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| 1 | Fault detection observer design for networked control system with long time-delays and data packet dropout显示文摘Focusing on the networked control system with long time-delays and data packet dropout,the problem of observerbased fault detection of the system is studied.According to conditions of data arrival of the controller,the state observers of the system are designed to detect faults when they occur in the system.When the system is normal,the observers system is modeled as an uncertain switched system.Based on the model,stability condition of the whole system is given.When conditions are satisfied,the system is asymptotically stable.When a fault occurs,the observers residual can change rapidly to detect the fault.A numerical example shows the effectiveness of the proposed method. | Xuan Li Xiaobei Wu Zhiliang Xu Cheng Huang | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 3 |
| 2 | Enhanced tumor homing of pathogen-mimicking liposomes driven by R848 stimulation: A new platform for synergistic oncology therapy显示文摘Although multifarious tumor-targeting modifications of nanoparticulate systems have been attempted in joint efforts by our predecessors,it remains challenging for nanomedicine to traverse physiological barriers involving blood vessels,tissues,and cell barriers to thereafter demonstrate excellent antitumor effects.To further overcome these inherent obstacles,we designed and prepared mycoplasma membrane(MM)-fused liposomes(LPs)with the goal of employing circulating neutrophils with the advantage of inflammatory cytokine-guided autonomous tumor localization to transport nanoparticles.We also utilized in vivo neutrophil activation induced by the liposomal form of the immune activator resiquimod(LPsR848).Fused LPs preparations retained mycoplasma pathogen characteristics and achieved rapid recognition and endocytosis by activated neutrophils stimulated by LPs-R848.The enhanced neutrophil infiltration in homing of the inflammatory tumor microenvironment allowed more nanoparticles to be delivered into solid tumors.Facilitated by the formation of neutrophil extracellular traps(NETs),podophyllotoxin(POD)-loaded MM-fused LPs(MM-LPs-POD)were concomitantly released from neutrophils and subsequently engulfed by tumor cells during inflammation.MM-LPs-POD displayed superior suppression efficacy of tumor growth and lung metastasis in a 4T1 breast tumor model.Overall,such a strategy of pathogen-mimicking nanoparticles hijacking neutrophils in situ combined with enhanced neutrophil infiltration indeed elevates the potential of chemotherapeutics for tumor targeting therapy. | Xiaobei Cheng Pei Yu Xiang Zhou Jiale Zhu Yubao Han Chao Zhang Lingyi Kong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 3 | PpTCP18 is upregulated by lncRNA5 and controls branch number in peach (Prunus persica) through positive feedback regulation of strigolactone biosynthesis显示文摘Branch number is an important agronomic trait in peach(Prunus persica)trees because plant architecture affects fruit yield and quality.Although breeders can select varieties with different tree architecture,the biological mechanisms underlying architecture remain largely unclear.In this study,a pillar peach(‘Zhaoshouhong’)and a standard peach(‘Okubo’)were compared.‘Zhaoshouhong’was found to have significantly fewer secondary branches than‘Okubo’.Treatment with the synthetic strigolactone(SL)GR24 decreased branch number.Transcriptome analysis indicated that PpTCP18(a homologous gene of Arabidopsis thaliana BRC1)expression was negatively correlated with strigolactone synthesis gene expression,indicating that PpTCP18 may play an important role in peach branching.Yeast one-hybrid,electrophoretic mobility shift,dual-luciferase assays and PpTCP18-knockdown in peach leaf buds indicated that PpTCP18 could increase expression of PpLBO1,PpMAX1,and PpMAX4.Furthermore,transgenic Arabidopsis plants overexpressing PpTCP18 clearly exhibited reduced primary rosette-leaf branches.Moreover,lncRNA sequencing and transient expression analysis revealed that lncRNA5 targeted PpTCP18,significantly increasing PpTCP18 expression.These results provide insights into the mRNA and lncRNA network in the peach SL signaling pathway and indicate that PpTCP18,a transcription factor downstream of SL signaling,is involved in positive feedback regulation of SL biosynthesis.This role of PpTCP18 may represent a novel mechanism in peach branching regulation.Our study improves current understanding of the mechanisms underlying peach branching and provides theoretical support for genetic improvement of peach tree architecture. | Xiaobei Wang Qiuping Wang Lixia Yan Yuhang Hao Xiaodong Lian Haipeng Zhang Xianbo Zheng Jun Cheng Wei Wang Langlang Zhang Xia Ye Jidong Li Bin Tan Jiancan Feng | 2023 | Horticulture Research2023，10，1： | 2 |
| 4 | Natural products:potential therapeutic agents for atherosclerosis显示文摘Atherosclerosis(AS)is an invisible killer among cardiovascular diseases(CVD),which has seriously threatened the life of quality.The complex pathogenesis of AS involves multiple interrelated events and cell types,such as macrophages,endothelial cells,vascular smooth muscle cells and immune cells.Currently,the efficacy of recommended statin treatment is not satisfactory.Natural products(NPs)have attracted increasing attention with regard to their broad structural diversity and biodiversity,which makes them a promising library in the demand for lead compounds with cardiovascular protective bio-activity.NPs can preclude the development of AS by regulating lipid metabolism,ameliorating inflammation,stabilizing plaques,and remodeling the gut microbiota,which lays a foundation for the application of NPs in clinical therapeutics. | CHENG Xiaobei ZHAO Caili JIN Zhiwei HU Jianping ZHANG Zhenzhen ZHANG Chao | 2022 | Chinese Journal of Natural Medicines2022，20，11： | 1 |
| 5 | Study on soot formation characteristics in the diesel combustion process based on an improved detailed soot model显示文摘 | Cheng Xiaobei Chen Liang Yan Fangqin | 2013 | Energy Conversion and Management2013，75，： | 1 |
| 6 | Tectonic Units Division of Crystalline Basement in the Tarim Basin, NW China显示文摘By the geological investigation for crystalline basement outcrops in Northeast and northwest margins of Tarim Basin,we provide essential constrains interpreting the structure,petrology and age of the pre-Sinian basement.On the basis of interpretation for aeromagnetic anomalies, | ZHOU Xiaobei LI Jianghai LI Wenshan CHENG Yalin WANG Honghao | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 1 |
| 7 | How to Stimulate Domestic Consumption?显示文摘DAYS ago I received an e-mail,the head-ing of which was 'No-one Should Buy Clothes in the Next Few Months Because Prices Will Soon Fall Sharply.'The sender is a casual acquaintance | CHENG XIAOBEI | 2009 | China Today2009，58，1： | 0 |
| 8 | Fuel Tax Reform Sparks Chain Reaction显示文摘THE fuel tax reform draft, long-awaited by Chinese consumers, was f inally released at the endof 2008. But the combined effect of the reform itself and depreciation of f inished oil in the domestic market disap-pointed domestic consumers. | CHENG XIAOBEI | 2009 | China Today2009，58，2： | 0 |
| 9 | Shanghai’s Hukou System Reform显示文摘CHINA’s f inancial center Shanghai re-cently aroused wide attention with its new hukou policy, which allows some non-locals to apply for per-manent residency in the city.In China, living in | CHENG XIAOBEI | 2009 | China Today2009，58，5： | 0 |
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