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| 1 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 2 | Release characteristics of mercury in chemical looping combustion of bituminous coal显示文摘This study evaluated the release characteristics of mercury from bituminous coal in chemical looping combustion(CLC)using Australian iron ore as the oxygen carrier in a fixed bed reactor.The effects of several parameters,such as temperature in the fuel reactor(FR)and air reactor(AR),gasification medium in the FR,and reaction atmosphere in the AR,on mercury release characteristics,were investigated.The mercury speciation and release amount in the FR and AR under different conditions were further explored.The results indicate that most of the mercury in coal was released in the FR,while the rest of it was released in the AR.Hg0 was found to be the major species in the released mercury.The results also indicate that a higher temperature in the FR led to an increase in the total mercury release amount and a decrease in Hg0 proportion.However,a higher temperature in the AR resulted in a decrease in the total mercury release amount and Hg 0 proportion.The increase in the H2O/CO2 ratio of gasification mediums in the FR was beneficial for the increase in the total mercury release amount and Hg 0 proportion.A higher O2 concentration in reaction atmosphere in AR had a negligible effect on the total mercury release amount,but a positive effect on Hg0 oxidization. | Ling Ji Qianwen Wang Zhiyue Zhang Hao Wu Changsong Zhou Hongmin Yang | 2020 | Journal of Environmental Sciences2020，32，8： | 5 |
| 3 | The influence of intimacy on the ’iterative reactions’ during OX-ZEO process for aromatic production显示文摘The oxide-zeolite process provides a promising way for one-step production of aromatics from syngas,whereas the reasons for the dramatic effect of intimacy between oxide and zeolite in the composite catalyst on the product selectivity are still unclear. In order to explore the optimal intimacy and the essential influence factors, ZnCrOxcombined with ZSM-5 are employed to prepare the composite catalysts with different distances between the two components by changing the mixing methods. An aromatic selectivity of 74%(with CO conversion to be 16%) is achieved by the composite catalyst when the intimacy is in the range of nanometer. A so-called ‘iterative reactions’ mechanism of intermediates over oxides is then proposed and studied: the intermediate chemical can undergo a hydrogenation reaction on oxide.So the shorter the intermediates stay on oxide, the more of chance for C-C coupling takes place on zeolite to form aromatics. Moreover, the aero-environments of reaction is found to impact on the extent of iterative reaction as well. Therefore, when the intimacy between the two components changes, the extent of iterative reactions vary, resulting in alteration of product distribution. This work provides new insight in understanding the mechanisms during the complex process of OX-ZEO composite catalysis and sheds light to the design of a high-yield catalyst for synthetization of aromatics from syngas. | Xiaoli Yang Ting Sun Junguo Ma Xiong Su Ruifeng Wang Yaru Zhang Hongmin Duan Yanqiang Huang Tao Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 4 | Influence of solution treatment on microstructure,mechanical and corrosion properties of Mg-4Zn alloy显示文摘The solution treatment parameters,mechanical properties and corrosion behavior of binary Mg-4Zn alloy were investigated.The results showed that after the solution treatment at 335℃ for 16 h,Mg-4Zn alloy had an ultimate tensile strength of 184.13 MPa and elongation of 9.43%.Furthermore,the corrosion resistance was evaluated by electrochemical measurements and immersion tests in 3.5%NaCl solution.The results revealed that the corrosion current density of the solution treatment Mg alloy was 11.2µA/cm^(−2),it was lower than 15.8µA/cm^(−2) for the as-cast Mg alloy under the same conditions,which was greatly associated with the micro-cathode effect of the second phases. | Hongmin Jia Xiaohui Feng Yuansheng Yang | 2015 | Journal of Magnesium and Alloys2015，3，3： | 4 |
| 5 | Effect of crystal orientation on corrosion behavior of directionally solidified Mg-4 wt% Zn alloy显示文摘Microstructure and crystallographic orientation of directionally solidified Mg-4 wt% Zn alloy were characterized by X-ray computed tomography(XCT) and electron backscatter diffraction(EBSD) in this study.Results reveal that Mg-4 wt% Zn alloy with dendritic microstructure exhibits typical {0002 } basal texture along growth direction. Based on this, the effect of grain orientation on corrosion behavior of directionally solidified Mg-4 wt% Zn alloy in 0.9 wt% NaCl solution was investigated. Result shows that {0002}oriented planes have better corrosion resistance than {1120} and {1010} ones, which is attributed to a synergistic effect of surface energy, atomic packing density and the stability of oxidation film. | Hongmin Jia Xiaohui Feng Yuansheng Yang | 2018 | Journal of Materials Science & Technology2018，34，7： | 4 |
| 6 | Nitrogen-doped hierarchically porous carbon spheres for low concentration CO_(2) capture显示文摘Synthesis of spherical carbon beads with effective CO_2 capture capability is highly desirable for large scale application of CO2 sorption, but remains challenging. Herein, a facile and efficient strategy to prepare nitrogen-doped hierarchically porous carbon spheres was developed via co-pyrolyzation of poly(vinylidene chloride) and melamine in alginate gel beads. In this approach, melamine not only serves as the nitrogen precursor, but also acts as a template for the macropores structures. The nitrogen contents in the hierarchically porous carbon spheres reach a high level, ranging from 11.8 wt% to 14.7 wt%, as the melamine amount increases. Owing to the enriched nitrogen functionalities and the special hierarchical porous structure, the carbon spheres exhibit an outstanding CO_2 capture performance, with the dynamic capacity of as much as about 7 wt% and a separation factor about 49 at 25 °C in a gas mixture of CO_2/N_2(0.5:99.5, v/v). | Yang Li Jing Wang Sisi Fan Fanan Wang Zheng Shen Hongmin Duan Jinming Xu Yanqiang Huang | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 7 | Identification of relevant active sites and a mechanism study for reverse water gas shift reaction over Pt/CeO_2 catalysts显示文摘Reverse water gas shift(RWGS) reaction can serve as a pivotal stage in the CO_2 conversion processes,which is vital for the utilization of CO_2.In this study,RWGS reaction was performed over Pt/CeO_2 catalysts at the temperature range of 200-500℃ under ambient pressure.Compared with pure CeO_2,Pt/CeO_2catalysts exhibited superior RWGS activity at lower reaction temperature.Meanwhile,the calculated TOF and E_a values are approximately the same over these Pt/CeO_2 catalysts pretreated under various calcination conditions,indicating that the RWGS reaction is not affected by the morphologies of anchored Pt nanoparticles or the primary crystallinity of CeO_2.TPR and XPS results indicated that the incorporation of Pt promoted the reducibility of CeO_2 support and remarkably increased the content of Ce^(3+) sites on the catalyst surface.Furthermore,the CO TPSR-MS signal under the condition of pure CO_2 flow over Pt/CeO_2catalyst is far lower than that under the condition of adsorbed CO_2 with H_2-assisted flow,revealing that CO_2 molecules adsorbed on Ce^(3+) active sites have difficult in generating CO directly.Meanwhile,the adsorbed CO_2 with the assistance of H_2 can form formate species easily over Ce^(3+) active sites and then decompose into Ce^(3+)-CO species for CO production,which was identified by in-situ FTIR. | Xiaodong Chen Xiong Su Binglian Liang Xiaoli Yang Xinyi Ren Hongmin Duan Yanqiang Huang Tao Zhang | 2016 | Journal of Energy Chemistry2016，25，6： | 3 |
| 8 | Extraction mechanism of rare earths from chloride acidic solution with ammonium-bifunctionalized ionic liquid extractants显示文摘A series of ammonium-bifunctionalized ionic liquid extractants(ammonium-Bif-ILEs) combined with a number of anions, including carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. Their extraction behavior and properties toward rare earth ions(REs(Ⅲ)) are systematically investigated in chloride media as a function of important parameters such as aqueous phase p H, salting-out agent concentrations, and extraction temperature. The separation performance of ammonium-Bif-ILEs toward REs(Ⅲ) are systematically discussed. The results demonstrate that ammonium-Bif-ILEs have a synergistic effect between the cation and anions in separation of REs(Ⅲ). The influences of different anions on separation factor(b) values are further studied. By comparison, ammonium-Bif-ILEs containing 1,3-diketonates have more potential applications in La(Ⅲ)/RE(Ⅲ) separation than those containing carboxylic acids. | Hualing Yang Ji Chen Wei Wang Hongmin Cui Wengang Liu Yu Liu | 2016 | Science China Chemistry2016，59，5： | 2 |
| 9 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 10 | Statistical Analysis of Dangerous Chemical Accidents in China显示文摘 | Kang Sun Hongmin Yang | 2012 | Fire Technology2012，48，2： | 1 |
| 11 | Catalytic pyrolysis of rice husk by mixing with zinc oxide: Characterization of bio-oil and its rheological behavior显示文摘 | Zhou Leiyu Yang Hongmin Wu Hao | 2013 | Fuel Processing Technology2013，，106： | 1 |
| 12 | Shape-selective alkylation of benzene with ethylene over a core–shell ZSM-5@MCM-41 composite material显示文摘A series of ZSM-5@MCM-41 core-shell composite materials prepared via a multi-cycle-sol-gel coating strategy is investigated as the catalyst for benzene alkylation with ethylene,in which both ethylbenzene and para-diethylbenzene(p-DEB)are aimed as the target products.With multi-cycle-sol-gel coating,the external acid sites on the samples are gradually passivated by the inert MCM-41 shell.As a result,the shape selectivity to p-DEB is greatly enhanced.Nevertheless,the coating of mesoporous MCM-41 shell on ZSM-5 accelerates deactivation of the catalyst only due to the dilution effect of ZSM-5 content in the catalyst at the same space velocity,which is a reason that core-shell ZSM-5@MCM-41 will potentially be a practical catalyst in shape selective alkylation of benzene.In order to enhance the yield of p-DEB on ZSM-5@MCM-41,the reaction conditions at the fixed bed reactor including temperature,the molar rate of benzene to ethylene and GHSV,are also optimized. | Zhenhao Shen Chongwei Ma Darui Wang Junlin He Hongmin Sun Zhirong Zhu Weimin Yang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 13 | Statistical analysis of dangerous chemical accidents in China显示文摘 | SUN Kang YANG Hongmin | 2012 | Fire Technology2012，48，2： | 1 |
| 14 | Glycine-assisted hydrothermal synthesis of peculiar porous α-Fe2O3 nanospheres with excellent gas-sensing properties 显示文摘 | Chen Hongmin Zhao Yingqiang Yang Mingqing | 2010 | Anal Chim Acta2010，659，1： | 1 |
| 15 | Air foam injec- tion for IOR:from laboratory to field implementation in Zhongyuan oilfield China显示文摘 | Hongmin Yu Baoquan Yang Guorui Xu | 2008 | SPE/DOE improved oil recovery symposium Oklahoma2008，，： | 1 |
| 16 | The Effect of Curcumin on Proliferation and Apoptosis in LNCaP Prostate Cancer Cells显示文摘OBJECTIVE To observe the effect of curcumin on proliferation and apop-tosis in the prostate cancer LNCaP cell line. METHODS The AXSYMTM system luciferase method was used to examine the effect of various concentratious of curcumin on the content of prostate specific antigen (PSA) in prostate cancer LNCaP cells. A pGL3-PSA luciferase expression vector, containing 640 bp DNA of the PSA gene 5' -promoter region was constructed and transfected into the LNCaP cells with lipofectin. By measuring luciferase activity, the effect of 10 μmol/L, 20 μmol/L, 30 and 40 μmol/L curcumin on the promoter was studied. Effects on cell growth and apoptosis were analyzed by microscopy, the MTT colorimetric assay and flow cytometry. Western-blotting was used to measure expression of the androgen receptor (AR) in the LNCaP cells treated with different concentrations of curcumin. RESULTS The results showed that the expression of PSA was inhibited as curcumin reduced the activity of luciferase. Curcumin also caused a sigificant concentration-dependent decrease in AR expession measured by Western -blotting. Cell growth was inhibited and apoptosis was induced. CONCLUSION By inhibiting AR expression, curcumin reduced the function of the PSA promoter and inhibited PSA protein expression. Curcumin decreased the cellular proliferation and induced apoptosis in LNCaP cells in a concention-dependent manner. | Lei Yang Lijun Chen Bin Meng Jiangrui Suo Hongmin Wang Hong Xie Qiuyue Jin Li Yao Ruimin Wang Lianying Zhang | 2006 | Chinese Journal of Clinical Oncology2006，3，1： | 1 |
| 17 | SO_2-tolerant Pt-MoO_3/C catalyst for oxygen reduction reaction显示文摘A Pt-MoO_3/C catalyst,aimed to eliminate the harmful effect of sulfur dioxide(SCb) on the performance of Pt nanoparticles(NPs) for catalysis of oxygen reduction reaction(ORR) in proton exchange membrane fuel cells(PEMFC),is developed and characterized by TEM,XRD and XPS.The results reveal that Pt-MoO_3/C catalyst exhibits not only a higher catalytic activity,but also a better SO_2 poisoning resistance and a better recovery performance than the commercial Pt/C catalyst does. | Xiao Liu Hongmin Wang Siguo Chen Xueqiang Qi Huiliang Gao Yi Hui Yang Bai Lin Guo Wei Ding Zidong Wei | 2014 | Journal of Energy Chemistry2014，23，3： | 1 |
| 18 | Advances in development and industrial application of ethylbenzene process显示文摘 | Yang Weimin Wang Zhengdong Sun Hongmin | 2016 | Chin J Catal2016，37，1： | 1 |
| 19 | Air foam injection for IOR:From laboratory to field implementation in Zhongyuan Oilfield China显示文摘 | Yu Hongmin Yang Baoquan Xu Guorui | 2008 | SPE 1139132008，，： | 1 |
| 20 | Photochemical removalof gaseous elemental mercury in a dielectric barrier dischargeplasma reactor显示文摘 | Hongmin Yang Hao Liu Hao Wu | 2012 | Plasma Chem Plasma Process2012，32，： | 1 |
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