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| 1 | Incidence,mortality and survival of female breast cancer during 2003-2011 in Jiangsu province,China显示文摘Objective: To assess the incidence, mortality and survival status of female breast cancer in Jiangsu province of China.Methods: Population-based cancer registry data in Jiangsu province were collected during 2003-2011. Crude rates, age-specific rates, age-standardized rates and annual percent changes of incidence and mortality were calculated to describe the epidemiologic characteristics and time trends. Patients diagnosed from 2003 to 2005 were chosen for analyzing the survival status of breast cancer.Results: From 2003 to 2011, 17,605 females were diagnosed with breast cancer and 4,883 died in selected registry areas in Jiangsu province. The crude incidence rate was 25.18/100,000, and the age-standardized rates by Chinese population(ASRC) and by world population(ASRW) were 19.03/100,000 and 17.92/100,000, respectively. During the same period, the crude mortality rate was 6.98/100,000 and the ASRC and ASRW were 4.93/100,000 and 4.80/100,000, respectively. From 2003 to 2011, the incidence and mortality increased with annual percent change of 11.37% and 5.78%, respectively. For survival analysis, 1,392 patients in 7 areas were identified in 2003-2005 and finished 5 years of follow-up. Survival rates were found to decrease with survival years, the 5-year observed survival rate was 45.9% and the relative survival rate was 52.0%. We also found that the survival rate varied across the province, which was lower in the north and higher in the south of Jiangsu province.Conclusions: Breast cancer has become a significant public health problem in Jiangsu province and China. More resources should be invested in primary prevention, earlier diagnosis and better health services in order to increase survival rates among Chinese females. | Xinran Yan Renqiang Han Jinyi Zhou Hao Yu Jie Yang Ming Wu | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 2 | A scalable sulfuration of WS2 to improve cyclability and capability of lithium-ion batteries显示文摘二维的转变金属 dichalcogenides (WS 2 和 SnS 2) 最近加入了精力存储材料的家庭(为锂离子电池和 supercapacitors ) 由于他们的有利离子置闰。到目前为止,在阶段纯的 WS 2, 的合成的挑战严重地在 WS 2 nanosheets,低电子传导性,和 WS 2, 的易碎的性质之间重新叠限制它的使用 Li 离子电池申请。此处,我们开发灵巧的低温度解决方案硫化进程戏剧性地改进电池性能。硫化过程被表明在把 WO 3 杂质变换成 WS 2, 并且在修理硫空缺有效,到改进 cyclability 和率能力。锂离子电池大小证明 WS 2 阳极的稳定的能力能被 48.4% 经由硫化 reprocessing 提高,即,从在 0.8 的相对高的当前的密度的 381.7 ~ 566.8 mAh/g,在 50 以后的 A/g 骑车。我们进一步证明硫化进程能乐意地被扩大到另外的 dichalcogenides,并且可以为锂离子电池向万用的电极材料的一个类提供改进电气化学的特征。 | Liyan Zhou Shancheng Yan Lijia Pan Xinran Wang Yuqiao Wang Yi Shi | 2016 | Nano Research2016，9，3： | 7 |
| 3 | Understanding the improved performance of sulfur-doped interconnected carbon microspheres for Na-ion storage显示文摘As one of the low-cost energy storage systems,Na-ion batteries(NIBs)have received tremendous attention.However,the performance of current anode materials still cannot meet the requirements of NIBs.In our work,we obtain sulfur-doped interconnected carbon microspheres(S-CSs)via a simple hydrothermal method and subsequent sulfurizing treatment.Our S-CSs exhibit an ultrahigh reversible capacity of 520 mAh g^(-1) at 100 mA g^(-1) after 50 cycles and an excellent rate capability of 257 mAh g^(-1),even at a high current density of 2 A g^(-1).The density functional theory calculations demonstrate that sulfur doping in carbon favors the adsorption of Na atom during the sodiation process,which is accountable for the performance enhancement.Furthermore,we also utilize operando Raman spectroscopy to analyze the electrochemical reaction of our S-CSs,which further highlights the sulfur doping in improving Na-ion storage performance. | Xinran Yuan Siming Chen Jinliang Li Junpeng Xie Genghua Yan Botian Liu Xibo Li Rui Li Likun Pan Wenjie Mai | 2021 | Carbon Energy2021，3，4： | 3 |
| 4 | Wind tunnel experiments on dust emissions from different landform types显示文摘The measurement and assessment of dust emissions from different landforms are important to understand the atmospheric loading of PM10(particulate matter ≤10 μm aerodynamic diameter) and to assess natural sources of dust; however, the methodology and technique for determining the dust still present significant research challenges. In the past, specialized field observation and field wind tunnel studies have been used to understand the dust emission. A series of wind tunnel tests were carried out to identify natural sources of dust and measure the magnitudes of dust emissions from different landforms. The method used in this study allowed the measurement of the PM10 emission rate using a laboratory based environmental boundary layer wind tunnel. Results indicated that PM10 emissions demonstrated strong temporal variation and were primarily driven by aerodynamic entrainment. Sand dunes, playa, and alluvial fans had the largest dust emission rates(0.8–5.4 mg/(m^2·s)) while sandy gravel, Gobi desert and abandoned lands had the lowest emission rates(0.003–0.126 mg/(m^2·s)). Dust emissions were heavily dependent on the surface conditions, especially the availability of loose surface dust. High dust emissions were a result of the availability of dustparticle materials for entrainment while low dust emissions were a result of surface crusts and gravel cover. Soil surface property(surface crusts and gravel cover) plays an important role in controlling the availability of dust-sized particles for entrainment. The dust emission rate depended not only on the surface conditions but also on the friction velocity. The emission rate of PM10 varies as a power function of the friction velocity. Although dynamic abrasion processes have a strong influence on the amount of dust entrainment, aerodynamic entrainment may provide an important mechanism for dust emissions. Large volumes of dust entrained by aerodynamic entrainment cannot only occur at low shear velocity without saltation, but may dominate the entrainment process in many arid and semi-arid environments. So it may also be responsible for large magnitude dust storms. Playa and alluvial fan landforms, prior to developing a surface crust, may be the main sources of dust storms in Qinghai Province. | WU Wei YAN Ping WANG Yong DONG Miao MENG Xiaonan JI Xinran | 2018 | Journal of Arid Land2018，10，4： | 3 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Cancer targeting Gene-Viro-Therapy specific for liver cancer by α-fetoproteincontrolled oncolytic adenovirus expression of SOCS3 and IL-24显示文摘为癌症治疗的基因治疗和 virotherapy 的联合收到了靠近的注意并且在癌症 biotherapy 的地里成为了一个趋势。称为指向 Gene-Viro-Therapy (CTGVT ) 或基因的癌症的策略武装了 Oncolytic 病毒的治疗(GAOVT ) 被建议了,在哪个 antitumor 基因被插入到 oncolytic 病毒的向量。在我们的以前的学习,有为正常房间和严格的肝的提高的安全的双调整 oncolytic 侵入人体气管粘膜的病菌指向癌症的能力,指明的 AdenAFPE1AE1B (55 )( 简短 AdenAFPD55 ) ,成功地被构造。在水流,工作, interleukin-24 (IL-24 ) 和表明 3 的 cytokine (SOCS3 ) 的 suppressor 基因被包装进 AdenAFPD55。新构造, AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) ,在 hepatoma 房间的显示出的改进 tumoricidal 活动与 oncolytic 相比排队病毒的向量 AdenAFPD55。AdenAFPD55-(IL-24 ) 和 AdenAFPD55-(SOCS3 ) 的合作管理在 vitro 并且在一个裸体老鼠异种皮移植模特儿独自比 AdenAFPD55-(IL-24 ) 或 AdenAFPD55-(SOCS3 ) 显示出好一些的 antitumor 效果。而且,我们的结果也在 HuH-7 房间由 AdenAFPD55-(SOCS3 ) 感染显示出 Jak/Stat3 小径的那封锁能下面调整一些 anti-apoptosis 蛋白质例如 XIAP, Bcl-xL,和 survivin,它可能敏化房间到导致的 AdenAFPD55-(IL-24 ) apoptosis。这些结果显示 AdenAFPD55-(IL-24 ) 的那个合作管理, AdenAFPD55-(SOCS3 ) 可以为肝癌症的治疗作为一个候选人服务治疗学的途径。 | Xin Cao Ruicheng Wei Xinran Liu Yan Zeng Hongling Huang Miao Ding Kangjian Zhang Xin-Yuan Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 1 |
| 7 | Spectral and biodistributional engineering of deep near-infrared chromophore显示文摘Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging. | Yan Dong Xicun Lu Yi Li Weichao Chen Lei Yin Jie Zhao Xinru Hu Xinran Li Zuhai Lei Yuyang Wu Hao Chen Xiao Luo Xuhong Qian Youjun Yang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 8 | Profiling the Bisecting N-acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry显示文摘Bisecting N-acetylglucosamine(GlcNAc),a GlcNAc linked to the coreβ-mannose residue via aβ1,4 linkage,is a special type of N-glycosylation that has been reported to be involved in various biological processes,such as cell adhesion and fetal development.This N-glycan structure is abundant in human trophoblasts,which is postulated to be resistant to natural killer cellmediated cytotoxicity,enabling a mother to nourish a fetus without rejection.In this study,we hypothesized that the human amniotic membrane,which serves as the last barrier for the fetus,may also express bisected-type glycans.To test this hypothesis,glycomic analysis of the human amniotic membrane was performed,and bisected N-glycans were detected.Furthermore,our proteomic data,which have been previously employed to explore human missing proteins,were analyzed and the presence of bisecting GlcNAc-modified peptides was confirmed.A total of 41glycoproteins with 43 glycopeptides were found to possess a bisecting GlcNAc,and 25 of these glycoproteins were reported to exhibit this type of modification for the first time.These results provide insights into the potential roles of bisecting GlcNAc modification in the human amniotic membrane,and can be beneficial to functional studies on glycoproteins with bisecting GlcNAc modifications and functional studies on immune suppression in human placenta. | Qiushi Chen Yuanliang Zhang Keren Zhang Jie Liu Huozhen Pan Xinran Wang Siqi Li Dandan Hu Zhilong Lin Yun Zhao Guixue Hou Feng Guan Hong Li Siqi Liu Yan Ren | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 9 | Enhancement of electro-strain performance of KTaO_(3)modified 0.94Bi_(0.5)Na_(0.5)TiO_(3)-0.06BaTiO_(3)ceramics显示文摘The(1−x)(0.94Bi_(0.5)Na_(0.5)TiO_(3)-0.06BaTiO_(3))-xKTaO_(3)(BNBT-xKT)lead-free ferroelectric ceramics were produced using the traditional solid-state sintering technique,and the phase structure,surface morphology,electrical properties were all thoroughly examined.Every ceramic has a single perovskite structure and there is no second phase,as shown by the XRD patterns and Raman spectra.Scanning electron microscopy revealed that all samples displayed dense microstructure and cubic grain.In addition,KT encourages grain growth due to the oxygen vacancies induced by doping or volatilization of ions at high temperatures.The Tm of the ceramics decreases with increasing doping levels due to oxygen vacancies acting as dipoles upon the addition of KT,and the dielectric loss of all samples is low at ambient temperature.In comparison to the pure BNBT ceramic’s bipolar strain value of 0.12%,the BNBT-2KT ceramic achieved a maximum bipolar strain of~0.506%and unipolar strain of~0.430%with the corresponding d33*up to 538 pm/V under 80 kV/cm field.Performance significantly improved as a result of this.A test of the correlation between temperature and ferroelectric properties shows that the largest strain value of the BNBT-2KT ceramic occurs at ambient temperature and that the phase change from ferroelectric to relaxor is complete.Additionally,it is discovered that the BNBT-3KT ceramic can sustain a stable strain across a broad temperature range,suggesting that it has good temperature stability.The aforementioned findings demonstrate that lead-based ceramics may be replaced with BNBT-xKT ceramics. | Xinran Wang Huanghui Nie Yan Yan Gang Liu | 2022 | Journal of Advanced Dielectrics2022，12，5： | 0 |
| 10 | Urine biomarkers discovery by metabolomics and machine learning for Parkinson’s disease diagnoses显示文摘Parkinson’s disease(PD)is a complex neurological disorder that typically worsens with age.A wide range of pathologies makes PD a very heterogeneous condition,and there are currently no reliable diagnostic tests for this disease.The application of metabolomics to the study of PD has the potential to identify disease biomarkers through the systematic evaluation of metabolites.In this study,urine metabolic profiles of 215 urine samples from 104 PD patients and 111 healthy individuals were assessed based on liquid chromatography-mass spectrometry.The urine metabolic profile was first evaluated with partial leastsquares discriminant analysis,and then we integrated the metabolomic data with ensemble machine learning techniques using the voting strategy to achieve better predictive performance.A combination of 8-metabolite predictive panel performed well with an accuracy of over 90.7%.Compared to control subjects,PD patients had higher levels of 3-methoxytyramine,N-acetyl-l-tyrosine,orotic acid,uric acid,vanillic acid,and xanthine,and lower levels of 3,3-dimethylglutaric acid and imidazolelactic acid in their urine.The multi-metabolite prediction model developed in this study can serve as an initial point for future clinical studies. | Xiaoxiao Wang Xinran Hao Jie Yan Ji Xu Dandan Hu Fenfen Ji Ting Zeng Fuyue Wang Bolun Wang Jiacheng Fang Jing Ji Hemi Luan Yanjun Hong Yanhao Zhang Jinyao Chen Min Li Zhu Yang Doudou Zhang Wenlan Liu Xiaodong Cai Zongwei Cai | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
| 11 | Research and Development of Field-scale Wind Information and Pollution Dispersion Fast Analysis Model显示文摘In order to response to sudden nuclear accident,air pollution and city terrorist attack,predicting wind information and smoke dispersion in time is very important for early emergency decision.At present,large-scale models are mainly used to analysis the dispersion of wind and pollution in our country,but it simplified the | WANG Xinran YAN Chao MIAO Shiguang CHENG Weiya ZHANG Liang | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome显示文摘As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B. | Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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