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| 1 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 2 | Modeling the yaw dynamics of an unmanned helicopter through modes partition method显示文摘The main difficulties in modeling yaw dynamics of a helicopter arise from the high nonlinearities,cross-couplings and dynam-ic uncertainties of these aerocraft.This paper proposes a new identification approach for yaw dynamics modeling through modes partition method(MPM) with a concentrated search space limited by implicit human factors.Working from first princi-ples and basic aerodynamics,the nonlinear equations of motion for yaw dynamics is derived.The model is linearized and transformed into a combination of dynamic modes,whose coefficients are identified from real-flight data through distributed genetic algorithm(DGA).The effectiveness of the approach is validated in terms of the identified model which can accurately capture the dynamic characters of the helicopter.Time-and frequency-domain results clearly demonstrate the potential of MPM in modeling such complex systems. | WANG GuanLin XIA Hui YUAN XiaMing FAN Yong ZHU JiHong | 2012 | Science China(Technological Sciences)2012，55，1： | 3 |
| 3 | Software Engineering in the Application of Virtual Instrument-Based Dynamics Testing System for UAV显示文摘 | Jing Huang Jihong Zhu Xiaming Yuan | 2013 | 通讯和计算机(中英文版)2013，10，7： | 2 |
| 4 | Design and hovering control of a twin rotor tail-sitter UAV显示文摘The tail-sitter unmanned aerial vehicles (UAVs)combine the vertical takeoff and landing (VTOL)capabilities of rotary-wing UAVs and the efficient long-distance flight capability of fixed-wing UAVs.When compared with other hybrid aircraft configurations such as tilt-rotor [1] and tilt-wing [2]UAVs, the tail-sitter UAV possesses the simplest configuration and requires no extra mechanisms for performing the VTOL maneuver. This brings several benefits including high payload and low susceptibility to malfunctions. | Wufan WANG Jihong ZHU Minchi KUANG Xiaming YUAN Yunfei TANG Yaqing LAI Lyujie CHEN Yunjie YANG | 2019 | Science China(Information Sciences)2019，62，9： | 1 |
| 5 | Lineage diversification and niche evolution in the Reeves’Butterfly Lizard Leiolepis reevesii(Agamidae)显示文摘We used mitochondrial cytochrome b and ND4 genes and 9 microsatellite loci to determine genetic diversity,population structure,evolutionary history,and migration patterns within the Reeves’butterfly lizard Leiolepis reevesii(Agamidae).Considering molecular-based phylogeographical lineages,we then performed niche equivalency and similarity tests between divergent lineages.Phylogenetic analyses based on mitochondrial DNA(mtDNA)data revealed 2 lineages(A and B)diverging≈0.84 million years ago and,respectively,restricted to the northern and southern portions of the Wuzhishan and Yinggeling mountain ranges.Lineage B contains individuals from southern Hainan;Lineage A includes individuals from all other localities and can be further divided into 3 clusters according to microsatellite data.The null hypothesis that the 2 lineages shared identical niches was rejected in all niche equivalency tests,indicating niche shifts during genetic divergence.Similarity tests provided evidence of niche conservatism,suggesting that the 2 lineages share more characteristics of their niche spaces than randomly expected.The niche similarity and equivalency tests indicated a complex niche pattern in which both lineages share a main portion of their ecological spaces.The climatic niche of Lineage B represented a marginal and specialized fraction of the entire ecological space of the climatic niche of Lineage A,with warmer conditions.Isolation caused by orogenesis and subsequent niche divergence,together with local adaptation,may have led to genetic differentiation and further lineage sorting in L.reevesii. | Xiaming ZHU Lei HUA Mengchao FANG Yu DU Chixian LIN Longhui LIN Xiang JI | 2021 | Integrative Zoology2021，16，3： | 1 |
| 6 | Cooperative prediction guidance law in target-attacker-defender scenario显示文摘Dear editor,The defending guidance problem for the target-attackerdefender(TAD)scenario is a challenge.The attacker(A)refers to the attacking missile,whose objective is to intercept the target aircraft(T),while the target aircraft is trying to avoid the attacker.The defender(D),namely the defensive missile,aims to intercept the attacker before a collision occurs between the attacker and the target. | Heng SHI Jihong ZHU Minchi KUANG Xiaming YUAN | 2021 | Science China(Information Sciences)2021，64，4： | 1 |
| 7 | Sexual Dimorphism and Female Reproductive Characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South China显示文摘We studied sexual dimorphism in body size and shape and female reproductive characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South China.In our sample the largest female and male were 61.1 and 55.2 mm snout-vent length(SVL),respectively.The mean SVL was larger in adult females(52.0 mm)than in adult males(48.3 mm).Juveniles were sexually dimorphic in head length but not in other examined morphological variables.Adult males were longer in head length and shorter in abdomen length and fore-limb length than adult females of the same SVL.Ontogenetic shifts in sexual dimorphism in body shape were evident,as revealed by the fact that morphological differences between the sexes were more pronounced in adults than in juveniles.Females produced a single litter of 3–6 offspring per season from early August to early September.Litter size,litter mass and offspring(neonate)mass were positively related to female SVL.Neonate mass was independent of relative fecundity.From the above findings we draw three main conclusions.First,females are the larger sex in T.hainanus,and sexual dimorphism in body shape is more pronounced in adults than in juveniles.Second,larger female T.hainanus produce more and larger offspring and thus heavier litters than smaller ones.Third,the offspring size-number trade-off does is not evident in T.hainanus. | Yu DU Xiaming ZHU Chixian LIN Yuntao YAO Xiang JI | 2024 | Asian Herpetological Research2024，15，1： | 0 |
| 8 | Robust autonomous landing of UAVs in non-cooperative environments based on comprehensive terrain understanding显示文摘Autonomous landing in non-cooperative environments is a key step toward full autonomy of unmanned aerial vehicles(UAVs).Existing studies have addressed this problem by finding a flat area of the ground as the landing place.However,all these methods have poor generalization ability and ignore the semantic feature of the terrain.In this paper,we propose a well-designed binocular-LiDAR sensor system and a robust terrain understanding model to overcome these deficiencies.Our model infers both morphologic and semantic features of the ground by simultaneously performing depth completion and semantic segmentation.Moreover,during the inference phase,it self-evaluates the accuracy of the predicted depth map and dynamically selects the LiDAR accumulation time to ensure accurate depth prediction,which greatly improves the robustness of the UAV in completely unknown environments.Through extensive experiments on our collected low-altitude aerial image dataset and real UAVs,we verified that our model effectively learned two tasks simultaneously and achieved better performance than existing depth estimation-based landing methods.Furthermore,the UAV can robustly select a safe landing site in several complex environments with about 98%accuracy. | Lyujie CHEN Yao XIAO Xiaming YUAN Yiding ZHANG Jihong ZHU | 2022 | Science China(Information Sciences)2022，65，11： | 0 |
| 9 | Next-generation Sequencing of MHC Class Ⅰ Genes Reveals Trans-species Polymorphism in Eutropis multifasciata and Other Species of Scincidae显示文摘The genes of the major histocompatibility complex(MHC) encode cell surface proteins that are essential for adaptive immunity. MHC genes show the most prominent genetic diversity in vertebrates,reflecting the adaptation of populations to their evolving environment, population survival and reproduction. In the present study, we used nextgeneration sequencing(NGS) to study the loci polymorphism of exon 3 of the MHC class Ⅰ genes in an ovoviviparous skink, the many-lined sun skink,Eutropis multifasciata and five other species of Scincidae, to quantify genetic variation. In addition,we genotyped the same MHC class Ⅰ genes of E.multifasciata using clone sequencing, to directly compare the effectiveness of both analytical techniques for MHC genotyping. NGS detected 20MHC class Ⅰ alleles in E. multifasciata, and 2 to 15 alleles in the other five Scincidae species. However,clone sequencing detected only 15 of those MHC class Ⅰ alleles in E. multifasciata. In addition, transspecies polymorphism of MHC class Ⅰ genes was studied by constructing a phylogenetic tree using the gene sequences obtained by NGS. Phylogenetic analysis revealed that MHC class I alleles were shared among different species of Scincidae with trans-species polymorphism, and did not exhibit specific genealogical inheritance. These results have important implications for understanding polymorphism interspecies diversity in the MHC genes of Scincidae, and the evolution of the MHC more broadly. | Shufang ZHANG Youfu LIN Yingzhi CHENG Haiyun YANG Xiaming ZHU Yu DU Longhui LIN Yanfu QU LianCHEN Hong LI | 2023 | Asian Herpetological Research2023，14，4： | 0 |
| 10 | Sexual Dimorphism,Female Reproductive Characteristics and Embryonic Thermosensitivity in the Tonkin Forest Skink(Sphenomorphus tonkinensis)from Hainan,South China显示文摘We collected 75 adult Tonkin forest skinks(Sphenomorphus tonkinensis) from Hainan, South China and incubated eggs at four constant temperatures ranging from 22 ℃ to 28 ℃ to study sexual dimorphism, female reproductive characteristics and embryonic thermosensitivity. The largest male was 53.4 mm snout-vent length(SVL), and the largest female was 54.3 mm SVL. The mean SVL was slightly greater in adult females(49.9 mm) than in adult males(48.8 mm), but the difference was not significant.Head length, head width, fore-limb length and hindlimb length were longer in adult males and abdomen length was longer in adult females after accounting for SVL. Accordingly, we conclude that S. tonkinensis is basically a sexually size-monomorphic species with sexual dimorphism in head size, abdomen(trunk)length and limb size. Females laid up to two clutches of 1–4 eggs each per egg-laying season from February to May. Egg mass, clutch size and clutch mass were independent of female SVL. Embryonic stages at laying varied from Dufaure and Hubert’s stage 30 to 31. With female SVL held constant, the negative correlation between egg mass and clutch size was not significant, suggesting that the offspring(egg) sizenumber trade-off between is not evident or eggs are well optimized for size in S. tonkinensis. None of the eggs at 28 ℃ hatched;hatching success was lower at 22 ℃ than at 24 ℃ or 26 ℃. The mean incubation length was 52.9 d at 22 ℃, 40.4 d at 24 ℃ and 33.6 d at 26 ℃. Hatchlings from eggs incubated at 22 ℃,24 ℃ and 26 ℃ did not differ morphologically at hatching, suggesting that temperatures within this range do not differentially affect hatchling morphology in S. tonkinensis. | Yu DU Chixian LIN Xiaming ZHU Yuntao YAO Xiang JI | 2023 | Asian Herpetological Research2023，14，4： | 0 |
| 11 | Correction to:Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘CORRECTION TO:PROTEIN CELL 2020,11(10):723–739 http://gffzzd3cc09b8251d45dfovo9xk9cbxwuc6qfb.ffgz.tsg.suse.edu.cn/10.1007/S13238-020-00768-W In the original publication the author’s name‘Dimitri Lavillete’is published incorrectly.The correct author name should be spelt as‘Dimitri Lavillette’is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit http://gffzzeb6f7f563f66445dhvo9xk9cbxwuc6qfb.ffgz.tsg.suse.edu.cn/licenses/by/4.0/. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillette Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2022 | Protein & Cell2022，13，10： | 0 |
| 12 | Lineage Diversification and Niche Evolution in the Chinese Cobra Naja atra (Elapidae)显示文摘Theroleof nicheevolution(niche conservatism or niche divergence)in lineage diversification is a poorly studied area.The Chinese cobra Naja atra(Elapidae)has diverged into three lineages:Lineage E in eastern China,Lineage S in southern China and Vietnam,and Lineage W in western China.However,whether the ecological niche is conserved or divergent among these three lineages is unknown.In the present study,we used ecological niche models in geographical space to study the ecological differences among lineages.We compared the niche overlap in environmental space to test niche conservatism and niche divergence.Our results showed that the three lineages of N.atra shared an ecological niche space between Lineages E and S/W,with the climatic niches of Lineages S and W representing a specialized fraction of the climatic niche of Lineage E.We speculated that the niche divergence between Lineages S and W was a consequence of geographical barriers limitinggeneflow.Ourstudyprovides evidence for lineage diversification associated with both geographical isolation and climatic niche evolution,suggesting that early niche divergence between Lineages S and W,followed by niche conservatism,causes niche divergence among lineages. | Xiaming ZHU Guanyan ZHU Shengnan ZHANG Yu DU Yanfu QU Longhui LIN Xiang JI | 2022 | Asian Herpetological Research2022，13，4： | 0 |
| 13 | Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Figure 1.Discovery of novel and potent DHODHi and their anti-influenza A virus activities.(A)The discovery and design of S312 and S416.The detailed descriptions of the discovery workflow are in Method.Binding analysis of S312(B)and S416(C).Thermodynamic analysis of the binding of S312 and S416 to DHODH was carried out at 25 C on a MicroCal iTC200 instrument.Kinetic analysis of the binding of S312 and S416 to DHODH was performed with a Biacore T200 instrument. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2021 | Protein & Cell2021，12，1： | 0 |
| 14 | Robust transition trajectory optimization for tail-sitter UAVs considering uncertainties显示文摘Dear editor,Transition flight is a challenge for tail-sitter unmanned aerial vehicles(UAVs)[1].Several different transition trajectories have been developed based on the trajectory optimization[2].Some typical examples are the minimum time transition[3],minimum energy transition[4],minimum altitude variation transition[5,6]and so on. | Yunjie YANG Xiangyang WANG Jihong ZHU Xiaming YUAN | 2023 | Science China(Information Sciences)2023，66，6： | 0 |
| 15 | Design of optimal trajectory transition controller for thrust-vectored V/STOL aircraft显示文摘Dear editor,In recent years,vertical and/or short take-off and landing(V/STOL)aircraft have attracted much attention because they combine the efficiency of fixed-wing vehicles with the flexibility of traditional vertical take-off and landing aircraft,such as a helicopter.Thrust-vectored V/STOL is often used for fighter jets(e.g.,F-35B).However,the design of an autonomous transition controller for trust-vectored V/STOL is challenging because of the nonlinearity and strong coupling in the transition process[1].In this study,the transition process refers to transiting from hover state to wing-borne flight or vice versa. | Zhiqiang CHENG Jihong ZHU Xiaming YUAN Xiangyang WANG | 2021 | Science China(Information Sciences)2021，64，3： | 0 |
| 16 | Attitude control of a novel tilt-wing UAV in hovering flight显示文摘Flexibility and endurance are the continuous pursuits of unmanned aerial vehicle(UAV)research.A fixed-wing UAV with vertical takeof and landing ability is ideal because it combines the advantages of long flight durations and freedom from runways[1].Therefore,tilt-wing and tilt-rotor UAVs have been developed.The former is more suitable for long-duration flight because the propeller slip-stream is less disturbed,and a longer wingspan can be designed[2]. | Jihong ZHU Yunjie YANG Xiangyang WANG Xiaming YUAN Xiao YANG | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
| 17 | Macroecological Patterns of Climatic Niche Breadth Variation in Lacertid Lizards显示文摘Measuring climatic niche position and breadth may help to determine where species can occur over space and time. Using GIS-based and phylogenetic comparative methods, we investigated global patterns of variation in climatic niche breadth in lacertid lizards to test the following three hypotheses about climatic niche widths. First, does a species' temperature or precipitation niche breadth relate to its temperature or precipitation niche position(the mean value of annual mean temperature or annual precipitation across sampled localities in the range of each species)? Second, are there trade-offs between a species' temperature niche breadth and precipitation niche breadth? Third, does a species' temperature or precipitation niche breadth relate to altitude or latitude? We expect that:(1) species distributed in cold regions are specialized for low-temperature environments(i.e. narrow niche breadth center around low temperatures);(2) a negative relationship between species niche breadth on temperature and precipitation axes according to the tradeoff hypothesis(i.e. species that tolerate a broad range of precipitation regimes cannot also tolerate a broad range of temperatures);(3) precipitation niche breadth decreases with altitude or latitude, whereas temperature climatic niche breadth increases with altitude or latitude. Based on the analytical results we found that:(1) temperature niche breadth and position are negatively related, while precipitation niche breadth and position are positively related;(2) there is no trade-off between temperature and precipitation niche breadths; and (3) temperature niche breadth and latitude/altitude are positively related, but precipitation niche breadth and latitude/altitude are not significantly related. Our results show many similarities with previous studies on climatic niche widths reported for amphibians and lizards, which provide further evidence that such macroecological patterns of variation in climatic niche breadths may be widespread. | Mengchao FANG Xiaming ZHU Yu DU Lin ZHANG Longhui LIN | 2019 | Asian Herpetological Research2019，10，1： | 0 |
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