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| 1 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 2 | Amine-based solvent for CO_2 absorption and its impact on carbon steel corrosion: A perspective review显示文摘Carbon dioxide(CO2)is one of the commonly emitted gaseous by-products in industrial processes.While CO2 gas is the main cause to greenhouse effect,various CO2 capture technologies have been proposed and implemented to sequester the CO2 before the waste gases being released into the atmosphere.One of the mature technologies for CO2 absorption is by using amine-based solvents.In this regard,different single amine solvents or blended amine solvents have been proven for their capability to remove CO2.However,the dissolution and reaction of CO2 gas with the amine solvents turn the solution corrosive.Such phenomenon is undesired as it posts corrosion problem to the absorption column,which normally built of carbon steel material.Henceforth,understanding the behaviour of different amine-based solvents in absorbing CO2 and its subsequent impact on carbon steel corrosion is very significant.In this review article,we will outline some of the more commonly used solvents and their respective advantages and disadvantages,motivating further investigation into the corrosion tendency.Meanwhile,existing gaps in this research area are discussed for future investigation. | Zhe Lun Ooi Pui Yee Tan Lian See Tan Swee Pin Yeap | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 7 |
| 3 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 4 | Testosterone and its metabolites: differential associations with cardiovascular and cerebrovascular events in men显示文摘当人们变得更老,当心血管的疾病的发生增加时,传播睾丸激素衰退。因此,是的性别荷尔蒙的角色 biomarkers,和到在增加的心血管的疾病的临床的表明的可能作出贡献的因素使人变老人口统计,吸引了可观的兴趣。这评论集中于内长的雄激素,也就是传播的睾丸激素和 dihydrotestosterone 的观察研究,它与象心肌的梗塞和击那样的心血管的事件检验了他们的协会。检验了内长的雌激素的协会的研究,也就是传播的 estradiol,与这些,结果也被讨论。在大未来的队研究主要中年并且老人,更低的传播睾丸激素一致地预言心血管的事件的更高的发生。笔记,更低的传播睾丸激素和更低的 dihydrotestosterone 与击的更高的发生被联系。当心肌的梗塞被看作结果时,这些协会是不太明显的。estradiol 的结果是不一致的。更低的传播睾丸激素被显示了预言更高心血管的疾病相关的死亡,作为有更低的传播 dihydrotestosterone。到心血管的事件或死亡结果的传播雄激素的关系可能 U 字形而非线性,是可能的,与定义在最低风险的人的一个最佳的范围。流行病学的研究在自然是观察的并且不证明诱发性。在内长的雄激素的研究观察的协会不必必然翻译成外长的雄激素的类似的效果。严密使随机化的控制试用被需要在人在心血管的风险上澄清睾丸激素处理的效果。 | Bu B Yeap | 2018 | Asian Journal of Andrology2018，20，2： | 3 |
| 5 | 云计算的服务安全体系结构和询问控制模型(英文)显示文摘Security is a key problem for the development of Cloud Computing. A common service security architecture is a basic abstract to support security research work. The authorization ability in the service security faces more complex and variable users and environment. Based on the multidimensional views, the service security architecture is described on three dimensions of service security requirement integrating security attributes and service layers. An attribute-based dynamic access control model is presented to detail the relationships among subjects, objects, roles, attributes, context and extra factors further. The model uses dynamic control policies to support the multiple roles and flexible authority. At last, access control and policies execution mechanism were studied as the implementation suggestion. | 闫丹凤 杨放春 Tet Yeap | 2011 | China Communications2011，8，6： | 3 |
| 6 | c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges显示文摘 | Marie A. Bogoyevitch Kevin R.W. Ngoei Teresa T. Zhao Yvonne Y.C. Yeap Dominic C.H. Ng | 2009 | BBA - Proteins and Proteomics2009，，3： | 3 |
| 7 | Sox2 Protein Expression is an Independent Poor Prognostic Indicator in Stage I Lung Adenocarcinoma显示文摘 | Lynette M. Sholl Justine A. Barletta Beow Y. Yeap Lucian R. Chirieac Jason L. Hornick | 2010 | The American Journal of Surgical Pathology2010，，8： | 2 |
| 8 | scFv Antibody: Principles and Clinical Application显示文摘 | Zuhaida Asra Ahmad Swee Keong Yeap Abdul Manaf Ali Wan Yong Ho Noorjahan Banu Mohamed Alitheen Muhajir Hamid T. Nakayama | 2012 | Clinical and Developmental Immunology2012，，： | 2 |
| 9 | 年龄≥65岁男性收缩压与血管疾病的相关性显示文摘老年人血压与血管疾病的关系尚不确定。1996-1999年,在澳大利亚西部帕斯普通人群中建立65~94岁男性7564人的前瞻性队列,评估收缩压与主要血管事件的相关性。测定基线和2001-2004年再调查时的收缩压。记录受试者的致命性及非致命性血管事件。 | Lacey B Golledge J Yeap BB Lewington S McCaul KA Norman PE Flicker L Almeida OP Hankey GJ 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 10 | 【特刊综述】性激素和心血管疾病显示文摘男人变老时雄激素水平会下降,这个变化的意义一直受到争论。支持低水平循环睾酮或其代谢产物双氢睾酮和雌二醇在男性动脉硬化和心血管疾病的发生中起作用的证据很有限。观测性研究把低于基线水平的睾酮与颈动脉粥样硬化、主动脉和周围血管疾病、以及心血管事件的发病率和死亡率联系起来。用质谱法的研究表明,当总睾酮测定最佳时,游离睾酮或双氢睾酮的测定计算并不一定会提高风险分层。能够支持雌二醇与心血管疾病有关联的证据很有限。用睾酮治疗男性冠状动脉疾病的干预性研究已经表明治疗对运动诱发的心肌缺血有利。然而,在男性的雄激素治疗中具有预定的心血管事件或死亡的结果的有安慰剂对照的随机临床试验还很少。对2010以前的随机对照试验的荟萃分析显示睾酮治疗对心血管事件、死亡率或前列腺癌没有什么提高。最近,针对有活动限制的老年男性的随机试验表明,大剂量睾酮对心血管是有害的。这种现象不是从适合比较的男子接受保守剂量睾酮的试验中得到的,报告建议在治疗有心血管疾病的体弱老年男性时应当采取审慎的态度。需要有充分有力的随机临床试验来证实在中老年男性中激素干预是否会减少心血管疾病的发病率。 | Bu Beng Yeap | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 11 | Antioxidant and radical scavenging activities of polyphenols from apple pomace显示文摘 | Yinrong Lu L. Yeap Foo | 1999 | Food Chemistry1999，，1： | 2 |
| 12 | Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation显示文摘 | Philip A. Linden Richard J. Gilbert Beow Y. Yeap Kathleen Boyle Aaron Deykin Michael T. Jaklitsch David J. Sugarbaker Raphael Bueno | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
| 13 | Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma 显示文摘 | Gordon G J Dung L Yeap BY | 2009 | J Natl Cancer Inst2009，101，： | 1 |
| 14 | Tin and gold mineralization in peninsular Malaysia and their relationshipas to the tectonic development显示文摘 | Yeap E B | 1993 | Journal of Southeast Asian Earth Sciences1993，8，1： | 1 |
| 15 | Development of central nervous system metastases in patients with advanced non -small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib显示文摘 | Heon S Yeap BY Britt GJ | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 16 | The androgen receptor mRNA显示文摘 | Yeap BB Wilce JA Leedman PJ | 2004 | Bioessays2004，26，6： | 1 |
| 17 | Long-term results of tibialis poste rior tendon transfer for drop-foot显示文摘 | Yeap J S Birch R Singh D | 2001 | Int Orthop2001，25，： | 1 |
| 18 | Effect ofcrizotinib on overall survival in patients with advancednon-small-cell lung cancer harbouring ALK generearrangement:a retrospective analysis 显示文摘 | Shaw A T Yeap B Y Solomon B J | 2011 | Lancet Oncol2011，12，11： | 1 |
| 19 | Androgens and cardiovascular disease 显示文摘 | Yeap BB | 2010 | Curr Opin Endocrinol Diabetes Obes2010，17，3： | 1 |
| 20 | Total synthesis,cytotoxic effects of damnacanthal,nordamnacanthal and\srelated anthraquinone analogues显示文摘 | Akhtar MN Zareen S Yeap SK | 2013 | Molecules2013，18，10： | 1 |
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