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| 1 | Altitude dependency of trends of daily climate extremes in southwestern China, 1961-2008显示文摘A total of 12 indices of temperature extremes and 11 indices of precipitation ex-tremes at 111 stations in southwestern China at altitudes of 285-4700 m were examined for the period 1961-2008. Significant correlations of temperature extremes and elevation in-cluded the trends of diurnal temperature range, frost days, ice days, cold night frequency and cold day frequency. Regional trends of growing season length, warm night frequency, coldest night and warmest night displayed a statistically significant positive correlation with altitude. These characteristics indicated the obvious warming with altitude. For precipitation extreme indices, only the trends of consecutive dry days, consecutive wet days, wet day precipitation and the number of heavy precipitation days had significant correlations with increasing alti-tude owing to the complex influence of atmospheric circulation. It also indicated the increased precipitation mainly at higher altitude areas, whereas the increase of extreme precipitation events mainly at lowers altitude. In addition, the clearly local influences are also crucial on climate extremes. The analysis revealed an enhanced sensitivity of climate extremes to ele-vation in southwestern China in the context of recent warming. | Li Zongxing He Yuanqing Theakstone, Wilfred H. Wang Xufeng Zhang Wei Cao Weihong Du Jiankuo Xin Huijuan Chang Li | 2012 | Journal of Geographical Sciences2012，22，3： | 36 |
| 2 | Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer显示文摘因为高发生和高死亡,肺癌症是在中国的最致命的癌症之一。Cyclooxygenase-2 (COX-2 ) 和容器 endothelial 生长因素 C (VEGF-C ) 被发现在恶意的肿瘤的 lymphangiogenesis 起一个重要作用。在这研究,我们调查了淋巴的 microvessel 密度(LMVD ) 是否与在非小的房间肺癌症(NSCLC ) 的预后有关是 COX-2 和 VEGF-C 的病人,和表情以便在 NSCLC lymphangiogenesis 决定 COX-2 和 VEGF-C 的可能的角色。嵌入的织物 NSCLC 取样的 65 修理福尔马林的石蜡被染色的 immunohistochemical 为 COX-2 和 VEGF-C 评估。估计肿瘤 lymphangiogenesis, LMVD 被 immunohistochemical 染色 VEGFR-3 polyclonal 决定抗体。在 COX-2 和 VEGF-C 表示, LMVD,和 clinicopathologic 参数之中的关系被分析。在 65 件样品之中,高 LMVD 显著地与淋巴节点转移和差的幸存被联系。Multivariate 幸存分析证明那 LMVD 价值和淋巴节点转移是独立预示的因素。COX-2 和 VEGF-C 的表示水平比邻近的纸巾的那些显著地高。在 NSCLC 的 COX-2 和 VEGF-C 表情显著地与淋巴节点转移,然而并非与耐心的性,年龄,肿瘤尺寸,或肿瘤相关,节点,转移分类舞台。COX-2- 或 VEGF-C-positive 肿瘤的吝啬的 LMVD 价值比 COX-2- 或 VEGF-C-negative 肿瘤的高。重要关联在 COX-2 和 VEGF-C 的表情之间被发现。这研究建议 LMVD 可以是为 NSCLC 病人的重要预示的因素之一。VEGF-C 可能在 COX-2 lymphangiogenic 小径起一个重要作用。COX-2 和 VEGF-C 可以由刺激 lymphangiogenesis 在肿瘤前进起一个重要作用。lymphangiogenesis, COX-2,或 VEGF-C 活动的抑制可以在 NSCLC 的控制有一个重要治疗学的好处。 | Xufeng Guo Yongbing Chen Zhonghua Xu Zhonghen Xu Yongyue Qian Xueyan Yu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 34 |
| 3 | Yield-related QTLs and Their Applications in Rice Genetic Improvement显示文摘Grain yield is one of the most important indexes in rice breeding,which is governed by quantitative trait loci (QTLs).Different map-ping populations have been used to explore the QTLs controlling yield related traits.Primary populations such as F 2 and recombi-nant inbred line populations have been widely used to discover QTLs in rice genome-wide,with hundreds of yield-related QTLs detected.Advanced populations such as near isogenic lines (NILs) are efficient to further fine-map and clone target QTLs.NILs for primarily identified QTLs have been proposed and confirmed to be the ideal population for map-based cloning.To date,20 QTLs directly affecting rice grain yield and its components have been cloned with NIL-F 2 populations,and 14 new grain yield QTLs have been validated in the NILs.The molecular mechanisms of a continuously increasing number of genes are being unveiled,which aids in the understanding of the formation of grain yield.Favorable alleles for rice breeding have been 'mined' from natural cultivars and wild rice by association analysis of known functional genes with target trait performance.Reasonable combination of favorable alleles has the potential to increase grain yield via use of functional marker assisted selection. | Xufeng Bai | 2012 | Journal of Integrative Plant Biology2012，54，5： | 22 |
| 4 | Spatial distribution and temporal trends in potential evapotranspiration over Hengduan Mountains region from 1960 to 2009显示文摘在 19612009 期间在 Hengduan 山区域基于 20 个车站的气象学的数据,潜在的土壤水分蒸发蒸腾损失总量的年度、季节的变化与 Penman-Monteith 模型一起在联合被分析。与在 ArcGIS 下面的花键插值的方法,潜在的土壤水分蒸发蒸腾损失总量的空间分发被介绍研究地区性的差别,并且关联分析被用来讨论影响潜在的土壤水分蒸发蒸腾损失总量的主导的因素。结果显示自从 1960 年代,年度潜在的土壤水分蒸发蒸腾损失总量显示出一个减少的趋势,特别从 1980 年代到 1990 年代,当自从 2000,它显示出一个增加的趋势时。地区性的潜在的土壤水分蒸发蒸腾损失总量显示出 0.17 公里 a1 的率。在 Hengduan 山的北方,中间和南方的潜在的土壤水分蒸发蒸腾损失总量在学习时期上展出了减少的趋势,并且它的地区性的趋势在从西南的衰落上到东北。 | ZHU Guofeng HE Yuanqing PU Tao WANG Xufeng JIA Wenxiong LI Zongxing XIN Huijuan | 2012 | Journal of Geographical Sciences2012，22，1： | 16 |
| 5 | Underground pressure characteristics analysis in back-gully mining of shallow coal seam under a bedrock gully slope显示文摘我们在一个基岩溪谷斜坡下面在浅煤缝接在背溪谷采矿期间学习了地下的压力和它的机制,借助于物理模拟,数字建模并且地监视。结果证明地下的压力的紧张与它在 coalface 的相对位置有关。地下的压力是集中的,当 coalface 在溪谷的底部时,支持抵抗到达最大值,而地下的压力是中等的并且当 coalface 传递溪谷时,逐渐地减少。当斜坡在不稳定的、多边的块依赖了的采矿和形式组织的背溪谷期间在一个颠倒的方向旋转了到斜坡剧降时,这些变化的机制被分析,由于滑倒。当块破碎是小的时,多边的块的沉淀是可观的,导致在地下的压力的庞大的变化。随块身体的团的增加,块排水量将被减少与一起一增加在废矿由未破损的岩石和破岩石夹钳效果,导致地下的压力的减少。 | Wang Xufeng Zhang Dongsheng Fan Gangwei Zhang Chengguo | 2011 | Mining Science and Technology2011，21，1： | 16 |
| 6 | Real-time drogue recognition and 3D locating for UAV autonomous aerial refueling based on monocular machine vision显示文摘Drogue recognition and 3D locating is a key problem during the docking phase of the autonomous aerial refueling(AAR). To solve this problem, a novel and effective method based on monocular vision is presented in this paper. Firstly, by employing computer vision with red-ring-shape feature, a drogue detection and recognition algorithm is proposed to guarantee safety and ensure the robustness to the drogue diversity and the changes in environmental conditions, without using a set of infrared light emitting diodes(LEDs) on the parachute part of the drogue. Secondly, considering camera lens distortion, a monocular vision measurement algorithm for drogue 3D locating is designed to ensure the accuracy and real-time performance of the system,with the drogue attitude provided. Finally, experiments are conducted to demonstrate the effectiveness of the proposed method. Experimental results show the performances of the entire system in contrast with other methods, which validates that the proposed method can recognize and locate the drogue three dimensionally, rapidly and precisely. | Wang Xufeng Kong Xingwei Zhi Jianhui Chen Yong Dong Xinmin | 2015 | Chinese Journal of Aeronautics2015，28，6： | 15 |
| 7 | Arabidopsis C3HC4-RING finger E3 ubiquitin ligase At AIRP4 positively regulates stress-responsive abscisic acid signaling显示文摘Degradation of proteins via the ubiquitin system is an important step in many stress signaling pathways in plants.E3 ligases recognize ligand proteins and dictate the high specificity of protein degradation, and thus, play a pivotal role in ubiquitination. Here, we identified a gene, named Arabidopsis thaliana abscisic acid(ABA)-insensitive RING protein 4(At AIRP4), which is induced by ABA and other stress treatments. At AIRP4 encodes a cellular protein with a C3HC4-RING finger domain in its C-terminal side, which has in vitro E3 ligase activity. Loss of At AIRP4 leads to a decrease in sensitivity of root elongation and stomatal closure to ABA, whereas overexpression of this gene in the T-DNA insertion mutant atairp4 effectively recovered the ABA-associated phenotypes. At AIRP4 overexpression plants were hypersensitive to salt and osmotic stresses during seed germination, and showed drought avoidance compared with the wild-type and atairp4 mutant plants. In addition, the expression levels of ABA- and droughtinduced marker genes in At AIRP4 overexpression plants were markedly higher than those in the wild-type and atairp4 mutant plants. Hence, these results indicate that At AIRP4 may act as a positive regulator of ABA-mediated drought avoidance and a negative regulator of salt tolerance in Arabidopsis. | Liang Yang Qiaohong Liu Zhibin Liu Hao Yang Jianmei Wang Xufeng Li Yi Yang | 2016 | Journal of Integrative Plant Biology2016，58，1： | 15 |
| 8 | Source of major anions and cations of snowpacks in Hailuogou No.1 glacier, Mt. Gongga and Baishui No.1 glacier, Mt. Yulong显示文摘积雪场样品是从二条冰河的 colleted:在 2006 年 6 月的 Baishui No.1 冰河和 Hailuogou No.1 冰河。海盐离子 tracer。 | LI Zongxing HE Yuanqing PANG Hongxi YANG Xiaomei JIA Wenxiong ZHANG Ningning WANG Xufeng NING Baoying YUAN Lingling SONG Bo | 2008 | Journal of Geographical Sciences2008，18，1： | 13 |
| 9 | Risk analysis of snow disaster in the pastoral areas of the Qinghai-Tibet Plateau显示文摘雪灾难是顶之一世界范围的十自然灾难,和最严重的自然灾难到影响 Qinghai 西藏高原的牧剧区域。基于从历史的记录收集的危险伤害数据和从这危险在 2010 影响的实体收集的数据,Qinghai西藏高原上的雪灾难的 18 个索引的全面分析被进行,包含危险伤害,物理暴露的数量忍受危险的实体脸,敏感到危险,和能力到对灾难作出回应。分析显示那:(1 ) 区域在 Qinghai 西藏高原上的雪灾难高风险在 Xinjiang 区域位于 Yecheng 和 Pishan 的县的某些区域;(2 ) 区域在雪中等风险灾难在 Qinghai 西藏高原,和南部的 Qinghai 高原的东南的部分的中央西方的部分在 Gangdise 山和喜马拉雅山脉之间被发现;(3 ) 雪灾难的风险在整个到 30 ‰ ? ? 的南方的大区域通常是低的 ????????????? ?? 吗?? | LIU Fenggui MAO Xufeng ZHANG Yili CHEN Qiong LIU Pei ZHAO Zhilong | 2014 | Journal of Geographical Sciences2014，24，3： | 13 |
| 10 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 11 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 12 | Environmental suitability evaluation for human settlements in an arid inland river basin: A case study of the Shiyang River Basin显示文摘学习采用斜坡,方面,陆地表面的消除度,陆地使用,植被索引,水文学和气候,当评估索引建立人的解决在 Shiyang 河盆为人的解决评估环境适用性的环境索引(HEI ) 模型。由例如空间覆盖分析,用 GIS 空间分析技术缓冲分析和密度分析,人的解决的环境适用性空间状况和空间模式被建立分析他们的空间分发。结果证明为在 Shiyang 河盆的人的解决的适用性的索引在 17.13 和 84.32 之间。一般来说,为人的解决的适用性从西南减少到东北。从一个区域模式看,合适的区域主要在 Minqin 绿洲, Wuwei 绿洲和 Changning 盆被散布,它为 2.59% 全部的区域是大约 1080.01 km2 和报道。更确切地说并且比较地合适的区域主要在 Tianzhu 的 Gulang, Yongchang 和北方的县附近被散布,它是大约 1100.30 km2。普通合适的区域主要在 Yongchang, Jinchuan 和 Minqin 县的大多数部分的县外面被散布,它是大约 23328.04 km2,为 56.08% 全部的区域的财务。不合适区域主要被散布在上游并且到河,是大约 9937.60 km2,的北方为 23.89% 全部的区域的财务。同时,最少的合适的区域在 Qilian 山附近被散布,它被雪和冷沙漠和谎言在在 Tengger 沙漠和 Badain Jaran 沙漠之间的交叉区域盖住。全部的区域是大约 6154.05 km2,为 14.79% 全部的区域的财务。为人的居住的合适的区域在在带子和批形式的河附近主要是分布式的,当其它被散布时。分发模式与居住空间模式相同。另外,在 HEI 之间的关系和另外的因素被分析了。在居住环境和人口之间有清楚的对数的关联,也就是说,在评估价值之间的关联系数和人口密度到达 0.851。也在居住环境和经济之间有积极关联,它到达在居住环境和 GDP 之间的 0.845 的评估价值。结果也证明环境从在 Shiyang 河盆容忍存在人口。人口的空间分发被严重环境问题深刻地影响,例如扩展沙漠,多山的地面和变化气候。表面水缺乏和慢经济的生长是为在 Shiyang 河盆的合适的人的解决的瓶颈。把这些问题与为新土地的建设和本地土地的利用计划相结合,一些居住区域应该被重定位改进居住环境。 | WEi Wei SHI Peiji ZHOU Junju FENG Haichun WANG Xufeng WANG Xueping | 2013 | Journal of Geographical Sciences2013，23，2： | 11 |
| 13 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 14 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 15 | Short Panicle 3 controls panicle architecture by upregulating APO2/RFL and increasing cytokinin content in rice显示文摘Inflorescence architecture is a major determinant of spikelet numbers per panicle, a key component of grain yield in rice. In this study, Short Panicle 3(SP3) was identified from a short panicle 3(sp3) mutant in which T-DNA was inserted in the promoter of SP3, resulting in a knockdown mutation. SP3 encodes a DNA binding with one finger(Dof) transcriptional activator. Quantitative real time(q RT)-PCR and RNA in situ hybridization assays confirmed that SP3 is preferentially expressed in the young rice inflorescence, specifically in the branch primordial regions. SP3 acts as a negative regulator of inflorescence meristem abortion by upregulating APO2/RFL. SP3 both up-and downregulates expression of genes involved in cytokinin biosynthesis and catabolism, respectively. Consequently, cytokinin concentrations are decreased in young sp3 panicles, thereby leading to small panicles having fewer branches and spikelets. Our findings support a model in which SP3 regulates panicle architecture by modulating cytokinin homeostasis. Potential applications to rice breeding, through gene-editing of the SP3 promoter are assessed. | Yong Huang Xufeng Bai Meifang Luo Yongzhong Xing | 2019 | Journal of Integrative Plant Biology2019，61，9： | 10 |
| 16 | Bioinspired mineralized collagen scaffolds for bone tissue engineering显示文摘Successful regeneration of large segmental bone defects remains a major challenge in clinical orthopedics,thus it is of important significance to fabricate a suitable alternative material to stimulate bone regeneration.Due to their excellent biocompatibility,sufficient mechanical strength,and similar structure and composition of natural bone,the mineralized collagen scaffolds(MCSs)have been increasingly used as bone substitutes via tissue engineering approaches.Herein,we thoroughly summarize the state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair,including their fabrication methods,critical factors for osteogenesis regulation,current opportunities and challenges in the future.First,the current fabrication methods for MCSs,mainly including direct mineral composite,in-situ mineralization and 3D printing techniques,have been proposed to improve their biomimetic physical structures in this review.Meanwhile,three aspects of physical(mechanics and morphology),biological(cells and growth factors)and chemical(composition and cross-linking)cues are described as the critical factors for regulating the osteogenic feature of MCSs.Finally,the opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out the future directions for building the next generation of MCSs that should be endowed with satisfactorily mimetic structures and appropriately biological characters for bone regeneration. | Zhengwei Li Tianming Du Changshun Ruan Xufeng Niu | 2021 | Bioactive Materials2021，6，5： | 9 |
| 17 | Advanced EMS and its trial operation in Shanghai power system显示文摘To meet the demand of high stability,high quality,and low losses of power systems,the advanced energy management system (AEMS) is established and revealed in this bulletin,which has been put into trial operation in Shanghai power system for almost half a year. The AEMS is novel from all aspects covering idea,theory,method,software,and engineering. The essence of AEMS is exercising the hybrid automatic control theory and technology to realize multi-objective optimal closed-loop control of power systems. Based on an 'event-driven' strategy,the AEMS transforms multi-objective optimal control problems into event identification and elimination by defining the unsatisfactory states of a power system as events. This bulletin concisely presents the theory and main advantages of AEMS,as well as its implementation in Shanghai power system. | LU Qiang HE GuangYu MEI ShengWei SUN YingYun RUAN QianTu WANG Wei ZHANG WangJun YU XuFeng | 2008 | Science China(Technological Sciences)2008，51，2： | 9 |
| 18 | Biomimetic delivery of signals for bone tissue engineering显示文摘Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation.Biomaterials play a pivotal role in providing a template and extracellular environment to support regenerative cells and promote tissue regeneration. A variety of signaling cues have been identified to regulate cellular activity, tissue development, and the healing process. Numerous studies and trials have shown the promise of tissue engineering, but successful translations of bone tissue engineering research into clinical applications have been limited, due in part to a lack of optimal delivery systems for these signals. Biomedical engineers are therefore highly motivated to develop biomimetic drug delivery systems, which benefit from mimicking signaling molecule release or presentation by the native extracellular matrix during development or the natural healing process. Engineered biomimetic drug delivery systems aim to provide control over the location, timing, and release kinetics of the signal molecules according to the drug's physiochemical properties and specific biological mechanisms. This article reviews biomimetic strategies in signaling delivery for bone tissue engineering, with a focus on delivery systems rather than specific molecules. Both fundamental considerations and specific design strategies are discussed with examples of recent research progress, demonstrating the significance and potential of biomimetic delivery systems for bone tissue engineering. | Ming Dang Laura Saunders Xufeng Niu Yubo Fan Peter X.Ma | 2018 | Bone Research2018，6，3： | 9 |
| 19 | Characteristics and stability of slope movement response to underground mining of shallow coal seams away from gullies显示文摘Underground pressure is abnormal during mining of shallow coal seams under gullies. We studied gully slope movements, subject to underground mining, with physical simulation and theoretical analysis. The rules disclose that the slope rock slides horizontally in response to mining in the direction of gullies and rotates reversely with the appearance of a polygon block in mining away from gullies. We focused our attention on the case of mining away from a gully. We built a mechanical model in terms of a polygon block hinged structure and investigated the variation of horizontal thrust and shear force at the hinged point in relation to the rotation angle under different fragmentations. The Sliding-Rotation instability conditions of the polygon block hinged structure are presented based on the analyses of sliding instability and rotation instability. These results can serve as a theoretical guide for roof control during mining away from gullies in a coalfield defined by gullies. | Zhang Dongsheng Fan Gangwei Wang Xufeng | 2012 | International Journal of Mining Science and Technology2012，22，1： | 8 |
| 20 | Potential and Suitability Evaluation of CO_2 Geological Storage in Major Sedimentary Basins of China,and the Demonstration Project in Ordos Basin显示文摘From 2010 to 2012, the China Geological Survey Center for Hydrogeology and Environmental Geology Survey(CHEGS) carried out the project 'Potential evaluation and demonstration project of CO2 Geological Storage in China'. During this project, we developed an evaluation index system and technical methods for the potential and suitability of CO2 geological storage based on China's geological conditions, and evaluated the potential and suitability of the primary basins for CO2 geological storage, in order to draw a series of regional scale maps(at a scale of 1:5000000) and develop an atlas of the main sedimentary basins in China. By using these tools, we delineated many potential targets for CO2 storage. We also built techniques and methods for site selection and the exploration and assessment of CO2 geological storage in deep saline aquifers. Furthermore, through cooperation with the China Shenhua Coal to Liquid and Chemical Co., Ltd., we successfully constructed the first coal-based demonstration project for CO2 geological storage in deep saline aquifers in the Yijinhuoluo Banner of Ordos in the Inner Mongolia Autonomous Region, which brought about the basic preliminary theories, techniques, and methods of geological CO2 storage in deep saline aquifers under China's geological conditions. | GUO Jianqiang WEN Dongguang ZHANG Senqi XU Tianfu LI Xufeng DIAO Yujie JIA Xiaofeng | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 8 |
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