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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Near-perfect elastoplasticity in pure nanocrystalline copper 显示文摘 | Yannick C Cyril L Sandrine G M | 2003 | Science2003，300，56： | 1 |
| 3 | Rheological Pro- perties of Hyperbranched Polymer/Poly (ethylene tereph- thalate) Reactive Blends显示文摘 | Seung B K Yannick A Yves L | 2003 | Polymer Engineering and Sci- ence2003，43，2： | 1 |
| 4 | Near-perfect elastoplasticity in pure nanocrystalline copper 显示文摘 | YANNICK C CYRIL L SANDRINE G M | 2003 | Science2003，300，5617： | 1 |
| 5 | Inhibition of cytochrome P450 2El by propofol in human and procine liver microsomes 显示文摘 | CORINNE L ALAIN F YANNICK M | 2002 | Biochem Pharmacol2002，780，： | 1 |
| 6 | The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle 显示文摘 | Yannick G Sylvie T Melanie L | 1999 | Journal of Cell Science1999，112，： | 1 |
| 7 | Linear osmoregulated periplasmic glucans are encoded by the opgGH locus of Pseudomonas aeruginosa 显示文摘 | Yannick L Eglantine R Aurelie D | 2007 | Microbiology2007，153，： | 1 |
| 8 | Synthesis of MnOOH Nanorods by Cluster Growth Route from (R=CH3,C2H5) Rational Conversion of MnOOH into Mn3O4 or MnO2 Nanorods显示文摘 | Benjamin F Joulia L Yannick G | 2005 | Solid State Chem2005，178，7： | 1 |
| 9 | Inflation, minimum wage and other wages : an econometric study on French macroeconomic data 显示文摘 | Yannick L' Horty Christophe Rault | 2004 | Applied Economics2004，，36： | 1 |
| 10 | Acute respiratory failure in the elderly: etiology, emergency diagnosis and prognosis显示文摘 | Patrick R Sophie B Yannick L | 2006 | Crit Care2006，10，3： | 1 |
| 11 | Self-assembly in surfactant oligomers:A coarse-grained description through molecular dynamics simulations显示文摘 | Prabal K M Yves L Mathew A G Matthew A Noel A Yannick R | 2002 | Langmiur2002，18，5： | 1 |
| 12 | Adsorption of SO x by oxide materials: A review显示文摘 | Yannick Mathieu Lydie Tzanis Michel Soulard Jo?l Patarin Matthieu Vierling Michel Molière | 2013 | Fuel Processing Technology2013，，： | 1 |
| 13 | Positive and negative regulation of insulin signaling through IRS-1 phosphorylation 显示文摘 | Philippe G Yannick L M Jean F T | 2005 | Biochimie2005，87，1： | 1 |
| 14 | Activity of purified QscR,a Pseudomonas aeruginosa orphan quorumsensing transcription factor显示文摘 | Joon-Hee L Yannick L Peter G | | 0，，02： | 1 |
| 15 | Quantitative analysis of wheat starch-water suspensions by pulsed NMR spectroscopy measurements显示文摘 | Rugraff Yannick L Desbois Pascal | 1996 | Carbohydrate Research1996，295，： | 1 |
| 16 | Preparation of optically active α-silyl carbonyl compounds using asymmetric alkylation of α-silylacetic esters and asymmetric metal -carbene insertion into the Si-H bond显示文摘 | YANNICK L DENIS P | 1997 | Tetrahedron1997，53，8： | 1 |
| 17 | Seasonal changes in pore water concentrations of nutrients and their diffusive fluxes at the sediment-water interface 显示文摘 | YANNICK L PIERRE L PIERRE LE C | 1990 | Journal of Experimental Marine Biology and Ecology1990，135，： | 1 |
| 18 | Near-perfect elastoplasticity in pure nanocrystalline copper显示文摘 | Yannick C Cyril L Sandrine G M | 2003 | Science2003，，300： | 1 |
| 19 | Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients显示文摘 | Alexandre O Patrick L Yannick LM | 2005 | Anesthesiology2005，103，4： | 1 |
| 20 | Microstructured optical fiber photonic wires with subwavelength core diameter 显示文摘 | Yannick L Eric M Vahid T | 2004 | Optics Express2004，12，14： | 1 |
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