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| 1 | APACHE system is better than Ranson system in the prediction of severity of acute pancreatitis显示文摘BACKGROUND: It has been suggested that addition of obesity score to the APACHE-Ⅱ system can lead to more accurate prediction of severity of acute pancreatitis. However there is scanty information on the usefulness of the combined APACHE-O scoring system in Asian patients. This study aimed to compare the accuracy of Ranson, APACHE-Ⅱ and APACHE-O systems in assessing severity of acute pancreatitis in a local Chinese population. METHODS: One hundred and one consecutive patients with acute pancreatitis were prospectively studied. Body mass index (BMI) was measured on admission. Ranson score, APACHE-Ⅱ and APACHE-O scores were recorded on admission and at 48 hours. By adopting the cut-off levels and definitions advocated in the Atlanta consensus for severe disease, the diagnostic accuracy of the three scoring systems was compared by the area under the curve (AUC) under the receiver operator characteristic curve. RESULTS: Of the 101 patients, 12 (11.9%) patients suffered from severe pancreatitis. Obesity was uncommon and only two patients (2.0%) had BMI >30. Eighty-two (81.2%) patients were normal weight (BMI≤25) whereas 17 (16.8%) were overweight ( BMI 25-30 ). Overweight or obesity (BMI >25) was not associated with severe pancreatitis (P= 0.40). The AUC for admission scores of Ranson, APACHE-Ⅱ, and APACHE-O systems was 0. 549, 0. 904 and 0. 904, respectively. The AUC for 48-hour scores of Ranson, APACHE-Ⅱ and APACHE-O systems was 0.808, 0.955 and 0.951, respectively. CONCLUSIONS: The APACHE-Ⅱ scoring system is more accurate than the Ranson scoring system of the prediction of severity in acute pancreatitis. Addition of obesity score does not significantly improve the predictive accuracy of the APACHE-Ⅱ system in our local population with a low prevalence of obesity. | Yuk Pang Yeung Billy Yeung Kit Lam Andrew Wai Chun Yip | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 41 |
| 2 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 3 | 京津冀城市群县域城市土地利用效率时空格局及驱动因素显示文摘研究目的:探索京津冀城市群县域城市土地利用效率时空格局与驱动因素机理。研究方法:DEA模型、变异系数、探索性空间数据分析与Tobit模型。研究结果:研究期内,京津冀城市群县域城市土地利用效率均值为0.709,年均效率显著提升,整体效率差异程度有所收敛。不同省市、不同层级区县效率均值存在显著的时空分化,空间集聚态势显著增强,“核心—外围”现象持续凸显。受区县行政级别和社会经济发展基础的双重梯度差距影响,不同因素的作用机理存在明显的差异性。研究结论:京津冀协同发展背景下,亟需严控县域城市用地低效蔓延,促进产业形态和资源配置转型升级。打破行政级别壁垒,完善产业和功能的县际传导,深化城市群核心区域对于外围区县的辐射带动作用。 | 宋洋 YEUNG Godfrey 朱道林 徐阳 赵江萌 | 2021 | 中国土地科学2021，35，3： | 24 |
| 4 | 收缩情境下城市用地结构时空格局演变及动力机制——以中国东北地区为例显示文摘构建城市用地结构时空格局演变分析框架,引入信息熵和偏移份额模型定量剖析2000—2017年中国东北地区城市用地结构时空格局演变特征,通过计量经济模型分阶段对比分析收缩情境下东北地区城市用地结构演变的动力机制。结果表明:东北地区城市用地总面积持续增长,用地结构信息熵整体呈现先上升、后下降的趋势。2011年以后,城市用地结构有序性、多样性不断提升,单一优势地类主导作用显著下降。公共设施用地、道路交通用地及绿地与广场用地为增长型地类,是东北地区城市用地规模扩张和结构演变的主要动因。用地结构竞争性偏移量具有显著的空间非均衡性,总体与辽中南和哈长两大城市群空间格局基本吻合,新增城市用地的集聚效应不断凸显。城市人口规模变迁、城市经济发展水平提升、产业结构升级与城市居住条件改善对城市用地结构演变具有显著的正向驱动作用。收缩情境下,各因素的拉动作用逐渐减弱,国家宏观政策的约束力不断增强,城市公共服务水平改善的强需求成为驱动用地结构演变的外在动力。 | 宋洋 朱道林 YEUNG Godfrey 徐阳 张立新 | 2021 | 地理研究2021，40，5： | 17 |
| 5 | Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury显示文摘Scutellarin, a bioactive flavone isolated from Scutellaria baicalensis, has anti-inflammatory, anti-neurotoxic, anti-apoptotic and anti-oxidative effects and has been used to treat cardiovascular and cerebrovascular diseases in China. However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. Cultures of primary astrocytes isolated from the cerebral cortex of neonatal Sprague-Dawley rats were pretreated with 2, 10 or 50 μM scutellarin for 30 minutes. The astrocytes were then subjected to oxygen/glucose deprivation by incubation for 2 hours in glucose-free Dulbecco's modified Eagle's medium in a 95% N2/5% CO_2 incubator, followed by simulated reperfusion for 22 hours. Cell viability was assessed by cell counting kit-8 assay. Expression levels of NOX2, connexin 43 and caspase-3 were assessed by western blot assay. Reactive oxygen species were measured spectrophotometrically. Pretreatment with 10 or 50 μM scutellarin substantially increased viability, reduced the expression of NOX2 and caspase-3, increased the expression of connexin 43, and diminished the levels of reactive oxygen species in astrocytes subjected to ischemia-reperfusion. We also assessed the effects of scutellarin in vivo in the rat transient middle cerebral artery occlusion model of cerebral ischemia-reperfusion injury. Rats were given intraperitoneal injection of 100 mg/kg scutellarin 2 hours before surgery. The Bederson scale was used to assess neurological deficit, and 2,3,5-triphenyltetrazolium chloride staining was used to measure infarct size. Western blot assay was used to assess expression of NOX2 and connexin 43 in brain tissue. Enzyme-linked immunosorbent assay was used to detect 8-hydroxydeoxyguanosine(8-OHd G), 4-hydroxy-2-nonenal(4-HNE) and 3-nitrotyrosin(3-NT) in brain tissue. Immunofluorescence double staining was used to determine the co-expression of caspase-3 and Neu N. Pretreatment with scutellarin improved the neurological function of rats with focal cerebral ischemia, reduced infarct size, diminished the expression of NOX2, reduced levels of 8-OHd G, 4-HNE and 3-NT, and reduced the number of cells co-expressing caspase-3 and Neu N in the injured brain tissue. Furthermore, we examined the effect of the NOX2 inhibitor apocynin. Apocynin substantially increased connexin 43 expression in vivo and in vitro. Collectively, our findings suggest that scutellarin protects against ischemic injury in vitro and in vivo by downregulating NOX2, upregulating connexin 43, decreasing oxidative damage, and reducing apoptotic cell death. | Jing-Bo Sun Yan Li Ye-Feng Cai Yan Huang Shu Liu Patrick KK Yeung Min-Zhen Deng Guang-Shun Sun Prince LM Zilundu Qian-Sheng Hu Rui-Xin An Li-Hua Zhou Li-Xin Wang Xiao Cheng | 2018 | Neural Regeneration Research2018，13，8： | 16 |
| 6 | Reflections on a Science and Technology Agenda for 21st Century Disaster Risk Reduction Based on the Scientific Content of the 2016 UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015–203显示文摘The first international conference for the post-2015 United Nations landmark agreements(Sendai Framework for Disaster Risk Reduction 2015–2030, Sustainable Development Goals, and Paris Agreement on Climate Change) was held in January 2016 to discuss the role of science and technology in implementing the Sendai Framework for Disaster Risk Reduction 2015–2030. The UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030 aimed to discuss and endorse plans that maximize science's contribution to reducing disaster risks and losses in the coming 15 years and bring together the diversity of stakeholders producing and using disaster risk reduction(DRR) science and technology. This article describes the evolution of the role of science and technology in the policy process building up to the Sendai Framework adoption that resulted in an unprecedented emphasis on science in the text agreed on by 187 United Nations member states in March 2015 and endorsed by the United Nations General Assembly in June 2015. Contributions assembled by the Conference Organizing Committee and teams including the conference concept notes and the conference discussions that involved a broad range of scientists and decision makers are summarized in this article. The conference emphasized how partnerships and networks can advance multidisciplinary research and bring together science, policy, and practice; how disaster risk is understood, and how risks are assessed and early warning systems are designed; what data, standards, and innovative practices would be needed to measure and report on risk reduction; what research and capacity gaps exist and how difficulties in creating and using science for effective DRR can be overcome. The Science and Technology Conference achieved two main outcomes:(1) initiating the UNISDR Science and Technology Partnership for the implementation of the Sendai Framework; and(2) generating discussion and agreement regarding the content and endorsement process of the UNISDR Science and Technology Road Map to 2030. | Amina Aitsi-Selmi Virginia Murray Chadia Wannous Chloe Dickinson David Johnston Akiyuki Kawasaki Anne-Sophie Stevance Tiffany Yeung | 2016 | International Journal of Disaster Risk Science2016，7，1： | 14 |
| 7 | 基于有限变形理论的非连续变形分析方法改进显示文摘非连续变形分析(DDA)方法将研究对象离散为块体单元,属于离散介质计算方法的一种。原有的DDA计算理论建立在小变形、小转动假设的基础上,通过时步的累加来模拟大变形、大转动,计算时会因此而产生误差,尤其是当块体发生大转动时往往会产生较大误差。采用有限变形理论对现有的DDA程序进行改进,计算时根据有限变形几何场对每一时步的计算结果进行更新,并通过2个算例对改进后的程序进行验证。结果表明,改进后程序可以很好地处理大转动问题,消除转动所带来的误差,并且在处理小位移、小转动问题时仍然有效,拓宽了DDA的使用范围,可作为工程计算的有效工具。 | 高亚楠 高峰 Man-chu Ronald YEUNG | 2011 | 岩石力学与工程学报2011，30，11： | 13 |
| 8 | Perfluorooctane sulfonate(PFOS) and related fluorochemicals in chicken egg in China显示文摘The ubiquitous occurrence of perfluorinated compounds(PFCs) in environmental samples has drawn much attention.Recent human exposure studies found relatively high perfluorooctane sulfonate(PFOS) concentrations in blood samples from several cities in China when compared with other countries.The objectives of the present study were:(1) to measure PFC concentrations and compositions in chicken egg samples from local markets in China;and(2) to conduct a preliminary human health risk assessment of egg consumption.Eight pooled egg samples from eight locations were analyzed for 11 PFCs.The results showed that close to 100% of the PFOS in the egg was distributed in egg yolk and PFOS was not detected in egg white(<0.08 ng/g wet weight,w/w).Of the perfluoroalkylsulfonates,only PFOS was detected in all egg samples,while of the perfluoroalkylcarboxylates,perfluoroundecanoic acid(PFUnDA) was detected in all samples,followed by perfluorooctanoate(PFOA)(75% occurrence) and perfluorodecanoic acid(PFDA)(50% occurrence).PFOS concentrations in egg ranged from 45.0 to 86.9 ng/g w/w.The results suggested that current concentrations of PFOS in domestic chicken eggs are unlikely to cause immediate harm to Chinese populations. | WANG Yuan YEUNG Leo Wai Yin YAMASHITA Nobuyoshi TANIYASU Sachi SO Man Ka Margaret B. MURPHY LAM Paul Kwan Sing | 2008 | Chinese Science Bulletin2008，53，4： | 13 |
| 9 | The ClassⅢHistone Deacetylase Sirtuin 1 in Immune Suppression and Its Therapeutic Potential in Rheumatoid Arthritis显示文摘Rheumatoid arthritis(RA) is a chronic debilitating disease of the joints.Both the innate and adaptive immune responses participate in the development and progression of RA.While several therapeutic reagents,such as TNF-αagonists,have been successfully developed for the clinical use in the treatment of RA,more than half of the patients do not respond to anti-TNF therapy.Therefore,new therapeutic reagents are needed.Recent studies have shown that sirtuin 1(Sirtl),a nicotinamide adenine dinucleotide(NAD)-dependent histone deacetylase,is a critical negative regulator of both the innate and adaptive immune response in mice,and its altered functions are likely to be involved in autoimmune diseases.Small molecules that modulate Sirtl functions are potential therapeutic reagents for autoimmune inflammatory diseases.This review highlights the role of Sirtl in immune regulation and RA. | Sinyi Kong Pricilla Yeung Deyu Fang | 2013 | Journal of Genetics and Genomics2013，40，7： | 12 |
| 10 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 11 | 为什么附睾肿瘤这么稀少?显示文摘附睾癌的发病率最多不超过所有男性癌症的0.03%。人类附睾亦可以表达干细胞和癌细胞的标记,基础表达致癌基因及那些让肿瘤细胞在易患癌的组织中逃避免疫监视的促增殖的和促血管生成的因子,但为什么它却可以不屈服于癌症呢?这是一个谜。人类附睾可逃避肿瘤发生的特殊功能在转基因小鼠模型上得到验证。其它的器官都可以被诱导发生肿瘤,唯独附睾中没有。看来附睾可以:(一)防止肿瘤发生(它可能没有干细胞,并具有较强的抗氧化机制,有效的肿瘤抑制基因和无效的致癌基因产品);(二)监控肿瘤和并破坏肿瘤(通过强大的免疫监视、免疫清除及细胞衰老);(三)避开增殖和血管生成(持久的细胞紧密连接,抗血管生成因子、错位的促血管形成因子的存在);(四)加速休眠和限制细胞分裂增生。附睾细胞可能对通常诱导肿瘤基础表达的因子的致癌刺激物无响应,也能抵抗正常的模拟了促进肿瘤生长的环境。因此附睾中肿瘤发生的阈值就可能要高于其他器官。一些抗肿瘤机制是维持精子静态和免疫沉默。因此附睾癌的发病率较低,可能是因为其在精子成熟和储存中扮演着其它的角色的关系。了解这些机制可以给一般癌症的预防和治疗带来一些启示。 | Ching-Hei Yeung Kai Wang Trevor G Cooper | 2012 | Asian Journal of Andrology2012，14，3： | 11 |
| 12 | Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies显示文摘Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients. | Liem Minh Phan Sai-Ching Jim Yeung Mong-Hong Lee | 2014 | Cancer Biology & Medicine2014，11，1： | 11 |
| 13 | 中国资源型城市产业结构升级对土地利用效率的影响显示文摘在中国经济面临结构转型和空间重塑的关键时期,探究资源型城市产业结构升级对土地利用效率的影响机理,对于破解资源型城市产业发展路径依赖与土地低效利用困境具有重要意义。基于中国115座地级资源型城市面板数据,运用产业结构层次指数与基于DEA的超效率SBM-Undesirable模型刻画资源型城市产业结构升级与土地利用效率的时空演化特征,通过面板Tobit模型探究资源型城市产业结构升级对土地利用效率的异质性影响及作用渠道。结果表明:①中国资源型城市产业结构升级成效显著,再生型、煤炭型和钢铁型城市升级效果更为明显。土地利用效率呈波动上升趋势,高值城市数量显著增加,以经济基础较好的再生型和成长型城市为主。②资源型城市产业结构升级对土地利用效率提升尚未形成普遍的驱动效应,其影响机制在不同类型城市中具有显著的异质性,仅再生型城市呈现显著的正向影响。③资源型城市产业结构升级通过经济产出提升、要素配置优化与环境污染控制等渠道驱动土地利用效率的动态演化。现阶段,土地经济产出偏低、用地结构失调、环境污染负外部性过高是制约资源型城市土地利用效率提升的主要症结。资源型城市转型具有长期性、系统性特征,应当因地制宜、因城施策,加快形成产业转型与用地转型的良性互动机制。 | 宋洋 贺灿飞 YEUNG Godfrey 徐阳 | 2023 | 地理研究2023，42，1： | 11 |
| 14 | Reduction of the ages at diagnosis and operation of biliary atresia in Taiwan: A 15-year population-based cohort study显示文摘AIM: To describe the ages at diagnosis and operation of biliary atresia(BA) and its incidence over a 15-year period in Taiwan.METHODS: This was a population-based cohort study. BA cases were identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases,Ninth Revision(ICD-9) code of BA 751.61 plus Kasai operation(ICD-9 procedure code 51.37) or liver transplantation(LT,ICD-9 procedure code 50.5). The patients' characteristics including sex,age at diagnosis,age at receiving Kasai operation and age at receiving LT were compared among three birth cohorts:(1) 1997 to 2001;(2) 2002 to 2006; and(3) 2007 to 2011.RESULTS: There were a total of 540 BA cases(275 females) with an incidence of 1.62 per 10000 live births. No seasonality of BA was noted. The mean ages at diagnosis of three cohorts were 57.9,55.6 and 52.6 d.A linear regression model demonstrated a decreasing trend of the mean age at diagnosis(1.27 d per year). The proportion of BA cases that received the Kasai operation within 60 d of age increased from 76% to 81%. A total of 189(35%) BA patients underwent LT. The mean age at LT was reduced from 3-year-old to 1-year-old. The rates of LT were 25.6% and 32.3% in patients who received the Kasai operation within 60 d or after 60 d of age,respectively. All patients who did not undergo a Kasai operation eventually required LT.CONCLUSION: The ages at diagnosis and operation in BA cases have decreased over time. Kasai operation performed at younger age reduces the need for LT. The incidence of BA in Taiwan fluctuates,but without certain trend. | Jen-Shyang Lin Solomon Chih-Cheng Chen Chin-Li Lu Hung-Chang Lee Chun-Yan Yeung Wai-Tao Chan | 2015 | World Journal of Gastroenterology2015，21，46： | 10 |
| 15 | Construction of TiO2/silane nanofilm on AZ31 magnesium alloy for controlled degradability and enhanced biocompatibility显示文摘A TiO2 nanofilm was prepared on the surface of AZ31 magnesium alloy with controllable thickness through atomic layer deposition(ALD) technique, which can adjust the corrosion behaviors of AZ31 Mg alloy.Compared with the untreated Mg alloys, corrosion current densities(icorr)can decline by 58% in the 200-cycles TiO2-covered Mg alloy and further decline by up to 74% with the thickness of nanofilm up to 63 nm(400 cycles).The subsequent modification with a cross-linked conversion layer of 3-aminopropyltriethoxysilane(APTES) by a dipping method can produce a compact silane coating on TiO2 nanofilm, which can seal pinholes of TiO2 nanofilm and serve as a barrier to further adjust the corrosion behavior of the substrate.The icorrcan decline about two orders of magnitude in the TiO2/silane composite coating.Making the adjustable corrosion rate come true, which can be attributed to the precise control on the thickness of metal oxide nanofilm and additional protection from the compact silane coating.In vitro study discloses that the TiO2/silane hybrid coating shows higher expression of alkaline phosphatase(ALP)and can promote cellular adhesion and proliferation with better cytocompatibility than untreated Mg alloy. | Lei Huang Kun Su Yu-Feng Zheng Kelvin Wai-Kwok Yeung Xiang-Mei Liu | 2019 | Rare Metals2019，38，6： | 9 |
| 16 | Awareness and knowledge of hepatitis B infection and prevention and the use of hepatitis B vaccination in the Hong Kong adult Chinese population显示文摘背景肝炎 B 病毒( HBV )感染仍然是一个全球公共健康问题,它是尖锐、长期、暴发性的肝炎,肝肝硬化和在在在 10 点未改变的仍然是的过去的十年的香港的 HBV 感染的 hepatocellular carcinoma.The 流行的一个重要原因,尽管有实现通用新生并且当前的局势对 HBV 传播和预防的不适当的了解和知识可归因的成年 vaccination.We | Wah, Chung Pui Hung, Suen Sik Ka, Chan Oi Hsi, Lao Tzu Yeung, Leung Tak | 2012 | Chinese Medical Journal2012，，3： | 8 |
| 17 | Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients显示文摘Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedure. It should be one of the treatment options available to pregnant women who require prenata l genetic diagnosis. | LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen Daljit S SAHOTA LEUNG Tse Ngong | 2005 | Chinese Medical Journal2005，，20： | 8 |
| 18 | 用亚微米级晶种涂层法合成NaA沸石膜及其结构表征显示文摘在大孔α Al2 O3 陶瓷管载体上 ,采用亚微米级晶种涂层法在澄清溶液体系中二次生长成膜 ,制备了NaA沸石膜 .采用TEM ,SEM和XRD等手段对晶种、陶瓷载体及沸石膜的结构、晶体形貌和成膜情况进行了表征 .结果表明 ,合成晶种的晶粒呈立方体 ,颗粒小 (约 1 5 0nm)而均匀 ,无杂晶 ,可作为晶种在载体上进行预涂 .载体的孔径大而不均匀 ,表面粗糙不平整 ,直接成膜则表面仅有较少的沸石晶粒沉积 ,不能连续成膜 .经亚微米级晶种涂层后 ,载体表面形成了一层均匀、光滑的晶种层(厚度为 2~ 3μm) ;水热晶化成膜后 ,膜表面晶粒相互交织生长完好 ,无晶间隙 ,所得膜致密 ,连续 ,规整 ,清晰 ,无裂缺 . | 张雄福 刘海鸥 王金渠 King Lun Yeung | 2004 | 催化学报2004，25，7： | 7 |
| 19 | 微创腰椎间盘分流术治疗椎间盘源性腰痛显示文摘目的探讨微创腰椎间盘分流术治疗椎间盘源性腰痛的作用机制并分析其近期临床疗效。方法通过体外实验测定尼龙线分流虹吸管作用的距离;动物椎问盘内置入尼龙线,其尾端埋于肌肉中,组织学检查尼龙线的生物相容性。15例经椎间盘造影诊断为椎间盘源性腰痛,局麻下行腰椎间盘分流术(应用特别设计的工具将尼龙线置人腰椎间盘内),L3-4例、L4-5,6例、L5s17例、L3-4合并L4-5,1例。术后1周、3、12和24个月采用疼痛视觉模拟评分(visualanalogueseale,VAS)、Oswestry功能障碍指数(Oswestrydisabilityindex,ODI)和影像学检查综合评估临床疗效。结果体外实验显示通过尼龙线可将乳酸溶液的pH值从低于4.0调高至7.14;体内实验表明绵羊椎问盘置人尼龙线后,椎问盘内蛋白多糖的含量随着时间推移逐渐增加,且尼龙线周围无炎症反应。所有患者均成功施行腰椎间盘分流术,无手术并发症。术后2年随访,患者VAS评分与ODI评分均有明显下降,VAS改善率达79.16%±12.33%,ODI改善率为77.42%±12.20%;X线片示术后2年椎间盘高度指数与术前相比,差异无统计学意义;MRI示根据改良Thompson分级,分流椎间盘的退变程度无加重,10例患者髓核信号有一定程度的增强。结论经皮腰椎问盘分流术能够明显缓解腰痛,改善腰背部功能,具有创伤小,风险低的优点,有望成为临床治疗椎问盘源性腰痛一种新的微创手术方式。 | 史金辉 杨炎 周峰 张洪涛 王震 王根林 姜为民 杨惠林 唐天驷 Jeffrey E Yeung Hansen A Yuan | 2014 | 中华骨科杂志2014，34，8： | 7 |
| 20 | Testicular sperm extraction and intracytoplasmic sperm injection in non obstructive azoospermia显示文摘Objective To report the experience in sperm extraction from testicular biopsies (TESE) performed from March 1996 to July 1998 in men with non obstructive azoospermia (NOA) Methods Comparisons of age, volume of both testes, serum FSH and testosterone in men, and histology of testicular samples in the first cycles between cycles with spermatozoa found and those without spermatozoa found were performed Comparisons of fertilization, cleavage and pregnancy rates between cycles with spermatozoa injected and those with spermatids injected were performed Results Spermatozoa were found in only 12 out of 26 first TESE cycles (46 2%) and other cycles had spermatids (round cells) only Age of men, history of mumps orchitis/oligozoospermia, volume of both testes and serum FSH/testosterone levels in men were not significantly different between cycles with and without spermatozoa The fertilization rate was significantly higher in cycles with spermatozoa injected than those with round cell injections (63 3% vs 23 2%, P <0 0001, Chi squared test) The pregnancy rate was 14 3% per cycle when spermatozoa were injected Conclusions TESE followed by Intracytoplasmic sperm injection (ICSI) is an effective treatment in patients with NOA Less than half of the patients undergoing TESE had spermatozoa recovered Age of men, volume of both testes and serum FSH/ testosterone levels in men were not useful in predicting successful recovery Compared to using ejaculated and epididymal spermatozoa, fertilization and pregnancy rates were achieved when testicular spermatozoa were used for | Ng Hung Yu Ernest, Lau Yee Lan, Yeung Shu Biu, So Wai Ki, Tam Po Chor and Ho Pak Chung | 2000 | Chinese Medical Journal2000，，3： | 7 |
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