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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo显示文摘Metal-organic frameworks(MOFs)as a class of porous functional materials have attracted more and more attention for biomedical applications.To date,MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas,high porosity,fluorescence functionalities and good biocompatibility.It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes,quantum dots,metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function.Importantly,excellent imaging capabilities are of great significance in living cells and in vivo for detection,diagnosis and cancer therapy.In this review,we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF-based nanocomposites and their potential biological clinical applications. | Meijia Liu Xiangling Ren Xianwei Meng Hongbo Li | 2021 | Chinese Journal of Chemistry2021，39，2： | 8 |
| 3 | Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China显示文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART. | Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 5 |
| 4 | Sensitive detection of dopamine and quinone drugs based on the quenching of the fluorescence of carbon dots显示文摘In this work,we demonstrated that the quinone structure can quench the fluorescence of the carbon dots(CDs).The sensitive determination of dopamine(DA) was studied primarily based on this principle.DA would be transformed into DA quinone under alkaline conditions,which resulted in fluorescence quenching of the CDs.A good linear range from 5 nmol/L to 0.4 mmol/L was obtained and the detection limit was 1 nmol/L.Moreover,the quenching effect of quinone structure on the fluorescence of CDs was confirmed by Fourier transform infrared spectra,time-correlated single-photon counting and X-ray photoelectron spectroscopy.Remarkably,CDs were firstly applied to detect the quinone drugs quantitatively which contained typical quinone structure based on the quenching mechanism.More than this,the sensing platform was demonstrated to provide credible selectivity and satisfactory stability in human serum solution with good liner range.Hence,our practical application and mechanism have showed great potential for diagnostic purposes. | Xiangling Ren Jiejie Ge Xianwei Meng Xiaozhong Qiu Jun Ren Fangqiong Tang | 2016 | Science Bulletin2016，61，20： | 3 |
| 5 | Prevalence trend and risk factors for anemia among patients with human immunodeficiency virus infection receiving antiretroviral therapy in rural China显示文摘OBJECTIVE: To estimate the prevalence trend and risk factors for anemia in patients with human immunodeficiency virus(HIV) infection receiving antiretroviral therapy(ART) in rural China.METHODS: We conducted cross-sectional studies among the same population in 2010, 2012, and2014, based on data from standard medical record registers. Factors associated with anemia were evaluated using a logistic regression model.RESULTS: The number of patients with HIV infec-tion included in each cross-sectional study was1456 in 2010, 1531 in 2012, and 1567 in 2014, and the prevalence of anemia was 44.3%, 34.7%, and27.6%, respectively. The prevalence of anemia was lower in female patients in 2010 [odds ratio(OR)0.68; 95% confidence interval(CI) 0.55-0.85]; however, there was no difference by sex in 2012(OR0.90; 95% CI 0.72-1.11) and 2014(OR 1.05; 95% CI0.84-1.32). Patients with a higher level of education had a lower risk of anemia in 2014(OR 0.72; 95% CI0.56-0.92), but there was no difference in 2010(OR1.00; 95% CI 0.79-1.25) and 2012(OR 0.99; 95% CI0.79-1.24). Patients who had received a longer duration of ART had a higher risk of anemia in 2014(OR1.74; 95% CI 1.15-2.64), but there was no difference in 2010 and 2012(P > 0.05). Patients receiving Traditional Chinese Medicine(TCM) therapy had a lower risk of anemia.CONCLUSION: The prevalence of anemia among patients with HIV infection receiving ART decreased between 2010 and 2014 in Henan Province but was still higher than the prevalence in the general population of China. TCM therapy can potentially decrease the risk of anemia among patients with HIV infection. | Jin Yantao Liu Sa Yuan Jun Meng Xiangle Guo Huijun Xu Liran Xu Qianlei | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 2 |
| 6 | Putative Phosphatase UvPsr1 Is Required for Mycelial Growth, Conidiation, Stress Response and Pathogenicity in Ustilaginonidea virens显示文摘Ustilaginoidea virens is the causal agent of rice false smut,which can be a highly destructive disease of rice.The plasma membrane phosphatase Psr1 proteins,which act as a regulator of the salinity stress response in yeast,are widely distributed across fungi,but their functional characterization is sketchy.In this study,we characterized the functions of Psr1 protein,UvPsr1,in U.virens.Analyses of the AUvpsr1 and its complementation strain showed that UvPsr1 is required for normal mycelial growth,conidiation and tolerance to oxidative,osmotic and cell wall stresses.When rice panicles were inoculated with the AUvpsr1 strains,no symptoms of false smut disease developed,showing that UvPSR1 also contributes to the pathogenicity of the fungus.The deletion mutant of UvPSR1 also appeared to produce a smaller titer of toxic compounds able to inhibit elongation of the germinated seeds.In conclusion,our results indicated that UvPsr1 is a new pathogenic factor of U.virens. | Xiong Meng Meng Shuai Qiu Jiehua Shi Huanbin Shen Xiangling Kou Yanjun | 2020 | Rice science2020，27，6： | 2 |
| 7 | Superoxide dismutase mimetic ability of Mn-doped ZnS QDs显示文摘Superoxide dismutase(SOD) is an important antioxidant enzyme in the body. SOD has special physiological activity and is the primary substance for scavenging free radicals in living organisms.However, the expensive and complex extraction processes, low SOD yield, as well as difficult to store at room temperature have seriously hindered its application pace. Herein, the enzyme mimetic function of Mn-doped ZnS quantum dots(QDs) was discovered. The improved Marklund and McCord method both showed that Mn-doped ZnS QDs possess intrinsic SOD-like activity. The effects of temperature and pH on the mimetic enzyme activity of Mn-doped ZnS QDs have been investigated compared with SOD enzymes.The low cost and easy to synthesize white Mn-doped ZnS QDs with good biocompatibility are expected to be used as a new type of SOD nanozymes in the biology-relevant fields. | Xiangling Ren Mingqian Wang Xing He Zheng Li Jing Zhang Wei Zhang Xudong Chen Hong Ren Xianwei Meng | 2018 | Chinese Chemical Letters2018，29，12： | 2 |
| 8 | Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis显示文摘Circular RNAs(circRNAs)play either oncogenic or tumor suppressive roles in gastric cancer(GC).A previous study demonstrated that circ_002059,a typical circRNA,was downregulated in GC tissues.However,the role and mechanism of circ_002059 in GC development are still unknown.In this study,the levels of circ_002059,miR-182,and metastasis suppressor-1(MTSS1)were examined by real-time quantitative polymerase chain reaction and western blot analysis.Cell proliferation and migration were evaluated by MTT assay and Transwell migration assay,respectively.The interactions between miR-182 and circ_002059 or MTSS1 were analyzed by dual-luciferase reporter assay.A GC xenograft model was established to validate the role of circ_002059 in GC progression in vivo.Overexpression of circ_002059 significantly inhibited,whereas knockdown of circ_002059 notably facilitated,cell proliferation and migration in GC cells.MTSS1 was found to be a direct target of miR-182 and circ_002059 upregulated MTSS1 expression by competitively sponging miR-182.Transfection with miR-182 mimic and MTSS1 silencing abated the inhibitory effect of circ_002059 on GC progression.Circ_002059 inhibited GC cell xenograft tumor growth by regulating miR-182 and MTSS1 expression.Collectively,Circ_002059 inhibited GC cell proliferation and migration in vitro and xenograft tumor growth in mice,by regulating the miR-182/MTSS1 axis. | Ting Li Xiaomin Zuo Xiangling Meng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 1 |
| 9 | 11-Mercaptoundecanoic acid functionalized gold nanoclusters as fluorescent probes for the sensitive detection of Cu^(2+) and Fe^(3+) ions显示文摘Metal ions are physiologically essential,but excessive metal ions may cause severe risk to plants and animals.Here,we prepared gold nanoclusters(Au NCs) protected by 11-mercaptoundecanoic acid(11-MUA),which have excellent fluorescence properties for the detection of metal ions.The results showed that the copper ions(Cu^(2+)) and iron ions(Fe^(3+)) in the solution have obvious quenching effect on the fluorescence intensity of Au NCs.The detection range of Fe^(3+) was 0.8–4.5 mmol/L(R^2= 0.992) and 4.5–11.0 mmol/L(R^2= 0.997).And Cu^(2+) has a lower linear range(0.1–1.0 mmol/L,R2= 0.993).When EDTA was added into the reaction system,it was observed that the quenching effect of Cu^(2+) and Fe^(3+)on Au NCs showed different phenomenon.Then,the effect of metal ions on the fluorescence of Au NCs was investigated.The selective detection of Cu^(2+) was achieved by EDTA masking of Fe^(3+).In addition,we realized the metal ions detection application of Au NCs in the | Zhiqun Bai Xiangling Ren Zhen Gong Chenxi Hao Yongmei Chen Pingyu Wan Xianwei Meng | 2017 | Chinese Chemical Letters2017，28，9： | 1 |
| 10 | Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus显示文摘Silica nanorattles(SNs) with zinc oxide(ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus(MRSA) for the first time. SNs loaded with ZnO nanoparticles,which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria. Nanorough silica shell surfaces maintain the high activity and stability of small-sized ZnO nanoparticles and gather ZnO nanoparticles together to enhance production, which improves the efficiency of free radicals against the cytomembranes of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles to MRSA cells shortens the effective touching distance between free radicals and MRSA, which also improves antibacterial activity. As we expected, the ZnO@SN nanoparticles exhibit a better antibacterial effect than free ZnO nanoparticles against MRSA in vitro and in vivo. We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate wound healing in MRSA skin inflammation models. This method of multilevel functionalization will be potentially applicable to the antibacterial field. | Qianqian Chai Qiong wu Tianlong Liu Longfei Tan Changhui Fu Xiangling Ren Yue Yang Xianwei Meng | 2017 | Science Bulletin2017，62，17： | 1 |
| 11 | Luminescent silver nanoclusters for efficient detection of adenosine triphosphate in a wide range of pH values显示文摘In this work,polymethacrylic acid(PMAA)-templated silver nanoclusters(Ag NCs)were developed as the fluorescent probe for the efficient and sensitive detection of adenosine triphosphate(ATP)in a wide range of pH values.The fluorescence intensity of the Ag NCs could keep stable with pH values ranging from2.5 to 9.3.The detection of ATP was based on the quenching of the fluorescent Ag NCs in the presence of ATP.The fluorescence quenching of the Ag NCs with increasing ATP concentration was studied at pH 2.5,4.5,7.0 and 8.5 which involved a wide pH environment in body fluids.The limit of detection(LOD)for ATP was as low as 0.1 mmol/L in an acidic environment with pH of 2.5 and all the linear correlation coefficients were satisfactory under wide-span pH values from 2.5 to 8.5.In addition,the sensitive determination of ATP was also achieved by adding copper ions(Cu^2+).The high selectivity and rapid detection process proved that the fluorescent probe had great potential to detect ATP in biological samples under different pH conditions. | Meijia Liu Xiangling Ren Xin Liu Longfei Tan Hui Li Jing Wei Changhui Fu Qiong Wu Jun Ren Hongbo Li Xianwei Meng | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 12 | Using Silver Nanopartiele to Enhance Current Response of Biosen- sor显示文摘 | REN Xiangling MENG Xianwei CHEN Dong | 2004 | Biosens Bioelectron2004，21，3： | 1 |
| 13 | Influence of hip frac ture type on outcome in elderly hip fracture 显示文摘 | Dai Bing Luo Hongtao Meng Xiangle | 2010 | Chin J clini cians2010，4，5： | 1 |
| 14 | Using silver nanoparticle to enhance current response of biosensor显示文摘 | Ren Xiangling Meng Xianwei Chen Dong | 2005 | Biosensors and Bioelectronics2005，21，3： | 1 |
| 15 | Novel injectable biomimetic hydrogels with carbon nanofibers and self assembled rosette nanotubes for myocardial applications显示文摘 | Xiangling Meng David A. Stout Linlin Sun Rachel L. Beingessner Hicham Fenniri Thomas J. Webster | 2012 | J Biomed Mater Res2012，，4： | 1 |
| 16 | A simpleand- sensitive fluorescence biosensor for detection of organophosphorus pesticides using H202-sensitive quantum dots/hi-enzyme 显示文摘 | Xianwei Meng Jianfei Wei Xiangling Ren et al | 2013 | Biosensors and Bioeleetronics2013，47，： | 1 |
| 17 | Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy显示文摘A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,named as COF-AP-IL@HA.AP loading rate in COF hollow-spheres(~30 nm shell thickness)was~40.3%,due to the interactions of hydrogen andπ-πbonds between AP and COF shell,and acidic environment destroyed COF structure,promoting AP release.Microwave sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect,and combined AP therapeutic ability,leading to their higher inhibitation on tumor,due to targeting ability of HA and the local release of apatinib.88.9%of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave(12.3%)and COF-IL@HA with microwave(37.5%),indicating a synergism of sensitized microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible factor.These results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized microwave hyperthermia and apatinib. | Qijun Du Jian Zou Zhongbing Huang Shimei Li Longfei Tan Xiangling Ren Guangfu Yin Yongfa Zheng Xianwei Meng | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 18 | Exceptionally high genetic variance of the doubled haploid(DH)population of poplar显示文摘Doubled haploid(DH)plants have been widely used for breeding and biological research in crops.Pop ulus spp.have been used as model woody plant species for biological research.However,the induction of DH poplar plants is onerous,and limited biological or breeding work has been carried out on DH individuals or populations.In this study,we provide an effective protocol for poplar haploid induction based on an anther culture method.A total of 96 whole DH plant lines were obtained using an F1hybrid of Populus simonii×P.nigra as a donor tree.The phenotypes of the DH population showed exceptionally high variance when compared to those of half-sib progeny of the donor tree.Each DH line displayed distinct features compared to those of the other DH lines or the donor tree.Additionally,some excellent homozygous lines have the potential to be model plants in genetic and breeding studies. | Caixia Liu Sui Wang Yi Liu Meng Wang Erqin Fan Chen Liu Shikai Zhang Chuanping Yang Junhui Wang Heike W.Sederoff Xiangling You Vincent L.Chiang Su Chen Ronald R.Sederoff Guanzheng Qu | 2023 | Journal of Forestry Research2023，34，6： | 0 |
| 19 | Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2显示文摘Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy.The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase(especially M2-type isozyme,PKM2),the rate limiting enzyme of glycolysis.This is helpful to the treatment of tumor.Herein,metal organic frameworks(MOFs) were found to inhibit the activity of PKM2.Nanoscale ZIF-8 was synthesized by standing and ultrasonic method,respectively.The ZIF-8 has the performance of inhibiting PKM2.Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8.Interestingly,the IC_(50) of ZIF-8 on PKM2 was one percent of that of zinc ion.This novel enzyme inhibitor is expected to be used in cancer therapy. | Xiangling Ren Xinyuan Huang Qiong Wu Longfei Tan Changhui Fu Yi Chen Xianwei Meng | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 20 | Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy显示文摘Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy. | Yuanwen Zou Wei Zhang Hongqiao Zhou Changhui Fu Longfei Tan Zhongbing Huang Xiangling Ren Jun Ren Xudong Chen Xianwei Meng | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
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