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| 1 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Perfluorinated compounds in the Pearl River and Yangtze River of China显示文摘 | So M K Miyake Y Yeung W Y | 2007 | Chemosphere2007，68，11： | 1 |
| 4 | Improvements in DNA sequencing by capillary electrophoresis at elevated temperature using poly (ethylene oxide) as a sieving matrix显示文摘 | Wei W Yeung ES | 2000 | J Chromatogr B2000，745，： | 1 |
| 5 | A simple chemical vapor deposition method for depositing thin titanium dioxide films显示文摘 | YEUNG K S LAM Y W | 1983 | Thin Solid Films1983，109，： | 1 |
| 6 | Linear network coding 显示文摘 | LIS Y R YEUNG R W CAIN | 2003 | IEEE Transactions on Information Theory2003，49，2： | 1 |
| 7 | Network error correction, part Ⅱ: Lower bounds 显示文摘 | Cai N Yeung R W | 2006 | Communications in Information and Systems2006，6，1： | 1 |
| 8 | The Effects of Risk - reducing Strate-gies on Consumer Perceived Risk and on Purchase Likelihood: A Modeling Approach 显示文摘 | Yeung R Yee W Morris J | 2010 | British Food Journal2010，112，3： | 1 |
| 9 | lnvestigation of nickel suppression and cytocompatibility of surface-treated nickel - titanium shape memory alloys by using plasma immersion ion implantation显示文摘 | Yeung K W Poon R W Liu X Y et a| | 2005 | JBiomed Mater Res A2005，72，13： | 1 |
| 10 | Linear network coding显示文摘 | Li S Y Yeung R W | | 0，，： | 1 |
| 11 | Linear network coding显示文摘 | LI Shuoyen YEUNG R W CAI Ning | | 0，，02： | 1 |
| 12 | Effect of subgrid models on the computed interscale energy transfer in isotropie turbulence 显示文摘 | MENON S YEUNG P KIM W | 1996 | Computer and Fluids1996，25，2： | 1 |
| 13 | Added mass and damping of a vertical cylinder in fi nite-depth water 显示文摘 | Yeung R W | 1981 | Applied Ocean Research1981，3，3： | 1 |
| 14 | Management of the Solitary thyroid nodule显示文摘 | Yeung M J Serpell J W | 2008 | Oncologist2008，13，2： | 1 |
| 15 | Pharmaeologie treatment for post- partum depression: a systematic review 显示文摘 | Ng RC Hirata CK Yeung W | 2010 | Pharmacotherapy2010，30，9： | 1 |
| 16 | Image classification with the use of radial basis function neural networks and the minimization of the loealized generalization error显示文摘 | Wing W Y N Dorado A Yeung D S | 2007 | Pattern Recognition2007，40，： | 1 |
| 17 | Assessment of the air quality in indoor car parks显示文摘 | Wong Y C Sin D W M Yeung L L | 2002 | Indoor and Built Enviment2002，11，3： | 1 |
| 18 | Effect of autoclave test on anisotropic conductive joints显示文摘 | TAN C W CHAN Y C YEUNG N H | 2003 | Microelectronics Reliability2003，43，2： | 1 |
| 19 | Network information flow 显示文摘 | Ahlswede R Cai N Li S Y R and Yeung R W | 2000 | IEEE Transactions on Information Theory2000，46，4： | 1 |
| 20 | Human Oviductal Cells Produce a Factor(s) That Maintains the Motility of Human Spermatozoa in Vitro显示文摘 | YAO Yuan-qing Ho P C Yeung W S B | 2000 | Fertil Steril2000，73，3： | 1 |
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