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| 1 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 2 | Performance evaluation of deep learning-based post-processing and diagnostic reporting system for coronary CT angiography: a clinical comparative study显示文摘To the Editor:Coronary computed tomography angiography(CCTA)has been increasingly,widely performed for diagnosing coronary artery,disease,lAnatomical diagnosis,that is,stenosis grading,is stillthe main diagnostic index provided'by most CCTA tests.Post-processing and interpretation of stenosis are 2 essential'steps that need to be performed bycardiovascular imaging professionals from scan completion to diagnosis conclusion,which is repetitive and time-consuming,taking an average of 30 minutes each case in China and becoming the bottleneck and gradually creating an imbalance between supply and demand.In ine with the rapid development of artificial intelligence(Al)technology in recent years,it has been expected to solve these specific problems.We developed an AI system for automating post-processing and diagnostic reporting of CCTA data using deep learning algorithms to establishanew1-clickworkflowforeverydayuse,namely,CCTA-AI(Figure 1).To further assess its capabilities,this study intends to answer 2 following questions:To what extent can it improve the efficiency of post-processing?To what extent can CCTA-AI detect and calculate coronary artery stenosis due to each atherosclerotic plaque? | Nan Luo Yi He Jitao Fan Ning Guo Guang Yang Yuanyuan Kong Jianyong Wei Tao Bi Jie Zhou Jiaxin Cao Xianjun Han Fang Li Shiyu Zhang Rujing Sun Zhaozhao Wang Tian Ma Lixue Xu Hui Chen Hongwei Li Zhenchang Wang Zhenghan Yang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 3 | Decay rate for a class of viscoelasticity equation with nonlinear damping on the boundary显示文摘 | Han Xianjun | 2008 | J Math Anal Appl2008，340，： | 1 |
| 4 | Extraction, purifica- tion of Lycium barbarum polysaccharides and bioactivity of purified fraction显示文摘 | KE Mang ZHANG Xianjun HAN Zihua | 2011 | Carbohydrate Polymers2011，86，1： | 1 |
| 5 | Multilevel coverage location model of earthquake relief material storage repository considering distribution time sequence characteristics显示文摘The scientific location of earthquake emergency supply warehouses is conducive to the effective distribution of emergency relief resources and improved rescue efficiency in earthquake hazard. Comprehensively considering the regional population as well as coverage quality at the demand points, this paper aims to divide the coverage thresholds of earthquake emergency rescue and logistic supplies according to their time-series features,and to build a location model for supply warehouses according to the variety and amount of stored supplies considering their time-series features, in hope of optimizing the set covering issue of earthquake relief supply warehouses. The solution is approached with two methods: the target deviation rate minimization model and NSGA-Ⅱ algorithm. The results obtained by solving the target deviation rate minimization model can balance every target. The branch and bound algorithm can find the global optimal solution at a certain calculation scale with high calculation efficiency, but its efficiency decreases significantly when the operation scale increases. The NSGA-Ⅱ algorithm is more suitable for large-scale solution calculations with high calculation efficiency, and it can output a set of non-inferior solutions for decision makers to select from according to different preference. Taking Aba Prefecture in Sichuan Province as illustration, the feasibility of the model is validated;meanwhile, the effectiveness and benefits of the two approaches in solving the problem of multi-objective set covering of the warehouses are compared and analyzed. | Xianjun Guan Han Zhou Mengxin Li Ligang Zhou Huayou Chen | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，2： | 1 |
| 6 | Effect of acupuncture on rabbit bladder with urodynamic indexes显示文摘OBJECTIVE: To study the effect of acupuncture on rabbit bladder with urodynamic indexes. METHODS: New Zealand male rabbits were divided into control group, model group, treatment group 1 treated by acupuncture at Shenshu (BL 23) and treatment group 2 treated by acupuncture at Zhongji (CV 3). The urine dynamic parameters through the urethral catheter were detected in each group in order: fluctuation of pressure at filling phase of urinary bladder and flow rate in urination phase, which were used as quantification indexes of urinary bladder function. The urinary bladder abnormal model was prepared by administration of cholinergic stimulant; Regulatory effects of acupuncture at Shenshu (BL 23) and Zhongji (CV 3) on the abnormal state of the urinary bladder were respectively observed. RESULTS: 1) In the filling phase of urinary bladder and in the urination phase, the intravesical pressure wave in infilling (IPWI) and intravesical discharge rate (IDR) could be respectively recorded. 2)IPWI and IDR could become abnormality by neostigmine methyl sulfate [stability type IPWI: the control group (n=20, 80%) vs the model group (n=15, 14.3%), P<0.01; IDR and time regression equation: the control group (n=20, y=24.3 - 0.878x) vs the model group (n=15, y=40.0-5.15x), P<0.01]. 3) Abnormal IPWI's could be normalized respectively by acupuncture at Shenshu (BL 23) and Zhongji (CV 3) [the stability type IPWI wave: the model group (n= 2, 14.3%) vs the treatment group 1 (n=3, 30%), P> 0.05; the instability type IPWI wave: the model group (n=13, 85.7%) in vs the treatment group 2 (n=6, 60%), P>0.05]; 4) Abnormal IDR also could be turned to normality by acupuncture at Shenshu (BL 23) and Zhongji (CV 3), respectively [IDR and the time regression equation: the model group (n=15, y=40.0-5.15x) vs the treatment group 1 (n=10, y= 18.9-0.499x), P<0.01; the model group (n=15, y= 40.0-5.15x) vs the treatment group 2 (n=10, y= 17.5-0.251x), P<0.01]. CONCLUSION: 1) Urodynamic indexes can be used for study of mechanism of acupuncture effects; 2) The effect of acupuncture in the bladder filling phase is smaller than that in the urination phase; 3) Acupuncture has a very obvious effect on intravesical discharge rate. | Xianjun Meng Jing Han Xiaoran Ye Xiaoqing Huang | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 0 |
| 7 | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_(s)显示文摘Dear Editor,The ten mammalian Frizzleds(FZD1–10)belong to the class F of G protein-coupled receptors(GPCRs)and mediate WNT signaling through interaction with transducer proteins including Dishevelled(DVL)or heterotrimeric G proteins.1 Their involvement in human disease has put FZDs at the forefront of drug targets,especially anti-cancer therapy. | Lu Xu Bo Chen Hannes Schihada Shane C.Wright Ainoleena Turku Yiran Wu Gye-Won Han Maria Kowalski-Jahn Pawel Kozielewicz Carl-Fredrik Bowin Xianjun Zhang Chao Li Michel Bouvier Gunnar Schulte Fei Xu | 2021 | Cell Research2021，31，12： | 0 |
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