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| 1 | PlantcircBase: A Database for Plant Circular RNAs显示文摘 | Qinjie Chu Xingchen Zhang Xintian Zhu Chen Liu Lingfeng Mao Chuyu Ye Qian-Hao Zhu Longjiang Fan | 2017 | Molecular Plant2017，10，8： | 15 |
| 2 | Contribution of ultrasonic surface rolling process to the fatigue properties of TB8 alloy with body-centered cubic structure显示文摘The effect of ultrasonic surface rolling process(USRP) as a severe plastic deformation technology was investigated on the evolution of microstructure, residual stress and surface morphology of TB8 alloys with body-centered cubic structure. Stress-controlled rotating-bending fatigue tests indicated increased fatigue strength in USRP samples prepared using different number of passes compared to the base material, which was attributed to the presence of gradient structure surface layers. Five subsequent USRP passes resulted in the highest fatigue strength, due to the optimal surface properties including higher extent of grain refinement, larger compressive residual stresses, 'smoother' surface morphology and increased micro-hardness. However, the effect of USRP technology on improving fatigue strength of TB8 alloy was not significant in comparison with that of other titanium alloys(for example, Ti6 Al4 V), which was attributed to the notable surface residual stresses relaxation revealed from measurements on postfatigued USRP samples. Electron backscatter diffraction analysis confirmed that fatigue crack initiation occurred in the larger grains on the surface with high Schmid factor. Small cracks were found to propagate into the core material in a mixed transgranular and intergranular mode. Further analysis indicated that grain growth existed in post-fatigued USRP-treated TB8 samples and that the average geometrically necessary dislocations value reduced after fatigue loading. | Dan Liu Daoxin Liu Mario Guagliano Xingchen Xu Kaifa Fan Sara Bagherifard | 2021 | Journal of Materials Science & Technology2021，，2： | 5 |
| 3 | A lipid-based LMP2-mRNA vaccine to treat nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a serious and highly invasive epithelial malignancy that is closely associated with Epstein‒Barr virus(EBV).Due to the lack of therapeutic vaccines for NPC,we selected EBV latent membrane protein 2(LMP2)as a preferable targeting antigen to develop a lipid-based LMP2-mRNA(mLMP2)vaccine.Full-length mLMP2 expressing LMP2 was first synthesized using an in vitro transcription method and then encapsulated into(2,3-dioleacyl propyl)trimethylammonium chloride(DOTAP)-based cationic liposomes to obtain the mRNA vaccine(LPX-mLMP2).The cell assays showed that the antigenpresenting cells were capable of highly efficient uptake of LPX-mLMP2 and expression of LMP2.LMP2 could subsequently be presented to form the peptide-major histocompatibility complex(pMHC).Furthermore,LPX-mLMP2 could accumulate in the spleen,express antigens,promote the maturation of dendritic cells and stimulate antigen-specific T-cell responses in vivo.It dramatically inhibited the tumor growth of the LMP2-expressing tumor model after three doses of vaccination.Additionally,the proliferation of antigen-specific T cells in the tumor site made a good sign for the promise of mRNA vaccines in virus-induced cancer.Overall,we provided a newly developed antigen-encoding mRNA vaccine with advantages against NPC.We also demonstrated that mRNA vaccines are attractive candidates for cancer immunotherapy. | Mengran Guo Xing Duan Xingchen Peng Zhaohui Jin Hai Huang Wen Xiao Qian Zheng Yongqi Deng Na Fan Kepan Chen Xiangrong Song | 2023 | Nano Research2023，16，4： | 1 |
| 4 | Analysis on Pigment and Photosynthetic Characteristics of Leaves of New Strain of Rehmannia glutinosa显示文摘Through the analysis on the leaf color and photosynthetic characteristics of new strains and main cultivars of Rehmannia glutinosa,it is expected to provide theoretical basis for breeding of new varieties. Chlorophyll,anthocyanin,and net photosynthetic rate(Pn),stomatal conductance(Cond),transpiration rate(Tr),and intercellular CO2concentration(Ci) in 8 varieties of Rehmannia glutinosa were measured by spectrophotometer and LI-6400 XT Portable Photosynthesis System. The results showed that the chlorophyll content of Huaidijin 8(2. 84 mg/g),Huaidi 81(2. 71 mg/g),Huaidi 85-5(2. 69 mg/g),Jinjiu(2. 66 mg/g) and Huaidi 83(2. 63 mg/g) was higher; the anthocyanin content of Jinjiu(0. 169) and Huaidijin 8(0. 165) was higher,while the anthocyanin content Huaidi 83(0. 060) was the lowest; Pn of Huaidi81[2. 41 μmol/(m2·s) ],Huaidi 83[2. 37 μmol/(m2·s) ]and Huaidijin 8[2. 25 μmol/(m2·s) ]was higher,and the anthocyanin content was positively correlated with Pn,while the anthocyanin content was negatively correlated with Pn; Huaidijin 8 and Huaidi 83 showed dominant advantages in single plant fresh weight,indicator component,and resistance over the main cultivars. This indicates that the new variety Huaidijin 8 and Huaidi 83 have excellent comprehensive traits and can be properly popularized. | Xing FAN Xiaoting ZHOU Jun WANG Xingchen SHANG Jianjun LI | 2017 | Asian Agricultural Research2017，9，6： | 1 |
| 5 | Protective effect ofLycium ruthenicum Murr against radiation injury in mice显示文摘 | DUAN YABIN CHEN FAN YAO XINGCHEN | 2015 | IntJ Env Res Pub He2015，12，7： | 1 |
| 6 | Spin relaxation induced by interfacial effects in GaN/Al_(0.25) Ga_(0.75) N heterostructures显示文摘Spin relaxation induced by the interfacial effects in GaN/Al_(0.25) Ga_(0.75) N heterostructures was carefully investigated using a photon-energy-dependent time-resolved Kerr rotation spectrum.The existence of the interfacial localized states with potential fluctuations at the GaN/AlGaN heterointerface leads to photoluminescence peaks showing blue and S-shaped shifts owing to the excitation power and temperature,respectively.Photoexcited electrons in the localized states show a spin relaxation time longer than 1 ns because of the suppression of the D’yakonov-Perel’(DP)scattering,while the spin relaxation time of free electrons was approximately only 10 ps because of the giant Rashba spin-orbit coupling induced by the interfacial polarization field under the framework of the DP scattering mechanism.Furthermore,it is found that the high electron mobility at the heterointerface results in a long spin diffusion length of 300 nm at high temperatures,which is promising for the development of GaN-based spintronic devices. | Shixiong Zhang Ning Tang Xiaoyue Zhang Xingchen Liu Lei Fu Yunfan Zhang Teng Fan Zhenhao Sun Fentao Wang Weikun Ge Bo Shen | 2021 | Fundamental Research2021，1，6： | 0 |
| 7 | Deformation mechanism and in-situ TEM compression behavior of TB8βtitanium alloy with gradient structure显示文摘Severe plastic deformation is known to induce grain refinement and gradient structure on metals’surfaces and improve their mechanical properties.However,the fundamental mechanisms behind the grain refinement and micromechanical properties of materials subjected to severe plastic deformation are not still well studied.Here,ultrasonic surface rolling process(USRP)was used to create a gradient microstructure,consisting of amorphous,equiaxed nano-grained,nano-laminated,ultrafine laminated and ultrafine grained structure on the surface of TB8βtitanium alloy.High energy and strain drove element co-segregation on sample surface leading to an amorphous structure during USRP processing.In situ transmission electron microscope compression tests were performed in the submicron sized pillar extracted from gradient structure and coarse grain,in order to reveal the micromechanics behavior of different grain morphologies.The ultrafine grained layer exhibited the lowest yield stress in comparison with single crystal and amorphous-nanocrystalline layers;the ultrafine grained layer and single crystal had an excellent strain hardening rate.The discrepancy among the grain sizes and activated dislocation sources led to the above mentioned different properties.Dislocation activities were observed in both compression test and microstructure evolution of USRP-treated TB8 alloy.An evolution of dislocation tangles and dislocation walls into low angle grain boundaries and subsequent high angle grain boundaries caused the grain refinement,where twinning could not be found and no phase transformation occurred. | Dan Liu Daoxin Liu Junfeng Cui Xingchen Xu Kaifa Fan Amin Ma Yuting He Sara Bagherifard | 2021 | Journal of Materials Science & Technology2021，，25： | 0 |
| 8 | Patterning of large area nanoscale domains in as-grown epitaxial ferroelectric PbTiO_(3)films显示文摘Effective tuning of nanoscale domain structures provides fundamental basis for controlling and engineering of various functionalities in ferroelectric materials.In this work,we demonstrate the precise patterning of nanoscopic domain structures in as-grown epitaxial PbTiO_(3)(PTO)films by merely introducing an ultrathin pre-patterned doping layer(e.g.,Fe-doped PTO).The doping layer can effectively reverse the interfacial built-in bias,consequent to a reversed initial polarization reorientation in the as-grown film,which makes it possible to transfer the nano-patterns in the doping layer into the domain structure of ferroelectric films.For instance,we have successfully fabricated large area ordered array of nanoscale cylindrical domains(downward polarization)embedded in the matrix domain with opposite polarization(upward polarization)in PTO film.These nanoscale cylinder domains also allow deterministic and reversible erasure and creation induced by biased tip scanning.The results provide an effective pathway for on-demand patterning of large area nanoscale domains in the as-grown films,which may find applications in a wide range of nanoelectronic devices. | Luyong Zhang Guo Tian Wenda Yang Dongfeng Zheng Chuanjie Lin Jianbiao Xian Yihang Guo Xingchen Zhang Xiuqin Qiu Lanping Zhang Zhen Fan Deyang Chen Zhipeng Hou Minghui Qin Jun-Ming Liu Xingsen Gao | 2023 | Journal of Materiomics2023，9，1： | 0 |
| 9 | Creation and erasure of polar bubble domains in PbTiO_(3)films by mechanical stress and light illuminations显示文摘The controllable manipulation of polar topological structures(e.g.skyrmion bubble)in ferroelectric materials have been considered as a cornerstone for future programmable nano-electronics.Here,we present the effective creation and erasure of polar bubble states PbTiO_(3)(PTO)multilayers trigged by mechanical stress and light illumination,respectively.It was found that applying atomic force microscope(AFM)tip force can induced formation of nanoscale bubble domains from the initial monodomain state.Moreover,the created bubble domain can be eliminated by exposure to ultraviolet or infrared light illumination.The above results can be understood by modulation of depolarization screening charges and bias fields,as reflected by scanning Kelvin potential microscopic(SKPM)observations,whereby the flexoelectric effect from the tip force tends to remove the screening charges on top surface and modulate the bias field that favors the formation of bubble state while light illumination tends to recover the screen charges and favor the monodomain state.The results provide a good example for multi-field manipulation of polar topologies,which might create a new avenue towards the immerging new concept electronic devices. | Xingchen Zhang Hongying Chen Guo Tian Wenda Yang Zhen Fan Zhipeng Hou Deyang Chen Min Zeng Minghui Qin Jinwei Gao Xingsen Gao Jun-Ming Liu | 2023 | Journal of Materiomics2023，9，4： | 0 |
| 10 | miR-338-3p acts as a tumor suppressor in lung squamous cell carcinoma by targeting FGFR2/FRS2显示文摘Background:Lung cancer refers to the occurrence of malignant tumors in the lung,and squamous cell carcinoma is one of the most common pathological types of non-small cell lung cancer.Studies have shown that microRNAs(miRNAs)play an important role in the occurrence,development,early diagnosis,and treatment of lung cancer.This study aimed to explore the role and possible mechanism of MicroRNA-338-3p(miR-338-3p)in lung squamous cell carcinoma(LUSC). | Xia Shan Cheng Zhang Chunyu Li Xingchen Fan Guoxin Song Jingfeng Zhu Risheng Cao Xiuwei Zhang Wei Zhu | 2023 | Cancer Pathogenesis and Therapy2023，1，2： | 0 |
| 11 | CsPbBr_(3)-DMSO merged perovskite micro-bricks for efficient X-ray detection显示文摘Inorganic perovskite wafers with good stability and adjustable sizes are promising in X-ray detection but the high synthetic temperature is a hindrance.Herein,dimethyl sulfoxide(DMSO)is used to prepare the CsPbBr_(3)micro-bricks powder at room temperature.The CsPbBr_(3)powder has a cubic shape with few crystal defects,small charge trap density,and high crystallinity.A trace amount of DMSO attaches to the surface of the CsPbBr_(3)micro-bricks via Pb-O bonding,forming the CsPbBr_(3)-DMSO adduct.During hot isostatic processing,the released DMSO vapor merges the CsPbBr_(3)micro-bricks,producing a compact and dense CsPbBr_(3)wafer with minimized grain boundaries and excellent charge transport properties.The CsPbBr_(3)wafer shows a large mobility-lifetime(μτ)product of 5.16×10^(-4)cm^(2)·V^(-1),high sensitivity of 14,430μC·Gyair^(-1)·cm^(-2),low detection limit of 564 nGyair·s^(-1),as well as robust stability in X-ray detection.The results reveal a novel strategy with immense practical potential pertaining to high-contrast X-ray detection. | Tongyu Shi Wenjun Liu Jiongtao Zhu Xiongsheng Fan Zhengyu Zhang Xingchen He Rui He Jiahong Wang Kezhen Chen Yongshuai Ge Xiangming Sun Yanliang Liu Paul K.Chu Xue-Feng Yu | 2023 | Nano Research2023，16，7： | 0 |
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