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| 1 | Ice radar investigation at Dome A, East Antarctica:Ice thickness and subglacial topography显示文摘Dome A, located in the central East Antarctic ice sheet (EAIS), is the highest summit of the Antarctic ice sheet. From ice-sheet evolution modeling results, Dome A is likely to preserve over one million years of the Earth's paleo-climatic and -environmental records, and considered an ideal deep ice core drilling site. Ice thickness and subglacial topography are critical factors for ice-sheet models to determine the timescale and location of a deep ice core. During the 21st and 24th Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05; CHINARE 24, 2007/08), ground-based ice radar systems were used to a three-dimensional investigation in the central 30 km×30 km region at Dome A. The successfully obtained high resolution and accuracy data of ice thickness and subglacial topography were then interpolated into the ice thickness distribution and subglacial topography digital elevation model (DEM) with a regular grid resolution of 140.5 m×140.5 m. The results of the ice radar investigation indicate that the average ice thickness in the Dome A central 30 km×30 km region is 2233 m, with a minimal ice thickness of 1618 m and a maximal ice thickness of 3139 m at Kunlun Station. The subglacial topography is relatively sharp, with an elevation range of 949-2445 m. The typical, clear mountain glaciation morphology is likely to reflect the early evolution of the Antarctic ice sheet. Based on the ice thickness distribution and subglacial topography characteristics, the location of Kunlun Station was suggested to carry out the first high-resolution, long time-scale deep ice core drilling. However, the internal structure and basal environments at Kunlun Station still need further research to determine. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
| 2 | Preliminary results of ice radar investigation along the traverse between Zhongshan and Dome A in East Antarctic ice sheet:Ice thickness and subglacial topography显示文摘During the 24th Chinese National Antarctic Research Expedition(CHINARE 24,2007/08),a ground-based ice radar was used to survey ice thickness and subglacial topography along the 1170 km traverse between Zhongshan and Dome A in East Antarctic ice sheet(EAIS).Ice-bedrock interface was detected along 82%of the traverse and data was collected at a horizontal resolution of <5.6 m.The data was processed to produce curves of ice thickness distribution and subglacial topography along the traverse.The results indicate that,along the traverse,the average ice thickness is 2037 m,smaller than the average ice thickness in EAIS;the thickest ice is at 730 km,and the thinnest ice(891 m)is at the edge of the ice sheet,but the slightly larger ice thickness(1078 m) in inland appears at 1020 km;the average subglacial topography elevation is 728 m,greatly larger than the average value in EAIS, and the largest elevation reaches up to 2650 m at 1034 km.The lowest terrain is located at 765 km.In further inland of 900?1170 km,the subglacial topography is relatively high due to the existence of the Gamburtsev Subglacial Mountains in the region.Generally,the influence of subglacial topography on ice surface is not significant,except at 900 km where great rise of subglacial topography causes evident uplift of ice surface.Where ice-bedrock interface was detected,the frequent and strong change of ice thickness and subglacial topography in small-scale means large bedrock roughness along the traverse,and is considered as the result of the integrated influence of ice flow,basal environments and geology.The segment where bedrock was not detected has very large ice thickness.The strong ice flow there also makes internal structure more complicated and induces serious attenuation of radar signals. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，24： | 8 |
| 3 | NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human coloreetal cancer显示文摘Colorectal 癌症(CRC ) 是与病态和死亡的增加的发生被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在 CRC 是下面调整的。在现在的学习,我们构造了 colorectal 织物 microarray 在 CRC 纸巾检验 NGX6, phospho-c-Jun N 终端 kinase (p-JNK ) ,和 phospho 细胞外的调整信号的 kinase (津贴) 的表示侧面。而 p-JNK 和津贴的表情在 CRC 纸巾是更高的,我们发现 NGX6 表示在 CRC 纸巾和变形淋巴节点是更低的,比在正常肠的 mucosa。NGX6, p-JNK,和津贴的表情与 colorectal 纸巾的临床的病理学的特征被联系。NGX6 overexpression 禁止了激活和 JNK1 的原子 translocation,它在细胞质导致了 p-JNK 的累积,但是没禁止激活和 ERK1/2 的原子 translocation。NGX6 也禁止了抄写因素 AP-1 (c-jun 和 c-fos ) 和 Ets-1 的表示。另外, NGX6 overexpression 减少了 cyclin D1 并且戏剧性地的表示压制了 cyclin D1 倡导者的 transcriptional 效率。我们建议那 NGX6 表情沉醉于人的 colorectal carcinogenesis 的多步过程。它的 overexpression 能禁止抄写因素的表示 AP-1 和 Ets-1,和下面调整在人的 CRC 的 cyclin D1 倡导者的 transcriptional 活动。 | Ya Peng Hongtao Li Minghua Wu Xiaoyan Wang Songqing Fan Fen Liu Bo Xiang Qin Guo Xueyuan Tang Shourong Shen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 8 |
| 4 | Structure of the internal isochronous layers at Dome A,East Antarctica显示文摘Dome A (Kunlun Station) is considered a likely place for finding an ice core record reaching back to one million years. The internal isochronous layering of the Antarctic Ice Sheet, revealed by ice radar, is a prerequisite for selecting sites for deep ice core drilling that can be used for studying the paleoclimatic record. In 2004/2005, during the 21st Chinese National Antarctic Research Expedition (CHINARE 21), a 200-km long, continuous radar profile was obtained across Dome A. The internal layers along the profile were derived from the stratigraphy detected by the radar. The morphology of the isochronous layers shows that: (1) The internal layers in the shallow ice sheet (0-500 m) are generally flat, with no more than 50 m of layer intervals, and have typical synclines and anticlines in some localized regions. (2) At 500-2000 m below the surface of the ice sheet, the layers appear as 'bright layers', and the width of the layer intervals expands to 50-100 m. (3) When the basal topographic wavelengths are approximate to the thickness of the ice (3 km), the traced internal layers, with localized bumps or concave folds, are asymptotic parallel to the subglacial topography. For the longer topographic wavelengths (~20 km) wider than the thickness of the ice, the layers do not rise and fall with the basal topography. The internal layers surrounding some mountain peaks representing the most extreme variation in the terrain are sharply disturbed by the subglacial topography. (4) Layer discontinuity and fracture were detected in the basal ice sheet. Finally, by combining this new information with that derived from existing data regarding ice thickness, we were able to select three potential sites for reconstructing the age-depth relationship of the ice core. | TANG XueYuan SUN Bo ZHANG ZhanHai ZHANG XiangPei CUI XiangBin LI Xin | 2011 | Science China Earth Sciences2011，54，3： | 6 |
| 5 | Chinese radioglaciological studies on the Antarctic ice sheet: progress and prospects显示文摘Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work. | CUI Xiangbin WANG Tiantian SUN Bo TANG Xueyuan GUO Jingxue | 2017 | Advances in Polar Science2017，28，3： | 6 |
| 6 | Dome Argus: Ideal site for deep ice drilling显示文摘Located on the centre of ice drainage range, the highest Dome Argus (Dome A) of East Antarctic Ice Sheet (EAIS), could be represented as an ideal site for deep ice cores drilling containing oldest paleo-climate records. To select a suitable drilling site for deep ice core, it needs gather all information pertaining to the local meteorology, ice sheet landforms, ice thickness, subglacial topography of bed rocks, ice velocity, internal structures of ice sheet, etc. Based on the International Partnerships in Ice Core Sciences (IPICS), we present recent achievement of glaciological research and its perspective at Dome A in this paper. We system-atically discussed the merits and possible ventures of potential drilling sites around Dome A. Among all the candidates, we find that the Chinese Antarctic Kunlun Station is the best site for carrying out the first deep ice core drilling campaign. We emphasize and assess further the possibility to obtain a replicate core for studying dynamics and evolution of climate change. | TANG Xueyuan SUN Bo LIYuansheng LI Xin CUI Xiangbin | 2012 | Advances in Polar Science2012，23，1： | 5 |
| 7 | Antarctic ice sheet GLIMMER model test and its simplified model on 2-dimensional ice flow显示文摘The 3-dimensional finite difference thermodynamic coupled model on Antarctic ice sheet,GLIMMER model,is described. An ide-alized ice sheet numerical test was conducted under the EISMINT-1 benchmark,and the characteristic curves of ice sheets under steady state were obtained. Based on this,this model was simplified from a 3-dimensional one to 2-dimensional one. Improvement of the dif-ference method and coordinate system was proposed. Evolution of the 2-dimensional ice flow was simulated under coupled temperature field conditions. The results showed that the characteristic curves deriving from the conservation of the mass,momentum and energy agree with the results of ice sheet profile simulated with GLIMMER model and with the theoretical results. The application prospect of the simplified 2-dimensional ice flow model to simulate the relation of age-depth-accumulation in Dome A region was discussed. | Xueyuan Tang Zhanhai Zhang Bo Sun Yuansheng Li Na Li Bangbing Wang Xiangpei Zhang | 2008 | Progress in Natural Science:Materials International2008，18，2： | 3 |
| 8 | The Discovery of Deep Potassium and Lithium Resources in the Huangjinkou Anticline, Northeast of Sichuan显示文摘Important clues have been found for potassiumprospecting in the Huangjinkou anticline of the northeastSichuan Basin in the 1970s (Zheng et al., 2015; Lin et al.,2004). In 2008, China Geological Survey launched aprospective investigation of potash resources in thewestern region of China, and the local governments andprivate-owned enterprises also responded positively. Then,during 2015-2016, the Land and Resources Department ofSichuan Province deployed potash prospecting drilling(borehole ZK601) in the Huangjinkou anticline, andobtained deep potassium and lithium resources. Theseresults may give a direction of marine potash prospectingin the Sichuan Basin. | ZHONG Jia'ai ZHENG Mianping TANG Xueyuan TANG Xue Yuan QI Wen ZHANG Zhen LIU Zhu WANG Fuming PANG Bo | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 2 |
| 9 | Resistance of Barnyard Grass(Echinochloa crusglli) to Quinclorac in Double-harvest Rice Area in Hunan Province of China显示文摘[Objective]The paper was to study the resistance of barnyard grass to quinclorac in double-harvest rice area in Hunan Province of China.[Method]Using whole-plant determination method,the resistance of 36 biotypes of barnyard grass to quinclorac in double-harvest rice area in Hunan Province was studied.[Result]The biotype collected from Lijiaping Town of Shaoyang County was the most susceptible barnyard grass to quinclorac,and the EC50value was 70.253 1 g a.i./hm2,so it was recognized as the sensitive biotype.The biotypes collected from Caowei Town of Yuanjiang County(HN3 and HN4 from direct seeding rice fields)and Zhongyukou Town of Nanxian County presented very high resistance to quinclorac;the EC50values were 1 999.122 5,1 664.544 6 and 1 022.739 5 g a.i./hm2,and their resistance indexes reached 28.46,23.69 and 14.56,respectively,indicating that these three biotypes had high level of resistance to quinclorac.EC50values of about 22 biotypes were ranged from 144.837 3 to 408.289 4 g a.i./hm2,and resistance indexes were ranged from 2.06 to 5.81,indicating that these biotypes had produced resistance to quinclorac.EC50values of other 10 biotypes were ranged from 98.032 6 to 138.660 9 g a.i./hm2,and the resistance indexes were ranged from 1.40 to 1.97,indicating that the sensitivity of barnyard grass in these places was decreasing.[Conclusion]The paper provided guidance for scientific and rational use of quinclorac in paddy fields. | Ma Guolan Liu Ducai Liu Xueyuan Tang Tao Peng Yajun | 2013 | Plant Diseases and Pests2013，4，5： | 1 |
| 10 | Radar isochronic layer dating for a deep ice core at Kunlun Station, Antarctica显示文摘The ages and accumulation rates of ice are important boundary conditions for paleoclimatic ice models. Radardetected isochronic layers can be used to date the ice column beneath the ice surface and infer past accumulation rates. A Deep Ice-Core Drilling Project has been carried out at Kunlun station in the Dome A region, East Antarctica. Radio echo sounding data are collected during the 2004/2005 Chinese National Research Expedition and the 2007/2008 Dome Connection East Antarctica project of the Alfred Wegener Institute(Germany). Radar isochronic layers from the dataset were linked to compare a new deep ice core site from Kunlun station and the Vostok ice core site. Ten visible layers, accounting for ~50% ice thickness at the Kunlun station ice core site, were dated based on the Vostok ice core chronology. At 1,640 m depth below surface, an age of ~160,400 yr was determined, corresponding to a bright layer at Kunlun station. These layers provided geometric information on the past surface of the ice sheet around the ice core site through the Wisconsin glacial stage, Eemian interglacial and Marine Isotope Stage6. Based on a simple ice flow model and the age-depth relationship, we concluded that the region around the Kunlun ice core site had lower past accumulation rates, consistent with the present pattern. The age-depth relationship would thus be expected to correlate and constrain the chronology of the deep ice core at Kunlun station in the future. | Xueyuan TANG Bo SUN Tiantian WANG | 2020 | Science China Earth Sciences2020，63，2： | 1 |
| 11 | Iterative algorithm for 显示文摘 | Qinghuo Liu Xueyuan Tang | 1998 | nonu- niform inverse fast Fourier transform (NU-IFVF) Electronics Letters1998，34，20： | 1 |
| 12 | Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione显示文摘新奇 chrysin 类似物 8-bromo-7-methoxychrysin (BrMC ) 被报导了导致各种各样的癌症房间线的 apoptosis。砷三氧化物(ATO ) 治疗在尖锐 promyelocytic 白血病病人导致临床的宽恕。有另外的代理人的 ATO 的联合被显示了在 vitro 并且在 vivo 改进治疗学的有效性。在这份报告,治疗与 BrMC 独自或在联合与 ATO 导致的 apoptosis 的机制在 U937, HL-60,和 Jurkat 房间被学习。我们的结果证明 BrMC 与 ATO 合作了在人的白血病房间导致 apoptosis。引起 mitochondrial transmembrane 潜力驱散并且,刺激了 mitochondrial apoptotic 小径的这个合作处理由细胞色素 c 版本, apoptosis (XIAP ) 和 Bcl-XL 的 X 连接禁止者的下面规定,和 Bax 的起来规定证实了。BrMC 独自或在有 ATO,减少的 Akt phosphorylation 以及细胞内部的减少的谷胱甘肽(GSH ) 的联合满足。thiol 抗氧化剂 N-acetylcysteine 和外长的 GSH 恢复了 GSH 内容并且稀释了合作处理与 ATO 正 BrMC 导致的 apoptosis。相反, non-thiol 抗氧化剂 butylated hydroxyanisole 和甘露糖醇没能那么做。这些调查结果建议那 GSH 弄空部分地至少解释由 BrMC 的导致 ATO 的 apoptosis 的 potentiation。 | Guangfen Xiao Xueyuan Tang Chenjiao Yao Chenghong Wang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 1 |
| 13 | Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease显示文摘Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease.Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains unelucidated.In the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first investigated.Citri Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of autophagy.In addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo model.Moreover,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was autophagy-dependent.Most importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease mice.As revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects. | Yong Tang Jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo Wu Jianming Wu Dalian Qin Xiaogang Zhou Betty Yuen-Kwan Law | 2024 | Neural Regeneration Research2024，19，11： | 0 |
| 14 | 10Be exposure ages of Quaternary Glaciers in Antarctica显示文摘In situ terrestrial cosmogenic nuclide(TCN)has been widely applied to date the ages of Quaternary glacial deposits in Antarctica and plays an important role in reconstructing the glacial evolution and climate change.It helps to under‐stand the Antarctic ice sheet's evolution process in Quaternary and shed light on the application of Cosmogenic Nu‐clide exposure dating technique in Glacial Geomorphology.In this paper,we retrieved 49510Be age samples in Ant‐arctica from literature published between 2004 and 2020 and recalculated the TCN ages using version 3.0 online cal‐culator of Cosmic-Ray Produced Nuclide Systematics on Earth(CRONUS-Earth).Several conclusions can be drawn from the results:(1)75%of the exposure ages are younger than 400 ka,and 91%younger than 1,100 ka.Northern Antarctic Peninsula exposure result is visibly younger than the main glaciers in East Antarctica due to climate change and geological evaluation since the LGM(Last Glacial Maximum).(2)TCN ages are relevant to the samples'relative positions in the Antarctic continent,but a relationship between their ages and elevations is yet to be determined based on the collected data. | WangJing Ni ZhiGang Zhang JingXue Guo XueYuan Tang | 2021 | Research in Cold and Arid Regions2021，13，4： | 0 |
| 15 | Mild Renal Dysfunction and Risk of Thromboembolism and Bleeding in Patients with Atrial Fibrillation:The Chinese Atrial Fibrillation Registry Study显示文摘Objective:Previous studies indicated that patients with atrial fibrillation(AF)and moderate-to-severe chronic kidney disease(CKD)are at a higher risk of thromboembolism and bleeding during anticoagulation.Whether mild CKD is associated with an increased risk of thromboembolism and bleeding in AF patients remains unknown.This study aimed to evaluate the impact of mild CKD on thromboembolism and major bleeding among patients with AF.Methods:Baseline serum creatinine was available in 17,559 of 25,512 patients enrolled in the China-AF study between August 2011 and December 2018.After excluding those who underwent AF ablation or with moderate-to-severe CKD,7191 non-valvular AF patients(2059 with mild CKD and 5132 with normal renal function)with regular follow-up for at least 6 months were included.Primary outcomes were the time to the first occurrence of thromboembolic and major bleeding events.Results:Over a mean follow-up of(44.4±23.4)months,639 thromboembolism and 231 major bleeding events occurred.The crude incidence rates of thromboembolism were higher in the mild CKD group than that of the normal renal function group(3.0/100 person-years vs.2.2/100 person-years,P<0.0001),while the crude incidence rates of major bleeding were comparable between the two groups(1.0/100 person-years vs.0.8/100 person-years,P=0.076).After multivariate analyses,mild CKD was not associated with an increased risk of thromboembolism(HR=1.05,95%CI:0.89-1.25,P=0.547)or major bleeding(HR=1.11,95%CI:0.84–1.47,P=0.476).Conclusions:Mild CKD was not an independent risk factor of thromboembolism or major bleeding in patients with AF. | Jingye Li Sitong Li Chao Jiang Jing Du Xueyuan Guo Songnan Li Chenxi Jiang Ribo Tang Caihua Sang Deyong Long Xin Du Jianzeng Dong Changsheng Ma | 2021 | Cardiology Discovery2021，1，1： | 0 |
| 16 | An assessment of precipitation and surface air temperature over China by regional climate models显示文摘 | Xueyuan WANG Jianping TANG Xiaorui NIU Shuyu WANG | 2016 | Frontiers of Earth Science2016，10，4： | 0 |
| 17 | An Improved Iterative Reconstruction Algorithm for Traveltime Tomography显示文摘AnImprovedIterativeReconstructionAlgorithmforTraveltimeTomography￥MaNing;HuZhengyi;TangXueyuan;WangYanping(CollegeofElectroni... | Ma Ning Hu Zhengyi Tang Xueyuan Wang Yanping (College of Electronic information,Wuhan University,Wuhan, 430072,China) | 1996 | Wuhan University Journal of Natural Sciences1996，1，1： | 0 |
| 18 | Towards an integrated study of subglacial conditions in Princess Elizabeth Land,East Antarctica显示文摘During the 21st century,the contribution of the Antarctic*Ice Sheet(AIS)to sea level rise has been increasing,affecting coastal regions and their large populations and economies(Moore et al.,2018).The ice loss from the AIS is driven primarily by increased melting of ice shelves by warm ocean waters and the subsequent acceleration,retreat and rapid thinning of the major outlet glaciers of the West Antarctic ice sheet(IPCC,2019).However,subglacial conditions(thermodynamics and hydrology)of AIS remain poorly understood,despite recent advances in satellite and ground-based observations,and this makes it difficult to project the amount of future ice loss.To better understand the most compelling scientific issues addressing subglacial conditions,and following several recent technical and operational advances,the National Natural Science Foundation of China(NSFC)launched a special program named the“Polar Basic Science Frontier”. | TANG Xueyuan SUN Bo | 2021 | Advances in Polar Science2021，32，2： | 0 |
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