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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 3 | Triptolide, A Potential Autophagy Modulator显示文摘As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator. | WEI Yan-ming WANG Yong-hui XUE Hui-qing LUAN Zhi-hua LIU Bi-wang REN Jin-hong | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 10 |
| 4 | Effect of yellow rice wine on anti-aging ability in aged mice induced by D-galactose显示文摘The present study is focused on investigation of the health protective effect of yellow rice wine(YRW)in mice and the potential underlying mechanism.Symptoms of aging were induced in mice by using Dgalactose(D-gal),and different doses of YRW(4,8,and 12 mL/kg BW)were orally administrated to D-galtreated mice for a period of six weeks.The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver.Furthermore,a forced swim test showed that moderate intake of YRW(8 mL/kg BW)significantly decreased the duration of immobility,reduced the blood content of urea nitrogen and lactic acid,and increased hepatic glycogen storage.Besides,results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3.The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action. | Rong Liu Zukang Fu Fengjie Zhang Qingzhong Mao Chunguang Luan Xinglin Han Jie Xue Deliang Wang Si Qin Feike Hao | 2020 | Food Science and Human Wellness2020，9，2： | 8 |
| 5 | Rapid remission of refractory synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome in response to the Janus kinase inhibitor tofacitinib: A case report显示文摘BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome is a rare autoinflammatory disease for which clinical treatment has not been standardized.Janus kinase(JAK)inhibitors represent a novel therapeutic option for rheumatoid arthritis,psoriatic arthritis,and some other autoinflammatory diseases.However,the clinical utility of JAK inhibitors in treating SAPHO syndrome has not been thoroughly investigated.In this study,we describe a patient with SAPHO syndrome who failed to respond to conventional treatment but demonstrated a remarkable and rapid response to the JAK inhibitor tofacitinib.CASE SUMMARY A 62-year-old female patient presented with swelling and pain at the sternoclavicular joints,back pain that limited her activities,arthralgia in the right knee,and cutaneous lesions.Her symptoms were unresponsive to nonsteroidal anti-inflammatory drugs,disease-modifying antirheumatic drugs,Tripterygium wilfordii hook f,and bisphosphonates.SAPHO syndrome was diagnosed in accordance with dermatological and osteoarticular manifestations and abnormal inflammatory factors.Multiple image studies have illustrated bone lesions and pathological fractures of vertebral bodies.Oral treatment with tofacitinib at 5 mg twice daily with methotrexate and bisphosphonates was initiated.The patient reported that her pain symptoms were relieved after 3 d and her cutaneous lesions were reduced after 4 wk of treatment.Vertebral lesions were improved after 6 mo on tofacitinib.No serious adverse effects were noted.CONCLUSION JAK inhibitor therapy may be a promising strategy to treat SAPHO syndrome. | Ben Li Guan-Wu Li Luan Xue Yue-Ying Chen | 2020 | World Journal of Clinical Cases2020，8，19： | 4 |
| 6 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 7 | Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis显示文摘Bacterial DNA(bacDNA) is frequently found in serum of patient with ulcerative colitis(UC) and Crohn's disease, even blood bacterial culture is negative. How bacDNA evades immune elimination and is translocated into blood remain unclear. Here, we showed that bacDNA avoids elimination and disables bacteriakilling function of antimicrobial peptide LL-37(Cramp in mice) by forming complex with LL-37, which is inducible after culture with bacteria or bacterial products. Elevated LL-37-bacDNA complex was found in plasma and lesions of patients with UC. LL-37-bacDNA promoted inflammation by inducing Th1, Th2 and Th17 differentiation and activating toll-like receptor-9(TLR9). The complex also increased paracellular permeability, which possibly combines its inflammatory effects to promote local damage and bacDNA translocation into blood. Cramp-bacDNA aggravated mouse colitis severity while interference with the complex ameliorated the disease. The study identifies that inflammatogenic bacDNA utilizes LL-37 as a vehicle for blood translocation and to evade immune elimination. Additionally, bacteria may make a milieu by releasing bacDNA to utilize and resist host antimicrobial peptides as a ‘trojan horse'. | Zilei Duan Yaqun Fang Yang Sun Ning Luan Xue Chen Mengrou Chen Yajun Han Yizhu Yin James Mwangi Junkun Niu Kunhua Wang Yinglei Miao Zhiye Zhang Ren Lai | 2018 | Science Bulletin2018，63，20： | 4 |
| 8 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 9 | Challenges in Treatment of Primary Sjogren’s Syndrome and Opportunities for Chinese Medicine显示文摘Primary Sjogren’s syndrome is a chronic autoimmune disease that can lead to systemic manifestations.At present,immunomodulatory agents have not shown good efocacy,many patients in China seek Chinese medicine treatment.Chinese medicine can comprehensively improve the symptoms of patients through Chinese pattern diagnosis and individualized treatment.Fundamental researches are providing scientioc bases for the therapeutic effect of Chinese medicine.Professional Chinese medicine treatment can be integrated into the conventional management of primary Sjogren’s syndrome. | HOU Jia-qi XUE Luan | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 2 |
| 10 | Nickel(hydro)oxide/graphdiyne Catalysts for Efficient Oxygen Production Reaction显示文摘The transition metal-based materials have been regarded as promising electrocatalysts for oxygen evolution reaction(OER).However,achieving higher efficiency is largely limited by the valence states of metal species.Herein,different graphdiyne(GDY)-nickel composites were designed and synthesized[Ni(OH)_(2)/GDY,NiOOH/GDY,and NiO_(x)/GDY]as the electrocatalysts for OER.The NiO_(x)/GDY possessing the mixed valence states can drive the OER more efficiently than Ni(OH)_(2)/GDY and NiOOH/GDY.NiO_(x)/GDY gives the smallest overpotential of 310 mV at 10 mA/cm^(2) for OER,which is even superior to commercial RuO_(2)electrocatalyst.Experimental results reveal that not only the fast charge transfer induced by GDY but also the prominent roles of mixed Ni^(2+)/Ni^(3+) valence states boost the OER electrocatalytic performances.The presence of the mixed valence state was demonstrated to be helpful for the charge transfer,resulting in the enhancement of the catalytic activity.This work may provide a new direction to design and fabricate high-performance materials for OER and beyond. | LUAN Xiaoyu XUE Yurui | 2021 | Chemical Research in Chinese Universities2021，37，6： | 2 |
| 11 | A Fusion Kalman Filter and UFIR Estimator Using the Influence Function Method显示文摘In this paper,the Kalman filter(KF)and the unbiased finite impulse response(UFIR)filter are fused in the discrete-time state-space to improve robustness against uncertainties.To avoid the problem where fusion filters may give up some advantages of UFIR filters by fusing based on noise statistics,we attempt to find a way to fuse without using noise statistics.The fusion filtering algorithm is derived using the influence function that provides a quantified measure for disturbances on the resulting filtering outputs and is termed as an influence finite impulse response(IFIR)filter.The main advantage of the proposed method is that the noise statistics of process noise and measurement noise are no longer required in the fusion process,showing that a critical feature of the UFIR filter is inherited.One numerical example and a practice-oriented case are given to illustrate the effectiveness of the proposed method.It is shown that the IFIR filter has adaptive performance and can automatically switch from the Kalman estimate to the UFIR estimates according to operating conditions.Moreover,the proposed method can reduce the effects of optimal horizon length on the UFIR estimate and can give the state estimates of best accuracy among all the compared methods. | Wei Xue Xiaoli Luan Shunyi Zhao Fei Liu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，4： | 2 |
| 12 | Uncontrolled central hyperthermia by standard dose of bromocriptine:A case report显示文摘BACKGROUND Some patients present to the intensive care unit due to noninfectious pathologies resulting in fever,especially acute neurological injuries,including brain trauma and intracranial haemorrhage.The cause has been identified to be central hyperthermia characterized by a high core temperature and a poor response to antipyretics and antibiotics.However,no proper guidelines on how to treat central hyperthermia have been developed for clinical practice.CASE SUMMARY A 63-year-old woman was transferred to our hospital due to injury after a traffic accident.Eight hours after admission,her pupils enlarged bilaterally from 2.5 mm to 4.0 mm.She developed severe coma and underwent decompressive craniectomy.She was diagnosed with central hyperthermia after surgery and was prescribed bromocriptine.The standard dose of bromocriptine could not control her hyperpyrexia,and we prescribed 30 mg a day to control her temperature.CONCLUSION Bromocriptine may be effective in controlling central hyperthermia and have a dosage effect. | Xin Ge Xue Luan | 2020 | World Journal of Clinical Cases2020，8，23： | 2 |
| 13 | Annual advances in traditional medicine for tumor therapy in 2019显示文摘Today,the treatment of tumors remains a difficult problem.Traditional medicine has been used to treat cancer in different countries worldwide.However,while traditional medicine is popular globally,it is not yet accepted by Western medicine as some of the ingredients and the mechanism of action for the therapeutic effect have not been fully elucidated.Thus,scholars studying traditional medicine in the treatment of cancer have strived to solve this problem.In this review,we summarized the research progress of several traditional medicines used as tumor therapies in 2019 from the PubMed database.Studies of tumors treated with traditional Chinese medicine(TCM)are popular worldwide and obtain the most attention,which attracts more researchers to this field.The anti-tumor effects of Chinese herbal medicine-derived phytochemicals,such as polyphenols,polysaccharides,saponins,and alkaloids were the new research targets for 2019.The anti-tumor effects of TCM formula such as Sijunzi decoction,and Xiaopi formula have attracted the most attention in the past year.In addition to TCM,we also focused on the anti-tumor studies of other traditional medicines,including Thai traditional medicine,traditional medicine in Sri Lanka,traditional African medicine,traditional Korean medicine,and traditional Japanese medicine. | Xue Yang Xin-Yuan Luan | 2020 | Traditional Medicine Research2020，5，2： | 2 |
| 14 | Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles:A panel study in Beijing,China显示文摘Susceptibility of patients with chronic obstructive pulmonary disease(COPD)to cardiovascular autonomic dysfunction asso-ciated with exposure to metals in ambient fine particles(PM2.5,particulate matter with aerodynamic diameter≤2.5µm)remains poorly evidenced.Based on the COPDB(COPD in Beijing)panel study,we aimed to compare the associations of heart rate(HR,an indicator of cardiovascular autonomic function)and exposure to metals in PM2.5 between 53 patients with COPD and 82 healthy controls by using linear mixed-effects models.In all participants,the HR levels were significantly associated with interquartile range increases in the average concentrations of Cr,Zn,and Pb,but the strength of the associations differed by exposure time(from 1.4%for an average 9 days(d)Cr exposure to 3.5%for an average 9 d Zn exposure).HR was positively associated with the average concentrations of PM2.5 and certain metals only in patients with COPD.Associations between HR and exposure to PM2.5,K,Cr,Mn,Ni,Cu,Zn,As,and Se in patients with COPD significantly differed from those in health controls.Furthermore,association between HR and Cr exposure was robust in COPD patients.In conclusion,our findings indicate that COPD could exacerbate difference in HR following exposure to metals in PM2.5. | Ke Gao Xi Chen Xiaoying Li Hanxiyue Zhang Mengxiao Luan Yuan Yao Yifan Xu Teng Wang Yiqun Han Tao Xue Junxia Wang Mei Zheng Xinghua Qiu Tong Zhu | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 15 | Expression of matrix metalloproteinase-1 mRNA in peripheral blood mononuclear cells of systemic lupus erythematosus patients and its relationship with atherosclerosis显示文摘背景矩阵 metalloproteinase-1 ( MMP-1 )在学习是与全身的豺狼座 erythematosus ( SLE )在病人的外部血 mononuclear 房间( PBMC )检验 MMP-1 mRNA 的表示的 atherosclerosis.This 起一个重要作用,并且在 SLE.Methods 与动脉粥样硬化探索它的关系荧光灯量的反向的抄写聚合酶链反应( RT-PCR )被用来在 80 个 SLE 病人在 PBMC 检验 MMP-1 mRNA 的表示,包括 39 对动脉粥样硬化(组 A )敏感并且 | ZHANG Hai-ying BAO Shu-meng SHOU Wei-ling LUAN Hai-xia ZHANG Yang FENG Xue TONG Da-wei ZHANG Shu-lan HU Chao-jun ZENG Xiao-feng LI Yong-zhe | 2009 | Chinese Medical Journal2009，，21： | 2 |
| 16 | Multimodality image registration by maximization of quantitative-qualitative measure of mutual information 显示文摘 | Luan H X Qi F H Xue Z | 2008 | Pattern Recognition2008，41，： | 1 |
| 17 | Microstructure and mechanical properties of frictionstir welded joints in 2219-T6 aluminum alloy显示文摘 | XUE W F LIU J H LUAN G H | 2009 | Materials & Design2009，30，9： | 1 |
| 18 | Direct evidence for hydroxyl radical scavenging activity of cerium oxide nanoparticles 显示文摘 | Xue Y Luan Q Yang D | 2011 | JPhys Chem C2011，115，11： | 1 |
| 19 | Evaluation of glycol chitosan-graft-carboxymethyl -cyelodextrin as potential pH- sensitive anticancer drug carrier by surface plasmon resonance 显示文摘 | Tan H N Xue Y Luan Q F | 2012 | Analytical Methods2012，4，9： | 1 |
| 20 | Multimodality image registration by maximization of quantitative -qualitative measure of mutual information显示文摘 | LUAN H X QI F H XUE Z | 2008 | Pattern Recognition2008，41，： | 1 |
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