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| 1 | 董事会中的不同声音:非控股股东董事的监督动机与监督效果显示文摘本文利用中国强制披露的上市公司董事投票数据,分析了非控股股东董事的监督动机和监督效果。研究发现,非控股股东董事倾向于对与非控股股东利益联系紧密的董事会议案投非赞成票。并且,持股比例较高的非控股股东派出的董事和未在上市公司领取薪酬的非控股股东董事更倾向于投非赞成票。通过检验非控股股东董事投非赞成票的监督效果,本文发现,非控股股东董事投非赞成票能降低上市公司的代理成本、提高上市公司的经营效率和企业价值。进一步研究发现,非控股股东董事的监督对独立董事履行监督职能具有溢出效应,且这一效应在经营风险较高的公司中,以及当独立董事和非控股股东董事的职业背景相似时更显著。本文的研究对于进一步提高董事会治理效率、深化混合所有制改革和完善中国特色现代企业制度具有积极的启示。 | 祝继高 李天时 YANG Tianxia | 2021 | 经济研究2021，56，5： | 18 |
| 2 | CCL5/CCR5 axis in human diseases and related treatments显示文摘To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among them, chemokines act as crucial regulators in defense systems. CCL5/CCR5 combination is known for facilitating inflammatory responses, as well as inducing the adhesion and migration of different T cell subsets in immune responses. In addition, recent studies have shown that the interaction between CCL5 and CCR5 is involved in various pathological processes including inflammation, chronic diseases, cancers as well as the infection of COVID-19. This review focuses on how CCL5/CCR5 axis participates in the pathological processes of different diseases and their relevant signaling pathways for the regulation of the axis. Moreover, we highlighted the gene therapy and chemotherapy studies for treating CCR5-related diseases, including the ongoing clinical trials. The barriers and perspectives for future application and translational research were also summarized. | Zhen Zeng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Genes & Diseases2022，9，1： | 12 |
| 3 | Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system显示文摘As one of the most important vegetables,tomato (Solanum lycopersicum) is extensively produced and consumed worldwide and substantially contributes to human nutrition and health (The Tomato Genome Consortium,2012).Although red tomatoes are the most common,pink tomatoes are more popular in Asia,particularly in China and Japan,because of their better taste (Ballester et al.,2010;Zhu et al.,2018).Compared with red tomatoes,pink tomatoes fail to accumulate the yellow-colored flavonoid pigment,naringenin chalcone (NarCh),in their peels,resulting in a colorless peel phenotype (Adato et al,2009;Ballester et al.,2010). | Tianxia Yang Lei Deng Wei Zhao Ruoxi Zhang Hongling Jiang Zhibiao Ye Chang-Bao Li Chuanyou Li | 2019 | Journal of Genetics and Genomics2019，46，10： | 8 |
| 4 | The Hippo signalling pathway and its implications in human health and diseases显示文摘As an evolutionarily conserved signalling network,the Hippo pathway plays a crucial role in the regulation of numerous biological processes.Thus,substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway,as well as its physiological functions,such as cell proliferation and differentiation,organ growth,embryogenesis,and tissue regeneration/wound healing.However,dysregulation of the Hippo pathway can cause a variety of diseases,including cancer,eye diseases,cardiac diseases,pulmonary diseases,renal diseases,hepatic diseases,and immune dysfunction.Therefore,therapeutic strategies that target dysregulated Hippo components might be promising approaches for the treatment of a wide spectrum of diseases.Here,we review the key components and upstream signals of the Hippo pathway,as well as the critical physiological functions controlled by the Hippo pathway.Additionally,diseases associated with alterations in the Hippo pathway and potential therapies targeting Hippo components will be discussed. | Minyang Fu Yuan Hu Tianxia Lan Kun-Liang Guan Ting Luo Min Luo | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 5 |
| 5 | Multifunctional regulatory protein connective tissue growth factor (CTGF):A potential therapeutic target for diverse diseases显示文摘Connective tissue growth factor(CTGF),a multifunctional protein of the CCN family,regulates cell proliferation,differentiation,adhesion,and a variety of other biological processes.It is involved in the disease-related pathways such as the Hippo pathway,p53 and nuclear factor kappa-B(NF-κB)pathways and thus contributes to the developments of inflammation,fibrosis,cancer and other diseases as a downstream effector.Therefore,CTGF might be a potential therapeutic target for treating various diseases.In recent years,the research on the potential of CTGF in the treatment of diseases has also been paid more attention.Several drugs targeting CTGF(monoclonal antibodies FG3149 and FG3019)are being assessed by clinical or preclinical trials and have shown promising outcomes.In this review,the cellular events regulated by CTGF,and the relationships between CTGF and pathogenesis of diseases are systematically summarized.In addition,we highlight the current researches,focusing on the preclinical and clinical trials concerned with CTGF as the therapeutic target. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 5 |
| 6 | Proteasomal deubiquitinase UCH37 inhibits degradation of β-catenin and promotes cell proliferation and motility显示文摘The ubiquitin–proteasome system degrades most cellular proteins in eukaryotes.UCH37,also known as UCH-L5,is a deubiquitinase binding to Rpn13,a receptor for ubiquitinated substrates in the 26 S proteasome.But,it remains unclear how UCH37 influences the proteasomal degradation of the ubiquitinated substrates.Because deletion of UCH37 is embryonically lethal in mice,this study aims to investigate the role of UCH37 in proteasomal degradation by constructing the UCH37-deficient cell lines using CRISPR/Cas9 technology.Our results demonstrated that deletion of UCH37 decreased the levels of proteasomal Rpn13,implying that UCH37 might facilitate incorporation of Rpn13 into the proteasome.Meanwhile,deletion of UCH37 decreased the levels of β-catenin and the early endosomal protein Rab8.β-Catenin interacts with TCF/LEF to control transcription,and is involved in development,tissue homeostasis and tumorigenesis.We further found that deletion of UCH37 increased the levels of the ubiquitinated β-catenin and accelerated the hydrogen peroxide-stimulated degradation of β-catenin.Deletion of UCH37 also down-regulated the transcription of c-Myc,a downstream effector of β-catenin,and inhibited cell proliferation and motility.These results raise the possibility that UCH37 maintains the homeostasis of proteasomal degradation reciprocally by assisting the recruitment of the ubiquitin receptor Rpn13 into the proteasome and by reversing ubiquitination of certain critical substrates of the 26 S proteasome. | Zijian Li Luming Zhou Tianxia Jiang Libin Fan Xiaoying Liu Xiaobo Qiu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 7 | Author correction to‘Multifunctional regulatory protein connective tissue growth factor(CTGF):A potential therapeutic target for diverse diseases’[Acta pharmaceutica sinica B 12(2022)1740-1760]显示文摘The authors regret that there was an error in 7.Conclusion and prospect section of the article.The last paragraph of this section‘Under particular external…integrins interact with CT domain’is supposed to be the content of the figure legend(Fig.1).It is superfluous in this part and should be deleted.The revision does not affect any conclusions of this work. | Minyang Fu Dandan Peng Tianxia Lan Yuquan Wei Xiawei Wei | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 3 |
| 8 | Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment显示文摘The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach are actively under clinical investigations, but the underlying mechanism is unclear. Histone homeostasis is critical to genome stability, transcriptional accuracy, DNA repair process, senescence, and survival. We have previously demonstrated that the HDAC inhibitor, trichostatin A(TSA), could promote the degradation of the core histones induced by γ-radiation or the DNAalkylating agent methyl methanesulfonate(MMS) in non-cancer cells, including mouse spermatocyte and embryonic fibroblast cell lines. In this study, we found that the joint treatment by TSA and MMS induced the death of the cultured cancer cells with an additive effect, but induced degradation of the core histones synergistically in these cells. We then analyzed various combinations of other HDAC inhibitors, including suberoylanilide hydroxamic acid and valproate sodium, with MMS or other DNAdamaging agents, including etoposide and camptothecin. Most of these combined treatments induced cell death additively, but all the tested combinations induced degradation of the core histones synergistically. Meanwhile, we showed that cell cycle arrest might not be a primary consequence for the joint treatment of TSA and MMS. Given that clinic treatments of cancers jointly with an HDAC inhibitor and a DNA-damaging approach often show synergistic effects, histone degradation might more accurately underlie the synergistic effects of these joint treatments in clinic applications than other parameters, such as cell death and cell cycle arrest. Thus, our studies might suggest that the degradation of the core histones can serve as a new target for the development of cancer therapies. | Yesheng Yin Qianqian Zhu Tianxia Jiang Libin Fan Xiaobo Qiu | 2019 | Science China(Life Sciences)2019，62，8： | 2 |
| 9 | Study on synchronization of two eccentric rotors driven by hy- draulic motors in one vibrating system显示文摘 | Zhang Tianxia Wen Bangchun Fan Jian | 1997 | Shock and Vibration1997，4，56： | 1 |
| 10 | CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis显示文摘 | Tianxia Jiang Jie Zhuang Hongxia Duan Yongting Luo Qiqun Zeng Kelong Fan Huiwen Yan Di Lu Zhongde Ye Junfeng Hao Jing Feng Dongling Yang Xiyun Yan | 2012 | Blood2012，，11： | 1 |
| 11 | Study of Periodical Message-Scheduling AL Algorithm Without Collision of CAN Bus显示文摘 | Cao Wanke Zhang Tianxia Liu Yingji | 2006 | Natural Science Research2006，8，6： | 1 |
| 12 | Enhancing Heterogeneous Catalytic Activity of Iron(II) Phthalocyanine by Ethanol and Its Application in 2,4-dichlorophenol Detection显示文摘A chemical system for facile and accurate detection of 2,4-dichlorophenol(DCP) via iron(II) phthalocyanine(Fe(II)Pc) catalyzed chromogenic reaction is reported for the fi rst time. In this system, DCP could be oxidized by dioxygen with the catalysis of Fe(II)Pc and then coupled with 4-aminoantipyrine(4-AAP) to generate pink antipyrilquinoneimine dye. Control experiments showed that the addition of ethanol could obviously enhance the catalytic activity of heterogeneous Fe(II)Pc catalysts because of the partial dissolution of Fe(II)Pc nanocubes, which was confirmed by the SEM analysis. On the basis of the detection results of DCP in the range from 2×10-5 to 9×10-4 mol/L, we obtained a regression equation(A = 0.187 5 + 0.01 209C(R2=0.995 6)) with the detection limit(3σ) of 3.26×10-6 mol/L, which could be successfully used in detecting the real samples. | 童伊琳 LI Dapeng HUANG Jun LI Kun DING Liyun WANG Tianxia GONG Jingjing | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 1 |
| 13 | Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment显示文摘For coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),15–30%of patients are likely to develop COVID-19-related acute respiratory distress syndrome(ARDS).There are still few effective and well-understood therapies available.Novel variants and short-lasting immunity are posing challenges to vaccine efficacy,so finding antiviral and antiinflammatory treatments remains crucial.Here,tripterin(TP),a traditional Chinese medicine,was encapsulated into liposome(TP lipo)to investigate its antiviral and antiinflammatory effects in severe COVID-19.By using two severe COVID-19 models in human ACE2-transgenic(hACE2)mice,an analysis of TP lipo’s effects on pulmonary immune responses was conducted.Pulmonary pathological alterations and viral burden were reduced by TP lipo treatment.TP lipo inhibits SARS-CoV-2 replication and hyperinflammation in infected cells and mice,two crucial events in severe COVID-19 pathophysiology,it is a promising drug candidate to treat SARS-CoV-2-induced ARDS. | Haiying Que Weiqi Hong Tianxia Lan Hao Zeng Li Chen Dandan Wan Zhenfei Bi Wenyan Ren Min Luo Jingyun Yang Cai He Ailing Zhong Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 1 |
| 14 | lncRNA LINC00960 promotes apoptosis by sponging ubiquitin ligase Nrdp1-targeting miR-183-5p显示文摘The ubiquitin ligase Nrdp1/RNF41 promotes the ubiquitin-dependent degradation of multiple important substrates,including BRUCE/BIRC6,a giant ubiquitin-conjugating enzyme inhibiting both apoptosis and autophagy.miR-183-5p is associated with various malignancies potentially by targeting dozens of genes.Here,we show that the lncRNA LINC00960 binds to the Nrdp1-targeting miR-183-5p and promotes apoptosis.Compared to other known miR-183-5p targets,Nrdp1 mRNA is among the few with top scores to complement miR-183-5p.miR-183-5p binds to the 3′UTR of Nrdp1 mRNA and downregulates Nrdp1 at both the mRNA and protein levels.The miR-183-5p mimics inhibit DNA damage-induced apoptosis probably by upregulating BRUCE level,whereas the miR-183-5p inhibitor suppresses the effects of miR-183-5p.LINC00960 is the noncoding RNA with the highest score to complement miR-183-5p.LINC00960 overexpression reduces,but its knockdown increases,the level of miR-183-5p,whereas LINC00960 overexpression increases,but its knockdown decreases,the level of Nrdp1 and apoptosis.Importantly,the expression of LINC00960,which is associated with multiple types of tumors,positively correlates with that of Nrdp1 in several tumors but inversely correlates with that of miR-183-5p in multiple human tumor cell lines,as analysed by quantitative PCR.Thus,miR-183-5p downregulates Nrdp1 expression and inhibits apoptosis,whereas LINC00960 upregulates Nrdp1 and promotes apoptosis by inhibiting miR-183-5p.These results may provide new ideas for the prevention,diagnosis and treatment of apoptosis-related diseases,such as tumors and neurodegenerative diseases. | Hao Yang Tianxia Jiang Libin Fan Xiaobo Qiu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 1 |
| 15 | Firmness and force relaxation characteristics of tomatoes stored intact or as slices显示文摘 | Wu Tianxia Abbott J A | 2002 | Postha vest Biology and Technology2002，24，： | 1 |
| 16 | Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity显示文摘Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism. | Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang Yang Jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao Jiang Cen Xie Xiuwei Yang Frank J.Gonzalez | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 17 | Quality and microbial changes of fresh-cut mango cubes held in controlled atmosphere显示文摘 | Nithiya R Yuen L Tianxia W | 2001 | HortScience2001，36，： | 1 |
| 18 | Role of TiF 3 catalyst in the tribological properties of biofuel soot-contaminated liquid paraffin显示文摘 | Enzhu Hu Xianguo Hu Tianxia Liu Ruhong Song Karl D Dearn Hongming Xu | 2014 | Tribology International2014，，： | 1 |
| 19 | Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants显示文摘The outbreak of coronavirus disease 2019(COVID-19)has posed great threats to global health and economy.Several effective vaccines are available now,but additional booster immunization is required to retain or increase the immune responses owing to waning immunity and the emergency of new variant strains.The deficiency of intramuscularly delivered vaccines to induce mucosal immunity urged the development of mucosal vaccines.Here,we developed an adjuvanted intranasal RBD vaccine and monitored its long-term immunogenicity against both wild-type and mutant strains of severe acute respiratory syndrome coronavirus-2(SARSCoV-2),including Omicron variants,in mice.Three-dose intranasal immunization with this vaccine induced and maintained high levels of neutralizing IgG antibodies in the sera for at least 1 year.Strong mucosal immunity was also provoked,including mucosal secretory IgA and lung-resident memory T cells(TRM).We also demonstrated that the long-term persistence of lung TRM cells is a consequence of local T-cell proliferation,rather than T-cell migration from lymph nodes.Our data suggested that the adjuvanted intranasal RBD vaccine is a promising vaccine candidate to establish robust,long-lasting,and broad protective immunity against SARS-CoV-2 both systemically and locally. | Hong Lei Aqu Alu Jingyun Yang Wenyan Ren Cai He Tianxia Lan Xuemei He Li Yang Jiong Li Zhenling Wang Xiangrong Song Wei Wang Guangwen Lu Xiawei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 1 |
| 20 | Quality and microbial changes of fresh-cut mango cubes held in controlled atmosphere 显示文摘 | Nithiya R Yuen L Tianxia W | 2001 | HortScience2001，36，： | 1 |
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