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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | An Uncanonical CCCH-Tandem Zinc-Finger Protein Represses Secondary Wall Synthesis and Controls Mechanical Strength in Rice显示文摘第二等的墙,代表生物资源的体积,在植物生长和改编上有大影响到环境。第二等的墙合成被一个复杂发信号 transduction 网络交换并且调整。然而,有这些规章的小径的有限理解。这里,我们报导(IIP4 )交往 ILA1 蛋白质 4 能镇压第二等的墙合成。IIP4 是象 Raf 一样 MAPKKK 的 phosphorylation 底层,但是它的功能是未知的。由产生 iip4 异种和相关转基因的植物,我们发现在 IIP4 的损害提高第二等的墙形成。基因表示和 transactivation 活动试金表明 IIP4 否定地调整 MYB61 和 CESA 的表示但是不绑 ? 他们的倡导者。IIP4 与 NAC29/NAC31 交往,第二等的墙合成的在上游的管理者,并且在植物压制下游地规章的小径。显示出的 Mutagenesis 分析那 phosphomimic IIP4 从原子核的蛋白质 translocate 到细胞质。而且,我们表明 IIP evolutionarily 被保存并且分享 unreported CCCH 主题,叫作 uncanonical CCCH 双人脚踏车锌手指蛋白质。一起,我们的学习提供机械学的卓见进第二等的墙合成的控制并且为在庄稼改进相关农学的特点介绍一个机会。 | Dongmei Zhang Zuopeng Xu Shaoxue Cao Kunling Chen Shance Li Xiangling Liu Caixia Gao Baocai Zhang Yihua Zhou | 2018 | Molecular Plant2018，11，1： | 14 |
| 3 | Arbuscular Mycorrhizal Fungi in Wetland Habitats and Their Application in Constructed Wetland: A Review显示文摘Over the last three decades, the presence and functional roles of arbuscular mycorrhizal(AM) fungi in wetland habitats have received increasing attention. This review summarized the mycorrhizal status in wetlands and the effect of flooding on AM fungal colonization. Plants of 99 families living in 31 different habitats have been found to be associated with AM fungi, even including submerged aquatic plants and several plant species that were thought to be nonmycorrhizal(Cyperaceae, Chenopodiaceae, and Plumbaginaceae). The functions of AM fungi in wetland ecological systems could be concluded as their influences on the composition,succession, and diversity of the wetland plant community, and the growth and nutrition of wetland plants. Affecting the composition,succession, and diversity of the wetland plant community, AM fungi have positive, negative, or neutral effects on the performance of different wetland species under different conditions. The factors that affect the application effect of AM fungi in constructed wetland(CW) include flooding, phosphorus, plant species, aerenchyma, salinity, CW types, operation modes of CW, and wastewater quality.The generalist AM fungi strains can be established spontaneously, rapidly, and extensively in wastewater bioremediation technical installations; therefore, AM fungi can be considered ideal inhabitants of technical installations for the plant-based bioremediation of groundwater contaminated by organic pollutants or other contaminants. In the future, roles of AM fungi and factors that affect the purifying capacity of AM-CW system must be understood to optimize CW ecosystem. | XU Zhouying BAN Yihui JIANG Yinghe ZHANG Xiangling LIU Xiaoying | 2016 | Pedosphere2016，26，5： | 12 |
| 4 | Genetic characterization and linkage disequilibrium mapping of resistance to gray leaf spot in maize(Zea mays L.)显示文摘Gray leaf spot(GLS),caused by Cercospora zeae-maydis,is an important foliar disease of maize(Zea mays L.)worldwide,resistance to which is controlled by multiple quantitative trait loci(QTL).To gain insights into the genetic architecture underlying the resistance to this disease,an association mapping population consisting of 161 inbred lines was evaluated for resistance to GLS in a plant pathology nursery at Shenyang in 2010 and 2011.Subsequently,a genome-wide association study,using 41,101 single-nucleotide polymorphisms(SNPs),identified 51 SNPs significantly(P<0.001)associated with GLS resistance,which could be converted into 31 QTL.In addition,three candidate genes related to plant defense were identified,including nucleotidebinding-site/leucine-rich repeat,receptor-like kinase genes similar to those involved in basal defense.Two genic SNPs,PZE-103142893 and PZE-109119001,associated with GLS resistance in chromosome bins 3.07 and 9.07,can be used for marker-assisted selection(MAS)of GLS resistance.These results provide an important resource for developing molecular markers closely linked with the target trait,enhancing breeding efficiency. | Liyu Shi Xiangling Lv Jianfeng Weng Hanyong Zhu Changlin Liu Zhuanfang Hao Yu Zhou Degui Zhang Mingshun Li Xiaoke Ci Xinhai Li Shihuang Zhang | 2014 | The Crop Journal2014，2，Z1： | 9 |
| 5 | Treatment effect investigation of underground continuous impervious curtain application in water-rich strata显示文摘Serious shaft lining failures often occur when shaft linings are constructed by passing them through the deep topsoil of Quaternary strata. This approach also leads to the formation of an aquifer at the bottom.Based on the theory of the additional stress which is the main reason for these failures, this study focuses on the treatment effect of underground continuous impervious curtain(UCIC) in terms of different factors, namely, the location, shape, range, and width, by using numerical simulation. Results show that the UCIC can reduce the stress concentration in the shaft lining formed in the bottom aquifer. The UCIC can also reinforce the shaft lining at different angles and can be applied in actual situations. The strength factors of the inner surface of the shaft lining increase after the UCIC are used. The material strength and width of the UCIC show an obvious effect on the stability of the shaft lining. Results proved that the UCIC could effectively strengthen the stability of the shaft lining when it was built in the aquifer or built in the aquifer and above and below the layer. | Tao Xiangling Ma Jinrong Zeng Wei | 2015 | International Journal of Mining Science and Technology2015，25，6： | 9 |
| 6 | Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo显示文摘Metal-organic frameworks(MOFs)as a class of porous functional materials have attracted more and more attention for biomedical applications.To date,MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas,high porosity,fluorescence functionalities and good biocompatibility.It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes,quantum dots,metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function.Importantly,excellent imaging capabilities are of great significance in living cells and in vivo for detection,diagnosis and cancer therapy.In this review,we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF-based nanocomposites and their potential biological clinical applications. | Meijia Liu Xiangling Ren Xianwei Meng Hongbo Li | 2021 | Chinese Journal of Chemistry2021，39，2： | 8 |
| 7 | TIMODAZ:A successful international cooperation project to investigate the thermal impact on the EDZ around a radioactive waste disposal in clay host rocks显示文摘Disposal of spent nuclear fuel and long lived radioactive waste in deep clay geological formations is one of the promising options worldwide. In this concept of the geological disposal system, the host clay formation is considered as a principal barrier on which the fulfillment of key safety functions rests. Between 2006 and 2010, the European Commission project TIMODAZ, which gathered 15 partners from 8 countries, has investigated the coupled thermo-hydro-mechanical (THM) effects on clay formations for geological disposal of radioactive waste, and specific attention was paid to investigating the thermal effect on the evolution of the damaged zone (DZ). Three types of potential host clay formations were investigated: the Boom Clay (Belgium), the Opalinus Clay (Switzerland) and the Callovo-Oxfordian argillite (France). Intensive experimental (laboratory and in situ in underground research laboratories) and numerical studies have been performed. Multi-scale approach was used in the course of the project. High degree of similarities between the failure modes, sealing process, stress paths, deformation, etc., observed in laboratories and in situ has been obtained, which increased the confidence in the applicability of laboratory test results and up-scaling perspective. The results of the laboratory and in situ tests obtained allowed the parameters for numerical models at various scales to be derived and provided the basis for the simplified performance assessment models that are used to assess the long-term safety of a repository. The good cooperation between the numerical modeler and experimenters has allowed an in-depth analysis of the experimental results and thus better understanding the underlying processes, and consequently increased the capabilities to model the THM effects in claystones. This paper presents the main achievements obtained by TIMODAZ project and shows how a European scientific community investigates a problem of concern in a collaborative way and how the obtained main results are applied to the performance assessment of a geological repository. | Xiangling Li | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，3： | 7 |
| 8 | Functional Diversity of CYCLOIDEA-like TCP Genes in the Control of Zygomorphic Flower Development in Lotus japonicus显示文摘CYCLOIDEA (CYC)-like TCP genes play key roles in dorsoventral differentiation of zygomorphic flowers in Papilionoideae legumes. In this study, we analyzed the kew mutants whose flowers lost lateral identity, and investigated the diverse functions of three LjCYC genes during zygomorphic flower development in the model legume Lotus japonicus. We showed that kew1 and kew3 are allelic mutants of LjCYC3, a CYC-like TCP gene. Through transgenic experiments, it was shown that LjCYC1 possesses dorsal activity similar to LjCYC2, and that LjCYC3 alone is sufficient to confer lateral activity, and an epistatic effect between dorsal and lateral activities was identified. Sequence analysis revealed a striking alteration at the 3 end of the LjCYC3 open reading frame (ORF) in comparison with those of LjCYC1 and LjCYC2 ORFs. Furthermore, it was found that LjCYC proteins could interact with each other and possess different activities by means of a transcriptional activity assay. Our data demonstrate that the sequence variation and the subsequent alteration of protein property play important roles in the functional diversity of different LjCYC genes in controlling zygomorphic flower development in Lotus japonicus. | Shilei Xu Yonghai Luo Zhigang Cai Xiangling Cao Xiaohe Hu Jun Yang Da Luo | 2013 | Journal of Integrative Plant Biology2013，55，3： | 6 |
| 9 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 10 | Antimonene:a long-term stable two-dimensional saturable absorption material under ambient conditions for the mid-infrared spectral region显示文摘We experimentally demonstrate a long-term stable two-dimensional saturable absorption material under ambient conditions—multi-layer antimonene feasible for the mid-infrared spectral region—for the first time to our knowledge. The multi-layer antimonene material prepared using a liquid-phase exfoliation method was coated on a quartz/Ca F_2 for characterizations and an Au mirror as a reflection-type saturable absorber(SA) device. It has a modulation depth of 10.5%, a saturation peak intensity of 0.26 GW∕cm^2, and a non-saturation loss of 19.1% measured at 2868.0 nm using the typical power-dependent method. By introducing the SA device into a linear-cavity Ho^(3+)∕ Pr^(3+)-codoped fluoride fiber laser at 2865.0 nm, stable Q-switched pulses were obtained. It generated a maximum output power of 112.3 m W and pulse energy of 0.72 μJ, while the shortest pulse duration and largest repetition rate were 1.74 μs and 156.2 k Hz, respectively. The long-term stability of the SA device was also checked using the same laser setup within 28 days. The results indicate that multi-layer antimonene is a type of promising long-term stable SA material under ambient conditions that can be applied in the mid-infrared spectral region. | HONGYU Luo XIANGLING TIAN YING GAO RONGFEI WEI JIANFENG LI JIANRONG QIU YONG LlU | 2018 | Photonics Research2018，6，9： | 5 |
| 11 | Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China显示文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART. | Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 5 |
| 12 | Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma显示文摘包括 3p21.3 区域,染色体 3p 的突变而产生之遗传的损失在 95100% 主要的鼻咽的癌(NPC ) 被发现活体检视,建议这个区域应该与 NPC 开发有关仔细怀有一些肿瘤 suppressor 基因(TSG ) 。在 3p21.3 定位的几 TSG 例如 RASSF1A, LTF 和 BLU,被表明了涉及 NPC 开发。LARS2 (leucyl-tRNA 合成酶 2, mitochondrial ) 另一基因位于染色体在 3p21.3 的 3 普通消除 region-1 (C3CER1 ) 。在这研究,我们在 NPC 集中了于 epigenetic 和 LARS2 的基因改变。LARS2 的 mRNA 表示被半量的反向的抄写聚合酶链反应(RTPCR ) 和即时 RTPCR 在 36 NPC 和 8 长期的鼻咽炎(NP ) 纸巾检测。随后, LARS2 的变化,突变而产生之遗传的损失,和 methylation 地位被聚合酶链 reaction-single-strand 符合构造多型性(PCR-SSCP ) 分析,同型结合的删除(HD ) 分析和 methylation 特定的聚合酶在主要 NPC 纸巾锁住反应。LARS2 的表示或下面规定都没在 78% 主要 NPC 纸巾被观察。没有变化,由定序的 PCR-SSCP 和 DNA 估计了,在倡导者区域和 exon 被发现在 NPC 纸巾的 1 LARS2,而 HD 在 LARS2 地点在 28% NPC 标本被检测。另外, LARS2 的 hypermethylation 在 64% NPC 样品被发现。我们的数据显示 LARS2 的那 inactivation 由基因并且 epigenetic 机制可以是在 NPC 的 carcinogenesis 的一个普通、重要的事件。 | Wen Zhou Xiangling Feng Hong Li Lei Wang Bin Zhu Weidong Liu Ming Zhao Kaitai Yao Caiping Ren | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 5 |
| 13 | Aeolian Facies Belts in the Taklimakan Desert显示文摘At least at the beginning of the last glacial epoch, the facies belts of dune sand, sandy loam and loess formed by winds had existed in the Taklimakan desert and areas south of it. There were no appreciable changes in the NE and NW wind systems and their wind fqrces that deposited dune sand, sandy loam and loess in the global cold stage since the last glacial epoch (accordingly no marked shifts of the boundaries of these aeolian facies belts took place. In the global warm stage since then, the climate in the Taklimakan desert and areas south of it became warm and dry, resulting in ablation of substantial volumes of ice and snow in their surrounding mountains and thus forming alluvial and diluvial deposits in the region. The alluvial-diluvial actions, however, failed to change the general framework of aeolian facies belts. | Li Baosheng, Dong Guangrong, Zhang Jiasheng, Li Sen,Jin Heling, Chen Huizhong, Wen Xiangle, Wang Yao, Lanzhou Desert Research Institute, Chinese Academy of Sciences, Lamhou, Gansuand Zhu YizhiXi’an Open Laboratory of Loess and Quaternary Geology, Chinese Academy of Sciences, Xi’an, Gansu Fei Zhenbi | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 4 |
| 14 | Optical detection of acetylcholine esterase based on CdTe quantum dots显示文摘In this study, we have constructed a simple, sensitive and rapid biosensor for detection of acetylcholine esterase (AChE) based on CdTe quantum dots (QDs). The detection limit of AChE by one-step enzyme reaction based on the thiolglycolic acid (TGA) stabilized QDs (TGA-QDs) was 10 U/L and the linear range was 10-100 and 100-1200 U/L, respectively. The detection limit of AChE by two-step enzyme reaction based on the 3-mercaptopropionic acid (MGA) stabilized QDs (MGA-QDs) was found to be 20 U/L and the linear range was 100-2500 U/L. The experimental conditions of biosensors were optimized, and the detection mechanism was studied. We also detected AChE in serum samples based on TGA-QDs or MGA-QDs. The linear range was 10-140 and 50-1000 U/L, respectively. The excellent performance of this novel biosensor demonstrated that this strategy has prodigious potential to be applied in practice detection of AChE. | CHEN ZhenZhen REN XiangLing TANG FangQiong | 2013 | Chinese Science Bulletin2013，58，21： | 3 |
| 15 | Sensitive detection of dopamine and quinone drugs based on the quenching of the fluorescence of carbon dots显示文摘In this work,we demonstrated that the quinone structure can quench the fluorescence of the carbon dots(CDs).The sensitive determination of dopamine(DA) was studied primarily based on this principle.DA would be transformed into DA quinone under alkaline conditions,which resulted in fluorescence quenching of the CDs.A good linear range from 5 nmol/L to 0.4 mmol/L was obtained and the detection limit was 1 nmol/L.Moreover,the quenching effect of quinone structure on the fluorescence of CDs was confirmed by Fourier transform infrared spectra,time-correlated single-photon counting and X-ray photoelectron spectroscopy.Remarkably,CDs were firstly applied to detect the quinone drugs quantitatively which contained typical quinone structure based on the quenching mechanism.More than this,the sensing platform was demonstrated to provide credible selectivity and satisfactory stability in human serum solution with good liner range.Hence,our practical application and mechanism have showed great potential for diagnostic purposes. | Xiangling Ren Jiejie Ge Xianwei Meng Xiaozhong Qiu Jun Ren Fangqiong Tang | 2016 | Science Bulletin2016，61，20： | 3 |
| 16 | Milled flaxseed-added diets ameliorated hepatic inflammation by reducing gene expression of TLR4/NF-κB pathway and altered gut microbiota in STZ-induced type 1 diabetic mice显示文摘Flaxseed has displayed the potential beneficial as functional foods.However,most studies focused on effects of flaxseed extracts or ingredients in flaxseed.Besides,few studies showed that flaxseed extracts contributed to anti-type 1 diabetes(T1D),yet the underlying mechanism is still unknown.In the present study,16.7% of milled flaxseed(MF)-added diet was given to diabetic mice induced by streptozocin for 6 weeks.The results showed that MF feeding 1)slightly decreased blood glucose levels and improved the ability of glucose tolerance by oral glucose tolerance test,2)decreased liver tumor necrosis factor-αlevels and increased liver glycogen levels with significance via down-regulating TLR4/NF-κB pathways,3)and significantly altered some beneficial bacteria in gut microbiota.In conclusion,the present study showed that milled flaxseed showed the potential on anti-T1D through anti-inflammation via TLR4/NF-κB and altering the gut microbiota in STZ-induced diabetic mice. | Hui Xia Xiangling Shi Beijia Zhou Jing Sui Chao Yang Hechun Liu Ligang Yang Shaokang Wang Guiju Sun | 2022 | Food Science and Human Wellness2022，11，1： | 3 |
| 17 | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery显示文摘The incidence rate of diabetes has been increasing every year in nearly all nations and regions.The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections.While microneedle arrays(MAs)have emerged as painless delivery techniques,the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized.In this study,we developed an iontophoresis-microneedle array patch(IMAP)powered by a portable smartphone for the active and controllable transdermal delivery of insulin.The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch,achieving a one-step drug administration strategy of“penetration,diffusion and iontophoresis”.The MA of the IMAP is first pressed on the skin to create microholes and then is retracted,followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner.This method has synergistically and remarkably enhanced controlled insulin delivery.The amount of insulin can be effectively regulated by the IMAP by applying different current intensities.This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model,with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis.The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care. | Jingbo Yang Yanjun Li Rui Ye Ying Zheng Xiangling Li Yuzhen Chen Xi Xie Lelun Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 18 | Effect of Draw Ratio on the Morphologies and Properties of BPDA/PMDA/ODA Polyimide Fibers显示文摘 | ZHANG Chunling ZHANG Qiong XUE Yanhu LI Guomin LIU Fangfang QIU Xuepeng JI Xiangling GAO Lianxun | 2014 | Chemical Research in Chinese Universities2014，30，1： | 3 |
| 19 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 20 | Prevalence trend and risk factors for anemia among patients with human immunodeficiency virus infection receiving antiretroviral therapy in rural China显示文摘OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection. | Jin Yantao Liu Sa Yuan Jun Meng Xiangle Guo Huijun Xu Liran Xu Qianlei | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 2 |
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