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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | A new feathered maniraptoran dinosaur fossil that fills a morphological gap in avian origin显示文摘Recent fossil discoveries have substantially reduced the morphological gap between non-avian and avian dinosaurs, yet avians including Archaeopteryx differ from non-avian theropods in their limb proportions. In particular, avians have proportionally longer and more robust forelimbs that are capable of supporting a large aerodynamic surface. Here we report on a new maniraptoran dinosaur, Anchiornis huxleyi gen. et sp. nov., based on a specimen collected from lacustrine deposits of uncertain age in western Liaoning, China. With an estimated mass of 110 grams, Anchiornis is the smallest known non-avian theropod dinosaur. It exhibits some wrist features indicative of high mobility, presaging the wing-folding mechanisms seen in more derived birds and suggesting rapid evolution of the carpus. Otherwise, Anchiornis is intermediate in general morphology between non-avian and avian dinosaurs, particularly with regard to relative forelimb length and thickness, and represents a transitional step toward the avian condition. In contrast with some recent comprehensive phylogenetic analyses, our phylogenetic analysis incorporates subtle morphological variations and recovers a conventional result supporting the monophyly of Avialae. | XU Xing ZHAO Qi NORELL Mark SULLIVAN Corwin HONE David ERICKSON Gregory WANG XiaoLin HAN FengLu GUO Yu | 2009 | Chinese Science Bulletin2009，54，3： | 15 |
| 3 | MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma显示文摘MicroRNAs(miRNAs) are endogenous small non-coding RNAs that repress their targets at post transcriptional level.Existing studies have shown that miRNAs are important regulatory genes in hepatocellular carcinoma(HCC),as either tumor suppressors or oncogenes.MiR-122 is normally downregulated in HCC and regarded as a tumor suppressor.Recently miR-122 has been reported to be regulated by CEBPA,which is then involved in a novel pathway to influence proliferation of tumor cells.However it is unknown whether CEBPA is regulated by miRNAs in HCC.In this study,we find that miR-182 is upregulated in HCC model rat,and represses CEBPA in both rat and human.This further improves the current CEBPA/miR-122 pathway that controls the proliferation of tumor cells.These results suggest that miR-182 is a potential oncogene in HCC and could be used as a diagnostic marker and drug target of HCC. | Chenggang Wang Ren Ren Haolin Hu Changjun Tan Miao Han Xiaolin Wang Yun Zheng | 2014 | Chinese Journal of Cancer Research2014，26，1： | 13 |
| 4 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 5 | Removal of 2-ClBP from soil–water system using activated carbon supported nanoscale zerovalent iron显示文摘We explored the feasibility and removal mechanism of removing 2-chlorobiphenyl(2-Cl BP)from soil–water system using granular activated carbon(GAC) impregnated with nanoscale zerovalent iron(reactive activated carbon or RAC).The RAC samples were successfully synthesized by the liquid precipitation method.The mesoporous GAC based RAC with low iron content(1.32%) exhibited higher 2-Cl BP removal efficiency(54.6%) in the water phase.The result of Langmuir–Hinshelwood kinetic model implied that the different molecular structures between 2-Cl BP and trichloroethylene(TCE) resulted in more difference in dechlorination reaction rates on RAC than adsorption capacities.Compared to removing2-Cl BP in the water phase,RAC removed the 2-Cl BP more slowly in the soil phase due to the significant external mass transfer resistance.However,in the soil phase,a better removal capacity of RAC was observed than its base GAC because the chemical dechlorination played a more important role in total removal process for 2-Cl BP.This important result verified the effectiveness of RAC for removing 2-Cl BP in the soil phase.Although reducing the total RAC removal rate of 2-Cl BP,soil organic matter(SOM),especially the soft carbon,also served as an electron transfer medium to promote the dechlorination of 2-Cl BP in the long term. | Wei Zhang Tian Yu Xiaolin Han Weichi Ying | 2016 | Journal of Environmental Sciences2016，28，9： | 8 |
| 6 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 7 | Effects of Brassinosteroid Associated with Auxin and Gibberellin on Apple Tree Growth and Gene Expression Patterns显示文摘Brassinosteroid is an important hormone that interacts with auxin and gibberellin to regulate plant growth and development. However,there is currently a relative lack of information regarding brassinosteroid in apple. Previous study confirmed that exogenous brassinosteroid treatments increased growth and endogenous brassinosteroid, auxin, as well as gibberellin levels of apple nursery trees. Here we succeeded to find that exogenous brassinosteroid treatments upregulated the transcript expression of auxin biosynthesis, transport, and positive signal transduction genes as well as gibberellin biosynthesis genes. In contrast, the application of exogenous brassinosteroid downregulated the expression of genes encoding negative regulators of auxin and gibberellin signal transductions. Rapid responses of several brassinosteroid-,auxin-, and gibberellin-related genes to the brassinosteroid and brassinazole treatments inferred the crosstalk of BR and IAA or GA. Furthermore,the expression levels of cell growth-related genes were also enhanced by exogenous brassinosteroid. Auxin and gibberellin treatments also influenced growth of apple tree and enhanced the expression of brassinosteroid-and cell growth-related genes. These results indicate that the growth of apple tree is regulated by the interaction between brassinosteroid, auxin, and gibberellin. Our work opened new avenues for deep portfolio of apple tree growth and laid the foundation for future studies aimed at elucidating the mechanisms regulating hormone interactionsmediated growth in apple trees. | Liwei Zheng Cai Gao Caide Zhao Lizhi Zhang Mingyu Han Na An Xiaolin Ren | 2019 | Horticultural Plant Journal2019，5，3： | 7 |
| 8 | Core-shell nanostructure of single-wall carbon nanotubes and covalent organic frameworks for supercapacitors显示文摘Covalent organic frameworks(COFs) were nano-coated onto single-walled carbon nanotubes(SWCNTs)by in situ polymerization of TpPa-COFs together with SWCNTs under solvothermal conditions. At the molecular level, the COF/SWCNT interface can be efficiently controlled. Thus, the TpPa-COF-SWCNTs nano-hybrid wire, which combines the excellent conductivity of SWCNTs and the high porosity and good redox activity of TpPa-COFs, was employed as active electrode materials for supercapacitors. The strategy reported in this work can give guidance for the design of other similar COF-based electrodes, and hold a great potential in energy | Yang Han Qin Zhang Nantao Hu Xue Zhang Yiyong Mai Jiaqiang Liu Xiaolin Hua Hao Wei | 2017 | Chinese Chemical Letters2017，28，12： | 5 |
| 9 | Vacancies and Antisites in B2 FeAl and DO_3 Fe_3Al with a Modified Analytic EAM Model显示文摘A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of vacancy and antisite were also calculated. The present calculations are in agreement with the experimental data and the theoretical results obtained by other authors. | Xiaolin SHU, Wan gyu HU, Hanning XIAO and Huiqiu DENG College of Materials Science and Engineering, Hunan University, Changsha 410082, China Ban gwei ZHANG International Centre of Materials Physics, Chinese Academy of Sciences, S | 2001 | Journal of Materials Science & Technology2001，17，6： | 4 |
| 10 | Active terahertz beam steering based on mechanical deformation of liquid crystal elastomer metasurface显示文摘Active metasurfaces are emerging as the core of next-generation optical devices with their tunable optical responses and flat-compact topography.Especially for the terahertz band,active metasurfaces have been developed as fascinating devices for optical chopping and compressive sensing imaging.However,performance regulation by changing the dielectric parameters of the integrated functional materials exhibits severe limitations and parasitic losses.Here,we introduce a C-shape-split-ring-based phase discontinuity metasurface with liquid crystal elastomer as the substrate for infrared modulation of terahertz wavefront.Line-focused infrared light is applied to manipulate the deflection of the liquid crystal elastomer substrate,enabling controllable and broadband wavefront steering with a maximum output angle change of 22°at 0.68THz.Heating as another control method is also investigated and compared with infrared control.We further demonstrate the performance of liquid crystal elastomer metasurface as a beam steerer,frequency modulator,and tunable beam splitter,which are highly desired in terahertz wireless communication and imaging systems.The proposed scheme demonstrates the promising prospects of mechanically deformable metasurfaces,thereby paving the path for the development of reconfigurable metasurfaces. | Xiaolin Zhuang Wei Zhang Kemeng Wang Yangfan Gu Youwen An Xueqian Zhang Jianqiang Gu Dan Luo Jiaguang Han Weili Zhang | 2023 | Light(Science & Applications)2023，12，1： | 4 |
| 11 | Modal identification of long-span Runyang Bridge using ambient responses recorded by SHMS显示文摘Runyang Bridge is a newly built cable-supported bridge that crosses the Yangtze River in China.The bridge is composed of one suspension bridge and one cable-stayed bridge.During the construction of the bridge,a structural health monitoring system(SHMS)was installed,which was designed by the Southeast University.Since the bridge was open to traffic,quantities of structural ambient responses have been recorded by the SHMS.And,it’s really important to extract structrural information from these records for health monitoring.This paper presents the study on modal identification of the bridge.The dynamic properites including modal frequencies,mode shapes and damping ratios are extracted from the ambient responses.Two identification methods are employed including the enhanced frequency domain decomposition and the stochastic subspace identification.The identified modal parameters from the two methods are compared.Results show that modal frequencies and mode shapes from the two methods are almost the same while the damping ratios are different. | QingGuo Fei AiQun Li XiaoLin Han ChangQing Miao | 2009 | Science China(Technological Sciences)2009，52，12： | 4 |
| 12 | Growth of covellite crystal onto azurite surface during sulfurization and its response to flotation behavior显示文摘In this work,the growth of copper sulfide crystal onto azurite surfaces during sulfurization and its response to flotation are investigated.Filed emission scanning electron microscopy-energy dispersive X-ray spectroscopy(FESEM) and X-ray diffraction(XRD) studies confirmed that the sulfurization of azurite is not limited to the mineral surface,but rather penetrates into the bulk to form covellite crystal(synCuS),creating favorable conditions for the stable adsorption of xanthate and greatly promoting the azurite flotation.Additionally,as demonstrated by X-ray photoelectron spectroscopy(XPS) and time of flight secondary ion mass spectrometry(TOF-SIMS) analyses,a redox reaction occurred during this process,and Cu(Ⅱ) onto the mineral surface was reduced to Cu(Ⅰ).Correspondingly,reduced S^(2-) was oxidized to(S_(2))^(2-),(S_n)^(-2),and even to deeper oxidation state S~0,(S_(x)O_(y))^(n-) and SO_(4)^(2-).Excess sodium sulfide strengthens copper sulfide to form onto the azurite surface,and provides enough raw material for crystal copper sulfide to grow,resulting in the formation of 'flake-like' covellite with a better crystallinity.However,the floatability of azurite decreased dramatically under this condition,because the generated massive colloidal copper sulfide in flotation pulp deteriorates the flotation environment,resulting in a decreased effective adsorption of collector onto azurite surfaces. | Jinpeng Cai Peilun Shen Dianwen Liu Xiaolin Zhang Jianjun Fang Chao Su Xingcai Yu Jiangli Li Han Wang | 2021 | International Journal of Mining Science and Technology2021，31，6： | 4 |
| 13 | The nodulation and nyctinastic leaf movement is orchestrated by clock gene LHY in Medicago truncatula显示文摘As sessile organisms,plants perceive,respond,and adapt to the environmental changes for optimal growth and survival.The plant growth and fitness are enhanced by circadian clocks through coordination of numerous biological events.In legume species,nitrogen-fixing root nodules were developed as the plant organs specialized for symbiotic transfer of ni-trogen between microsymbiont and host.Here,we report that the endogenous circadian rhythm in nodules is regulated by MtLHY in legume species Medicago truncatula.Loss of function of MtLHY leads to a reduction in the number of nodules formed,resulting in a diminished ability to assimilate nitrogen.The operation of the 24-h rhythm in shoot is further influenced by the availability of nitrogen produced by the nodules,leading to the irregulated nyctinastic leaf movement and reduced biomass in mtlhy mutants.These data shed new light on the roles of MtLHY in the orchestration of circadian oscillator in nodules and shoots,which provides a mechanistic link between nodulation,nitrogen assimilation,and clock function. | Yiming Kong Lu Han Xiu Liu Hongfeng Wang Lizhu Wen Xiaolin Yu Xiaodong Xu Fanjiang Kong Chunxiang Fu Kirankumar S.Mysore Jiangqi Wen Chuanen Zhou | 2020 | Journal of Integrative Plant Biology2020，62，12： | 4 |
| 14 | Efficient production of CYTL1 protein using mouse IgGK signal peptide in the CHO cell expression system显示文摘 | Xiaolin Wang Huihui Liu Wanqiong Yuan Yingying Cheng Wenling Han | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 3 |
| 15 | Highly Efficient Photoelectrocatalytic Reduction of CO2 to Methanol by a p–n Heterojunction CeO2/CuO/Cu Catalyst显示文摘Photoelectrocatalytic reduction of CO2 to fuels has great potential for reducing anthropogenic CO2 emissions and also lessening our dependence on fossil fuel energy.Herein,we report the successful development of a novel photoelectrocatalytic catalyst for the selective reduction of CO2 to methanol,comprising a copper catalyst modified with flower-like cerium oxide nanoparticles(CeO2 NPs)(a n-type semiconductor)and copper oxide nanoparticles(CuO NPs)(a p-type semiconductor).At an applied potential of−1.0 V(vs SCE)under visible light irradiation,the CeO2 NPs/CuO NPs/Cu catalyst yielded methanol at a rate of 3.44μmol cm^−2 h^−1,which was approximately five times higher than that of a CuO NPs/Cu catalyst(0.67μmol cm^−2 h^−1).The carrier concentration increased by^108 times when the flower-like CeO2 NPs were deposited on the CuO NPs/Cu catalyst,due to synergistic transfer of photoexcited electrons from the conduction band of CuO to that of CeO2,which enhanced both photocatalytic and photoelectrocatalytic CO2 reduction on the CeO2 NPs.The facile migration of photoexcited electrons and holes across the p–n heterojunction that formed between the CeO2 and CuO components was thus critical to excellent light-induced CO2 reduction properties of the CeO2 NPs/CuO NPs/Cu catalyst.Results encourage the wider application of composite semiconductor electrodes in carbon dioxide reduction. | Zhengbin Pan Ershuan Han Jingui Zheng Jing Lu Xiaolin Wang Yanbin Yin Geoffrey INWaterhouse Xiuguo Wang Peiqiang Li | 2020 | Nano-Micro Letters2020，12，2： | 3 |
| 16 | Joint DOA and polarization estimation for unequal power sources based on reconstructed noise subspace显示文摘In most literature about joint direction of arrival(DOA) and polarization estimation, the case that sources possess different power levels is seldom discussed. However, this case exists widely in practical applications, especially in passive radar systems. In this paper, we propose a joint DOA and polarization estimation method for unequal power sources based on the reconstructed noise subspace. The invariance property of noise subspace(IPNS) to power of sources has been proved an effective method to estimate DOA of unequal power sources. We develop the IPNS method for joint DOA and polarization estimation based on a dual polarized array. Moreover, we propose an improved IPNS method based on the reconstructed noise subspace, which has higher resolution probability than the IPNS method. It is theoretically proved that the IPNS to power of sources is still valid when the eigenvalues of the noise subspace are changed artificially. Simulation results show that the resolution probability of the proposed method is enhanced compared with the methods based on the IPNS and the polarimetric multiple signal classification(MUSIC) method. Meanwhile, the proposed method has approximately the same estimation accuracy as the IPNS method for the weak source. | Yong Han Qingyuan Fang Fenggang Yan Ming Jin Xiaolin Qiao | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 2 |
| 17 | Fermented soy whey induced changes on intestinal microbiota and metabolic influence in mice显示文摘Soy whey(SW)is generated as process waste while preparing soy protein isolates(SPI),and causing severe environmental pollution.Therefore,its value-added utilization is of prime importance for transforming and upgrading traditional industry.This study aims to utilize SW as a substrate for the growth of probiotics and produce a SW based synbiotics.By a series of trials,the effect of the dietary supplementation with this fermented SW(FSW)was analyzed on ICR mice's body weight,metabolites,and intestinal microbiota in 4 weeks.The results showed that,when SW was concentrated 15 times,the count of viable Lactobacillus casei reached 3.4×10^(9) CFU/mL by liquid fermentation method,which was the highest viable cell count among all test strains.In this FSW,the protein,amino acid,total dietary fibre,soluble dietary fibre,and oligosaccharide were 2.10%,1.63%,0.52%,0.51% and 0.79%,respectively.Compared to two control group,the total yields of the short chain fatty acids(SCFAs)were significantly improved(75%-125% at average),while the SCFAs structure was also significantly changed(especially acetic acid and butyrate)in the faeces of mice fed FSW.Meanwhile,FSW dietary addition was associated with the diversity and richness of the intestinal microbiota.Obviously,with mice's body weight loss,Firmicutes/Bacteroides ratio reduced accordingly(<1.21),and the abundance of Akkermansia muciniphila was significantly increased(the maximum amount was about 0.013%).In summary,our results indicated that the dietary supplementation of FSW affected mice's intestinal microbiota and metabolism and improved their health profile. | Wei Han Xuhui Zhuang Qian Liu Bo Sun Haijiang Miao Xiaolin Zhang | 2022 | Food Science and Human Wellness2022，11，1： | 2 |
| 18 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 19 | A taxonomy of peer-to-peer desktop grid paradigms显示文摘 | Zhao Han Liu Xiaoxin Li Xiaolin | 2011 | Cluster Computing2011，14，2： | 1 |
| 20 | Advances in inorganic nanoparticles trapping stiffness measurement:A promising tool for energy and environmental study显示文摘Optical tweezers system has emerged as an efficient tool to manipulate tiny particles in a non-invasive way.Trapping stiffness,as an essential parameter of an optical potential well,represents the trapping stability.Additionally,trapping inorganic nanoparticles such as metallic nanoparticles or other functionalized inorganic nanoparticles is important due to their properties of good stability,high conductivity,tolerable toxicity,etc.,which makes it an ideal detection strategy for bio-sensing,force calculation,and determination of particle and environmental properties.However,the trapping stiffness measurement(TSM)methods of inorganic nanoparticles have rarely been analyzed and summarized.Here,in this review,the principle and methods of TSM are analyzed.We also systematically summarize the progress in acquiring inorganic particles trapping stiffness and its promising applications.In addition,we provide prospects of the energy and environment applications of optical tweezering technique and TSM.Finally,the challenges and future directions of achieving the nanoparticles trapping stiffness are discussed. | Xiaolin Chen Jiajie Chen Jianxing Zhou Xiaoqi Dai Yuhang Peng Yili Zhong Ho-Pui Ho Bruce Zhi Gao Han Zhang Junle Qu Yonghong Shao | 2023 | Energy Reviews2023，2，2： | 1 |
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