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| 1 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 2 | 显示文摘 | Liu Daoping Xu Yi Song Meifeng | 2003 | Energyand the Environment - Proceedings of the International Conference on Energy and the Environment2003，，1： | 1 |
| 3 | A Study on the Application of the Chinese English Competence Scale in College English Teaching显示文摘The results of the assessment of College Students'English Reading Comprehension Scale based on the Chinese EnglishCompetence Scale show that the assessment of language competence scale can diagnose English teaching and learning in HigherVocational colleges. In order to construct the scale of Chinese college students'ability to speak and act in English, we should ensurethe universality, representativeness and authority of the source of descriptive language and the accuracy, clarity, conciseness,independence and affirmation of descriptive language. Learners can also use the scale to self-evaluate and establish their ownlearning goals. At the same time, the learning time required for each stage is not the same. The learner should determine his ownlearning plan according to his own situation and the standard reference provided by the scale. Its ability grading reflects thecorrespondence between the English level of students in each scholastic school and the ability to describe the descriptors, and it istargeted and instructive for college English teaching. In order to continuously improve the learning effect of college Englishteaching. | Xu Daoping Zhao Weihong Tang Dongdong | 2019 | 教育研究前沿(中英文版)2019，9，3： | 0 |
| 4 | A Study on the Integration of Chinese Excellent Traditional Culture and College English Teaching显示文摘At present, the education of English curriculum has become one of the main courses of higher education in China. The purpose ofEnglish teaching is to enable students to master the language and use it for intercultural communication. As the main body offoreign exchange in the new era, college students are facing the heavy responsibility of the development of the new era and theimportant carrier of foreign exchange. The infiltration of Chinese excellent traditional culture into college English teaching can notonly deepen students'understanding of Western culture, but also enable them to appreciate the vastness and depth of their ownnational culture, thus promoting cultural integration and improving students' English cognitive and application level. Infiltration inEnglish teaching is an innovation in the ways and methods of ideological and moral education. Strengthen the teaching of Chinesetraditional Chinese culture in college English, encourage English teachers to integrate into the teaching innovation of Chineseexcellent traditional culture, create a classroom teaching atmosphere of Chinese excellent traditional culture, and innovate teachingmethods to create an environment for the introduction of Chinese excellent traditional culture. | Zhao Weihong Xu Daoping Wang Hongxia | 2019 | 教育研究前沿(中英文版)2019，9，3： | 0 |
| 5 | Fintech, Macroprudential Supervision and Systematic Risk in China’s Banks显示文摘In recent years,the rapid development of fi ntech has brought far-reaching changes to the fi nancial sector.At the same time,fi ntech may cause potential systemic risk in the fi nancial sector,which has aroused special concerns from fi nancial regulatory authorities.Based on the micro data of China’s listed banks from 2013 to 2020,this paper analyzes the impact of fi ntech development on systemic risk in China’s banking industry and its mechanism.It reveals that for a micro bank,fintech progress increases its risk-taking and enhances inter-bank linkages,which results in signifi cantly amplifi ed systemic risk,and the impact is time-lagged and persistent.In addition,the heterogeneity analysis shows that the impacts of fi ntech on state-owned banks and other banks are heterogeneous and the margining risk of state-owned banks is lower when the fi ntech improves.It is also found that enhancing macroprudential supervision can reduce the systemic risk spillover of fintech.Robustness analyses including GMM regression and the method of instrumental variables prove that the conclusion is robust.This paper is of theoretical and policy signifi cance for the prevention of systemic risk in the banking industry as China develops fi ntech. | Daoping Wang Yangjingzhuo Liu Yuxuan Xu Linlin Liu | 2022 | China Finance and Economic Review2022，11，4： | 0 |
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