4篇
您的检索式：作者名="Xuling Xue"
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| 1 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 2 | Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons显示文摘Activation of the heart normally begins in the sinoatrial node(SAN).Electrical impulses spontaneously released by SAN pacemaker cells(SANPCs)trigger the contraction of the heart.However,the cellular nature of SANPCs remains controversial.Here,we report that SANPCs exhibit glutamatergic neuron-like properties.By comparing the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse,we found that SANPCs co-clustered with cortical neurons.Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system,expressing genes encoding glutamate synthesis pathway(G/s),ionotropic and metabotropic glutamate receptors(Grina,Gria3,Grm1 and Grm5)t and glutamate transporters(Slc17a7).SANPCs highly expressed cell markers of glutamatergic neurons(Snap25 and S/-c17a7)t whereas Gad1,a marker of GABAergic neurons,was negative.Functional studies revealed that inhibition of glutamate receptors or transporters reduced spontaneous pacing frequency of isolated SAN tissues and spontaneous Ca2+transients frequency in single SANPC.Collectively,our work suggests that SANPCs share dominant biological properties with glutamatergic neurons,and the glutamatergic neurotransmitter system may act as an intrinsic regulation module of heart rhythm,which provides a potential intervention target for pacemaker cell-associated arrhythmias. | Dandan Liang Zhigang Xue Jinfeng Xue Duanyang Xie Ke Xiong Huixing Zhou Fulei Zhang Xuling Su Guanghua Wang Qicheng Zou Yi Liu Jian Yang Honghui Ma Luying Peng Chunyu Zeng Gang Li Li Wang Yi-Han Chen | 2021 | Protein & Cell2021，12，7： | 1 |
| 3 | Selection footprints reflect genomic changes associated with breeding efforts in 56 cucumber inbred lines显示文摘Cucumber selective breeding over recent decades has dramatically increased productivity and quality,but the genomic characterizations and changes associated with this breeding history remain unclear.Here,we analyzed the genome resequencing data of 56 artificially selected cucumber inbred lines that exhibit various phenotypes to detect trait-associated sequence variations that reflect breeding improvement.We found that the 56 cucumber lines could be assigned to group 1 and group 2,and the two groups formed a distinctive genetic structure due to the breeding history involving hybridization and selection.Differentially selected regions were identified between group 1 and group 2,with implications for genomic-selection breeding signatures.These regions included known quantitative trait loci or genes that were reported to be associated with agronomic traits.Our results advance knowledge of cucumber genomics,and the 56 selected inbred lines could be good germplasm resources for breeding. | Bin Liu Dailu Guan Xuling Zhai Sen Yang Shudan Xue Shuying Chen Jing Huang Huazhong Ren Xingwang Liu | 2019 | Horticulture Research2019，6，1： | 0 |
| 4 | Using bio-orthogonally catalyzed lethality strategy to generate mitochondria-targeting anti-tumor metallodrugs in vitro and in vivo显示文摘Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies.To exploit the synthetic lethality concept in the design of chemical anti-cancer agents,we developed a bio-orthogonally catalyzed lethality(BCL)strategy to generate targeting anti-tumor metallodrugs both in vitro and in vivo.Metallodrug Ru-rhein was generated from two non-toxic species Ru-N_(3)and rhein-alkyne via exclusive endogenous copper-catalyzed azide alkyne cycloaddition(Cu AAC)reaction without the need of an external copper catalyst.The non-toxic species Ru-arene complex Ru-N_(3)and rhein-alkyne were designed to perform this strategy,and the mitochondrial targeting product Ru-rhein was generated in high yield(>83%)and showed high anti-tumor efficacy in vitro.This BCL strategy achieved a remarkable tumor suppression effect on the tumor-bearing mice models.It is interesting that the combination of metal-arene complexes with rhein via Cu AAC reaction could transform two non-toxic species into a targeting anti-cancer metallodrug both in vitro and in vivo,while the product Ru-rhein was non-toxic towards normal cells.This is the first example that exclusive endogenous copper was used to generate metal-based anti-cancer drugs for cancer treatment.The anti-cancer mechanism of Ru-rhein was studied and autophagy was induced by increased reactive oxygen species and mitochondrial damage.The generality of this BCL strategy was also studied and it could be extended to other metal complexes such as Os-arene and Ir-arene complexes.Compared with the traditional methods for cancer treatment,this work presented a new approach to generating targeting metallodrugs in vivo via the BCL strategy from non-toxic species in metal-based chemotherapy. | Xuling Xue Chenggen Qian Qin Tao Yuanxin Dai Mengdi Lv Jingwen Dong Zhi Su Yong Qian Jing Zhao Hong-Ke Liu Zijian Guo | 2021 | National Science Review2021，8，9： | 0 |
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