|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multi‐tasking of helper T cells显示文摘 | Yisong Y.Wan | 2010 | Immunology2010，，2： | 2 |
| 2 | Intricacies of TGF-βsignaling in Treg and Th17 cell biology显示文摘Balanced immunity is pivotal for health and homeostasis.CD4+helper T(Th)cells are central to the balance between immune tolerance and immune rejection.Th cells adopt distinct functions to maintain tolerance and clear pathogens.Dysregulation of Th cell function often leads to maladies,including autoimmunity,inflammatory disease,cancer,and infection.Regulatory T(Treg)and Th17 cells are critical Th cell types involved in immune tolerance,homeostasis,pathogenicity,and pathogen clearance.It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease.Cytokines are instrumental in directing Treg and Th17 cell function.The evolutionarily conserved TGF-β(transforming growth factor-β)cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory,pathogenic,and immune regulatory.How TGF-βsuperfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades.Here,we introduce the fundamental biology of TGF-βsuperfamily signaling,Treg cells,and Th17 cells and discuss in detail how the TGF-βsuperfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks. | Junying Wang Xingqi Zhao Yisong Y.Wan | 2023 | Cellular & Molecular Immunology2023，20，9： | 2 |
| 3 | The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance显示文摘Acute viral infection causes illness and death.In addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly understood.Since its initial identification as a marker for resident memory CD8^(+)T cells in barrier tissues,the function and regulation of CD103 integrin(encoded by ITGAE gene)have been extensively investigated.Nonetheless,the function and regulation of the resident CD103^(+)CD8^(+)T cell response to acute viral infection remain unclear.Although TGFβsignaling is essential for CD103 expression,the precise molecular mechanism behind this regulation is elusive.Here,we reveal a TGFβ–SKI–Smad4 pathway that critically and specifically directs resident CD103^(+)CD8^(+)T cell generation for protective immunity against primary and secondary viral infection.We found that resident CD103^(+)CD8^(+)T cells are abundant in both lymphoid and nonlymphoid tissues from uninfected mice.CD103 acts as a costimulation signal to produce an optimal antigenic CD8^(+)T cell response to acute viral infection.There is a reduction in resident CD103^(+)CD8^(+)T cells following primary infection that results in increased susceptibility of the host to secondary infection.Intriguingly,CD103 expression inversely and specifically correlates with SKI proto-oncogene(SKI)expression but not R-Smad2/3 activation.Ectopic expression of SKI restricts CD103 expression in CD8^(+)T cells in vitro and in vivo to hamper viral clearance.Mechanistically,SKI is recruited to the Itgae loci to directly suppress CD103 transcription by regulating histone acetylation in a Smad4-dependent manner.Our study therefore reveals that resident CD103^(+)CD8^(+)T cells dictate protective immunity during primary and secondary infection.Interfering with SKI function may amplify the resident CD103^(+)CD8^(+)T cell response to promote protective immunity. | Bing Wu Ge Zhang Zengli Guo Gang Wang Xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian Zheng Yisong Y.Wan | 2021 | Cellular & Molecular Immunology2021，18，10： | 1 |
| 4 | 查看详情显示文摘 | Y.Wan H.Wang Q.Zhao M.Klingstedt O.Terasaki and D.Zhao | | 0，，12： | 1 |
| 5 | Commissioning and first results from the new 2×100 TW laser at the WIS显示文摘At the Weizmann Institute of Science,a new high-power-laser laboratory has been established that is dedicated to the fundamental aspects of laser–matter interaction in the relativistic regime and aimed at developing compact laser-plasma accelerators for delivering high-brightness beams of electrons,ions,and x rays.The HIGGINS laser system delivers two independent 100 TW beams and an additional probe beam,and this paper describes its commissioning and presents the very first results for particle and radiation beam delivery. | E.Kroupp S.Tata Y.Wan D.Levy S.Smartsev E.Y.Levine O.Seemann M.Adelberg R.Piliposian T.Queller E.Segre K.Ta Phuoc M.Kozlova V.Malka | 2022 | Matter and Radiation at Extremes2022，7，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员