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| 1 | Heterogeneity of aberrant immunoglobulin expression in cancer cells显示文摘Accumulating evidence has shown that immunoglobulin(Ig)is‘unexpectedly’expressed by epithelial cancer cells and that it can promote tumor growth.The main purpose of this study was to explore the components of the cancerous Ig and its possible function.The presence of cancerous Ig in the Golgi apparatus was confirmed by immunofluorescence,indirectly suggesting that the cancerous Ig was processed and packaged in cancer cells.Western blot analysis and ELISA results indicated that cancer cells produced membrane Ig and secreted Ig into the supernatant fraction.The cancerous Ig consists of an a heavy chain and a k light chain.Finally,by analyzing the Ig components pulled down by protein A beads,the cancerous Ig was found to be structurally distinct from normal Ig.The cancerous Ig was truncated or aberrant.Although the underlying mechanism that causes the abnormalities has not been determined,our current discoveries strengthen our previous findings and promise fruitful future explorations. | Duosha Hu Zhi Duan Ming Li Yiqun Jiang Haidan Liu Hui Zheng Lili Li Ann M Bode Zigang Dong Ya Cao | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | YKL40 expression in CD14^+ liver cells in acute and chronic injury显示文摘AIM:To demonstrate that CD14 + cells are an important source of the growth factor YKL40 in acute and chronic liver damage.METHODS:Rats were inoculated with one dose of CCl4 to induce acute damage.Liver biopsies were obtained at 0,6,12,24,48 and 72 h.For chronic damage,CCl4 was administered three days per week for 6 or 8 wk.Tissue samples were collected,and cellular populations were isolated by liver digestion and purified by cell sorting.YKL40 mRNA and protein expression were evaluated by realtime polymerase chain reaction and western blot.RESULTS:Acute liver damage induced a rapid increase of YKL40 mRNA beginning at 12 h.Expression peaked at 24 h,with a 26fold increase over basal levels.By 72 h however,YKL40 expression levels had nearly returned to control levels.On the other hand,chronic damage induced a sustained increase in YKL40 expression,with 7and 9fold higher levels at 6 and 8 wk,respectively.The pattern of YKL40 expression in different subpopulations showed that CD14+cells,which include Kupffer cells,are a source of YKL40 after acute damage at 72 h[0.09 relative expression units(REU)]as well as after chronic injury at 6 wk(0.11 REU).Hepatocytes,in turn,accounted for 0.06 and 0.01 REU after 72 h(acute)or 6 wk(chronic),respectively.The rest of the CD14cells(including T lymphocytes,B lymphocytes,natural killer and natural killer T cells) yielded 0.07 and 0.15 REU at 72 h and 6 wk,respectively.YKL40 protein expression in liver was detected at 72 h as well as 6 and 8 wk,with the highest expression relative to controls(11fold;P≤0.05)seen at 6 wk.Macrophages were stimulated by lipopolysaccharide.We demonstrate that under these conditions,these cells showed maximum expression of YKL40 at 12 h,with P<0.05 compared with controls.CONCLUSION:Hepatic CD14 + cells are an YKL40 mRNA and protein source in acute and chronic liver injury,with expression patterns similar to growth factors implicated in inflammationfibrogenesis. | Oscar Pizano-Martínez Irinea Yaez-Sánchez Pilar Alatorre-Carranza Alejandra Miranda-Díaz Pablo C Ortiz-Lazareno Trinidad García-Iglesias Adrian Daneri-Navarro Mónica Vázquez-Del Mercado Mary Fafutis-Morris Vidal Delgado-Rizo | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | 关于Tau变分法研究电子光学成像系统的时间像差理论显示文摘本文采用新的时间像差定义,考察了“Tau变分法”研究电子光学成像系统的时间像差理论.本文表明,“Tau变分法”所给出的以微分方程形式表示的几何时间像差系数,亦可获得积分形式的表示式,证明了“直接积分法”与“Tau变分法”这两条途径殊途同归. | 周立伟 M A Monastyrski. M Ya Schelev 张智铨 李元 | 2006 | 电子学报2006，34，2： | 2 |
| 5 | Continuous on a compact subset of and analytic in its interior by functions bianalytic in its neighborhoods显示文摘 | Mazalov M Ya | 2001 | Mathematical Notes2001，69，2： | 1 |
| 6 | Electresynthesis of 2,2,6,6-tetramothyl-4-hydroxypiperdine显示文摘 | TSARKOVA T G AVRUTSKAYA I A FIOSHIN M Ya | 1984 | Elektrokhimiya1984，20，3： | 1 |
| 7 | Crystallization behavior of sprayformed and melt-spun A189La6Ni5 hybrid composites with amorphous and nanostructured phases显示文摘 | Ted Guo M L Tcao Chi YA | 2005 | Materials Science and Engineering A2005，404，： | 1 |
| 8 | Lipid emulsion improves re- covery from bupivacaine-induced cardiac arrest,hut not from ropi- vacaine- or mepivacainc-induced cardiac arrest显示文摘 | Zausig YA Zink W Keil M | 2009 | Anesth Analg2009，109，4： | 1 |
| 9 | Intravenous lipid emulsions to deliveromega 3 fatty acids显示文摘 | Carpentier YA Hacquebard M | 2006 | Prostaqlandins Leukot Essent Fatty Acids2006，75，3： | 1 |
| 10 | ssociation of Filaggrin loss-of-function-mutations with atopic dermatitisand asthma in the Early Treatment of the Atopic Child (ETAC) population显示文摘 | Müller S Marenholz I Lee YA | 2009 | Pediatr Allergy Immunol2009，20，4： | 1 |
| 11 | Effect of titanium on the structure and properties of maraging tool steel 05Kh12N6D2SGTMF显示文摘 | Zykova R A Ya I Spektor Yu M Politaev | 1986 | Metallovedenie i Termicheskaya Obrabotka Metallov1986，，9： | 1 |
| 12 | E- volution of the nanostructure of VVER-1000 RPV materials under neutron irradiation and post irradiation annealing显示文摘 | Miller M K Chernobaeva A A Shtrombakh Ya I | 2009 | J Nuel Mater2009，385，3： | 1 |
| 13 | Rhinovirus wheezing illness and genetic risk of childhood-onset asthma显示文摘 | Caliskan M Bochkov YA Kreiner-Mφller E | | 0，，15： | 1 |
| 14 | Bactericidal activity of various antibiotics against biofilm-producing Pesudomonas aeruginosa显示文摘 | Abdi-Ali A Mohammadi-Mehr M Alaei YA | 2006 | Int J Antimicrob Agents2006，27，3： | 1 |
| 15 | Correction of severe bimaxillary protrusion with first premolar extractions and total arch distalization with palatal anchorage plates显示文摘 | Kook YA Park JH Bayome M | 2015 | Am J Orthod Dentofacial Orthop2015，148，2： | 1 |
| 16 | Recent a dvances in the biosynthesis and accumulation of anthocyanins 显示文摘 | Springob K Nakaji ma J YA Mazaki M | 2003 | Nat ProdRep2003，20，： | 1 |
| 17 | Impact of donor age on living related donor kidney transplantation 显示文摘 | Sobh M E1-Salam YA Shokeir A | 1992 | Transpl Int1992，5，1： | 1 |
| 18 | Antidiabetic effect of long-term supplenlentation with Siraitia grosvenori on the spontaneously diabetic Goto-Kakizaki rat显示文摘 | SUZUKI YA TOMODA M MURATA Y | 2007 | British Journal of Nutrition2007，97，4： | 1 |
| 19 | Electrosynthesis of 2,2, 6, 6-tetramethyl-4-hydroxypiperdine 显示文摘 | Tsarkova T G Avrutskaya I A Fioshin M Ya | 1984 | Elektrokhimiya1984，20，3： | 1 |
| 20 | Synthesis of 1 , 2, 3, 4-tetrazino benzo-1 , 2, 3, 4-terazine 1 , 3, 7, 9-tetraoxides 显示文摘 | Frumkin A E ChurakovA M Strelenko YA | 2006 | Russian Chemical Bulletin International Edi- tion2006，55，9： | 1 |
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