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| 1 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 2 | Classification of facial nerve aberration in congenital malformation of middle ear:Implications for surgery of hearing restoration显示文摘Objectives: Facial nerve aberration is the most troublesome situation in congenital malformations of middle ear.The aim of our study is to investigate its imaging and clinical features as well as relevant choice of surgical techniques for hearing improvement.Methods: A retrospective study involving review of clinical data of 227 patients(256 ears) with congenital middle ear anomaly was undertaken, including preoperative computed tomography(CT) data, surgical records and videos.Results: Aberration involving intratemporal facial nerve was found in 82/256 ears(32.03%) with congenital middle ear anomaly. The most common forms of aberration included overhanging over the oval window(50/82 ears, 60.98%), bifurcation(3/82 ears, 3.66%) and transverse over the promontory(3/82 ears, 3.66%), counting for 68.29%(56/82) of the cases with facial nerve aberration. Concomitant stapes malformation was found in 76/82 ears(92.68%) and atresia or stenosis of the oval window in 27/82 ears(32.93%). In 9/82 ears(10.98%) both stapes and oval window was absent. Elective surgeries for the purpose of hearing improvement included stapodotomy + piston implantation, labyrinthotomy, labyrinthotomy + total ossicular replacement prosthesis(TORP) implantation and Vibrant Soundbridge(VSB) implantation.Conclusion: The majority of facial nerve aberration in congenital malformation of middle ear involves displacement of facial nerve, in addition to concomitant malformations of the stapes and/or oval window, which may influence the choice of surgery for hearing improvement. VSB implantation may be considered as a useful option. | Jin Hao Liping Xu Shuling Li Xinxing Fu Shouqin Zhao | 2018 | Journal of Otology2018，13，4： | 1 |
| 3 | A text segmentation method of text to speech technology based on agricultural ontology theory and semantic search显示文摘 | Li Xinxing Fu Zetian Zhang Lingxian | 2012 | Journal of Food Agriculture and Environment2012，10，1： | 1 |
| 4 | A text segmentation method of text to speech technology based on agricultural ontology theory and semantic search显示文摘 | Li Xinxing Fu Zetian Zhang Lingxian | 2012 | Journal of Food Agriculture and Environment2012，10，1： | 1 |
| 5 | Minimal solution for estimating fundamental matrix under planar motion显示文摘Dear editor,Fundamental matrix estimation from point correspondences is a basic problem in computer vision and robotics.It is applicable in many areas,such as visual servoing(visionbased control)and structure-from-motion when the camera is uncalibrated. | Qiang FU Xinxing MU Yu WANG | 2021 | Science China(Information Sciences)2021，64，10： | 1 |
| 6 | Structural design and thermal performance simulation of shade roof of double-slope greenhouse for mushroom-vegetable cultivation显示文摘A new type of roof structure was developed for the shade room in a double-slope greenhouse used for mushroom-vegetable planting.A simulation model was developed to evaluate the thermal performance of the new roof with an insulation thickness of 0.12 m in Beijing,China.The results showed that(1)the indoor air temperature of the shade room with the newly implemented shade roof was 2.7℃-4.9℃ higher than that of an ordinary shade room during the winter months;(2)The indoor air temperature of the solar room adjacent to the shade room with the new roof was higher than that of the ordinary solar room and the minimum indoor air temperature of the solar room was increased 1.9℃ at winter night;(3)the indoor temperature of the shade room with the new roof design was 2℃-4℃ lower than that of the ordinary shade room during the summer months;(4)Under factory production conditions,which were conducted in a controlled environment to promote the annual growth of the edible fungus,the heating energy consumption of the shade room after the implementation of the new roof structure was reduced by 69.3%,the amounted to total energy savings of 61.3% per year.The new roof structure provided a significant improvement in the thermal environment compared to an ordinary shade room,improved the vegetable growth in the winter,and also significantly reduced the energy consumption and production costs. | Yunfei Ma Xinxing Li Zetian Fu Lingxian Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，3： | 0 |
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