduction. Pt particles were isolated by DWCNT/WO3 nanorods and secondary accumulation could be prevented when Pt particles appeared in the DWCNT/WO3 nanorod/EG dispersion solution. Therefore, Pt nanoparticles with mean diameters of 2–6 nm could be obtained. Pt-deposited on DWCNT/WO3 nanorods exhibited high electrochemical activity, which could facilitate the low-cost mass production of Pt catalyst. | Yanhong Yin Chun'an Ma Ziping Wu Man Zhao Litao Chen Youqun Chu | 2015 | Journal of Materials Science & Technology2015，31，9： | 4 |
| 10 | Three-dimensional carbon framework as high-proportion sulfur host for high-performance lithium-sulfur batteries显示文摘Lithium-sulfur(Li-S)batteries are anticipated as one of the most promising candidates for the highenergy-density storage systems.However,the insulating nature and shuttling effect of sulfur severely limits their performance.The incorporation of sulfur with carbon materials has been deemed as one of the most powerful strategies to improve electrical conductivity and suppress soluble polysulfide shuttling.Herein,a novel three-dimensional carbon framework(3DCF)is prepared and employed as a sulfur host(3DCF@S)for Li-S batteries.The 3DCF not only supplies abundant paths for lithium ion diffusion and electron transport,but also strengthens polysulfide immobilization during the lithium/sulfur conversion reactions.As a result,the 3DCF@S with high sulfur content of 90%exhibits a high capacity of 1366 mA h/g at 0.1 C and excellent cycling stability with a satisfactory capacity of 601 mA h/g after 600 cycles at 2.0 C.The resultant Li-S button battery based 3DCF@S electrode could power a light-emitting diode for 2 h.The acquired 3DCF@S is expected to be widely used in Li-S batteries and this study will promote developments of carbon/sulfur composites for Li-S batteries. | Xianbin Liu Zechen Xiao Changgan Lai Shuai Zou Ming Zhang Kaixi Liu Yanhong Yin Tongxiang Liang Ziping Wu | 2020 | Journal of Materials Science & Technology2020，47，13： | 4 |
| 11 | Linking microbial community composition to farming pattern in selenium-enriched region:Potential role of microorganisms on Se geochemistry显示文摘Selenium(Se)is an essential micronutrient for lives.Indigenous microbial communities play an important role on Se geochemistry in soils.In this study,the microbial community composition and functions of 53 soil samples were investigated using high-throughput sequencing.Samples were divided into 3 groups with different farming types based on the measured geochemical parameters and microbial functional structures.Results indicated that putative Se related bacteria Bacillus,Dyella,Paenibacillus,Burkholderia and Brevibacillus were dominant in dryland plantation soils which were characterized with higher available Se and low contents of H_(2)O,total organic carbon(TOC),NH_(4)^(+) and NO_(2)^(-).In contrast,the putative denitrifier Pseudomonas dominated in flooded paddy soils with higher TOC,NO_(3)^(-) and organic Se,whereas genera Rhizobium,Nitrosospira,and Geobacter preferred woodland soils with higher oxidation-reduction potential(ORP),pH,NH_(4)^(+) and Fe.Farming patterns resulted in distinct geochemical parameters including moisture,pH,ORP,TOC,and contents of soluble Fe,NO_(2)^(-) and NH_(4)^(+),shaping the microbial communities,which in turn affected Se forms in soils.This study provides a valuable insight into understanding of Se biogeochemistry in soils and prospective strategy for Se-rich agriculture production. | Yanhong Wang Xinyan Shi Xianxin Huang Chunlei Huang Helin Wang Hanqin Yin Yixian Shao Ping Li | 2022 | Journal of Environmental Sciences2022，34，2： | 3 |
| 12 | A facile synthesis of goodyeroside A from (S)-malic acid显示文摘Goodyeroside A 1,a natural product with hepatoprotective activity,was efficiently synthesized in a total yield of 47% in five steps starting from (S)-malic acid. The spectral data of the target compound 1 is identical with those of the natural product. | Feng Zhang Jun Wei DaLi Yin HaiHong Huang YanHong Zhang | 2009 | Science China Chemistry2009，52，12： | 2 |
| 13 | Cohort study of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in China:evaluation of risk models and new predictor of pulmonary consolidation on computed tomography显示文摘Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare but severe diseases.This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China.Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included.Results showed that the severity-of-illness score for TEN(SCORTEN)had a good discrimination(area under the receiver operating characteristic curve(AUC),0.78),and it was superior to auxiliary score(AS)and ABCD-10,which indicates age,bicarbonate level,cancer,dialysis,and 10%involved body surface area(AUC,0.69 and 0.68,respectively).The calibration of SCORTEN(Hosmer-Lemeshow goodness-of-fit test,P=0.69)was also better than that of AS(P=0.25)and ABCD-10(P=0.55).SCORTEN and ABCD-10 were similar(Brier score(BS),0.04 and 0.04)in terms of accuracy of predictions.In addition,the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality.Refined models were formed using the variables and this imaging appearance.The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN(0.74 vs.0.78,P=0.23;0.74 vs.0.78,P=0.30,respectively).Therefore,SCORTEN showed good discrimination performance,calibration,and accuracy,and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available. | Yanhong Shou Lu Yang Yongsheng Yang Xiaohua Zhu Feng Li Bo Yin Yingyan Zheng Jinhua Xu | 2021 | Frontiers of Medicine2021，15，4： | 2 |
| 14 | Industrial-Scale Polypropylene–Polyethylene Physical Alloying Toward Recycling显示文摘Polypropylene(PP)and polyethylene(PE)play central roles in our daily life.However,their immiscibility presents a major hurdle in both industry and academia when recycling them into alloys with favorable mechanical properties.Moreover,typical compatibilizer-enabled approaches are limited due to increased environmental concerns.Herein,inspired by a traditional Chinese technique,we report a facile,industry-scale methodology that produces a PP/PE binary blend with a highly ordered honeycomb nanostructure without any additives.Due to its nanostructure,the blend exhibits enhanced tensile properties in com-parison with the parent components or with a sample prepared using an internal mixer.This approach has potential for applications not only in immiscible polymer blending,but also in non-sorting,compatibilizer-free waste plastics recycling.Through this technique,we expect that an environmentally friendly and sustainable plastic wastes recycling avenue can be found,and great economic benefits can be gained. | Jinping Qu Zhaoxia Huang Zhitao Yang Guizhen Zhang Xiaochun Yin Yanhong Feng Hezhi He Gang Jin Ting Wu Guangjian He Xianwu Cao | 2022 | Engineering2022，8，2： | 2 |
| 15 | Geochemical features of the meteorite impact around Eocene/Oligocene boundary layer in central eastern Pacific region显示文摘 | YIN Yanhong WANG Tianfeng SUN Jiashi | 2004 | Journal of Ocean University of China2004，34，2： | 1 |
| 16 | Synthesis of novel anode Li4Ti5O12/C with PAN as carbon source and its electrochemical performance显示文摘 | Yanhong Yin Shaoyu Li Zhijuan Fan | | 0，，： | 1 |
| 17 | On the extraterrestrial impact and plate tectonic dynamics: A possible interpretation 显示文摘 | Wan Tianfeng Yin Yanhong Zhang Changhou | 1997 | Proceedings of 30th International GeologicalCongress1997，26，： | 1 |
| 18 | A multi-Agent and distributed ruler based approach to production scheduling of agile manufacturing systems显示文摘 | WANG Yanhong YIN Chaowan ZHANG Y | 2003 | International Journal Computer Integrated Manufacturing2003，16，2： | 1 |
| 19 | Factors influencing pre-hospital delay among acute ischemic stroke patients in the midlands of China显示文摘 | Huajie Yang Juan Zhang Jun Xie Chen Yang Xiaoxin Dong Yanhong Gong Shiyi Cao Xiaoxv Yin Zhihong Wang Zuxun Lu | 2014 | International Journal of Cardiology2014，，： | 1 |
| 20 | Purification,characterization and molecular cloning of a novel endo-β-1,4-glucanase AC-EG65 from the mollusc Ampullari acrossean显示文摘 | LI Yanhong YIN Qiuyu DING Ming | 2009 | Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology2009，153，2： | 1 |
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