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| 1 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 2 | Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study显示文摘Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereas there were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged between September 2015 and August 2016 in seven cities/counties in China were collected, together with their demographic information and clinical details. Former patients in the same hospitals were sampled to collect information on annual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost was obtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness(ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalization were itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD=6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urban patients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancer patients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACI was associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among the population in China. Preferential policies of medical insurance should be designed to tackle with this burden and further reduce the health care inequalities. | Zhixun Yang Hongmei Zeng Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，4： | 22 |
| 3 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 4 | COMPRESSIBLE VIRTUAL WINDOW ALGORITHM IN PICKING PROCESS CONTROL OF AUTOMATED SORTING SYSTEM显示文摘Compared to fixed virtual window algorithm(FVWA),the dynamic virtual window algorithm(DVWA)determines the length of each virtual container according to the sizes of goods of each order,which saves space of virtual containers and improves the picking efficiency.However,the interval of consecutive goods caused by dispensers on conveyor can not be eliminated by DVWA, which limits a further improvement of picking efficiency.In order to solve this problem,a compressible virtual window algorithm(CVWA)is presented.It not only inherits the merit of DVWA but also compresses the length of virtual containers without congestion of order accumulation by advancing the beginning time of order picking and reasonably coordinating the pace of order accumulation.The simulation result proves that the picking efficiency of automated sorting system is greatly improved by CVWA. | WU Yaohua ZHANG Yigong WU Yingying | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 15 |
| 5 | ORDER-PICKING OPTIMIZATION FOR AUTOMATED PICKING SYSTEM WITH PARALLEL DISPENSERS显示文摘Based on the characteristics of parallel dispensers in automated picking system,an order-picking optimization problem is presented.Firstly,the working principle of parallel dispensers is introduced,which implies the time cost of picking each order is influenced by the order-picking sequence.So the order-picking optimization problem can be classified as a dynamic traveling salesman problem (TSP).Then a mathematical model of the problem is established and an improved max-rain ant system (MMAS) is adopted to solve the model.The improvement includes two aspects. One is that the initial assignment of ants depends on a probabilisfic formula instead of a random deployment;the other is that the heuristic factor is expressed by the extra picking time of each order instead of the total.At last,an actual simulation is made on an automated picking system with parallel dispensers.The simulation results proved the optimization value and the validity of improvement on MMAS. | WU Yaohua ZHANG Yigong | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 7 |
| 6 | 基于禁忌搜索算法的内燃机配气机构优化设计显示文摘运用禁忌搜索算法和Matlab语言,对内燃机配气凸轮机构的动力学数学模型进行了仿真优化计算,结果与原设计相比,丰满系数提高了1.2 4 % ,动态最大正加速度在上升段下降了0 .87% ,在下降段上升了5 .2 3% ,动态最大负加速度下降了5 .93% ,加速度变化趋于平稳。 | 李智 常晓萍 Lou Yigong | 2005 | 农业机械学报2005，36，4： | 7 |
| 7 | Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis:a retrospective study显示文摘OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective study.METHOD:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and doctor.The CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health condition.The outcomes(dependent variables) were incidence and intensity of AR and concomitant medications used.Data were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables positively.After controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment course.CONCLUSION:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR. | Jin Peng Xiaqiu Wu Jingqing Hu Yigong Fang Mingjie Zi Baoyan Liu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 7 |
| 8 | 基于改进型蚁群算法的内燃机配气凸轮机构型线动力学优化设计显示文摘针对内燃机配气机构工作时的振动、冲击和噪声问题,建立内燃机配气凸轮机构型线的动力学数学模型。对蚁群算法在内燃机配气凸轮机构型线参数优化设计进行详细分析,并对蚁群算法存在的容易陷入局部解问题,将蚁群算法和遗传算法进行有效地结合,使得改进后的蚁群算法能够高效率地对内燃机配气凸轮机构型线参数进行优化设计。运用改进型蚁群算法和Matlab语言,对内燃机配气凸轮机构型线数学模型进行仿真优化计算,与原设计相比,仿真结果表明,丰满系数提高,动态最大正加速度在上升段降低,在下降段增加,动态最大负加速度降低,使得系统动态速度和动态加速度趋于平稳,有效地减少了内燃机配气机构的冲击振动,提高了内燃机的动力性能。 | 李智 常晓萍 Yigong LOU | 2005 | 机械强度2005，27，2： | 6 |
| 9 | Apoptosome and inflammasome: conserved machineries for caspase activation显示文摘Apoptosome and inlammasome are multimeric protein complexes that mediate the activation of speciic caspases at the onset of apoptosis and inlammation.he central component of apoptosome or inlammasome is a tripartite scafold protein,exempliied by Apaf-1 and NLRC4,which contains an amino-terminal homotypic interaction motif,a central nucleotide-binding oligomerization domain and a carboxyl-terminal ligand-sensing domain.In the absence of death cue or an inlammatory signal,Apaf-1 or NLRC4 exists in an auto-inhibited,monomeric state,which is stabilized by adenosine diphosphate(ADP).Binding to an apoptosis-or inlammation-inducing ligand,together with replacement of ADP by adenosine triphosphate(ATP),results in the formation of a multimeric apoptosome or inlammasome.he assembled apoptosome and inlammasome serve as dedicated machineries to facilitate the activation of speciic caspases.In this review,we describe the structure and functional mechanisms of mammalian inlammasome and apoptosomes from three representative organisms.Emphasis is placed on the molecular mechanism of caspase activation and the shared features of apoptosomes and inlammasomes. | Jijie Chai Yigong Shi | 2014 | National Science Review2014，1，1： | 6 |
| 10 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus显示文摘 | Yigong Shi Joan Massagué | 2003 | Cell2003，，6： | 5 |
| 11 | Structure of the human activated spliceosome in three conformational states显示文摘在拼接的 pre-mRNA 的每个周期期间, pre 催化的 spliceosome (B 建筑群) 被变换成激活的 spliceosome (B 行为 建筑群) ,它有一个合法活跃地点但是不能继续到分叉的反应。这里,我们在场人的 B 处于三个不同 conformational 状态的行为 建筑群。他们地图允许将近所有的原子建模 U2 小原子 ribonucleoprotein (snRNP ) 的蛋白质部件,包括三 SF3a 建筑群和七 SF3b 建筑群。人的 B 行为 建筑群包含 52 蛋白质, U2, U5,和 U6 小原子 RNA (snRNA ) ,和 pre-mRNA。三不同符合构造被捕获了,代表人的 B 行为 建筑群。这些建筑群在开关环的取向不同 Prp8,拼接的因素 RNF113A 和 NY-CO-10,和十九建筑群(NTC ) 和 NTC 相关的建筑群的大多数部件。有 B 和 C 建筑群的这三建筑群和比较的分析在 B-to-B 行为 和 B 行为 -to-B* 转移,它最终为分叉的反应告知活跃地点。 | Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei, Yigong Shi Jianlin Lei Yigong Shi | 2018 | Cell Research2018，28，3： | 4 |
| 12 | Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex显示文摘The nuclear pore complex(NPC)mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells.Here we report the cryo-electron tomography(cryo-ET)structure of the luminal ring(LR)of the NPC from Xenopus laevis oocyte.The observed key structural features of the LR are independently confirmed by single-particle cryo-electron microscopy(cryo-EM)analysis.The LR comprises eight butterfly-shaped subunits,each containing two symmetric wings.Each wing consists of four elongated,tubular protomers.Within the LR subunit,the eight protomers form a Finger domain,which directly contacts the fusion between the inner and outer nuclear membranes and a Grid domain,which serves as a rigid base for the Finger domain.Two neighboring LR subunits interact with each other through the lateral edges of their wings to constitute a Bumper domain,which displays two major conformations and appears to cushion neighboring NPCs.Our study reveals previously unknown features of the LR and potentially explains the elastic property of the NPC. | Yanqing Zhang Sai Li Chao Zeng Gaoxingyu Huang Xuechen Zhu Qifan Wang Kunpeng Wang Qiang Zhou Chuangye Yan Wusheng Zhang Guangwen Yang Minhao Liu Qinghua Tao Jianlin Lei Yigong Shi | 2020 | Cell Research2020，30，6： | 4 |
| 13 | Structures of the human pre-catalytic spliceosome and its precursor spliceosome显示文摘The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (Bact complex). The pre-B-to-B and B-to-Bact transitions are driven by the ATPase/helicases Prp28 and Brr2,respectively. In this study,we report the cryo-electron microscopy structures of the human pre-B complex and the human B complex at an average resolution of 5.7 and 3.8 A,respectively. In the pre-B complex,U1 and U2 small nuclear ribonucleoproteins (snRNPs) associate with two edges of the tetrahedron-shaped U4/U6.U5 tri-snRNP. The pre-mRNA is yet to be recognized by U5 or U6 small nuclear RNA (snRNA),and loop I of U5 snRNA remains unengaged. In the B complex,U1 snRNP and Prp28 are dissociated,the 5’-exon is anchored to loop I of U5 snRNA,and the 5’-splice site is recognized by U6 snRNA through duplex formation. In sharp contrast to S. cerevisiae,most components of U2 snRNP and tri-snRNP,exemplified by Brr2,undergo pronounced rearrangements in the human pre-B-to-B transition. Structural analysis reveals mechanistic insights into the assembly and activation of the human spliceosome. | Xiechao Zhan Chuangye Yan Xiaofeng Zhang Jianlin Lei Yigong Shi | 2018 | Cell Research2018，28，12： | 4 |
| 14 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus显示文摘 | Yigong Shi Joan Massagué | 2003 | Cell2003，，6： | 4 |
| 15 | Recombinant scFv Antibodies against E Protein and N Protein of Severe Acute Respiratory Syndrome Virus显示文摘Three single chain antibodies (scFv) against the proteins of severe acute respiratory syndrome coronavirus (SARS-CoV) were isolated by phage display from an scFv antibody library. Bio-panning was carried out against immobilized purified envelope (E) and nucleocapsid (N) proteins of SARS-CoV. Their binding activity and specificity to E or N protein of SARS-CoV were characterized by phage-ELISA. Two of them, B10 and C20, could recognize non-overlapping epitopes of the E protein according to the two-site binding test result. Clone A17 could recognize N protein. The sequence of the epitope or overlapping epitope of scFv antibody A17 was PTDSTDNNQNGGRNGARPKQRRPQ. The affinity (equilibrium dissociation constant, Kd) of SARS-CoV E protein was 5.7×10–8 M for B10 and 8.9×10–8 M for C20. The affinity of A17 for N protein was 2.1×10–6 M. All three scFv antibodies were purified with affinity chromatography and determined by Western blot. | HuiLIU Yan-LiDING WeiHAN Mei-YunLIU Rui-YangTIAN Sheng-LiYANG YiGONG | 2004 | Acta Biochimica et Biophysica Sinica2004，36，8： | 3 |
| 16 | Functional characterization of humar equilibrative nucleoside transporter 1显示文摘 | Weiyun Huang Xin Zeng Yigong Shi Minhao Liu | 2017 | Protein & Cell2017，8，4： | 3 |
| 17 | 粒子群算法在化工过程优化中的应用显示文摘对基本粒子群算法进行了智能化改进,并运用改进粒子群算法和MATLAB语言,对化工生产过程中的苯-甲苯闪蒸过程进行了优化仿真计算。仿真结果表明,在有效地调整温度、压力及分流系数的条件下,使得气相产物中苯的产量达到最大,实现了苯-甲苯闪蒸过程的最优化,同时也证明了粒子群算法可以有效地解决化工生产过程中的优化问题。 | 常晓萍 秦建华 Yigong LOU | 2007 | 石油化工高等学校学报2007，20，1： | 3 |
| 18 | 基于免疫算法的内燃机配气机构型线动力学优化设计显示文摘建立了内燃机配气凸轮机构型线的动力学数学模型,运用免疫遗传算法和Matlab语言,对该数学模型进行了仿真优化计算,与原设计相比,仿真结果表明:丰满系数提高了1.24%,动态最大正加速度在上升段下降了0.87%,在下降段上升了5.23%,动态最大负加速度下降了5.93%,使得系统动态速度和动态加速度趋于平稳,有效的减少内燃机配气机构的冲击振动,提高了内燃机的动力性能。 | 李智 孙江波 Yigong LOU | 2005 | 振动与冲击2005，24，6： | 2 |
| 19 | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis显示文摘The nuclear pore complex(NPC)exhibits structural plasticity and has only been characterized at local resolutions of up to 15 A for the cytoplasmic ring(CR).Here we present a single-particle cryo-electron microscopy(cryo-EM)structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9A,with local resolutions reaching 4.5 A.Improved resolutions allow identification and placement of secondary structural elements in the majority of the CR components.The two Y complexes in each CR subunit interact with each other and associate with those from flanking subunits,forming a circular scaffold.Within each CR subunit,the Nup358-containing region wraps around the stems of both Y complexes,likely stabilizing the scaffold.Nup205 connects the short arms of the two Y complexes and associates with the stem of a neighboring Y complex.The Nup214-containing region uses an extended coiled-coil to link Nup85 of the two Y complexes and protrudes into the axial pore of the NPC.These previously uncharacterized structural features reveal insights into NPC assembly. | Gaoxingyu Huang Yanqing Zhang Xuechen Zhu Chao Zeng Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2020 | Cell Research2020，30，6： | 2 |
| 20 | Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex显示文摘Nuclear pore complex(NPC)mediates nucleocytoplasmic shuttling.Here we present single-particle cryo-electron microscopy structure of the inner ring(IR)subunit from the Xenopus laevis NPC at an average resolution of 4.2Å.A homo-dimer of Nup205 resides at the center of the IR subunit,flanked by two molecules of Nup188.Four molecules of Nup93 each places an extended helix into the axial groove of Nup205 or Nup188,together constituting the central scaffold.The channel nucleoporin hetero-trimer of Nup62/58/54 is anchored on the central scaffold.Six Nup155 molecules interact with the central scaffold and together with the NDC1–ALADIN hetero-dimers anchor the IR subunit to the nuclear envelope and to outer rings.The scarce inter-subunit contacts may allow sufficient latitude in conformation and diameter of the IR.Our structure reveals the molecular basis for the IR subunit assembly of a vertebrate NPC. | Gaoxingyu Huang Xiechao Zhan Chao Zeng Ke Liang Xuechen Zhu Yanyu Zhao Pan Wang Qifan Wang Qiang Zhou Qinghua Tao Minhao Liu Jianlin Lei Chuangye Yan Yigong Shi | 2022 | Cell Research2022，32，5： | 1 |
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