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| 1 | Preparation of Titanium-based Polyoxometalatxiue-ionic Liquid Catalysts and Application in the Synthesis of Degradable Polyester显示文摘Three kinds of Keggin-type titanium-based polyoxometalate-ionic liquid catalysts were prepared,and the chemical structure,crystal structure and thermal stability of the three catalysts were analyzed and tested by infrared spectrometer,ultraviolet-visible spectrometer,X-ray diffractometer,and thermogravimetric analyzer,respectively.Afterwards,their performance in catalyzing the coupling reaction of ethylene carbonate(EC)and dimethyl succinate(DMSu)to synthesize polyethylene succinate(PES)was studied,and the effects of different metals on the catalytic performance and the mechanism of action were discussed.The optimal process parameters for the coupling reaction were explored.Finally,the chemical structure of PES was characterized by infrared spectrometer.The results show that under the same process parameters,the polyoxometalate-ionic liquid catalyst Bmim_(5)[Ti(H_(2)O)TiMo_(11)O_(39)]had the best catalytic effect.Under the optimal process parameters,Bmim_(5)[Ti(H_(2)O)TiMo_(11)O_(39)]had obvious inhibitory effect on side reactions,and the yield and selectivity of PES prepolymer were up to 72.23%and 88.64%. | Ran CHEN Changyuan YU Liying GUO Kun LIU Xiudan ZHAO Zezhong JIANG | 2022 | Meteorological and Environmental Research2022，13，4： | 1 |
| 2 | MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin显示文摘Mesoporous silica cocoon materials(MSNCs) and MgO doped mesoporous silica cocoons(MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin(IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy(TEM), powder X-Ray diffraction(XRD) and differential scanning calorimetry(DSC). The effect of the Mg/Si molar ratio on the kinetics and equilibrium of IMC adsorption on MgO-MSNCs was thoroughly examined, and it was found that the increase in the Mg/Si molar ratio resulted in an increasing IMC adsorption rate due to the increased affinity between alkaline MgO-MSNCs and weak acid IMC. The adsorption kinetics fitted a pseudo second-order model well. The Freundlich isotherm showed a better fit, indicating that the coverage of IMC on the surface of MgO-MSNCs was heterogeneous. The maximum adsorption capacity of adsorbent was calculated by the Langmuir isotherm equation. The Temkin equation provided further support that the IMC adsorption on MgO-MSNCs was dominated by a chemisorption process. MgO-MSNCs also have the advantage of allowing an adjustment of the drug release rate of weak acid drug. The cytotoxicity assay indicated good biocompatibility of MgO-MSNCs. Our research on MgO-MSNCs carriers demonstrated their potential therapeutic benefit for safe and effective management of IMC adsorption and in vitro release. | Xin Zheng Shuang Feng Xiudan Wang Zhenning Shi Yuling Mao Qinfu Zhao Siling Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 0 |
| 3 | Author correction to“Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors”[Acta Pharmaceutica Sinica B 12(2022)4501-4518]显示文摘The authors regret that there is an error in the article Fig.9D1 due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading,and also a mislabled error in the supporting Information Fig.S9 and S10. | Yuling Mao Xiudan Wang Caishun Chen Qinfu Zhao Yanfeng Liu Jinghai Zhang Siling Wang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 4 | Immune-awakening Saccharomyces-inspired nanocarrier for oral target delivery to lymph and tumors显示文摘Utilization of the intestinal lymphatic pathway will allow extraordinary gains in lymph and tumors cascade-targeted delivery of oral drugs and awakening the innate/adaptive immunity of the body and the lesion microenvironment,in addition to improving oral bioavailability relative to other means of delivery of oral drugs.Here,inspired by the specific invasion route of intestinal microorganisms,we pioneered an immune-awakening Saccharomyces-inspired mesoporous silicon nanoparticle(yMSN)for the ingenious cascade-targeted delivery of therapeutic cancer vaccines and antitumor drugs to lymph and tumors via the intestinal lymphatic pathway.Encouragingly,yMSN high-loaded tumor-specific antigens(OVA,11.9%)and anti-tumor drugs(Len,28.6%)with high stability,namely Len/OVA/yMSN,efficiently co-delivered OVA and Len to their desired target sites.Moreover,yMSN concomitantly awakened the innate antitumor immunity of dendritic cells and macrophages,strengthening vaccine-induced adaptive immune responses and reversing macrophage-associated immunosuppression in the tumor microenvironment.Surprisingly,Len/OVA/yMSN treatment resulted in excellent synergistic antitumor efficacy and long-term antitumor memory in OVA-Hepa1-6-bearing mice.This high-performance nanocarrier provides a novel approach for lesion-targeting delivery of oral drugs accompanied with awakening of the innate/adaptive immunity of the lesion environment,and also represents a novel path for the oral delivery of diverse therapeutic agents targeting other lymph-mediated diseases. | Yuling Mao Xiudan Wang Caishun Chen Qinfu Zhao Yanfeng Liu Jinghai Zhang Siling Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 0 |
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